A new potential approach to block HIV-1 replication via protein-protein interaction and strand-transfer inhibition

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 7, 2014, Pages 2269-2279

  Ferro, Stefania ^a   De Luca, Laura ^a   Lo Surdo, Giuseppa ^a   Morreale, Francesca ^a   Christ, Frauke ^b   Debyser, Zeger ^b   Gitto, Rosaria ^a   Chimirri, Alba ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Docking studies; Protein protein interaction; Strand transfer; Synthesis

Indexed keywords

3 ACETYL 1 (2,4 BIS TRIFLUOROMETHYLBENZYL) 5 CHLORO 1H INDOLE; 3 ACETYL 1 (2,4 BIS TRIFLUOROMETHYLBENZYL) 5 FLUORO 1H INDOLE; 3 ACETYL 1 (2,4 BIS TRIFLUOROMETHYLBENZYL) 5 METHOXY 1H INDOLE; 3 ACETYL 1 (2,4,6 TRIMETHYLBENZYL) 5 CHLORO 1H INDOLE; 3 ACETYL 1 (2,4,6 TRIMETHYLBENZYL) 5 FLUORO 1H INDOLE; 3 ACETYL 1 (2,4,6 TRIMETHYLBENZYL) 5 METHOXY 1H INDOLE; 3 ACETYL 1 (3,5 DIMETHYLBENZYL) 5 CHLORO 1H INDOLE; 3 ACETYL 1 (3,5 DIMETHYLBENZYL) 5 FLUORO 1H INDOLE; 3 ACETYL 1 (3,5 DIMETHYLBENZYL) 5 METHOXY 1H INDOLE; 3 ACETYL 1 (4 PHENYLBENZYL) 5 CHLORO 1H INDOLE; 3 ACETYL 1 (4 PHENYLBENZYL) 5 FLUORO 1H INDOLE; 3 ACETYL 1 (4 PHENYLBENZYL) 5 METHOXY 1H INDOLE; 3 ACETYL 1 (4 TERT BUTYLBENZYL) 5 CHLORO 1H INDOLE; 3 ACETYL 1 (4 TERT BUTYLBENZYL) 5 FLUORO 1H INDOLE; 3 ACETYL 1 (4 TERT BUTYLBENZYL) 5 METHOXY 1H INDOLE; 3 ACETYL 1 (4 TRIFLUOROMETHYLBENZYL) 5 CHLORO 1H INDOLE; 3 ACETYL 1 (4 TRIFLUOROMETHYLBENZYL) 5 FLUORO 1H INDOLE; 3 ACETYL 1 (4 TRIFLUOROMETHYLBENZYL) 5 METHOXY 1H INDOLE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ETHYL 4 [1 (2,4,6 TRIMETHYLBENZYL) 5 CHLORO 1H INDOL 3 YL] 2 HYDROXY 4 OXOBUT 2 ENOATE; ETHYL 4 [1 (3,5 DIMETHYLBENZYL) 5 CHLORO 1H INDOL 3 YL] 2 HYDROXY 4 OXOBUT 2 ENOATE; ETHYL 4 [1 (4 PHENYLBENZYL) 5 CHLORO 1H INDOL 3 YL] 2 HYDROXY 4 OXOBUT 2 ENOATE; ETHYL 4 [1 (4 PHENYLBENZYL) 5 FLUORO 1H INDOL 3 YL] 2 HYDROXY 4 OXOBUT 2 ENOATE; ETHYL 4 [1 (4 TERT BUTYLBENZYL) 5 CHLORO 1H INDOL 3 YL] 2 HYDROXY 4 OXOBUT 2 ENOATE; ETHYL 4 [1 [2,4 BIS(TRIFLUOROMETHYL)BENZYL] 5 CHLORO 1H INDOL 3 YL] 2 HYDROXY 4 OXOBUT 2 ENOATE; ETHYL 4 [1 [4 (TRIFLUOROMETHYL)BENZYL] 5 CHLORO 1H INDOL 3 YL] 2 HYDROXY 4 OXOBUT 2 ENOATE; INDOLE DERIVATIVE; LENS EPITHELIUM DERIVED GROWTH FACTOR; PROTEIN P75; UNCLASSIFIED DRUG; UNINDEXED DRUG; BENZYL DERIVATIVE; INTEGRASE; INTEGRASE INHIBITOR; LENS EPITHELIUM-DERIVED GROWTH FACTOR; PROTEIN BINDING; SIGNAL PEPTIDE;

ANTIVIRAL SUSCEPTIBILITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; LIFE CYCLE; LYMPHOCYTE; MOLECULAR DOCKING; NONHUMAN; PROTEIN PROTEIN INTERACTION; STRAND TRANSFER INHIBITION; STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION; VIRUS REPLICATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; MICROBIAL SENSITIVITY TEST; PHYSIOLOGY; SYNTHESIS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ANTI-HIV AGENTS; BENZYL COMPOUNDS; DOSE-RESPONSE RELATIONSHIP, DRUG; HIV INTEGRASE; HIV-1; INDOLES; INTEGRASE INHIBITORS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

EID: 84897424738     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.02.012     Document Type: Article

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