7-Ketocholesterol inhibits isocitrate dehydrogenase 2 expression and impairs endothelial function via microRNA-144

Free Radical Biology and Medicine

Volumn 71, Issue , 2014, Pages 1-15

  Fu, Xiaodong ^a   Huang, Xiuwei ^b   Li, Ping ^a   Chen, Weiyu ^a   Xia, Min ^b  

^a GUANGZHOU MEDICAL UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

7 KC; Endothelial function; IDH2; miRNA; Oxysterol

Indexed keywords

7 OXOCHOLESTEROL; GLUTATHIONE; ISOCITRATE DEHYDROGENASE 2; MESSENGER RNA; MICRORNA; MICRORNA 144; NITRIC OXIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RNA ANTIBODY; UNCLASSIFIED DRUG; 3' UNTRANSLATED REGION; 7-KETOCHOLESTEROL; ARGONAUTE PROTEIN; CHOLESTEROL DERIVATIVE; EIF2C1 PROTEIN, HUMAN; EIF2C2 PROTEIN, HUMAN; INITIATION FACTOR; ISOCITRATE DEHYDROGENASE; ISOCITRATE DEHYDROGENASE 2, HUMAN; MIRN144 MICRORNA, HUMAN; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

3' UNTRANSLATED REGION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOAVAILABILITY; BLOOD VESSEL REACTIVITY; COMPUTER MODEL; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME ACTIVITY; GENE OVEREXPRESSION; HOMEOSTASIS; HUMAN; HUMAN AORTIC ENDOTHELIAL CELL; HUMAN CELL; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; INFUSION; MALE; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; AORTA; ATHEROSCLEROSIS; BOVINAE; C57BL MOUSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; OXIDATION REDUCTION REACTION; PATHOLOGY; SIGNAL TRANSDUCTION;

3' UNTRANSLATED REGIONS; ANIMALS; AORTA; ARGONAUTE PROTEINS; ATHEROSCLEROSIS; CATTLE; ENDOTHELIAL CELLS; EUKARYOTIC INITIATION FACTORS; GENE EXPRESSION REGULATION; GLUTATHIONE; HUMANS; ISOCITRATE DEHYDROGENASE; KETOCHOLESTEROLS; MALE; MICE; MICE, INBRED C57BL; MICRORNAS; MITOCHONDRIA; NADP; OXIDATION-REDUCTION; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 84897400095     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.03.010     Document Type: Article

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