Small molecules targeting the interaction between HIV-1 integrase and LEDGF/p75 cofactor

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 21, 2010, Pages 7515-7521

  De Luca, Laura ^a   Ferro, Stefania ^a   Gitto, Rosaria ^a   Barreca, Maria Letizia ^b   Agnello, Stefano ^a   Christ, Frauke ^c   Debyser, Zeger ^c   Chimirri, Alba ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF PERUGIA   (Italy)

^c UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

GRID; HIV 1 integrase; LEDGF p75; Molecular docking; Protein protein interactions

Indexed keywords

INTEGRASE; INTEGRASE INHIBITOR; LENS EPITHELIUM DERIVED GROWTH FACTOR; PROTEIN P75;

ARTICLE; CHEMICAL MODIFICATION; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROPHOBICITY; MOLECULAR DOCKING; PROTEIN PROTEIN INTERACTION;

BINDING SITES; COMPUTER SIMULATION; DRUG DESIGN; HIV INTEGRASE; HIV-1; HUMANS; INDOLES; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; PROTEIN BINDING;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 77958015795     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.08.051     Document Type: Article

References (19)

1. L. De Luca, M.L. Barreca, S. Ferro, F. Christ, N. Iraci, R. Gitto, A.M. Monforte, Z. Debyser, and A. Chimirri ChemMedChem 4 2009 1311
2. E. De Clercq Med. Res. Rev. 2009
3. M.L. Barreca, N. Iraci, L. De Luca, and A. Chimirri ChemMedChem 4 2009 1446
4. G.N. Nikolenko, K.A. Delviks-Frankenberry, and V.K. Pathak J. Virol. 84 2010 5238
5. R. Broglia, Y. Levy, and G. Tiana Curr. Opin. Struct. Biol. 18 2008 60
6. J.A. Garcia-Rivera, M.T. Bueno, E. Morales, J.R. Kugelman, D.F. Rodriguez, and M. Llano J. Virol. 84 2010 740
7. K. Busschots, A. Voet, M. De Maeyer, J.C. Rain, S. Emiliani, R. Benarous, L. Desender, Z. Debyser, and F. Christ J. Mol. Biol. 365 2007 1480
8. W.C. Greene, Z. Debyser, Y. Ikeda, E.O. Freed, E. Stephens, W. Yonemoto, R.W. Buckheit, J.A. Este, and T. Cihlar Antiviral. Res. 80 2008 251
9. S. Hare, M.C. Shun, S.S. Gupta, E. Valkov, A. Engelman, and P. Cherepanov PLoS Pathog. 5 2009 e1000259
10. L. Du, Y. Zhao, J. Chen, L. Yang, Y. Zheng, Y. Tang, X. Shen, and H. Jiang Biochem. Biophys. Res. Commun. 375 2008 139
11. P. Cherepanov, A.L. Ambrosio, S. Rahman, T. Ellenberger, and A. Engelman Proc. Natl. Acad. Sci. U.S.A. 102 2005 17308
12. L.Q. Al-Mawsawi, F. Christ, R. Dayam, Z. Debyser, and N. Neamati FEBS Lett. 582 2008 1425
13. F. Christ, A. Voet, A. Marchand, S. Nicolet, B.A. Desimmie, D. Marchand, D. Bardiot, N.J. Van der Veken, B. Van Remoortel, S.V. Strelkov, M. De Maeyer, P. Chaltin, and Z. Debyser Nat. Chem. Biol. 6 2010 442
14. Grid 22, Molecular Discovery Ltd, Pinner, Middlesex, UK.
15. sybyl, Version 7.1; Tripos Inc.: 1699 South Hanley Road, Suite 303, St. Louis, MO 63144, 2005.
16. G. Jones, P. Willett, R.C. Glen, A.R. Leach, and R. Taylor J. Mol. Biol. 267 1997 727
17. S. Ferro, M.L. Barreca, L. De Luca, A. Rao, A.M. Monforte, Z. Debyser, M. Witvrouw, and A. Chimirri Arch. Pharm. (Weinheim) 340 2007 292
18. S. Ferro, S. De Grazia, L. De Luca, M.L. Barreca, Z. Debyser, and A. Chimirri Heterocycles 78 2009 947
19. The PyMOL Molecular Graphics System, W. L. DeLano, DeLano Scientific LLC, San Carlos, CA, USA, 2008; http://www.pymol.org.