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Results of BENCHMRK-1, a phase III study evaluating the efficacy and safety of MK-0518, a novel HIV-1 integrase inhibitor
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Results of BENCHMRK-2, a phase III study evaluating the efficacy and safety of MK-0518, a novel HIV-1 integrase inhibitor
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Steigbigel R, Kumar P, Eron J, et al. Results of BENCHMRK-2, a phase III study evaluating the efficacy and safety of MK-0518, a novel HIV-1 integrase inhibitor, in patients with triple-class resistant virus. Presented at the 14th conference on retroviruses and opportunistic infections, Los Angeles, CA, February 25-28, 2007.
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patients with triple-class resistant virus. Presented at the 14th conference on retroviruses and opportunistic infections
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Steigbigel, R.1
Kumar, P.2
Eron, J.3
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6
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Antiviral activity, pharmacokinetics, and dose response of the HIV-1 integrase inhibitor GS-9137 (JTK-303) in treatment-naïve and treatment-experienced patients
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The HIV integrase inhibitor GS-9137 demonstrates potent antiretroviral activity in treatment-experienced patients
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Zolopa A, Mullen M, Berger D, et al. The HIV integrase inhibitor GS-9137 demonstrates potent antiretroviral activity in treatment-experienced patients. Presented at the 14th conference on retroviruses and opportunistic infections, Los Angeles, CA, February 25-28, 2007.
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14th conference on retroviruses and opportunistic infections
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Zolopa, A.1
Mullen, M.2
Berger, D.3
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8
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33749865167
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Potent antiretroviral effect of MK-0518, a novel HIV-1 integrase inhibitor, as part of combination ART in treatment-naïve HIV-1 infected patients
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Markowitz M, Nguyen BY, Gotuzzo F, et al. Potent antiretroviral effect of MK-0518, a novel HIV-1 integrase inhibitor, as part of combination ART in treatment-naïve HIV-1 infected patients. Presented at the 16th international AIDS conference, Toronto, Canada, August 13-18, 2006.
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16th international AIDS conference
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Markowitz, M.1
Nguyen, B.Y.2
Gotuzzo, F.3
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9
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Requirement for integrase during reverse transcription of human immunodeficiency virus type-1 and the effect of cysteine mutations of integrase on its interactions with reverse transcriptase
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Safety, tolerability and pharmacokinetics after single and multiple doses of MK-0518 in healthy subjects
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Wenning, L.A.2
Laethem, M.3
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13
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Antiretroviral activity, pharmacokinetics, and tolerability of MK-0518, a novel inhibitor of HIV-1 integrase, dosed as monotherapy for 10 days in treatment-naïve HIV-1-infected individuals
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Markowitz M, Morales-Ramirez JO, Nguyen BY, et al. Antiretroviral activity, pharmacokinetics, and tolerability of MK-0518, a novel inhibitor of HIV-1 integrase, dosed as monotherapy for 10 days in treatment-naïve HIV-1-infected individuals. J Acquir Immune Defic Syndr 2006;43:509-15.
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Markowitz, M.1
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Nguyen, B.Y.3
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14
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Biochemical and antiviral activity of MK-0518, a potent HIV integrase inhibitor
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Presented at the, Toronto, Canada, August 13-18
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Miller M, Witmer M, Stillmock K, et al. Biochemical and antiviral activity of MK-0518, a potent HIV integrase inhibitor. Presented at the 16th international AIDS conference, Toronto, Canada, August 13-18, 2006.
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16th international AIDS conference
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Miller, M.1
Witmer, M.2
Stillmock, K.3
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15
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37249040661
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Absorption, metabolism and excretion of MK-0518, a potent HIV-1 integrase inhibitor
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San Francisco, CA, September 27-30
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Kassahun K, McIntosh I, Hreniuk D, et al. Absorption, metabolism and excretion of MK-0518, a potent HIV-1 integrase inhibitor, in healthy male volunteers. Presented at the 46th interscience conference on antimicrobial agents and chemotherapy, San Francisco, CA, September 27-30, 2006.
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healthy male volunteers. Presented at the 46th interscience conference on antimicrobial agents and chemotherapy
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Kassahun, K.1
McIntosh, I.2
Hreniuk, D.3
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16
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38049037959
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Lack of a pharmacokinetic interaction of MK-0518 on midazolam (MDZ)
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Presented at the, Glasgow, United Kingdom, November 12-16
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Iwamoto M, Wenning LA, Troyer MD, et al. Lack of a pharmacokinetic interaction of MK-0518 on midazolam (MDZ). Presented at the 8th international congress on drug therapy in HIV infection, Glasgow, United Kingdom, November 12-16, 2006.
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8th international congress on drug therapy in HIV infection
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Iwamoto, M.1
Wenning, L.A.2
Troyer, M.D.3
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17
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33745198847
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Safety and pharmacokinetics of single oral dose JTK-303/GS-9137, a novel integrase inhibitor
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Denver, CO, February 5-9
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Kawaguchi I, Ishikawa T, Ishibashi M, Irie S, Kakee A. Safety and pharmacokinetics of single oral dose JTK-303/GS-9137, a novel integrase inhibitor, in healthy volunteers. Presented at the 13th conference on retrovirus and opportunistic infections, Denver, CO, February 5-9, 2006.
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healthy volunteers. Presented at the 13th conference on retrovirus and opportunistic infections
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Kawaguchi, I.1
Ishikawa, T.2
Ishibashi, M.3
Irie, S.4
Kakee, A.5
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18
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33746816830
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Pharmacokinetics/ pharmacodynamics of GS-9137, an HIV integrase inhibitor
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Presented at the, Lisbon, Portugal, April 20-22
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Kearney BP, Mathias M, Zhong, L, et al. Pharmacokinetics/ pharmacodynamics of GS-9137, an HIV integrase inhibitor. Presented at the 7th international workshop on clinical pharmacology of HIV therapy, Lisbon, Portugal, April 20-22, 2006.
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Kearney, B.P.1
Mathias, M.2
Zhong, L.3
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19
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34248203565
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Resistance profile of HIV-1 mutations in vitro selected by the HIV-1 integrase inhibitor, GS-9137 (JTK-303)
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Presented at the, Los Angeles, CA, February 25-28
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Jones C, Ledford R, Yu F, McColl D. Resistance profile of HIV-1 mutations in vitro selected by the HIV-1 integrase inhibitor, GS-9137 (JTK-303). Presented at the 14th conference on retroviruses and opportunistic infections, Los Angeles, CA, February 25-28, 2007.
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14th conference on retroviruses and opportunistic infections
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Jones, C.1
Ledford, R.2
Yu, F.3
McColl, D.4
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20
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37549006934
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Atazanavir and ritonavir increase plasma levels of MK-0518
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Presented at the, Glasgow, United Kingdom, November 12-16
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Mistry GC, Wenning LA, Merschman S, et al. Atazanavir and ritonavir increase plasma levels of MK-0518. Presented at the 8th international congress on drug therapy in HIV infection, Glasgow, United Kingdom, November 12-16, 2006.
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8th international congress on drug therapy in HIV infection
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Mistry, G.C.1
Wenning, L.A.2
Merschman, S.3
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21
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34247396153
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Effect of tipranavir + ritonavir (tpv + rtv) on pharmacokinetics of MK-0518
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Presented at the, San Francisco, CA, September 27-30
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Wenning LA, Hanley H, Stone J, et al. Effect of tipranavir + ritonavir (tpv + rtv) on pharmacokinetics of MK-0518. Presented at the 46th interscience conference on antimicrobial agents and chemotherapy, San Francisco, CA, September 27-30, 2006.
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46th interscience conference on antimicrobial agents and chemotherapy
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Wenning, L.A.1
Hanley, H.2
Stone, J.3
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22
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37249045158
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Minimal effect of ritonavir (RTV) and efavirenz (EFV) on the pharmacokinetics (PK) of MK-0518
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Presented at the, San Francisco, CA, September 27-30
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Iwamoto M, Wenning LA, Petry AS, et al. Minimal effect of ritonavir (RTV) and efavirenz (EFV) on the pharmacokinetics (PK) of MK-0518. Presented at the 46th interscience conference on antimicrobial agents and chemotherapy, San Francisco, CA, September 27-30, 2006.
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46th interscience conference on antimicrobial agents and chemotherapy
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Iwamoto, M.1
Wenning, L.A.2
Petry, A.S.3
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23
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34548073641
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Rifampin (RIF) modestly reduces plasma levels of MK-0518
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Presented at the, Glasgow, United Kingdom, November 12-16
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Iwamoto M, Wenning LA, Liou SY, et al. Rifampin (RIF) modestly reduces plasma levels of MK-0518. Presented at the 8th international congress on drug therapy in HIV infection, Glasgow, United Kingdom, November 12-16, 2006.
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8th international congress on drug therapy in HIV infection
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Iwamoto, M.1
Wenning, L.A.2
Liou, S.Y.3
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24
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58149530512
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Pharmacokinetic evaluation of drug interactions with ritonavir-boosted HIV integrase inhibitor GS-9137 (elvitegravir) and acid-reducing agents
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Presented at the, Budapest, Hungary, April 16-18
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Ramanthan S, Shen G, Hinkle J, Enejosa J, Kearney BP. Pharmacokinetic evaluation of drug interactions with ritonavir-boosted HIV integrase inhibitor GS-9137 (elvitegravir) and acid-reducing agents. Presented at the 8th international workshop on clinical pharmacology of HIV therapy, Budapest, Hungary, April 16-18, 2007.
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8th international workshop on clinical pharmacology of HIV therapy
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Ramanthan, S.1
Shen, G.2
Hinkle, J.3
Enejosa, J.4
Kearney, B.P.5
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25
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58149530512
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Lack of clinically relevant drug interactions between ritonavir-boosted HIV integrase inhibitor GS-9137 (elvitegravir) and stavudine, didanosine or abacavir
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Presented at the, Budapest, Hungary, April 16-18
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Ramanthan S, Shen G, Hinkle J, Enejosa J, Kearney BP. Lack of clinically relevant drug interactions between ritonavir-boosted HIV integrase inhibitor GS-9137 (elvitegravir) and stavudine, didanosine or abacavir. Presented at the 8th international workshop on clinical pharmacology of HIV therapy, Budapest, Hungary, April 16-18, 2007.
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8th international workshop on clinical pharmacology of HIV therapy
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Ramanthan, S.1
Shen, G.2
Hinkle, J.3
Enejosa, J.4
Kearney, B.P.5
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26
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34347347164
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Pharmacokinetics of emtricitabine, tenofovir and GS-9137 following coadministration of emtricitabine/tenofovir disoproxil fumarate and ritonavir-boosted GS-9137
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Presented at the, Toronto, Canada, August 13-18
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Ramanathan S, Shen G, Cheng A, Kearney BP. Pharmacokinetics of emtricitabine, tenofovir and GS-9137 following coadministration of emtricitabine/tenofovir disoproxil fumarate and ritonavir-boosted GS-9137. Presented at the 16th international AIDS conference, Toronto, Canada, August 13-18, 2006.
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(2006)
16th international AIDS conference
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Ramanathan, S.1
Shen, G.2
Cheng, A.3
Kearney, B.P.4
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27
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34248212660
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Lack of clinically relevant drug-drug interaction between the ritonavir-boosted HIV integrase inhibitor GS-9137/r and zidovudine
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Presented at the, Toronto, Canada, August 13-18
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Ramanathan S, Lagan K, Plummer A, et al. Lack of clinically relevant drug-drug interaction between the ritonavir-boosted HIV integrase inhibitor GS-9137/r and zidovudine. Presented at the 16th international AIDS conference, Toronto, Canada, August 13-18, 2006.
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(2006)
16th international AIDS conference
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Ramanathan, S.1
Lagan, K.2
Plummer, A.3
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