The role of emollients in the management of diseases with chronic dry skin

Skin Pharmacology and Physiology

Volumn 21, Issue 2, 2008, Pages 75-80

  Proksch, E ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

Atopic dermatitis; Chronic dry skin; Emollients

Indexed keywords

ANTIPRURITIC AGENT; CORTICOSTEROID; DEXPANTHENOL; EMOLLIENT AGENT; HUMECTANT; HYDROCORTISONE; PANTOTHENIC ACID; PIMECROLIMUS; SKIN LIPID; TACROLIMUS;

ATOPIC DERMATITIS; CHRONIC KIDNEY FAILURE; DIABETES MELLITUS; DRY SKIN; ECZEMA; EMULSION; HUMAN; PRIORITY JOURNAL; PRURITUS; PSORIASIS; REVIEW;

ADMINISTRATION, TOPICAL; CHRONIC DISEASE; DERMATITIS, ATOPIC; DIABETES COMPLICATIONS; EMOLLIENTS; HUMANS; ICHTHYOSIS; KIDNEY FAILURE, CHRONIC; LIPID BILAYERS; PSORIASIS;

EID: 41149164104     PISSN: 16605527     EISSN: None     Source Type: Journal    
DOI: 10.1159/000112957     Document Type: Review

References (44)

1. Proksch E, Lachapelle JM: The management of dry skin with topical emollients - Recent perspectives. J Dtsch Dermatol Ges 2005;10:768-774.
2. Gisondi P, Ellis CN, Girolomoni G: Pimecrolimus in dermatology: atopic dermatitis and beyond. Int J Clin Pract 2005;59:969-974.
3. Jensen JM, Folster-Holst R, Baranowsky A, Schunck M, Winoto-Morbach S, Neumann C, Schutze S, Proksch E: Impaired sphingomyelinase activity and epidermal differentiation in atopic dermatitis. J Invest Dermatol 2004;122:1423-1431.
4. Proksch E, Fölster-Holst R, Jensen JM: Skin barrier function, epidermal proliferation and differentiation in eczema. J Dermatol Sci 2006;43:159-169.
5. Cookson W: The immunogenetics of asthma and eczema: a new focus on the epithelium. Nat Rev Immunol 2004;4:978-988.
6. Palmer CN, Irvine AD, Terron-Kwiatkowski A, Zhao Y, Liao H, Lee SP, Goudie DR, Sandilands A, Campbell LE, Smith FJ, O'Regan GM, Watson RM, Cecil JE, Bale SJ, Compton JG, DiGiovanna JJ, Fleckman P, Lewis-Jones S, Arseculeratne G, Sergeant A, Munro CS, El Houate B, McElreavey K, Halkjaer LB, Bisgaard H, Mukhopadhyay S, McLean WH: Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet 2006;38:441-446.
7. Irvine AD, McLean WH: Breaking the (un)sound barrier: filaggrin is a major gene for atopic dermatitis. J Invest Dermatol 2006;126:1200-1202.
8. Rawlings AV, Matts PJ: Stratum corneum moisturization at the molecular level: an update in relation to the dry skin cycle. J Invest Dermatol 2005;124:1099-1010.
9. Takahashi M, Ikezawa Z: Dry skin in atopic dermatitis and patients on hemodialysis; in Loden M, Maibach HI (eds): Dry Skin and Moisturizers: Chemistry and Function. Boca Raton, CRC Press, 2000, pp 135-146.
10. Charlesworth EN, Beltrani VS Sr: Pruritic dermatoses: overview of etiology and therapy. Am J Med 2002;113:25S-33S.
11. Nakamura M, Toyoda M, Morohashi M: Pruritogenic mediators in psoriasis vulgaris: comparative evaluation of itch-associated cutaneous factors. Br J Dermatol 2003;149:718-730.
12. Ronayne C, Bray G, Robertson G: The use of aqueous cream to relieve pruritis in patients with liver disease. Br J Nurs 1993;9:527-528.
13. National Prescribing Centre: Atopic eczema in primary care. MeReC Bull 2003;14:1-4.
14. Pascual JC, Fleisher AB Jr: Tacrolimus ointment (Protopic) for atopic dermatitis. Skin Therapy Lett 2004;9:1-5.
15. Witman PM: Topical therapies for localized psoriasis. Mayo Clin Proc 2001;76:943-949.
16. Giardina E, Capon F, De Rosa MC, Mango R, Zambruno G, Orecchia A, Chimenti S, Giardina B, Novelli G: Characterization of the loricrin (LOR) gene as a positional candidate for the PSORS4 psoriasis susceptibility locus. Ann Hum Genet 2004;68:639-645.
17. Motta S, Monti M, Sesana S, Mellesi L, Ghidoni R, Caputo R: Abnormality of water barrier function in psoriasis. Role of ceramide fractions. Arch Dermatol 1994;130:452-456.
18. Hagemann I, Proksch E: Topical treatment by urea reduces epidermal hyperproliferation and induces differentiation in psoriasis. Acta Derm Venerol (Stockh) 1996;76:353-356.
19. American Diabetes Association: Skin complications. http://www.diabetes. org/for-parents-and-kids/what-is-diabetes/skin-complications.jsp.
20. Diabetes UK: Skin care for diabetes. 2000.
21. Pham HT, Exelbert L, Segal-Owens AC, Veves A: A prospective, randomized, controlled double-blind study of a moisturizer for xerosis of the feet in patients with diabetes. Ostomy Wound Manage 2002;48:30-36.
22. Moloney FJ, Keane S, O'Kelly P, Conlon PJ, Murphy GM: The impact of skin disease following renal transplantation on quality of life. Br J Dermatol 2005;153:574-578.
23. Fortina AB, Piaserico S, Alaibac M, Caforio A L, Brandolisio L, Zacchello G, Zanon GF, Zancan L, Peserico A: Skin disorders in patients transplanted in childhood. Transpl Int 2005;18:360-365.
24. Zucker I, Yosipovitch G, David M, Gafter U, Boner G: Prevalence and characterization of uremic pruritus in patients undergoing hemodialysis: uremic pruritus is still a major problem for patients with end-stage renal disease. J Am Acad Dermatol 2003;49:842-846.
25. Green C, Colquitt JL, Kirby J, Davidson P, Payne E: Clinical and cost-effectiveness of once daily versus more frequent use of same potency topical corticosteroids for atopic eczema: a systematic review and economic evaluation. Health Technol Assess 2004;8:1-120.
26. Lucky AW, Leach AD, Laskarzewski P, Wenck H: Use of an emollient as a steroid-sparing agent in the treatment of mild to moderate atopic dermatitis in children. Pediatr Dermatol 1997;14:321-324.
27. Reitamo S, Ortonne JP, Sand C, Cambazard F, Bieber T, Folster-Holst R, Vena G, Bos JD, Fabbri P, Groenhoej Larsen C; European Tacrolimus Ointment Study Group: A multicentre, randomized, double blind, controlled study of long-term treatment with 0.1% tacrolimus ointment in adults with moderate to severe atopic dermatitis. Br J Dermatol 2005;152:1282-1289.
28. Breuer K, Werfel T, Kapp A: Safety and efficacy of topical calcineurin inhibitors in the treatment of childhood atopic dermatitis. Am J Clin Dermatol 2005;6:65-77.
29. Becker JC, Houben R, Vetter C, Broecker EB: The carcinogenic potential of tacrolimus ointment beyond immune suppression: a hypothesis creating case report. BMC Cancer 2006;6:7.
30. Engelke M, Jensen JM, Ekanayake-Mudiyanselage S, Proksch E: Effects of xerosis and ageing on epidermal proliferation and differentiation. Br J Dermatol 1997;137:219-225.
31. Clark C: How to choose a suitable emollient. Pharm J 2004;273:351-353.
32. Imokawa G, Abe A, Jin K, Higaki Y, Kawashima M, Hidano A: Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin. J Invest Dermatol 1991;96:523-526.
33. Choi MJ, Maibach HI: Role of ceramides in barrier function of healthy and diseased skin. Am J Clin Dermatol 2005;6:215-223.
34. Loden M: The clinical benefit of moisturizers. J Eur Acad Dermatol Venereol 2005;19:672-688.
35. Ghadially R, Halkier-Sorensen L, Elias PM: Effects of petrolatum on stratum corneum structure and function. J Am Acad Dermatol 1992;26:387-396.
36. Coderch L, Lopez O, de la Maza A, Parra JL: Ceramides and skin function. Am J Clin Dermatol 2003;4:107-129.
37. Summers RS, Summers B, Chandar P, Feinberg C, Gursky R, Rawlings AV: The effect of lipids, with and without humectant, on skin xerosis. J Soc Cosmet Chem 1996;47:27-39.
38. Hachem J-P, De Paepe K, Kaufman L, Rogiers V, Roseeuw D: The effect of two moisturizers on skin barrier damage in allergic contact dermatitis. Eur J Dermatol 2002;12:136-138.
39. Stander S, Weisshaar E, Mettang T, Szepietowski JC, Carstens E, Ikoma A, Bergasa NV, Gieler U, Misery L, Wallengren J, Darsow U, Streit M, Metze D, Luger TA: Clinical classification of itch: a position paper of the international forum for the study of itch. Acta Derm Venereol 2007;87:291-294.
40. Weimann BJ, Hermann D: Studies on wound healing effects of calcium D-pantothenate on the migration, proliferation and protein synthesis of human dermal fibroblasts in culture. Internat J Vitam Nutr Res 1999;66:113-119.
41. Gehring W, Gloor M: Effect of topically applied dexpanthenol on epidermal barrier function and stratum corneum hydration. Results of a human in vivo study. Arzneimittelforschung 2000;50:659-663.
42. Proksch E, Nissen HP: Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate-induced irritation. J Dermatolog Treat 2002;13:173-178.
43. Natalizio A, Berry N, Weltert Y, Maares Y, De Bony R, Sirvent A, Girard F: Managing dry skin clinical evaluation of two new formulas: bepanthol ultra protect lotion and bepanthol body spray. Real Ther Derm Venereol 2003;136:42-48.
44. Berardesca E, Barbareschi M, Veraldi S, Pimpinelli N: Evaluation of efficacy of a skin lipid mixture in patients with irritant contact dermatitis, allergic contact dermatitis or atopic dermatitis: a multicenter study. Contact Dermatitis 2001;45:280-285.