Control of cholesterol metabolism and plasma high-density lipoprotein levels by microRNA-144

Circulation Research

Volumn 112, Issue 12, 2013, Pages 1592-1601

  Ramírez, Cristina M ^a   Rotllan, Noemi ^a   Vlassov, Alexander V ^b,c   Dávalos, Alberto ^a   Li, Mu ^c   Goedeke, Leigh ^a   Aranda, Juan F ^a   Cirera Salinas, Daniel ^a   Araldi, Elisa ^a   Salerno, Alessandro ^a   Wanschel, Amarylis ^a   Zavadil, Jiri ^c   Castrillo, Antonio ^d,e   Kim, Jungsu ^f   Suárez, Yajaira ^a   Fernández Hernando, Carlos ^a  

^a Division of Cardiology   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Life Technologies   (United States)

^d UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^e UNIVERSITY OF LAS PALMAS DE GRAN CANARIA   (Spain)

^f WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

ABCA1; cardiovascular research; cholesterol efflux; cholesterol homeostatis; high density lipoprotein; lipids and lipoprotein metabolism; microRNAs

Indexed keywords

ABC TRANSPORTER A1; APOLIPOPROTEIN A1; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN; LIGAND; LIVER X RECEPTOR; MICRORNA; MICRORNA 144; OLIGONUCLEOTIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOGENESIS; CELL STIMULATION; CHOLESTEROL METABOLISM; CONTROLLED STUDY; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; GENE SILENCING; IN VITRO STUDY; IN VIVO STUDY; LIPID ANALYSIS; LIPOPROTEIN BLOOD LEVEL; LIVER CELL; MALE; METABOLIC REGULATION; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ABCA1; CARDIOVASCULAR RESEARCH; CHOLESTEROL EFFLUX; CHOLESTEROL HOMEOSTATIS; HIGH-DENSITY LIPOPROTEIN; LIPIDS AND LIPOPROTEIN METABOLISM; MICRORNAS;

ANIMALS; ANTICHOLESTEREMIC AGENTS; APOLIPOPROTEIN A-I; ATP-BINDING CASSETTE TRANSPORTERS; CERCOPITHECUS AETHIOPS; CHOLESTEROL, HDL; COS CELLS; DIET, HIGH-FAT; GENE EXPRESSION PROFILING; HEP G2 CELLS; HEPATOCYTES; HOMEOSTASIS; HUMANS; HYDROCARBONS, FLUORINATED; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICRORNAS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OLIGONUCLEOTIDES; ORPHAN NUCLEAR RECEPTORS; SULFONAMIDES;

EID: 84880031381     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.112.300626     Document Type: Article

References (35)

1. Glass CK, Witztum JL. Atherosclerosis. The road ahead. Cell. 2001;104:503-516
2. Lusis AJ. Atherosclerosis. Nature. 2000;407:233-241
3. Gelissen IC, Harris M, Rye KA, Quinn C, Brown AJ, Kockx M, Cartland S, Packianathan M, Kritharides L, Jessup W. ABCA1 and ABCG1 synergize to mediate cholesterol export to apoA-I. Arterioscler Thromb Vasc Biol. 2006;26:534-540
4. Tall AR. Cholesterol efflux pathways and other potential mechanisms involved in the athero-protective effect of high density lipoproteins. J Intern Med. 2008;263:256-273 (Pubitemid 351207349)
5. Tall AR, Yvan-Charvet L, Terasaka N, Pagler T, Wang N. HDL, ABC transporters, and cholesterol efflux: implications for the treatment of atherosclerosis. Cell Metab. 2008;7:365-375 (Pubitemid 351598023)
6. Bodzioch M, Orso E, Klucken J, et al. The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease. Nat Genet. 1999;22:347-351 (Pubitemid 29369524)
7. Brooks-Wilson A, Marcil M, Clee SM, et al. Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency. Nat Genet. 1999;22:336-345 (Pubitemid 29369523)
8. Rust S, Rosier M, Funke H, Real J, Amoura Z, Piette JC, Deleuze JF, Brewer HB, Duverger N, Denèfle P, Assmann G. Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1. Nat Genet. 1999;22:352-355 (Pubitemid 29369525)
9. Venkateswaran A, Laffitte BA, Joseph SB, Mak PA, Wilpitz DC, Edwards PA, Tontonoz P. Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha. Proc Natl Acad Sci USA. 2000;97:12097-12102
10. Beaven SW, Tontonoz P. Nuclear receptors in lipid metabolism: targeting the heart of dyslipidemia. Annu Rev Med. 2006;57:313-329 (Pubitemid 43261994)
11. Zelcer N, Hong C, Boyadjian R, Tontonoz P. LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor. Science. 2009;325:100-104
12. Ambros V. The functions of animal microRNAs. Nature. 2004;431: 350-355 (Pubitemid 39265675)
13. Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell. 2009;136:215-233
14. Filipowicz W, Bhattacharyya SN, Sonenberg N. Mechanisms of posttranscriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet. 2008;9:102-114
15. Elmén J, Lindow M, Silahtaroglu A, Bak M, Christensen M, Lind- Thomsen A, Hedtjärn M, Hansen JB, Hansen HF, Straarup EM, McCullagh K, Kearney P, Kauppinen S. Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver. Nucleic Acids Res. 2008;36:1153-1162 (Pubitemid 351330933)
16. Esau C, Davis S, Murray SF, et al. miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting. Cell Metab. 2006;3:87-98
17. Gerin I, Bommer GT, McCoin CS, Sousa KM, Krishnan V, MacDougald OA. Roles for miRNA-378/378, in adipocyte gene expression and lipogenesis. Am J Physiol Endocrinol Metab. 2010;299:E198-E206
18. Iliopoulos D, Drosatos K, Hiyama Y, Goldberg IJ, Zannis VI. MicroRNA-370 controls the expression of microRNA-122 and Cpt1alpha and affects lipid metabolism. J Lipid Res. 2010;51:1513-1523
19. Kim J, Yoon H, Ramirez CM, Lee SM, Hoe HS, Fernandez-Hernando C. Mir-106b impairs cholesterol efflux and increases abeta levels by repressing abca1 expression. Exp Neurol. 2012;235:476-483
20. Marquart TJ, Allen RM, Ory DS, Baldán A. miR-33 links SREBP-2 induction to repression of sterol transporters. Proc Natl Acad Sci USA. 2010;107:12228-12232
21. Najafi-Shoushtari SH, Kristo F, Li Y, Shioda T, Cohen DE, Gerszten RE, Näär AM. MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis. Science. 2010;328:1566-1569
22. Ramirez CM, Dávalos A, Goedeke L, Salerno AG, Warrier N, Cirera- Salinas D, Suárez Y, Fernández-Hernando C. MicroRNA-758 regulates cholesterol efflux through posttranscriptional repression of ATP-binding cassette transporter A1. Arterioscler Thromb Vasc Biol. 2011;31:2707-2714
23. Rayner KJ, Suárez Y, Dávalos A, Parathath S, Fitzgerald ML, Tamehiro N, Fisher EA, Moore KJ, Fernández-Hernando C. MiR-33 contributes to the regulation of cholesterol homeostasis. Science. 2010;328:1570-1573
24. Dávalos A, Goedeke L, Smibert P, et al. miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling. Proc Natl Acad Sci USA. 2011;108:9232-9237
25. Rayner KJ, Sheedy FJ, Esau CC, Hussain FN, Temel RE, Parathath S, van Gils JM, Rayner AJ, Chang AN, Suarez Y, Fernandez-Hernando C, Fisher EA, Moore KJ. Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis. J Clin Invest. 2011;121:2921-2931
26. Rayner KJ, Esau CC, Hussain FN, et al. Inhibition of miR-33a/b in nonhuman primates raises plasma HDL and lowers VLDL triglycerides. Nature. 2011;478:404-407
27. Froh M, Konno A, Thurman RG. Isolation of liver Kupffer cells. Curr Protoc Toxicol. 2003;14:14.4.
28. Elmén J, Lindow M, Schütz S, Lawrence M, Petri A, Obad S, Lindholm M, Hedtjärn M, Hansen HF, Berger U, Gullans S, Kearney P, Sarnow P, Straarup EM, Kauppinen S. LNA-mediated microRNA silencing in nonhuman primates. Nature. 2008;452:896-899
29. Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 1993;75:843-854 (Pubitemid 24014542)
30. Wightman B, Ha I, Ruvkun G. Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell. 1993;75:855-862 (Pubitemid 24014543)
31. Sun D, Zhang J, Xie J, Wei W, Chen M, Zhao X. MiR-26 controls LXRdependent cholesterol efflux by targeting ABCA1 and ARL7. FEBS Lett. 2012;586:1472-1479
32. Ou Z, Wada T, Gramignoli R, Li S, Strom SC, Huang M, Xie W. Microrna hsa-mir-613 targets the human lxralpha gene and mediates a feedback loop of lxralpha autoregulation. Mol Endocrinol. 2011;25:584-596
33. Suárez Y, Wang C, Manes TD, Pober JS. Cutting edge: TNF-induced microRNAs regulate TNF-induced expression of E-selectin and intercellular adhesion molecule-1 on human endothelial cells: feedback control of inflammation. J Immunol. 2010;184:21-25
34. Karreth FA, Tay Y, Perna D, et al. In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma. Cell. 2011;147:382-395
35. Tay Y, Kats L, Salmena L, Weiss D, Tan SM, Ala U, Karreth F, Poliseno L, Provero P, Di Cunto F, Lieberman J, Rigoutsos I, Pandolfi PP. Codingindependent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. Cell. 2011;147:344-357.