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Volumn 50, Issue 3, 2014, Pages 209-217

Elvitegravir for the treatment of HIV infection

(1)  Reviriego, Carlota a  

a NONE

Author keywords

Cytochrome P450 3A4 inhibitors; Elvitegravir; GS 9137; HIV infection; HIV integrase inhibitors

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; ATAZANAVIR; COBICISTAT; COBICISTAT PLUS ELVITEGRAVIR PLUS EMTRICITABINE PLUS TENOFOVIR DISOPROXIL; CYTOCHROME P450 3A; DARUNAVIR; ELVITEGRAVIR; EMTRICITABINE; ETRAVIRINE; FOSAMPRENAVIR; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 1A3; INTEGRASE INHIBITOR; LOPINAVIR; MARAVIROC; PLACEBO; RALTEGRAVIR; RIFABUTIN; RITONAVIR; TENOFOVIR DISOPROXIL; TIPRANAVIR; TRIACYLGLYCEROL; ZIDOVUDINE;

EID: 84897378155     PISSN: 16993993     EISSN: 16994019     Source Type: Journal    
DOI: 10.1358/dot.2014.050.03.2122120     Document Type: Article
Times cited : (7)

References (64)
  • 1
    • 0032731970 scopus 로고    scopus 로고
    • Natural history of HIV infection in the era of combination antiretroviral therapy
    • DOI 10.1097/00002030-199910010-00017
    • Moore, R.D., Chaisson, R.E. Natural history of HIV infection in the era of combination antiretroviral therapy. AIDS 1999, 13(14): 1933-42 (Pubitemid 29509554)
    • (1999) AIDS , vol.13 , Issue.14 , pp. 1933-1942
    • Moore, R.D.1    Chaisson, R.E.2
  • 3
    • 84886790685 scopus 로고    scopus 로고
    • The end of AIDS: HIV infection as a chronic disease
    • Deeks, S.G., Lewin, S.R., Havlir, D.V. The end of AIDS: HIV infection as a chronic disease. Lancet 2013, 382(9903): 1525-33
    • (2013) Lancet , vol.382 , Issue.9903 , pp. 1525-1533
    • Deeks, S.G.1    Lewin, S.R.2    Havlir, D.V.3
  • 4
    • 79954626457 scopus 로고    scopus 로고
    • HIV-1 integrase inhibitor resistance and its clinical implications
    • Blanco, J.L., Varghese, V., Rhee, S.Y., Gatell, J.M., Shafer, R.W. HIV-1 integrase inhibitor resistance and its clinical implications. J Infect Dis 2011, 203(9): 1204-14
    • (2011) J Infect Dis , vol.203 , Issue.9 , pp. 1204-1214
    • Blanco, J.L.1    Varghese, V.2    Rhee, S.Y.3    Gatell, J.M.4    Shafer, R.W.5
  • 5
    • 84880333268 scopus 로고    scopus 로고
    • Advances in antiretroviral therapy
    • Arribas, J.R., Eron, J. Advances in antiretroviral therapy. Curr Opin HIV AIDS 2013, 8(4): 341-9
    • (2013) Curr Opin HIV AIDS , vol.8 , Issue.4 , pp. 341-349
    • Arribas, J.R.1    Eron, J.2
  • 6
    • 79952077699 scopus 로고    scopus 로고
    • Clinical pharmacokinetic and pharmacodynamic profile of the HIV integrase inhibitor elvitegravir
    • Ramanathan, S., Mathias, A.A., German, P., Kearney, B.P. Clinical pharmacokinetic and pharmacodynamic profile of the HIV integrase inhibitor elvitegravir. Clin Pharmacokinet 2011, 50(4): 229-44
    • (2011) Clin Pharmacokinet , vol.50 , Issue.4 , pp. 229-244
    • Ramanathan, S.1    Mathias, A.A.2    German, P.3    Kearney, B.P.4
  • 8
    • 74549114178 scopus 로고    scopus 로고
    • Integrase inhibitors: A novel class of antiretroviral agents
    • Schafer, J.J., Squires, K.E. Integrase inhibitors: a novel class of antiretroviral agents. Ann Pharmacother 2010, 44(1): 145-56
    • (2010) Ann Pharmacother , vol.44 , Issue.1 , pp. 145-156
    • Schafer, J.J.1    Squires, K.E.2
  • 9
    • 83455184893 scopus 로고    scopus 로고
    • Elvitegravir once-daily is non inferior to raltegravir twice-daily in treatment experienced patients: 48 week results from a phase 3 multicenter, randomized, double blind study
    • (July 17-20, Rome), Abst WELBB05
    • Molina, J.M., LaMarca, A., Andrade Villanueva, J. et al. Elvitegravir once-daily is non inferior to raltegravir twice-daily in treatment experienced patients: 48 week results from a phase 3 multicenter, randomized, double blind study. 6th IAS Conf HIV Pathog Treat Prev (July 17-20, Rome) 2011, Abst WELBB05
    • (2011) 6th IAS Conf HIV Pathog Treat Prev
    • Molina, J.M.1    Lamarca, A.2    Andrade Villanueva, J.3
  • 10
    • 38049014447 scopus 로고    scopus 로고
    • Integrase inhibitors: A new treatment option for patients with human immunodeficiency virus infection
    • Correll, T., Klibanov, O.M. Integrase inhibitors: a new treatment option for patients with human immunodeficiency virus infection. Pharmacotherapy 2008, 28(1): 90-101
    • (2008) Pharmacotherapy , vol.28 , Issue.1 , pp. 90-101
    • Correll, T.1    Klibanov, O.M.2
  • 11
    • 84897388588 scopus 로고    scopus 로고
    • [news release]. U.S. Food and Drug Administration, August 27, 2012., Accessed March 17
    • FDA approves new combination pill for HIV treatment for some patients [news release]. U.S. Food and Drug Administration, August 27, 2012. http://www.fda.gov/ NewsEvents/Newsroom/PressAnnouncements/ucm317004.htm. Accessed March 17, 2014
    • (2014) FDA Approves New Combination Pill for HIV Treatment for Some Patients
  • 14
    • 84897401471 scopus 로고    scopus 로고
    • EPAR summary for the public
    • EMA/593111/2013 European Medicines Agency, November 2013, Accessed March 17
    • EPAR summary for the public. Vitekta, elvitegravir. EMA/593111/2013 European Medicines Agency, November 2013. http://www.ema.europa.eu/docs/en-GB/ document-library/EPAR-Sumary-for-the-public/human/002577/WC500155578.pdf. Accessed March 17, 2014
    • (2014) Vitekta, Elvitegravir
  • 17
    • 70449411340 scopus 로고    scopus 로고
    • Elvitegravir: A new HIV integrase inhibitor
    • Shimura, K., Kodama, E.N. Elvitegravir: a new HIV integrase inhibitor. Antivir Chem Chemother 2009, 20(2): 79-85
    • (2009) Antivir Chem Chemother , vol.20 , Issue.2 , pp. 79-85
    • Shimura, K.1    Kodama, E.N.2
  • 21
    • 85027938452 scopus 로고    scopus 로고
    • HIV-2 antiviral potency and selection of drug resistance mutations by the integrase strand transfer inhibitor elvitegravir and NRTIs emtricitabine and tenofovir in vitro
    • Andreatta, K., Miller, M.D., White, K.L. HIV-2 antiviral potency and selection of drug resistance mutations by the integrase strand transfer inhibitor elvitegravir and NRTIs emtricitabine and tenofovir in vitro. J Acquir Immune Defic Syndr 2013, 62(4): 367-74
    • (2013) J Acquir Immune Defic Syndr , vol.62 , Issue.4 , pp. 367-374
    • Andreatta, K.1    Miller, M.D.2    White, K.L.3
  • 23
    • 33746816830 scopus 로고    scopus 로고
    • Pharmacokinetics/ pharmacodynamics of GS-9137 an HIV integrase inhibitor
    • (April 20-22, Lisbon), Abst 75
    • Kearney. B.P., M., M., Zhong, L. et al. Pharmacokinetics/ pharmacodynamics of GS-9137 an HIV integrase inhibitor. 7th Int Workshop Clin Pharmacol HIV Ther (April 20-22, Lisbon) 2006, Abst 75
    • (2006) 7th Int Workshop Clin Pharmacol HIV Ther
    • Kearney, B.P.M.M.1    Zhong, L.2
  • 24
    • 84155164041 scopus 로고    scopus 로고
    • Efficacy and safety of once daily elvitegravir versus twice daily raltegravir in treatment-experienced patients with HIV-1 receiving a ritonavir-boosted protease inhibitor: Randomised, double-blind, phase 3, non-inferiority study
    • Molina, J.M., Lamarca, A., Andrade-Villanueva, J. et al. Efficacy and safety of once daily elvitegravir versus twice daily raltegravir in treatment-experienced patients with HIV-1 receiving a ritonavir-boosted protease inhibitor: randomised, double-blind, phase 3, non-inferiority study. Lancet Infect Dis 2012, 12(1): 27-35
    • (2012) Lancet Infect Dis , vol.12 , Issue.1 , pp. 27-35
    • Molina, J.M.1    Lamarca, A.2    Andrade-Villanueva, J.3
  • 25
    • 77749267991 scopus 로고    scopus 로고
    • Activity of elvitegravir, a once-daily integrase inhibitor, against resistant HIV Type 1: Results of a phase 2, randomized, controlled, doseranging clinical trial
    • Zolopa, A.R., Berger, D.S., Lampiris, H. et al. Activity of elvitegravir, a once-daily integrase inhibitor, against resistant HIV Type 1: results of a phase 2, randomized, controlled, doseranging clinical trial. J Infect Dis 2010, 201(6): 814-22
    • (2010) J Infect Dis , vol.201 , Issue.6 , pp. 814-822
    • Zolopa, A.R.1    Berger, D.S.2    Lampiris, H.3
  • 26
    • 84897456240 scopus 로고    scopus 로고
    • Efficacy and safety results from a randomized, double blind, active controlled trial of elvitegravir (once-daily) versus raltegravir (twice-daily) in treatment-experienced HIV-positive patients: Long term 96-week data
    • (July 22-27, Washington, D.C.), Abst TUAB0105
    • Elion, R., Molina, J.M., Arribas Lopez, J.R. et al. Efficacy and safety results from a randomized, double blind, active controlled trial of elvitegravir (once-daily) versus raltegravir (twice-daily) in treatment-experienced HIV-positive patients: Long term 96-week data. 19th Int AIDS Conf (July 22-27, Washington, D.C.) 2012, Abst TUAB0105
    • (2012) 19th Int AIDS Conf
    • Elion, R.1    Molina, J.M.2    Arribas Lopez, J.R.3
  • 27
    • 57749197592 scopus 로고    scopus 로고
    • Dose-response of ritonavir on hepatic CYP3A activity and elvitegravir oral exposure
    • Mathias, A.A., West, S., Hui, J., Kearney, B.P. Dose-response of ritonavir on hepatic CYP3A activity and elvitegravir oral exposure. Clin Pharmacol Ther 2009, 85(1): 64-70
    • (2009) Clin Pharmacol Ther , vol.85 , Issue.1 , pp. 64-70
    • Mathias, A.A.1    West, S.2    Hui, J.3    Kearney, B.P.4
  • 28
    • 62649112895 scopus 로고    scopus 로고
    • Impact of different low-dose ritonavir regimens on lipids, CD36, and adipophilin expression
    • Collot-Teixeira, S., De Lorenzo, F., Waters, L. et al. Impact of different low-dose ritonavir regimens on lipids, CD36, and adipophilin expression. Clin Pharmacol Ther 2009, 85(4): 375-8
    • (2009) Clin Pharmacol Ther , vol.85 , Issue.4 , pp. 375-378
    • Collot-Teixeira, S.1    De Lorenzo, F.2    Waters, L.3
  • 31
    • 84897411987 scopus 로고    scopus 로고
    • Subgroup analyses of 96-week efficacy and safety of elvitegravir/ cobicistat/ emtricitabine/tenofovir DF
    • (June 30-July 3, Kuala Lumpur), Abst TUPE281
    • Cooper, D., Zolopa, A., Rockstroh, J. et al. Subgroup analyses of 96-week efficacy and safety of elvitegravir/cobicistat/ emtricitabine/tenofovir DF. IAS Conf HIV Pathog Treat Prev (June 30-July 3, Kuala Lumpur) 2013, Abst TUPE281
    • (2013) IAS Conf HIV Pathog Treat Prev
    • Cooper, D.1    Zolopa, A.2    Rockstroh, J.3
  • 32
    • 84897469317 scopus 로고    scopus 로고
    • Safety and tolerability of switching from twice daily raltegravir plus truvada to STRIBILD in virologically suppressed HIV-1-infected subjects at Week 24
    • (June 30-July 3 Kuala Lumpur), Abst TUPE283
    • Crofoot, G., Ortiz, R., Mills, A., et al. Safety and tolerability of switching from twice daily raltegravir plus truvada to STRIBILD in virologically suppressed, HIV-1-infected subjects at week 24. IAS Conf HIV Pathog Treat Prev (June 30-July 3, Kuala Lumpur) 2013, Abst TUPE283
    • (2013) IAS Conf HIV Pathog Treat Prev
    • Crofoot, G.1    Ortiz, R.2    Mills, A.3
  • 33
    • 52349115099 scopus 로고    scopus 로고
    • Lack of pharmocokinetic interaction between ritonavir-boosted GS-9137 (elvitegravir) and darunavir/r
    • (July 22-25, Sydney), Abst TUPDB03
    • Mathias, A., Shen, G., Enejosa, J., Sekar, V., Mack, R., Tomaka, F., Kearney, B. Lack of pharmocokinetic interaction between ritonavir-boosted GS-9137 (elvitegravir) and darunavir/r. 4th IAS Conf HIV Pathog Treat Prev (July 22-25, Sydney) 2007, Abst TUPDB03
    • (2007) 4th IAS Conf HIV Pathog Treat Prev
    • Mathias, A.1    Shen, G.2    Enejosa, J.3    Sekar, V.4    Mack, R.5    Tomaka, F.6    Kearney, B.7
  • 34
    • 52349115099 scopus 로고    scopus 로고
    • Lack of pharmacokinetic interaction between ritonavir-boosted GS-9137 (elvitegravir) and tipranavir/r
    • (July 22-25, Sydney), Abst TUPDB06
    • Mathias, A., Hinkle, J., Enejosa, J., Piliero, P., Kearney, B. Lack of pharmacokinetic interaction between ritonavir-boosted GS-9137 (elvitegravir) and tipranavir/r. 4th IAS Conf HIV Pathog Treat Prev (July 22-25, Sydney) 2007, Abst TUPDB06
    • (2007) 4th IAS Conf HIV Pathog Treat Prev
    • Mathias, A.1    Hinkle, J.2    Enejosa, J.3    Piliero, P.4    Kearney, B.5
  • 35
    • 42149147700 scopus 로고    scopus 로고
    • Lack of clinically relevant drug-drug interaction between ritonavir-boosted GS-9137 (elvitegravir) and fosamprenavir/ r
    • (July 22-25, Sydney), Abst WEPEB014
    • Ramanathan, S., Mathias, A.A., Shen, G., Holmes, C., Kearney, B.P. Lack of clinically relevant drug-drug interaction between ritonavir-boosted GS-9137 (elvitegravir) and fosamprenavir/ r. 4th IAS Conf HIV Pathog Treat Prev (July 22-25, Sydney) 2007, Abst WEPEB014
    • (2007) 4th IAS Conf HIV Pathog Treat Prev
    • Ramanathan, S.1    Mathias, A.A.2    Shen, G.3    Holmes, C.4    Kearney, B.P.5
  • 36
    • 58149489322 scopus 로고    scopus 로고
    • Pharmacokinetics of elvitegravir and etravirine following coadministration of ritonavir-boosted elvitegravir and etravirine
    • Ramanathan, S., Kakuda, T.N., Mack, R., West, S., Kearney, B.P. Pharmacokinetics of elvitegravir and etravirine following coadministration of ritonavir-boosted elvitegravir and etravirine. Antivir Ther 2008, 13(8): 1011-7
    • (2008) Antivir Ther , vol.13 , Issue.8 , pp. 1011-1017
    • Ramanathan, S.1    Kakuda, T.N.2    Mack, R.3    West, S.4    Kearney, B.P.5
  • 38
    • 67650712621 scopus 로고    scopus 로고
    • Lack of clinically relevant drug-drug interaction between the ritonavir-boosted HIV integrase inhibitor GS-9137/r and zidovudine (ZDV)
    • (August 13-18, Toronto), Abst TUPE0088
    • Ramanathan, S., Lagan, K., Plummer, A., Hui, J., Shen, G., Cheng, A., Kearney, B.P. Lack of clinically relevant drug-drug interaction between the ritonavir-boosted HIV integrase inhibitor GS-9137/r and zidovudine (ZDV). 16th Int AIDS Conf (August 13-18, Toronto) 2006, Abst TUPE0088
    • (2006) 16th Int AIDS Conf
    • Ramanathan, S.1    Lagan, K.2    Plummer, A.3    Hui, J.4    Shen, G.5    Cheng, A.6    Kearney, B.P.7
  • 39
    • 84897395857 scopus 로고    scopus 로고
    • Renal safety of elvitegravir/cobicistat/emtricitabine/tenofovir DF (STB) and cobicistat-boosted protease inhibitor regimens in HIV-1- infected patients with mild to moderate renal impairment
    • (June 30-July 3, Kuala Lumpur), Abst TUPE280
    • Post, F., Villanueva, J.A., Fisher, M. et al. Renal safety of elvitegravir/cobicistat/emtricitabine/tenofovir DF (STB) and cobicistat-boosted protease inhibitor regimens in HIV-1- infected patients with mild to moderate renal impairment. IAS Conf HIV Pathog Treat Prev (June 30-July 3, Kuala Lumpur) 2013, Abst TUPE280
    • (2013) IAS Conf HIV Pathog Treat Prev
    • Post, F.1    Villanueva, J.A.2    Fisher, M.3
  • 45
    • 84887484928 scopus 로고    scopus 로고
    • Pharmaco - Kinetics and drug interaction profile of cobicistat boosted- EVG with atazanavir rosuvastatin or rifabutin
    • (April 16-18, Barcelona), Abst O-03
    • Ramanathan, S., Wang, H., Stondell, T. et al. Pharmaco - kinetics and drug interaction profile of cobicistat boosted- EVG with atazanavir, rosuvastatin or rifabutin. 13th Int Workshop Clinical Pharmacol HIV Ther (April 16-18, Barcelona) 2012, Abst O-03
    • (2012) 13th Int Workshop Clinical Pharmacol HIV Ther
    • Ramanathan, S.1    Wang, H.2    Stondell, T.3
  • 46
    • 58149530512 scopus 로고    scopus 로고
    • Pharmacokinetic evaluation of drug interactions with ritonavir-boosted HIV integrase inhibitor GS-9137 (elvitegravir) and acid-reducing agents
    • (April 16-18, Budapest), Abst 69
    • Ramanathan, S., Shen, G., Hinkle, J. Pharmacokinetic evaluation of drug interactions with ritonavir-boosted HIV integrase inhibitor GS-9137 (elvitegravir) and acid-reducing agents. 8th Int Workshop Clinical Pharmacol HIV Ther (April 16-18, Budapest) 2007, Abst 69
    • (2007) 8th Int Workshop Clinical Pharmacol HIV Ther
    • Ramanathan, S.1    Shen, G.2    Hinkle, J.3
  • 49
    • 40549125135 scopus 로고    scopus 로고
    • Resistance and cross-resistance to first generation integrase inhibitors: Insights from a phase 2 study of elvitegravir (GS-9137)
    • McColl, D., Fransen, S., Gupta, S. et al. Resistance and cross-resistance to first generation integrase inhibitors: Insights from a phase 2 study of elvitegravir (GS-9137). Antivir Ther 2007, 12(Suppl. 1): S11
    • (2007) Antivir Ther , vol.12 , Issue.SUPPL.1
    • McColl, D.1    Fransen, S.2    Gupta, S.3
  • 50
    • 54049102468 scopus 로고    scopus 로고
    • Drug resistance profiles for the HIV integrase gene in patients failing raltegravir salvage therapy
    • Charpentier, C., Karmochkine, M., Laureillard, D. et al. Drug resistance profiles for the HIV integrase gene in patients failing raltegravir salvage therapy. HIV Med 2008, 9(9): 765-70
    • (2008) HIV Med , vol.9 , Issue.9 , pp. 765-770
    • Charpentier, C.1    Karmochkine, M.2    Laureillard, D.3
  • 51
    • 84861136225 scopus 로고    scopus 로고
    • Broad phenotypic cross-resistance to elvitegravir in HIV-infected patients failing on raltegravir-containing regimens
    • Garrido, C., Villacian, J., Zahonero, N. et al. Broad phenotypic cross-resistance to elvitegravir in HIV-infected patients failing on raltegravir-containing regimens. Antimicrob Agents Chemother 2012, 56(6): 2873-8
    • (2012) Antimicrob Agents Chemother , vol.56 , Issue.6 , pp. 2873-2878
    • Garrido, C.1    Villacian, J.2    Zahonero, N.3
  • 52
    • 84882353303 scopus 로고    scopus 로고
    • Multiple genetic pathways involving amino acid position 143 of HIV-1 integrase are preferentially associated with specific secondary amino acid substitutions and confer resistance to raltegravir and cross-resistance to elvitegravir
    • Huang, W., Frantzell, A., Fransen, S., Petropoulos, C.J. Multiple genetic pathways involving amino acid position 143 of HIV-1 integrase are preferentially associated with specific secondary amino acid substitutions and confer resistance to raltegravir and cross-resistance to elvitegravir. Antimicrob Agents Chemother 2013, 57(9): 4105-13
    • (2013) Antimicrob Agents Chemother , vol.57 , Issue.9 , pp. 4105-4113
    • Huang, W.1    Frantzell, A.2    Fransen, S.3    Petropoulos, C.J.4
  • 53
    • 84877641836 scopus 로고    scopus 로고
    • Effect of primary elvitegravir resistance mutations in HIV-1 integrase on drug susceptibility and viral replicative fitness
    • (June 5-9, Sitges), Abst 3
    • Abram, M.E., Hluhanich, R.M., Goodman, D.D. et al. Effect of primary elvitegravir resistance mutations in HIV-1 integrase on drug susceptibility and viral replicative fitness. Int HIV Hepat Virus Drug Resist Workshop Curativ Strategies (June 5-9, Sitges) 2012, Abst 3
    • (2012) Int HIV Hepat Virus Drug Resist Workshop Curativ Strategies
    • Abram, M.E.1    Hluhanich, R.M.2    Goodman, D.D.3
  • 55
    • 77956017859 scopus 로고    scopus 로고
    • Identification of novel mutations responsible for resistance to MK-2048, a second-generation HIV-1 integrase inhibitor
    • Bar-Magen, T., Sloan, R.D., Donahue, D.A. et al. Identification of novel mutations responsible for resistance to MK-2048, a second-generation HIV-1 integrase inhibitor. J Virol 2010, 84(18): 9210-6
    • (2010) J Virol , vol.84 , Issue.18 , pp. 9210-9216
    • Bar-Magen, T.1    Sloan, R.D.2    Donahue, D.A.3
  • 56
    • 79957668616 scopus 로고    scopus 로고
    • Elvitegravir overcomes resistance to raltegravir induced by integrase mutation Y143
    • Metifiot, M., Vandegraaff, N., Maddali, K. et al. Elvitegravir overcomes resistance to raltegravir induced by integrase mutation Y143. AIDS 2011, 25(9): 1175-8
    • (2011) AIDS , vol.25 , Issue.9 , pp. 1175-1178
    • Metifiot, M.1    Vandegraaff, N.2    Maddali, K.3
  • 57
    • 84877843704 scopus 로고    scopus 로고
    • Impact of primary elvitegravir resistance-associated mutations in HIV-1 integrase on drug susceptibility and viral replication fitness
    • Abram, M.E., Hluhanich, R.M., Goodman, D.D. et al. Impact of primary elvitegravir resistance-associated mutations in HIV-1 integrase on drug susceptibility and viral replication fitness. Antimicrob Agents Chemother 2013, 57(6): 2654-63
    • (2013) Antimicrob Agents Chemother , vol.57 , Issue.6 , pp. 2654-2663
    • Abram, M.E.1    Hluhanich, R.M.2    Goodman, D.D.3
  • 58
    • 37849002059 scopus 로고    scopus 로고
    • Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK- 303/GS-9137)
    • Shimura, K., Kodama, E., Sakagami, Y. et al. Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK- 303/GS-9137). J Virol 2008, 82(2): 764-74
    • (2008) J Virol , vol.82 , Issue.2 , pp. 764-774
    • Shimura, K.1    Kodama, E.2    Sakagami, Y.3
  • 59
    • 84873337035 scopus 로고    scopus 로고
    • Prevalence of primary resistance mutations to integrase inhibitors in treatment-naive and -experienced patients infected with B and non-B HIV-1 variants
    • Gutierrez, C., Hernandez-Novoa, B., Perez-Elias, M.J. et al. Prevalence of primary resistance mutations to integrase inhibitors in treatment-naive and -experienced patients infected with B and non-B HIV-1 variants. HIV Clin Trials 2013, 14(1): 10-6
    • (2013) HIV Clin Trials , vol.14 , Issue.1 , pp. 10-16
    • Gutierrez, C.1    Hernandez-Novoa, B.2    Perez-Elias, M.J.3
  • 60
    • 84897397244 scopus 로고    scopus 로고
    • Resistance associated imitations in HIV-1 subtype C primary viruses after in vitro passage with integrase inhibitors raltegravir, elvitegravir and dolutegravir
    • (June 4-8, Toronto), Abst 79
    • Mphahlele, M., Hewer, R., Bronze, M. et al. Resistance associated imitations in HIV-1 subtype C primary viruses after in vitro passage with integrase inhibitors raltegravir, elvitegravir and dolutegravir. Int HIV Hepat Virus Drug Resist Workshop Curativ Strategies (June 4-8, Toronto) 2013, Abst 79
    • (2013) Int HIV Hepat Virus Drug Resist Workshop Curativ Strategies
    • Mphahlele, M.1    Hewer, R.2    Bronze, M.3
  • 61
    • 54549099338 scopus 로고    scopus 로고
    • HIV-2 integrase gene polymorphism and phenotypic susceptibility of HIV-2 clinical isolates to the integrase inhibitors raltegravir and elvitegravir in vitro
    • Roquebert, B., Damond, F., Collin, G. et al. HIV-2 integrase gene polymorphism and phenotypic susceptibility of HIV-2 clinical isolates to the integrase inhibitors raltegravir and elvitegravir in vitro. J Antimicrob Chemother 2008, 62(5): 914-20
    • (2008) J Antimicrob Chemother , vol.62 , Issue.5 , pp. 914-920
    • Roquebert, B.1    Damond, F.2    Collin, G.3
  • 62
    • 48749125376 scopus 로고    scopus 로고
    • Genetic diversity of integrase (IN) sequences in antiretroviral treatment-naive and treatment-experienced HIV type 2 patients
    • Xu, L., Anderson, J., Ferns, B. et al. Genetic diversity of integrase (IN) sequences in antiretroviral treatment-naive and treatment-experienced HIV type 2 patients. AIDS Res Hum Retroviruses 2008, 24(7): 1003-7
    • (2008) AIDS Res Hum Retroviruses , vol.24 , Issue.7 , pp. 1003-1007
    • Xu, L.1    Anderson, J.2    Ferns, B.3
  • 63
    • 79952344732 scopus 로고    scopus 로고
    • Hot spots of integrase genotypic changes leading to HIV-2 resistance to raltegravir
    • Charpentier, C., Roquebert, B., Delelis, O. et al. Hot spots of integrase genotypic changes leading to HIV-2 resistance to raltegravir. Antimicrob Agents Chemother 2011, 55(3): 1293- 5
    • (2011) Antimicrob Agents Chemother , vol.55 , Issue.3 , pp. 1293-1295
    • Charpentier, C.1    Roquebert, B.2    Delelis, O.3
  • 64
    • 84897466205 scopus 로고    scopus 로고
    • Primary and secondary analyses of emergent drug resistance through week 96 from the phase III studies of elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate
    • (June 4-8, Toronto), Abst 80
    • White, K.L., Kulkarni, R., Abram, M., Rhee, M., Fordyce, M., Miller, M.D. Primary and secondary analyses of emergent drug resistance through week 96 from the phase III studies of elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate. Int HIV Hepat Virus Drug Resist Workshop Curativ Strategies (June 4-8, Toronto) 2013, Abst 80.
    • (2013) Int HIV Hepat Virus Drug Resist Workshop Curativ Strategies
    • White, K.L.1    Kulkarni, R.2    Abram, M.3    Rhee, M.4    Fordyce, M.5    Primary, M.D.6


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