Children with dry skin and atopic predisposition: Daily use of emollients in a participant-blinded, randomized, prospective trial

Skin Pharmacology and Physiology

Volumn 27, Issue 4, 2014, Pages 208-216

  Schario, Marianne ^a   Lünnemann, Lena ^a   Stroux, Andrea ^a,b   Reisshauer, Anett ^c   Zuberbier, Torsten ^a   Blume Peytavi, Ulrike ^a   Garcia Bartels, Natalie ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b Departments of Medical Statistics and Clinical Epidemiology   (Germany)

^c Departments of Physical Medicine and Rehabilitation   (Germany)

Author keywords

Atopic dermatitis; Children; Dry skin; Emollient; Ice plant; Skin barrier; Skin pH; Stratum corneum hydration; TEWL; Transepidermal water loss

Indexed keywords

EMOLLIENT AGENT; PETROLATUM BASED EMOLLIENT; PLANT EXTRACT; PRESSED ICE PLANT JUICE; UNCLASSIFIED DRUG; PETROLATUM; PRESSED ICE PLANT JUICE EXTRACT;

ARTICLE; ATOPIC DERMATITIS; BODY SURFACE; CHILD; CHILDHOOD DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; DRUG EFFECT; DRUG USE; DRY SKIN; FEMALE; FOREARM; FOREHEAD; HUMAN; HYDRATION; MALE; PH; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; SKIN CARE; SKIN CONDUCTANCE; SKIN EXAMINATION; SKIN FUNCTION; SKIN PROTECTION; SKIN SURFACE; SKIN WATER LOSS; STRATUM CORNEUM; OUTCOME ASSESSMENT; BODY WATER; DERMATITIS, ATOPIC; EPIDERMIS; METABOLISM; PRESCHOOL CHILD; PROCEDURES;

BODY WATER; CHILD; CHILD, PRESCHOOL; DERMATITIS, ATOPIC; EMOLLIENTS; EPIDERMIS; FEMALE; HUMANS; HYDROGEN-ION CONCENTRATION; MALE; PLANT EXTRACTS; PROSPECTIVE STUDIES; SKIN CARE;

EID: 84897359500     PISSN: 16605527     EISSN: 16605535     Source Type: Journal    
DOI: 10.1159/000360546     Document Type: Article

References (73)

1. Böhme M, et al: Hanifin's and Rajka's minor criteria for atopic dermatitis: which do 2-yearolds exhibit? J Am Acad Dermatol 2000; 43: 785-792.
2. Cork MJ, Danby S: Skin barrier breakdown: a renaissance in emollient therapy. Br J Nurs 2009; 18: 876-877.
3. Flohr C, et al: Filaggrin loss-of-function mutations are associated with early-onset eczema, eczema severity and transepidermal water loss at 3 months of age. Br J Dermatol 2010; 163: 1333-1336.
4. Proksch E, Lachapelle JM: The management of dry skin with topical emollients: recent perspectives. J Dtsch Dermatol Ges 2005; 3: 768-774.
5. Simpson EL, et al: A pilot study of emollient therapy for the primary prevention of atopic dermatitis. J Am Acad Dermatol 2010; 63: 587-593.
6. Seidenari S, Giusti G: Objective assessment of the skin of children affected by atopic dermatitis: a study of pH, capacitance and TEWL in eczematous and clinically uninvolved skin. Acta Derm Venereol 1995; 75: 429-433.
7. Horii I, et al: Stratum corneum hydration and amino acid content in xerotic skin. Br J Dermatol 1989; 121: 587-592.
8. Berry N, et al: A clinical, biometrological and ultrastructural study of xerotic skin. Int J Cosmet Sci 1999; 21: 241-252.
9. Moncrieff G, et al: Use of emollients in dryskin conditions: consensus statement. Clin Exp Dermatol 2013; 38: 231-238.
10. Pons-Guiraud A: Dry skin in dermatology: a complex physiopathology. J Eur Acad Dermatol Venereol 2007; 21(suppl 2):1-4.
11. Nikolovski J, et al: Barrier function and water-holding and transport properties of infant stratum corneum are different from adult and continue to develop through the first year of life. J Invest Dermatol 2008; 128: 1728-1736.
12. Chaumont A, et al: Interactions between domestic water hardness, infant swimming and atopy in the development of childhood eczema. Environ Res 2012; 116: 52-57.
13. Seyfarth F, et al: Dry skin, barrier function, and irritant contact dermatitis in the elderly. Clin Dermatol 2011; 29: 31-36.
14. Seidenari S, et al: Thickness and echogenicity of the skin in children as assessed by 20-MHz ultrasound. Dermatology 2000; 201: 218-222.
15. Stamatas GN, et al: Infant skin physiology and development during the first years of life: a review of recent findings based on in vivo studies. Int J Cosmet Sci 2011; 33: 17-24.
16. Garcia Bartels N, et al: Influence of bathing or washing on skin barrier function in newborns during the first four weeks of life. Skin Pharmacol Physiol 2009; 22: 248-257.
17. Garcia Bartels N, et al: Effect of standardized skin care regimens on neonatal skin barrier function in different body areas. Pediatr Dermatol 2010; 27: 1-8.
18. Fluhr JW, et al: Impact of anatomical location on barrier recovery, surface pH and stratum corneum hydration after acute barrier disruption. Br J Dermatol 2002; 146: 770-776.
19. Reuter J, Merfort I, Schempp CM: Botanicals in dermatology: an evidence-based review. Am J Clin Dermatol 2010; 11: 247-267.
20. Ring J, et al: Guidelines for treatment of atopic eczema (atopic dermatitis). Part II. J Eur Acad Dermatol Venereol 2012; 26: 1176-1193.
21. Serup J: EEMCO guidance for the assessment of dry skin (xerosis) and ichthyosis: clinical scoring systems. Skin Res Technol 1995; 1: 109-114.
22. Diepgen TL, Fartasch M, Hornstein OP: Criteria of atopic skin diathesis. Derm Beruf Umwelt 1991; 39: 79-83.
23. Diepgen TL, Sauerbrei W, Fartasch M: Development and validation of diagnostic scores for atopic dermatitis incorporating criteria of data quality and practical usefulness. J Clin Epidemiol 1996; 49: 1031-1038.
24. Hanifin JM, Rajka G: Diagnostic features of atopic dermatitis. Acta Derm Venereol 1980; 92(suppl):44-47.
25. Turner L, et al: Consolidated Standards of Reporting Trials (CONSORT) and the completeness of reporting of randomised controlled trials (RCTs) published in medical journals. Cochrane Database Syst Rev 2012; 11:MR000030.
26. Kunz B, et al: Clinical validation and guidelines for the SCORAD index: consensus report of the European Task Force on Atopic Dermatitis. Dermatology 1997; 195: 10-19.
27. Severity scoring of atopic dermatitis: the SCORAD index. Consensus Report of the European Task Force on Atopic Dermatitis. Dermatology 1993; 186: 23-31.
28. Charman C, Chambers C, Williams H: Measuring atopic dermatitis severity in randomized controlled clinical trials: what exactly are we measuring? J Invest Dermatol 2003; 120: 932-941.
29. Schmitt J, et al: What are the best outcome measurements for atopic eczema? A systematic review. J Allergy Clin Immunol 2007; 120: 1389-1398.
30. Oranje AP, et al: Practical issues on interpretation of scoring atopic dermatitis: the SCORAD index, objective SCORAD and the three-item severity score. Br J Dermatol 2007; 157: 645-648.
31. Schram ME, et al: EASI, (objective) SCORAD and POEM for atopic eczema: responsiveness and minimal clinically important difference. Allergy 2012; 67: 99-106.
32. Schmitt J, et al: Assessment of clinical signs of atopic dermatitis: a systematic review and recommendation. J Allergy Clin Immunol 2013; 132: 1337-1347.
33. Zeger SL, Liang KY, Albert PS: Models for longitudinal data: a generalized estimating equation approach. Biometrics 1988; 44: 1049-1060.
34. Lodén M: Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders. Am J Clin Dermatol 2003; 4: 771-788.
35. Proksch E: The role of emollients in the management of diseases with chronic dry skin. Skin Pharmacol Physiol 2008; 21: 75-80.
36. Fluhr JW, et al: Infant epidermal skin physiology: adaptation after birth. Br J Dermatol 2012; 166: 483-490.
37. Guenther L, et al: Pathway to dry skin prevention and treatment. J Cutan Med Surg 2012; 16: 23-31.
38. Garcia Bartels N, et al: Effect of baby swimming and baby lotion on the skin barrier of infants aged 3-6 months (in English, German). J Dtsch Dermatol Ges 2011; 9: 1018-1025.
39. Fischer TW, Wigger-Alberti W, Elsner P: Assessment of 'dry skin': current bioengineering methods and test designs. Skin Pharmacol Appl Skin Physiol 2001; 14: 183-195.
40. Yosipovitch G, et al: Skin barrier properties in different body areas in neonates. Pediatrics 2000; 106: 105-108.
41. Garcia Bartels N, et al: Standardized diaper care regimen: a prospective, randomized pilot study on skin barrier function and epidermal IL-1 in newborns. Pediatr Dermatol 2012; 29: 270-276.
42. Leung DY, Bieber T: Atopic dermatitis. Lancet 2003; 361: 151-160.
43. Abramovits W: Atopic dermatitis. J Am Acad Dermatol 2005; 53(suppl 1):S86-S93.
44. Fluhr JW, Pfisterer S, Gloor M: Direct comparison of skin physiology in children and adults with bioengineering methods. Pediatr Dermatol 2000; 17: 436-439.
45. Szczepanowska J, Reich A, Szepietowski JC: Emollients improve treatment results with topical corticosteroids in childhood atopic dermatitis: a randomized comparative study. Pediatr Allergy Immunol 2008; 19: 614-618.
46. Hon KL, et al: The ideal moisturizer: a survey of parental expectations and practice in childhood-onset eczema. J Dermatol Treat 2013; 24: 7-12.
47. Fluhr JW, Darlenski R, Surber C: Glycerol and the skin: holistic approach to its origin and functions. Br J Dermatol 2008; 159: 23-34.
48. Harding CR, et al: Dry skin, moisturization and corneodesmolysis. Int J Cosmet Sci 2000; 22: 21-52.
49. Crowther JM, et al: Measuring the effects of topical moisturizers on changes in stratum corneum thickness, water gradients and hydration in vivo. Br J Dermatol 2008; 159: 567-577.
50. Scott IR, Harding CR: Filaggrin breakdown to water binding compounds during development of the rat stratum corneum is controlled by the water activity of the environment. Dev Biol 1986; 115: 84-92.
51. Rawlings AV, Matts PJ: Stratum corneum moisturization at the molecular level: an update in relation to the dry skin cycle. J Invest Dermatol 2005; 124: 1099-1110.
52. Sator PG, Schmidt JB, Hönigsmann H: Comparison of epidermal hydration and skin surface lipids in healthy individuals and in patients with atopic dermatitis. J Am Acad Dermatol 2003; 48: 352-358.
53. Patzelt A, et al: In vivo investigations on the penetration of various oils and their influence on the skin barrier. Skin Res Technol 2012; 18: 364-369.
54. Boralevi F, et al: Long-term emollient therapy improves xerosis in children with atopic dermatitis. J Eur Acad Dermatol Venereol 2013, Epub ahead of print.
55. Evangelista MT, Abad-Casintahan F, Lopez-Villafuerte L: The effect of topical virgin coconut oil on SCORAD index, transepidermal water loss, and skin capacitance in mild to moderate pediatric atopic dermatitis: a randomized, double-blind, clinical trial. Int J Dermatol 2014; 53: 100-108.
56. Lodén M: Effect of moisturizers on epidermal barrier function. Clin Dermatol 2012; 30: 286-296.
57. Rippke F, et al: Stratum corneum pH in atopic dermatitis: impact on skin barrier function and colonization with Staphylococcus aureus. Am J Clin Dermatol 2004; 5: 217-223.
58. Rippke F, Schreiner V, Schwanitz HJ: The acidic milieu of the horny layer: new findings on the physiology and pathophysiology of skin pH. Am J Clin Dermatol 2002; 3: 261-272.
59. Harder J, Schröder JM, Gläser R: The skin surface as antimicrobial barrier: present concepts and future outlooks. Exp Dermatol 2013; 22: 1-5.
60. Hachem JP, et al: Acute acidification of stratum corneum membrane domains using polyhydroxyl acids improves lipid processing and inhibits degradation of corneodesmosomes. J Invest Dermatol 2010; 130: 500-510.
61. Rawlings AV, et al: Effect of lactic acid isomers on keratinocyte ceramide synthesis, stratum corneum lipid levels and stratum corneum barrier function. Arch Dermatol Res 1996; 288: 383-390.
62. Hatano Y, et al: Maintenance of an acidic stratum corneum prevents emergence of murine atopic dermatitis. J Invest Dermatol 2009; 129: 1824-1835.
63. Chamlin SL, et al: Ceramide-dominant, barrier-repair lipids improve childhood atopic dermatitis. Arch Dermatol 2001; 137: 1110-1112.
64. Morren MA, et al: Atopic dermatitis: triggering factors. J Am Acad Dermatol 1994; 31: 467-473.
65. Reuter J, et al: Which plant for which skin disease Part 1. Atopic dermatitis, psoriasis, acne, condyloma and herpes simplex. J Dtsch Dermatol Ges 2010; 8: 788-796.
66. Casetti F, et al: Dermocosmetics for dry skin: a new role for botanical extracts. Skin Pharmacol Physiol 2011; 24: 289-293.
67. Romojaro A, et al: Nutritional and antioxidant properties of wild edible plants and their use as potential ingredients in the modern diet. Int J Food Sci Nutr 2013; 64: 944-952.
68. Ibtissem B: Antioxidant and antibacterial properties of Mesembryanthemum crystallinum and Carpobrotus edulis extracts. Adv Chem Eng Sci 2012; 2: 359-365.
69. Lee BH, Lee CC, Wu SC: Ice plant (Mesembryanthemum crystallinum) improves hyperglycemia and memory impairments in STZ-induced diabetic Wistar rats. J Sci Food Agric 2013, Epub ahead of print.
70. Bouftira I, Abdelly C, Sfar S: Characterization of cosmetic cream with Mesembryanthemum crystallinum plant extract: influence of formulation composition on physical stability and anti-oxidant activity. Int J Cosmet Sci 2008; 30: 443-452.
71. Hanen F, et al: Interspecific variability of antioxidant activities and phenolic composition in Mesembryanthemum genus. Food Chem Toxicol 2009; 47: 2308-2313.
72. Deters AM, Meyer U, Stintzing FC: Time-dependent bioactivity of preparations from cactus pear (Opuntia ficus indica) and ice plant (Mesembryanthemum crystallinum) on human skin fibroblasts and keratinocytes. J Ethnopharmacol 2012; 142: 438-444.
73. Wende K, et al: Dank Trockenstress zum Hautpflegemittel. Pharmazeutische Zeitung 2006; 151: 322-324.