Overexpression of CREMa in T Cells aggravates lipopolysaccharide-induced acute lung injury

Journal of Immunology

Volumn 191, Issue 3, 2013, Pages 1316-1323

  Verjans, Eva ^a   Ohl, Kim ^a   Yu, Yin ^a   Lippe, Ralph ^b   Schippers, Angela ^a   Wiener, Anastasia ^a   Roth, Johannes ^b   Wagner, Norbert ^a   Uhlig, Stefan ^a   Tenbrock, Klaus ^a   Martin, Christian ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT MODULATOR; CYCLIC AMP RESPONSIVE ELEMENT MODULATOR ALPHA; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 6; RAG 1 PROTEIN; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; HOMEODOMAIN PROTEIN; LIPOPOLYSACCHARIDE; RAG-1 PROTEIN;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE COURSE; GENE OVEREXPRESSION; HISTOPATHOLOGY; INFLAMMATION; LUNG FUNCTION; LUNG INJURY; LUNG LAVAGE; LYMPHOCYTE COUNT; MALE; MOUSE; NEUTROPHIL COUNT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE; TRANSGENIC MOUSE; UPREGULATION; ACUTE LUNG INJURY; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CHEMICALLY INDUCED DISORDER; CYTOLOGY; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; NEUTROPHIL; SYSTEMIC LUPUS ERYTHEMATOSUS; TRANSPLANTATION;

ACUTE LUNG INJURY; ADOPTIVE TRANSFER; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CD4-POSITIVE T-LYMPHOCYTES; CYCLIC AMP RESPONSE ELEMENT MODULATOR; FORKHEAD TRANSCRIPTION FACTORS; HOMEODOMAIN PROTEINS; INFLAMMATION; INTERLEUKIN-17; INTERLEUKIN-2; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; LUPUS ERYTHEMATOSUS, SYSTEMIC; LYMPHOCYTE COUNT; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUTROPHILS; T-LYMPHOCYTES, REGULATORY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84880662176     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1203147     Document Type: Article

References (42)

1. Rubenfeld, G. D., E. Caldwell, E. Peabody, J. Weaver, D. P. Martin, M. Neff, E. J. Stern, and L. D. Hudson. 2005. Incidence and outcomes of acute lung injury. N. Engl. J. Med. 353: 1685-1693.
2. Vadász, I., and J. I. Sznajder. 2011. Update in acute lung injury and critical care 2010. Am. J. Respir. Crit. Care Med. 183: 1147-1152.
3. Tsushima, K., L. S. King, N. R. Aggarwal, A. De Gorordo, F. R. D'Alessio, and K. Kubo. 2009. Acute lung injury review. Intern. Med. 48: 621-630.
4. Togbe, D., S. Schnyder-Candrian, B. Schnyder, I. Couillin, I. Maillet, F. Bihl, D. Malo, B. Ryffel, and V. F. Quesniaux. 2006. TLR4 gene dosage contributes to endotoxin-induced acute respiratory inflammation. J. Leukoc. Biol. 80: 451-457.
5. Valles, P. G., S. Melechuck, A. Gonzalez, W. Manucha, V. Bocanegra, and R. Valles. 2012. Toll-like receptor 4 expression on circulating leucocytes in hemolytic uremic syndrome. Pediatr. Nephrol. 27: 407-415.
6. Reiss, L. K., U. Uhlig, and S. Uhlig. 2012. Models and mechanisms of acute lung injury caused by direct insults. Eur. J. Cell Biol. 91: 590-601.
7. D'Alessio, F. R., K. Tsushima, N. R. Aggarwal, E. E. West, M. H. Willett, M. F. Britos, M. R. Pipeling, R. G. Brower, R. M. Tuder, J. F. McDyer, and L. S. King. 2009. CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury. J. Clin. Invest. 119: 2898-2913.
8. Nakajima, T., C. J. Suarez, K. W. Lin, K. Y. Jen, J. E. Schnitzer, S. S. Makani, N. Parker, D. L. Perkins, and P. W. Finn. 2010. T cell pathways involving CTLA4 contribute to a model of acute lung injury. J. Immunol. 184: 5835-5841.
9. Hilberath, J. N., T. Carlo, M. A. Pfeffer, R. H. Croze, F. Hastrup, and B. D. Levy. 2011. Resolution of Toll-like receptor 4-mediated acute lung injury is linked to eicosanoids and suppressor of cytokine signaling 3. FASEB J. 25: 1827-1835.
10. Li, J., K. W. Lin, F. Murray, T. Nakajima, Y. Zhao, D. L. Perkins, and P. W. Finn. 2013. Regulation of cytotoxic T lymphocyte antigen 4 by cyclic AMP. Am. J. Respir. Cell Mol. Biol. 48: 63-70.
11. Moore, A. R., and D. A. Willoughby. 1995. The role of cAMP regulation in controlling inflammation. Clin. Exp. Immunol. 101: 387-389.
12. Zhang, Y., Y. Luo, Q. Zhai, L. Ma, and M. E. Dorf. 2003. Negative role of cAMP-dependent protein kinase A in RANTES-mediated transcription of proinflammatory mediators through Raf. FASEB J. 17: 734-736.
13. De Cesare, D., and P. Sassone-Corsi. 2000. Transcriptional regulation by cyclic AMP-responsive factors. Prog. Nucleic Acid Res. Mol. Biol. 64: 343-369.
14. Sassone-Corsi, P. 1998. Coupling gene expression to cAMP signalling: role of CREB and CREM. Int. J. Biochem. Cell Biol. 30: 27-38.
15. Tenbrock, K., Y. T. Juang, M. Tolnay, and G. C. Tsokos. 2003. The cyclic adenosine 59-monophosphate response element modulator suppresses IL-2 production in stimulated T cells by a chromatin-dependent mechanism. J. Immunol. 170: 2971-2976.
16. Lippe, R., K. Ohl, G. Varga, T. Rauen, J. C. Crispin, Y. T. Juang, S. Kuerten, F. Tacke, M. Wolf, K. Roebrock, et al. 2012. CREMa overexpression decreases IL-2 production, induces a T(H)17 phenotype and accelerates autoimmunity. J. Mol. Cell Biol. 4: 121-123.
17. Nicklin, A., and R. W. Byard. 2011. Lethal manifestations of systemic lupus erythematosus in a forensic context. J. Forensic Sci. 56: 423-428.
18. Hedrich, C. M., T. Rauen, and G. C. Tsokos. 2011. cAMP-responsive element modulator (CREM)a protein signaling mediates epigenetic remodeling of the human interleukin-2 gene: implications in systemic lupus erythematosus. J. Biol. Chem. 286: 43429-43436.
19. Zhumabekov, T., P. Corbella, M. Tolaini, and D. Kioussis. 1995. Improved version of a human CD2 minigene based vector for T cell-specific expression in transgenic mice. J. Immunol. Methods 185: 133-140.
20. Ahlmann, M., G. Varga, K. Sturm, R. Lippe, K. Benedyk, D. Viemann, T. Scholzen, J. Ehrchen, F. U. Müller, M. Seidl, et al. 2009. The cyclic AMP response element modulator alpha suppresses CD86 expression and APC function. J. Immunol. 182: 4167-4174.
21. Grommes, J., and O. Soehnlein. 2011. Contribution of neutrophils to acute lung injury. Mol. Med. 17: 293-307.
22. Togbe, D., S. Schnyder-Candrian, B. Schnyder, E. Doz, N. Noulin, L. Janot, T. Secher, P. Gasse, C. Lima, F. R. Coelho, et al. 2007. Toll-like receptor and tumour necrosis factor dependent endotoxin-induced acute lung injury. Int. J. Exp. Pathol. 88: 387-391.
23. Venet, F., C. S. Chung, X. Huang, J. Lomas-Neira, Y. Chen, and A. Ayala. 2009. Lymphocytes in the development of lung inflammation: a role for regulatory CD4+ T cells in indirect pulmonary lung injury. J. Immunol. 183: 3472-3480.
24. Morris, P. E., J. Glass, R. Cross, and D. A. Cohen. 1997. Role of T-lymphocytes in the resolution of endotoxin-induced lung injury. Inflammation 21: 269-278.
25. Clark, J. G., D. K. Madtes, R. C. Hackman, W. Chen, M. A. Cheever, and P. J. Martin. 1998. Lung injury induced by alloreactive Th1 cells is characterized by host-derived mononuclear cell inflammation and activation of alveolar macrophages. J. Immunol. 161: 1913-1920.
26. Pietropaoli, A., and S. N. Georas. 2009. Resolving lung injury: a new role for Tregs in controlling the innate immune response. J. Clin. Invest. 119: 2891-2894.
27. Aggarwal, N. R., F. R. D'Alessio, K. Tsushima, V. K. Sidhaye, C. Cheadle, D. N. Grigoryev, K. C. Barnes, and L. S. King. 2010. Regulatory T cell-mediated resolution of lung injury: identification of potential target genes via expression profiling. Physiol. Genomics 41: 109-119.
28. Price, A. E., R. L. Reinhardt, H. E. Liang, and R. M. Locksley. 2012. Marking and quantifying IL-17A-producing cells in vivo. PLoS One 7: e39750.
29. Ferretti, S., O. Bonneau, G. R. Dubois, C. E. Jones, and A. Trifilieff. 2003. IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharideinduced airway neutrophilia: IL-15 as a possible trigger. J. Immunol. 170: 2106-2112.
30. Dumoutier, L., M. de Heusch, C. Orabona, N. Satoh-Takayama, G. Eberl, J. C. Sirard, J. P. Di Santo, and J. C. Renauld. 2011. IL-22 is produced by gCindependent CD25+ CCR6+ innate murine spleen cells upon inflammatory stimuli and contributes to LPS-induced lethality. Eur. J. Immunol. 41: 1075-1085.
31. Kaneko, K., M. Matsuda, Y. Sekijima, W. Hosoda, T. Gono, K. Hoshi, H. Shimojo, and S. Ikeda. 2005. Acute respiratory distress syndrome due to systemic lupus erythematosus with hemophagocytic syndrome: an autopsy report. Clin. Rheumatol. 24: 158-161.
32. Kim, W. U., S. I. Kim, W. H. Yoo, J. H. Park, J. K. Min, S. C. Kim, Y. S. Hong, S. H. Lee, S. H. Park, C. S. Cho, and H. Y. Kim. 1999. Adult respiratory distress syndrome in systemic lupus erythematosus: causes and prognostic factors: a single center, retrospective study. Lupus 8: 552-557.
33. Leslie, K. O., S. Trahan, and J. Gruden. 2007. Pulmonary pathology of the rheumatic diseases. Semin. Respir. Crit. Care Med. 28: 369-378.
34. Tenbrock, K., Y. T. Juang, M. F. Gourley, M. P. Nambiar, and G. C. Tsokos. 2002. Antisense cyclic adenosine 59-monophosphate response element modulator up-regulates IL-2 in T cells from patients with systemic lupus erythematosus. J. Immunol. 169: 4147-4152.
35. Liu, B., and R. L. Whisler. 1998. Transcriptional activation and redox regulation of the tumor necrosis factor-Alpha promoter in human T cells: role of the CRE/kappa3 promoter region. J. Interferon Cytokine Res. 18: 999-1007.
36. Dendorfer, U., P. Oettgen, and T. A. Libermann. 1994. Multiple regulatory elements in the interleukin-6 gene mediate induction by prostaglandins, cyclic AMP, and lipopolysaccharide. Mol. Cell. Biol. 14: 4443-4454.
37. Lo Re, S., L. Dumoutier, I. Couillin, C. Van Vyve, Y. Yakoub, F. Uwambayinema, B. Marien, S. van den Brǔle, J. Van Snick, C. Uyttenhove, et al. 2010. IL-17A-producing gammadelta T and Th17 lymphocytes mediate lung inflammation but not fibrosis in experimental silicosis. J. Immunol. 184: 6367-6377.
38. Iwakura, Y., S. Nakae, S. Saijo, and H. Ishigame. 2008. The roles of IL-17A in inflammatory immune responses and host defense against pathogens. Immunol. Rev. 226: 57-79.
39. Girtsman, T., Z. Jaffar, M. Ferrini, P. Shaw, and K. Roberts. 2010. Natural Foxp3 (+) regulatory T cells inhibit Th2 polarization but are biased toward suppression of Th17-driven lung inflammation. J. Leukoc. Biol. 88: 537-546.
40. Fehérvari, Z., and S. Sakaguchi. 2004. CD4+ Tregs and immune control. J. Clin. Invest. 114: 1209-1217.
41. Lu, L. F., and A. Rudensky. 2009. Molecular orchestration of differentiation and function of regulatory T cells. Genes Dev. 23: 1270-1282.
42. Shevach, E. M. 2011. Biological functions of regulatory T cells. Adv. Immunol. 112: 137-176.