Oxidized cholesterol in the diet accelerates the development of atherosclerosis in LDL receptor- and apolipoprotein E-deficient mice

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 20, Issue 3, 2000, Pages 708-714

  Staprans, Ilona ^a   Pan, Xian Mang ^b   Rapp, Joseph H ^b   Grunfeld, Carl ^b   Feingold, Kenneth R ^b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b NONE

Author keywords

Atherosclerosis; Cardiovascular disease; Oxidized cholesterol; Oxidized lipid diet

Indexed keywords

APOLIPOPROTEIN E; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; TRIACYLGLYCEROL;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; CHOLESTEROL INTAKE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HYPERLIPOPROTEINEMIA TYPE 3; HYPOBETALIPOPROTEINEMIA; MALE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DEFECT; RISK FACTOR;

EID: 0034101443     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.20.3.708     Document Type: Article

References (56)

1. Steinberg D. Oxidative modification of LDL and atherogenesis. Circulation. 1997;95:1062-1071.
2. Chisolm GM, Penn MS. Oxidized lipoproteins and atherosclerosis. In: Fuster V, Ross R, Topol EJ, eds. Atherosclerosis and Coronary Heart Disease. New York, NY: Raven Press; 1996:129-149.
3. Carew TE, Schwenke DC, Steinberg D. Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that anti-oxidants in vivo can selectively inhibit LDL degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit. Proc Natl Acad Sci U S A. 1987;84:7725-7729.
4. Kita T, Nagano Y, Yokode M, Ishii K, Kume N, Ooshima A, Yoshida H, Kawai C. Probucol prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbit, an animal model for familial hypercholesterolemia. Proc Natl Acad Sci U S A. 1987;84:5928-5931.
5. Parker AR, Sabrah T, Cap M, Gill BT. Relation of vascular oxidative stress, α-tocopherol, and hypercholesterolemia to early atherosclerosis in hamsters. Arterioscler Thromb Vasc Biol. 1995;15:349-358.
6. Palinski W, Rosenfeld ME, Yla-Herttuala S, Gurtner GC, Socher SS, Butler SW, Parthasarathy S, Carew TE, Steinberg D, Witztum JL. Low density lipoprotein undergoes oxidative modification in vivo. Proc Natl Acad Sci U S A. 1989;86:1372-1376.
7. Yla-Herttuala S, Palinski W, Rosenfeld ME, Parthasarathy S, Carew TE, Butler S, Witztum JL, Steinberg D. Evidence for the presence of oxidatively modified LDL in atherosclerotic lesions of rabbit and man. J Clin Invest. 1989;84:1086-1095.
8. Staprans I, Pan X-M, Miller M, Rapp JH. Effect of dietary lipid peroxides on metabolism of serum chylomicrons in rats. Am J Physiol. 1993;264: G561-G568.
9. Staprans I, Rapp JH, Pan X-M, Feingold KR. The effect of oxidized lipid in the diet on serum lipoprotein peroxides in control and diabetic rats. J Clin Invest. 1993;92:638-643.
10. Staprans I, Rapp JH, Pan X-M, Feingold KR. Oxidized lipids in the diet are incorporated by the liver into VLDL in rats. J Lipid Res. 1996;37: 420-430.
11. Aw TY, Williams MW, Gray L. Absorption and lymphatic transport of peroxidized lipids by rat small intestine in vivo: role of mucosal GSH. Am J Physiol. 1992;262:G99-G106.
12. Grootveld M, Atherton MD, Sheerin AN, Hawkes J, Blake DR, Richens TE, Silwood CJ, Lynch E, Claxson AW. In vivo absorption, metabolism, and urinary excretion of α,β-unsaturated aldehydes in experimental animals: relevance to the development of cardiovascular diseases by the dietary ingestion of thermally stressed polyunsaturate-rich culinary oils. J Clin Invest. 1998;101:1210-1218.
13. Staprans I, Rapp JH, Pan XM, Kim KY, Feingold KR. Oxidized lipids in the diet are a source of oxidized lipid in chylomicrons of human serum. Arterioscler Thromb. 1994;14:1900-1905.
14. Staprans I, Hardman DA, Pan X-M, Feingold KR. Effect of oxidized lipids in the diet on oxidized lipid levels in serum chylomicrons of diabetic patients. Diabetes Care. 1999;22:300-306.
15. Smith LL, Johnson BH. Biological activities of oxysterols. Free Radic Biol Med. 1989;7:285-332.
16. Addis PB, Park PW, Guardiola F, Codony R. Analysis and health effects of cholesterol oxides. In: McDonald RE, Min DB, eds. Food Lipids and Health. New York, NY: Marcel Dekker Inc. 1996;9:199-240.
17. Peng SK, Phillips GA, Xia G-Z, Morin RJ. Transport of cholesterol autoxidation products in rabbit lipoproteins. Atherosclerosis. 1987; 64:1-6.
18. Vine DF, Mamo JCL, Beilin LJ, Mon TA, Croft KD. Dietary oxysterols are incorporated in plasma triglyceride-rich lipoproteins, increase their susceptibility to oxidation and increase aortic cholesterol concentration in rabbits. J Lipid Res. 1998;39:1995-2004.
19. Bascoul J, Domerque N, Mourot J, Derby G, Crastes de Paulet A. Intestinal absorption and fecal excretion of 5,6α-epoxy-5α-cholesta-3β-ol by male Wistar rat. Lipids. 1986;21:744-747.
20. Osada K, Sasaki E, Sugano M. Lymphatic absorption of oxidized cholesterol in rats. Lipids. 1994;29:555-559.
21. Emanuel HA, Hassel CA, Addis PB, Bergmann SD, Zavoral JH. Plasma cholesterol oxidation products (oxysterols) in human subjects fed a meal rich in oxysterols. J Food Sci. 1991;56:843-847.
22. Staprans I, Rapp JH, Pan X-M, Hardman DA, Feingold KR. Oxidized lipids in the diet accelerate lipid deposition in the arteries of cholesterol-fed rabbits. Arterioscler Thromb Vasc Biol. 1996;16:533-538.
23. Staprans I, Pan X-M, Rapp JH, Feingold KR. Oxidized cholesterol in the diet accelerates the development of aortic atherosclerosis in cholesterol-fed rabbits. Arterioscler Thromb Vasc Biol. 1998;18:977-983.
24. Mahley RW. Alterations in plasma lipoproteins induced by cholesterol feeding in animals including man. In: Dietschy JM, Gotto AM, Ontko JA, eds. Disturbances in Lipid and Lipoprotein Metabolism. Bethesda, Md: American Physiological Society; 1978:181-197.
25. Breslow JL, Plump A, Dammerman M. New mouse models of lipoprotein disorders and atherosclerosis. In: Fuster V, Ross R, Topol EJ, eds. Atherosclerosis and Coronary Artery Disease. Philadelphia, Pa: Lippincott-Raven Publishers; 1996:363-377.
26. Ishibashi S, Goldstein JL, Brown MS, Herz J, Burns DK. Massive xanthomatosis and atherosclerosis in cholesterol-fed LDL receptor-negative mice. J Clin Invest. 1994;93:1885-1893.
27. Zhang SH, Reddick RL, Piedrahita JA, Maeda N. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science. 1992;258:468-471.
28. Tangirala RK, Rubin EM, Palinski W. Quantitation of atherosclerosis in murine models: correlation between lesions in the aortic origin and in the entire aorta, and differences in the extent of lesions between sexes in LDL receptor-deficient and apolipoprotein E-deficient mice. J Lipid Res. 1995; 36:2320-2328.
29. Hughes H, Mathews B, Lenz ML, Guyton JR. Cytotoxicity of oxidized LDL to porcine aortic smooth muscle cells is associated with oxysterols 7-ketocholesterol and 7-hydroxycholesterol. Arterioscler Thromb. 1994; 14:1177-1185.
30. Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem. 1957; 226:497-509.
31. Addis PB, Emanuel HA, Bergmann SD, Zavoral JH, Capillary GC quantification of cholesterol oxidation products in plasma lipoproteins of fasted humans. Free Radic Biol Med. 1989;7:179-182.
32. Addis PB, Warner GJ, Hassel CA. Dietary lipid oxidation products: are they atherogenic? Can J Cardiol. 1993;9(suppl B):6B-10B.
33. Addis PB. Occurrence of lipid oxidation products in foods. Food Chem Toxicol. 1986;24:1021-1030.
34. Sander BD, Addis PB, Park SW, Smith DE. Quantification of cholesterol oxidation products in a variety of foods. J Food Protect 1989;52-109-114.
35. Sander BD, Smith DE, Addis PB, Park SW. Effects of prolonged and adverse storage conditions on levels of cholesterol oxidation products in dairy products. J Food Sci. 1989;54:874-879.
36. Zhang WB, Addis PB. Prediction of levels of cholesterol oxides in heated tallow by dielectric measurement. J Food Sci. 1990;55:1673-1675.
37. Park SW, Addis PB. Cholesterol oxidation products in some muscle foods. J Food Sci. 1987;52:1504-1505.
38. Noourrooz-Zadeh J, Appelquist LA. Cholesterol oxides in Swedish foods and food ingredients: fresh eggs and dehydrated egg products. J Food Sci. 1988;53:74-79.
39. van der Bovenkamp P, Kosmeijer-Schuil TG, Katan MB. Quantification of oxysterols in Dutch foods: egg products and mixed diets. Lipids. 1988;23:1079-1085.
40. Krut LH, Yang JW, Schonfeld G, Ostlund RE. The effect of oxidized cholesterols on gastrointestinal absorption, plasma clearance, tissue distribution, and processing by endothelial cells. Arterioscler Thromb Vasc Biol. 1997;17:778-785.
41. Sutherland WHF, Walker RJ, de Jong SA, van Rij AM, Phillips V, Walker HL. Reduced postprandial serum paraoxonase activity after a meal rich in used cooking oil. Arterioscler Thromb Vasc Biol. 1999;19: 1340-1347.
42. Aviram M, Rosenblat M, Bisgaier CL, Newton RS, Primo-Parmo SL, La Du BN. Paraoxonase inhibits high density lipoprotein oxidation and preserves its function. J Clin Invest. 1998;101:1581-1590.
43. Jacobson MS, Price MG, Shamoo AE, Heald FP. Atherogenesis in White Cameau pigeons: effect of low-level cholestanetriol feeding. Atherosclerosis. 1985;57:209-217.
44. Higley NA, Beery JT, Taylor SL, Porter JW, Dziuba JA, Lalich JJ. Comparative atherogenic effects of cholesterol and cholesterol oxides. Atherosclerosis. 1986;62:91-104.
45. Brown AJ, Jessup W. Oxysterols and atherosclerosis. Atherosclerosis. 1999;142:1-28.
46. Sevanian A, Hodis HN, Hwang J, McLeod LL, Peterson H. Characterization of endothelial cell injury by cholesterol oxidation products found in oxidized LDL. J Lipid Res. 1995;36:1971-1986.
47. Chisolm GM, Ma G, Irwin KC, Martin LL, Gunderson KG, Linberg LF, Morel DW, DiCorleto PE. 7β-Hydroperoxycholest-5-en-3β-ol, a component of human atherosclerotic lesions, is a primary cytotoxin of oxidized human low density lipoprotein. Proc Natl Acad Sci U S A. 1994;91:11452-11456.
48. Peng SK, Sevanian A, Morin RJ. Cytotoxicity of cholesterol oxides. In: Peng SK, Morin RJ, eds. Biological Effects of Cholesterol Oxides. Boca Raton, Fla: CRC Press; 1992:147-166.
49. Coffey MD, Cole RA, Colles SM, Chisolm GM. In vitro cell injury by oxidized low density lipoprotein involves lipid hydroperoxide-induced formation of alkoxyl, lipid, and peroxyl radicals. J Clin Invest. 1995;96: 1866-1873.
50. Imai H, Werthessen NT, Subramanyam V, Lequesne PW, Soloway AH, Kanisawa M. Angiotoxicity of oxygenated sterols and possible precursors. Science. 1980;207:651-653.
51. Taylor CB, Peng S-K, Werthessen NT, Tham P, Lee KT. Spontaneous occurring angiotoxic derivatives of cholesterol. Am J Clin Nutr. 1979;32: 40-57.
52. Matthias D, Becker CH, Godicke W, Schmidt R, Ponsold K. Action of cholestane-3β,5α,6β-triol on rats with particular reference to the aorta. Atherosclerosis. 1987;63:115-124.
53. Peng SK, Taylor CB, Hill JC, Morin RJ. Cholesterol oxidation derivatives and endothelial damage. Atherosclerosis. 1985;54:121-125.
54. Colles SM, Irwin KC, Chisolm GM. Roles of multiple oxidized LDL lipids in cellular injury: dominance of 7β-hydroperoxycholesterol. J Lipid Res. 1996;37:2018-2028.
55. Rangaswamy S, Penn MS, Saidel GM, Chisolm GM. Exogenous oxidized low-density lipoprotein injures and alters the barrier function of endothelium in rats in vivo. Circ Res. 1997;80:37-44.
56. Rong JX, Rangaswamy S, Shen L, Dave R, Chang Yi H, Peterson H, Hodis HN, Chisolm GM, Sevanian A. Arterial injury by cholesterol oxidation products causes endothelial dysfunction and arterial wall cholesterol accumulation. Arterioscler Thromb Vasc Biol. 1998;18: 1885-1894.