Aging mesenchymal stem cells fail to protect because of impaired migration and antiinflammatory response

American Journal of Respiratory and Critical Care Medicine

Volumn 189, Issue 7, 2014, Pages 787-798

  Bustos, Martha L ^a   Huleihel, Luai ^a,b   Kapetanaki, Maria G ^a   Lino Cardenas, Christian L ^a   Mroz, Lyle ^a   Ellis, Bryon M ^a   McVerry, Bryan J ^a   Richards, Thomas J ^a   Kaminski, Naftali ^a   Cerdenes, Nayra ^a   Mora, Ana L ^a   Rojas, Mauricio ^a,c  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^c MCGOWAN INSTITUTE FOR REGENERATIVE MEDICINE   (United States)

Author keywords

Aging; ARDS; Lung injury; Lung repair; Mesenchymal stem cells

Indexed keywords

CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CX3CR1; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR5; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR 1; GELATINASE B; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; KERATINOCYTE GROWTH FACTOR; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; MARCKS PROTEIN; STRESS ACTIVATED PROTEIN KINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2;

ACUTE LUNG INJURY; ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL AGING; CELL MIGRATION; CELL PROTECTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE PREDISPOSITION; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPERIMENTAL ENDOTOXEMIA; FEMALE; GENE EXPRESSION; HEMATOPOIETIC STEM CELL; HUMAN; INFLAMMATION; MESENCHYMAL STEM CELL; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SENESCENCE;

ACUTE LUNG INJURY; AGING; ANIMALS; BIOLOGICAL MARKERS; BONE MARROW CELLS; CELL MOVEMENT; CHEMOKINES; CYTOKINES; DOWN-REGULATION; FEMALE; MESENCHYMAL STROMAL CELLS; MICE; MICE, INBRED C57BL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; WOUND HEALING;

EID: 84897403227     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201306-1043OC     Document Type: Article

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