-
1
-
-
2642709177
-
Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection
-
Palella FJ, Jr., Delaney KM, Moorman AC, et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. N Engl J Med 1998; 338:853-860.
-
(1998)
N Engl J Med
, vol.338
, pp. 853-860
-
-
Palella Jr., F.J.1
Delaney, K.M.2
Moorman, A.C.3
-
2
-
-
33645943739
-
Effects of drug resistance on viral load in patients failing antiretroviral therapy
-
Machouf N, Thomas R, Nguyen VK, et al. Effects of drug resistance on viral load in patients failing antiretroviral therapy. J Med Virol 2006; 78:608-613.
-
(2006)
J Med Virol
, vol.78
, pp. 608-613
-
-
Machouf, N.1
Thomas, R.2
Nguyen, V.K.3
-
3
-
-
48449083017
-
HIV-1 drug resistance mutations: An updated framework for the second decade of HAART
-
Shafer RW, Schapiro JM. HIV-1 drug resistance mutations: an updated framework for the second decade of HAART. AIDS Rev 2008; 10:67-84.
-
(2008)
AIDS Rev
, vol.10
, pp. 67-84
-
-
Shafer, R.W.1
Schapiro, J.M.2
-
4
-
-
0026330796
-
HIV-1 DNA integration: Mechanism of viral DNA cleavage and DNA strand transfer
-
Engelman A, Mizuuchi K, Craigie R. HIV-1 DNA integration: mechanism of viral DNA cleavage and DNA strand transfer. Cell 1991; 67:1211-1221.
-
(1991)
Cell
, vol.67
, pp. 1211-1221
-
-
Engelman, A.1
Mizuuchi, K.2
Craigie, R.3
-
5
-
-
0026459411
-
Requirement of active human immunodeficiency virus type 1 integrase enzyme for productive infection of human T-lymphoid cells
-
LaFemina RL, Schneider CL, Robbins HL, et al. Requirement of active human immunodeficiency virus type 1 integrase enzyme for productive infection of human T-lymphoid cells. J Virol 1992; 66:7414-7419.
-
(1992)
J Virol
, vol.66
, pp. 7414-7419
-
-
LaFemina, R.L.1
Schneider, C.L.2
Robbins, H.L.3
-
6
-
-
54449088130
-
Raltegravir: The first in a new class of integrase inhibitors for the treatment of HIV
-
Sayana S, Khanlou H. Raltegravir: the first in a new class of integrase inhibitors for the treatment of HIV. Expert Rev Anti Infect Ther 2008; 6:419-426.
-
(2008)
Expert Rev Anti Infect Ther
, vol.6
, pp. 419-426
-
-
Sayana, S.1
Khanlou, H.2
-
7
-
-
47949120697
-
Raltegravir with optimized background therapy for resistant HIV-1 infection
-
Steigbigel RT, Cooper DA, Kumar PN, et al. Raltegravir with optimized background therapy for resistant HIV-1 infection. N Engl J Med 2008; 359:339-354.
-
(2008)
N Engl J Med
, vol.359
, pp. 339-354
-
-
Steigbigel, R.T.1
Cooper, D.A.2
Kumar, P.N.3
-
8
-
-
47949114939
-
Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection
-
Cooper DA, Steigbigel RT, Gatell JM, et al. Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection. N Engl J Med 2008; 359:355-365.
-
(2008)
N Engl J Med
, vol.359
, pp. 355-365
-
-
Cooper, D.A.1
Steigbigel, R.T.2
Gatell, J.M.3
-
9
-
-
33748113778
-
Antiviral activity, pharmacokinetics, and dose response of the HIV-1 integrase inhibitor GS-9137 (JTK-303) in treatment-naive and treatment-experienced patients
-
Dejesus E, Berger D, Markowitz M, et al. Antiviral activity, pharmacokinetics, and dose response of the HIV-1 integrase inhibitor GS-9137 (JTK-303) in treatment-naive and treatment-experienced patients. J Acquir Immune Defic Syndr 2006; 43:1-5.
-
(2006)
J Acquir Immune Defic Syndr
, vol.43
, pp. 1-5
-
-
Dejesus, E.1
Berger, D.2
Markowitz, M.3
-
10
-
-
34248199833
-
The HIV integrase inhibitor GS-9137 demonstrates potent antiretroviral activity in treatment-experienced patients
-
25-28 February, Los Angeles, CA, USA. Abstract 143LB
-
Zolopa A, Mullen M, Berger D, et al. The HIV integrase inhibitor GS-9137 demonstrates potent antiretroviral activity in treatment-experienced patients. 14th Conference on Retroviruses and Opportunistic Infections. 25-28 February 2007, Los Angeles, CA, USA. Abstract 143LB.
-
(2007)
14th Conference on Retroviruses and Opportunistic Infections
-
-
Zolopa, A.1
Mullen, M.2
Berger, D.3
-
11
-
-
33644863638
-
Novel HIV-1 integrase inhibitors derived from quinolone antibiotics
-
Sato M, Motomura T, Aramaki H, et al. Novel HIV-1 integrase inhibitors derived from quinolone antibiotics. J Med Chem 2006; 49:1506-1508.
-
(2006)
J Med Chem
, vol.49
, pp. 1506-1508
-
-
Sato, M.1
Motomura, T.2
Aramaki, H.3
-
12
-
-
52449097240
-
Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection
-
Summa V, Petrocchi A, Bonelli F, et al. Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection. J Med Chem 2008; 51: 5843-5855.
-
(2008)
J Med Chem
, vol.51
, pp. 5843-5855
-
-
Summa, V.1
Petrocchi, A.2
Bonelli, F.3
-
13
-
-
53249087908
-
Selection of diverse and clinically relevant integrase inhibitor-resistant human immunodeficiency virus type 1 mutants
-
Kobayashi M, Nakahara K, Seki T, et al. Selection of diverse and clinically relevant integrase inhibitor-resistant human immunodeficiency virus type 1 mutants. Antiviral Res 2008; 80:213-222.
-
(2008)
Antiviral Res
, vol.80
, pp. 213-222
-
-
Kobayashi, M.1
Nakahara, K.2
Seki, T.3
-
14
-
-
37849002059
-
Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137)
-
Shimura K, Kodama E, Sakagami Y, et al. Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137). J Virol 2008; 82:764-774.
-
(2008)
J Virol
, vol.82
, pp. 764-774
-
-
Shimura, K.1
Kodama, E.2
Sakagami, Y.3
-
15
-
-
54549099338
-
HIV-2 integrase gene polymorphism and phenotypic susceptibility of HIV-2 clinical isolates to the integrase inhibitors raltegravir and elvitegravir in vitro
-
Roquebert B, Damond F, Collin G, et al. HIV-2 integrase gene polymorphism and phenotypic susceptibility of HIV-2 clinical isolates to the integrase inhibitors raltegravir and elvitegravir in vitro. J Antimicrob Chemother 2008; 62:914-920.
-
(2008)
J Antimicrob Chemother
, vol.62
, pp. 914-920
-
-
Roquebert, B.1
Damond, F.2
Collin, G.3
-
16
-
-
1542319002
-
Susceptibility of HIV-2, SIV and SHIV to various anti-HIV-1 compounds: Implications for treatment and postexposure prophylaxis
-
Witvrouw M, Pannecouque C, Switzer WM, et al. Susceptibility of HIV-2, SIV and SHIV to various anti-HIV-1 compounds: implications for treatment and postexposure prophylaxis. Antivir Ther 2004; 9:57-65.
-
(2004)
Antivir Ther
, vol.9
, pp. 57-65
-
-
Witvrouw, M.1
Pannecouque, C.2
Switzer, W.M.3
-
17
-
-
0028172345
-
Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase. Implications for mechanisms of drug inhibition and resistance
-
Tantillo C, Ding J, Jacobo-Molina A, et al. Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase. Implications for mechanisms of drug inhibition and resistance. J Mol Biol 1994; 243:369-387.
-
(1994)
J Mol Biol
, vol.243
, pp. 369-387
-
-
Tantillo, C.1
Ding, J.2
Jacobo-Molina, A.3
-
18
-
-
8644231282
-
Human cell proteins and human immunodeficiency virus DNA integration
-
Turlure F, Devroe E, Silver PA, Engelman A. Human cell proteins and human immunodeficiency virus DNA integration. Front Biosci 2004; 9:3187-3208.
-
(2004)
Front Biosci
, vol.9
, pp. 3187-3208
-
-
Turlure, F.1
Devroe, E.2
Silver, P.A.3
Engelman, A.4
-
19
-
-
51549116289
-
Comparison of raltegravir and elvitegravir on HIV-1 integrase catalytic reactions and on a series of drug-resistant integrase mutants
-
Marinello J, Marchand C, Mott BT, et al. Comparison of raltegravir and elvitegravir on HIV-1 integrase catalytic reactions and on a series of drug-resistant integrase mutants. Biochemistry 2008; 47:9345-9354.
-
(2008)
Biochemistry
, vol.47
, pp. 9345-9354
-
-
Marinello, J.1
Marchand, C.2
Mott, B.T.3
-
20
-
-
34147128555
-
In-silico docking of HIV-1 integrase inhibitors reveals a novel drug type acting on an enzyme/DNA reaction intermediate
-
Savarino A. In-silico docking of HIV-1 integrase inhibitors reveals a novel drug type acting on an enzyme/DNA reaction intermediate. Retrovirology 2007; 4:21.
-
(2007)
Retrovirology
, vol.4
, pp. 21
-
-
Savarino, A.1
-
21
-
-
31544474642
-
HIV integrase inhibitors with nucleobase scaffolds: Discovery of a highly potent anti-HIV agent
-
Nair V, Chi G, Ptak R, Neamati N. HIV integrase inhibitors with nucleobase scaffolds: discovery of a highly potent anti-HIV agent. J Med Chem 2006; 49:445-447.
-
(2006)
J Med Chem
, vol.49
, pp. 445-447
-
-
Nair, V.1
Chi, G.2
Ptak, R.3
Neamati, N.4
-
22
-
-
70449330470
-
INH-I001, a HIV integrase inhibitor with potent in vitro anti-HIV activity: Microsome and cytosol stability studies, cytochrome P450 data and pharmaco kinetics
-
3-6 February, Boston, MA, USA. Abstract 734
-
Nair V, Ma X, White C, et al. INH-I001, a HIV integrase inhibitor with potent in vitro anti-HIV activity: microsome and cytosol stability studies, cytochrome P450 data and pharmaco kinetics. 15th Conference on Retroviruses and Opportunistic Infections. 3-6 February 2008, Boston, MA, USA. Abstract 734.
-
(2008)
15th Conference on Retroviruses and Opportunistic Infections
-
-
Nair, V.1
Ma, X.2
White, C.3
-
23
-
-
70449374083
-
-
ClinicalTrials.gov. Phase 3 study of the safety and efficacy of ritonavir-boosted elvitegravir (EVG/r) versus raltegravir (RAL). (Updated 20 April 2009. Accessed 28 August 2009.) Available from http://www.clinicaltrials.gov/ct2/show/NCT00707733
-
ClinicalTrials.gov. Phase 3 study of the safety and efficacy of ritonavir-boosted elvitegravir (EVG/r) versus raltegravir (RAL). (Updated 20 April 2009. Accessed 28 August 2009.) Available from http://www.clinicaltrials.gov/ct2/show/NCT00707733
-
-
-
-
25
-
-
70350179571
-
GS-9350: A pharmacoenhancer without anti-HIV activity
-
8-11 February, Montreal, QC, Canada. Abstract 40
-
Mathias A, Lee M, Callebaut C, et al. GS-9350: a pharmacoenhancer without anti-HIV activity. 16th Conference on Retroviruses and Opportunistic Infections. 8-11 February 2009, Montreal, QC, Canada. Abstract 40.
-
(2009)
16th Conference on Retroviruses and Opportunistic Infections
-
-
Mathias, A.1
Lee, M.2
Callebaut, C.3
-
26
-
-
34347347164
-
Pharmacokinetics of emtricitabine, tenofovir, and GS-9137 following coadministration of emtricitabine/tenofovir disoproxil fumarate and ritonavir-boosted GS-9137
-
Ramanathan S, Shen G, Cheng A, Kearney BP. Pharmacokinetics of emtricitabine, tenofovir, and GS-9137 following coadministration of emtricitabine/tenofovir disoproxil fumarate and ritonavir-boosted GS-9137. J Acquir Immune Defic Syndr 2007; 45:274-279.
-
(2007)
J Acquir Immune Defic Syndr
, vol.45
, pp. 274-279
-
-
Ramanathan, S.1
Shen, G.2
Cheng, A.3
Kearney, B.P.4
-
27
-
-
40549145842
-
The naphthyridinone GSK364735 is a novel, potent human immunodeficiency virus type 1 integrase inhibitor and antiretroviral
-
Garvey EP, Johns BA, Gartland MJ, et al. The naphthyridinone GSK364735 is a novel, potent human immunodeficiency virus type 1 integrase inhibitor and antiretroviral. Antimicrob Agents Chemother 2008; 52:901-908.
-
(2008)
Antimicrob Agents Chemother
, vol.52
, pp. 901-908
-
-
Garvey, E.P.1
Johns, B.A.2
Gartland, M.J.3
-
28
-
-
55249105017
-
Resistance mutations in human immunodeficiency virus type 1 integrase selected with elvitegravir confer reduced susceptibility to a wide range of integrase inhibitors
-
Goethals O, Clayton R, van Ginderen M, et al. Resistance mutations in human immunodeficiency virus type 1 integrase selected with elvitegravir confer reduced susceptibility to a wide range of integrase inhibitors. J Virol 2008; 82:10366-10374.
-
(2008)
J Virol
, vol.82
, pp. 10366-10374
-
-
Goethals, O.1
Clayton, R.2
van Ginderen, M.3
-
29
-
-
40549125135
-
Resistance and cross-resistance to first generation integrase inhibitors: Insights from a Phase II study of elvitegravir (GS-9137)
-
McColl DJ, Fransen S, Gupta S, et al. Resistance and cross-resistance to first generation integrase inhibitors: insights from a Phase II study of elvitegravir (GS-9137). Antivir Ther 2007; 12 Suppl 1:S11.
-
(2007)
Antivir Ther
, vol.12
, Issue.SUPPL. 1
-
-
McColl, D.J.1
Fransen, S.2
Gupta, S.3
-
30
-
-
54049102468
-
Drug resistance profiles for the HIV integrase gene in patients failing raltegravir salvage therapy
-
Charpentier C, Karmochkine M, Laureillard D, et al. Drug resistance profiles for the HIV integrase gene in patients failing raltegravir salvage therapy. HIV Med 2008; 9:765-770.
-
(2008)
HIV Med
, vol.9
, pp. 765-770
-
-
Charpentier, C.1
Karmochkine, M.2
Laureillard, D.3
-
31
-
-
17344390474
-
Antiretroviral drug resistance testing in adults with HIV infection: Implications for clinical management. International AIDS Society-USA Panel
-
Hirsch MS, Conway B, D'Aquila RT, et al. Antiretroviral drug resistance testing in adults with HIV infection: implications for clinical management. International AIDS Society-USA Panel. JAMA 1998; 279:1984-1991.
-
(1998)
JAMA
, vol.279
, pp. 1984-1991
-
-
Hirsch, M.S.1
Conway, B.2
D'Aquila, R.T.3
-
32
-
-
23844557339
-
HIV genetic diversity: Any implications for drug resistance?
-
Julg B, Goebel FD. HIV genetic diversity: any implications for drug resistance? Infection 2005; 33:299-301.
-
(2005)
Infection
, vol.33
, pp. 299-301
-
-
Julg, B.1
Goebel, F.D.2
-
33
-
-
0038298453
-
Polymorphism in HIV-1 non-subtype B protease and reverse transcriptase and its potential impact on drug susceptibility and drug resistance evolution
-
Kantor R, Katzenstein D. Polymorphism in HIV-1 non-subtype B protease and reverse transcriptase and its potential impact on drug susceptibility and drug resistance evolution. AIDS Rev 2003; 5:25-35.
-
(2003)
AIDS Rev
, vol.5
, pp. 25-35
-
-
Kantor, R.1
Katzenstein, D.2
-
34
-
-
34447263572
-
Natural polymorphism of the HIV-1 integrase gene and mutations associated with integrase inhibitor resistance
-
Lataillade M, Chiarella J, Kozal MJ. Natural polymorphism of the HIV-1 integrase gene and mutations associated with integrase inhibitor resistance. Antivir Ther 2007; 12:563-570.
-
(2007)
Antivir Ther
, vol.12
, pp. 563-570
-
-
Lataillade, M.1
Chiarella, J.2
Kozal, M.J.3
-
35
-
-
48749125376
-
Genetic diversity of integrase (IN) sequences in antiretroviral treatment-naive and treatment-experienced HIV type 2 patients
-
Xu L, Anderson J, Ferns B, et al. Genetic diversity of integrase (IN) sequences in antiretroviral treatment-naive and treatment-experienced HIV type 2 patients. AIDS Res Hum Retroviruses 2008; 24:1003-1007.
-
(2008)
AIDS Res Hum Retroviruses
, vol.24
, pp. 1003-1007
-
-
Xu, L.1
Anderson, J.2
Ferns, B.3
-
36
-
-
3242769788
-
Integrase inhibitors and cellular immunity suppress retroviral replication in rhesus macaques
-
Hazuda DJ, Young SD, Guare JP, et al. Integrase inhibitors and cellular immunity suppress retroviral replication in rhesus macaques. Science 2004; 305:528-532.
-
(2004)
Science
, vol.305
, pp. 528-532
-
-
Hazuda, D.J.1
Young, S.D.2
Guare, J.P.3
-
37
-
-
39449128792
-
Human immunodeficiency virus integrase inhibitors efficiently suppress feline immunodeficiency virus replication in vitro and provide a rationale to redesign antiretroviral treatment for feline AIDS
-
Savarino A, Pistello M, D'Ostilio D, et al. Human immunodeficiency virus integrase inhibitors efficiently suppress feline immunodeficiency virus replication in vitro and provide a rationale to redesign antiretroviral treatment for feline AIDS. Retrovirology 2007; 4:79.
-
(2007)
Retrovirology
, vol.4
, pp. 79
-
-
Savarino, A.1
Pistello, M.2
D'Ostilio, D.3
-
38
-
-
0036784324
-
Inhibition of human immunodeficiency virus type 1 integration by diketo derivatives
-
Pluymers W, Pais G, Van Maele B, et al. Inhibition of human immunodeficiency virus type 1 integration by diketo derivatives. Antimicrob Agents Chemother 2002; 46:3292-3297.
-
(2002)
Antimicrob Agents Chemother
, vol.46
, pp. 3292-3297
-
-
Pluymers, W.1
Pais, G.2
Van Maele, B.3
-
39
-
-
3843108916
-
A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase
-
Hazuda DJ, Anthony NJ, Gomez RP, et al. A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase. Proc Natl Acad Sci U S A 2004; 101:11233-11238.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 11233-11238
-
-
Hazuda, D.J.1
Anthony, N.J.2
Gomez, R.P.3
|