New 4-[(1-benzyl-1H-indol-3-yl)carbonyl]-3-hydroxyfuran-2(5H)-ones, β-diketo acid analogs as HIV-1 integrase inhibitors

Archiv der Pharmazie

Volumn 340, Issue 6, 2007, Pages 292-298

  Ferro, Stefania ^a   Barreca, Maria Letizia ^a   De Luca, Laura ^a   Rao, Angela ^a   Monforte, Anna Maria ^a   Debyser, Zeger ^b   Witvrouw, Myriam ^b   Chimirri, Alba ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

HIV 1 IN inhibitors; Hydroxyfuran 2(5H) ones; Microwave assisted synthesis; Parallel synthesis; Pharmacophore model

Indexed keywords

4 (1 BENZYL 1H INDOL 3 OYL) 3 HYDROXYFURAN 2(5H) ONE; 4 (1 BENZYL 5 CHLORO 1H INDOL 3 OYL) 3 HYDROXYFURAN 2(5H) ONE; 4 (1 BENZYL 5 METHOXY 1H INDOL 3 OYL) 3 HYDROXYFURAN 2(5H) ONE; 4 (4 CHLOROBENZOYL) 3 HYDROXY 5 PHENYL FURAN 2(5H) ONE; 4 [(1 BENZYL 1H INDOL 3 YL)CARBONYL] 3 HYDROXYFURAN 2(5H) ONE; 4 [1 (4 CYANOBENZYL) 5 METHOXY 1H INDOL 3 OYL] 3 HYDROXYFURAN 2(5H) ONE; 4 [1 (4 CYANOBENZYL) 5 METHOXY 1H INDOL 3 YL] 2 HYDROXY 4 OXOBUT 2 ENOIC ACID; 4 [1 (4 FLUOROBENZYL) 1H INDOL 3 OYL] 3 HYDROXYFURAN 2(5H) ONE; 4 [1 (4 FLUOROBENZYL) 5 CHLORO 1H INDOL 3 OYL] 3 HYDROXYFURAN 2(5H) ONE; 4 [1 (4 FLUOROBENZYL) 5 METHOXY 1H INDOL 3 OYL] 3 HYDROXYFURAN 2(5H) ONE; 4 [5 METHOXY 1 [4 (TRIFLUOROMETHYL)BENZYL] IH INDOL 3 OYL] 3 HYDROXYDURAN 2(5H) ONE; HIV 1 INTEGRASE INHIBITOR; INTEGRASE; INTEGRASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG SYNTHESIS; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; VIRUS REPLICATION;

4-BUTYROLACTONE; CELL LINE; CELL SURVIVAL; DRUG DESIGN; ENZYME-LINKED IMMUNOSORBENT ASSAY; HIV; HIV INTEGRASE INHIBITORS; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; KETO ACIDS; LYMPHOCYTES; MICROWAVES; MODELS, MOLECULAR; MOLECULAR STRUCTURE;

EID: 34250802548     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.200700066     Document Type: Article

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