Nucleotide signaling in astrogliosis

Neuroscience Letters

Volumn 565, Issue , 2014, Pages 14-22

  Franke, Heike ^a   Illes, Peter ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Astrogliosis; Neuroinflammation; Nucleotides; P2 receptors; Stroke; Traumatic CNS injury

Indexed keywords

ABC TRANSPORTER; ADENOSINE RECEPTOR; ADENOSINE TRIPHOSPHATE; GAP JUNCTION PROTEIN; NUCLEOTIDE;

ASTROCYTE; ASTROCYTOSIS; BRAIN ISCHEMIA; CELL DAMAGE; CELL DEATH; CELL PROLIFERATION; DEGENERATIVE DISEASE; EPILEPSY; EXCITOTOXICITY; EXPERIMENTAL CNS INJURY; GLIA CELL; HUMAN; IN VIVO STUDY; NERVOUS SYSTEM INFLAMMATION; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; REVIEW; SECOND MESSENGER; SIGNAL TRANSDUCTION;

ASTROGLIOSIS; NEUROINFLAMMATION; NUCLEOTIDES; P2 RECEPTORS; STROKE; TRAUMATIC CNS INJURY;

ADENOSINE TRIPHOSPHATE; ANIMALS; ASTROCYTES; BRAIN; BRAIN INJURIES; BRAIN ISCHEMIA; GLIOSIS; HUMANS; RECEPTORS, PURINERGIC P2X; RECEPTORS, PURINERGIC P2Y; SPINAL CORD; SPINAL INJURIES;

EID: 84897102733     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2013.09.056     Document Type: Review

References (84)

1. Abbracchio M.P., Saffrey M.J., Hopker V., Burnstock G. Modulation of astroglial cell proliferation by analogues of adenosine and ATP in primary cultures of rat striatum. Neuroscience 1994, 59:67-76.
2. Abbracchio M.P., Burnstock G., Boeynaems J.M., Barnard E.A., Boyer J.L., Kennedy C., Knight G.E., Fumagalli M., Gachet C., Jacobson K.A., Weisman G.A. International union of pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy. Pharmacol. Rev. 2006, 58:281-341.
3. Abbracchio M.P., Burnstock G., Verkhratsky A., Zimmermann H. Purinergic signaling in the nervous system: an overview. Trends Neurosci. 2009, 32:19-29.
4. 12 receptor protein in cortical gray matter lesions in multiple sclerosis. Cereb. Cortex 2010, 20:1263-1273.
5. Araque A., Parpura V., Sanzgiri R.P., Haydon P.G. Tripartite synapses: glia, the unacknowledged partner. Trends Neurosci. 1999, 22:208-215.
6. Boison D. Adenosine dysfunction in epilepsy. Glia 2012, 60:1234-1243.
7. Brambilla R., Neary J.T., Cattabeni F., Cottini L., D'Ippolito G., Schiller P.C., Abbracchio M.P. Induction of COX-2 and reactive gliosis by P2Y receptors in rat cortical astrocytes is dependent on ERK1/2 but independent of calcium signaling. J. Neurochem. 2002, 83:1285-1296.
8. Brambilla R., Cottini L., Fumagalli M., Ceruti S., Abbracchio M.P. Blockade of A2A adenosine receptors prevents basic fibroblast growth factor-induced reactive astrogliosis in rat striatal primary astrocytes. Glia 2003, 43:190-194.
9. Burnstock G. Cotransmission. Curr. Opin. Pharmacol. 2004, 4:47-52.
10. Burnstock G., Krugel U., Abbracchio M.P., Illes P. Purinergic signaling: from normal behaviur to pathological brain function. Prog. Neurobiol. 2011, 95:229-274.
11. Choo A.M., Miller W.J., Chen Y.C., Nibley P., Patel T.P., Goletiani C., Morrison B., Kutzing M.K., Firestein B.L., Sul J.Y., Haydon P.G., Meaney D.F. Antagonism of purinergic signaling improves recovery from traumatic brain injury. Brain 2013, 136:65-80.
12. Davalos D., Grutzendler J., Yang G., Kim J.V., Zuo Y., Jung S., Littman D.R., Dustin M.L., Gan W.B. ATP mediates rapid microglial response to local brain injury in vivo. Nat. Neurosci. 2005, 8:752-758.
13. Delarasse C., Auger R., Gonnord P., Fontaine B., Kanellopoulos J.M. The purinergic receptor P2X7 triggers α-secretase-dependent processing of the amyloid precursor protein. J. Biol. Chem. 2011, 286:2596-2606.
14. Di Virgilio V.F., Ceruti S., Bramanti P., Abbracchio M.P. Purinergic signaling in inflammation of the central nervous system. Trends Neurosci. 2009, 32:79-87.
15. Duan S., Anderson C.M., Keung E.C., Chen Y., Chen Y., Swanson R.A. P2X7 receptor-mediated release of excitatory amino acids from astrocytes. J. Neurosci. 2003, 23:1320-1328.
16. Dusart I., Schwab M.E. Secondary cell death and the inflammatory reaction after dorsal hemisection of the rat spinal cord. Eur. J. Neurosci. 1994, 6:712-724.
17. Engel T., Jimenez-Pacheco A., Miras-Portugal M.T., Diaz-Hernandez M., Henshall D.C. P2X7 receptor in epilepsy; role in pathophysiology and potential targeting for seizure control. Int. J. Physiol. Pathophysiol. Pharmacol. 2012, 4:174-187.
18. 2+ by P2X and P2Y receptor-subtypes in cultured cortical astroglia of the rat. Neuroscience 2009, 160:767-783.
19. Franke H., Krugel U., Grosche J., Heine C., Hartig W., Allgaier C., Illes P. P2Y receptor expression on astrocytes in the nucleus accumbens of rats. Neuroscience 2004, 127:431-441.
20. Franke H., Gunther A., Grosche J., Schmidt R., Rossner S., Reinhardt R., Faber-Zuschratter H., Schneider D., Illes P. P2X7 receptor expression after ischemia in the cerebral cortex of rats. J. Neuropathol. Exp. Neurol. 2004, 63:686-699.
21. Franke H., Grummich B., Hartig W., Grosche J., Regenthal R., Edwards R.H., Illes P., Krugel U. Changes in purinergic signaling after cerebral injury - involvement of glutamatergic mechanisms?. Int. J. Dev. Neurosci. 2006, 24:123-132.
22. Franke H., Illes P. Involvement of P2 receptors in the growth and survival of neurons in the CNS. Pharmacol. Ther. 2006, 109:297-324.
23. Franke H., Schepper C., Illes P., Krugel U. Involvement of P2X and P2Y receptors in microglial activation in vivo. Purinergic Signal. 2007, 3:435-445.
24. Franke H., Sauer C., Rudolph C., Krugel U., Hengstler J.G., Illes P. P2 receptor-mediated stimulation of the PI3-K/Akt-pathway in vivo. Glia 2009, 57:1031-1045.
25. Franke H., Verkhratsky A., Burnstock G., Illes P. Pathophysiology of astroglial purinergic signaling. Purinergic Signal. 2012, 8:629-657.
26. Franke H., Parravicini C., Lecca D., Zanier E.R., Heine C., Bremicker K., Fumagalli M., Rosa P., Longhi L., Stocchetti N., De Simoni M.G., Weber M., Abbracchio M.P. Changes of the GPR17 receptor, a new target for neurorepair, in neurons and glial cells in patients with traumatic brain injury. Purinergic Signal. 2013, 9:451-462.
27. 2 receptors. J. Neurosci. 2003, 23:6728-6739.
28. Gosselin R.D., Suter M.R., Ji R.R., Decosterd I. Glial cells and chronic pain. Neuroscientist 2010, 16:519-531.
29. Guthrie P.B., Knappenberger J., Segal M., Bennett M.V., Charles A.C., Kater S.B. ATP released from astrocytes mediates glial calcium waves. J. Neurosci. 1999, 19:520-528.
30. Honda S., Sasaki Y., Ohsawa K., Imai Y., Nakamura Y., Inoue K., Kohsaka S. Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-coupled P2Y receptors. J. Neurosci. 2001, 21:1975-1982.
31. Illes P., Alexandre Ribeiro J. Molecular physiology of P2 receptors in the central nervous system. Eur. J. Pharmacol. 2004, 483:5-17.
32. Illes P., Verkhratsky A., Burnstock G., Franke H. P2X receptors and their roles in astroglia in the central and peripheral nervous system. Neuroscientist 2012, 18:422-438.
33. Imura Y., Morizawa Y., Komatsu R., Shibata K., Shinozaki Y., Kasai H., Moriishi K., Moriyama Y., Koizumi S. Microglia release ATP by exocytosis. Glia 2013, 61:1320-1330.
34. Jabs R., Matthias K., Grote A., Grauer M., Seifert G., Steinhauser C. Lack of P2X receptor mediated currents in astrocytes and GluR type glial cells of the hippocampal CA1 region. Glia 2007, 55:1648-1655.
35. 2+ signaling in glial cell pathology in the central nervous system. Eur. J. Pharmacol. 2002, 447:247-260.
36. Jimenez-Pacheco A., Mesuret G., Sanz-Rodriguez A., Tanaka K., Mooney C., Conroy R., Miras-Portugal M.T., Diaz-Hernandez M., Henshall D.C., Engel T. Increased neocortical expression of the P2X7 receptor after status epilepticus and anticonvulsant effect of P2X7 receptor antagonist A-438079. Epilepsia 2013, 54:1551-1561.
37. John G.R., Simpson J.E., Woodroofe M.N., Lee S.C., Brosnan C.F. Extracellular nucleotides differentially regulate interleukin-1β signaling in primary human astrocytes: implications for inflammatory gene expression. J. Neurosci. 2001, 21:4134-4142.
38. Kharlamov A., Jones S.C., Kim D.K. Suramin reduces infarct volume in a model of focal brain ischemia in rats. Exp. Brain Res. 2002, 147:353-359.
39. 6 receptor. J. Immunol. 2011, 186:3701-3709.
40. Kim J.E., Kwak S.E., Jo S.M., Kang T.C. Blockade of P2X receptor prevents astroglial death in the dentate gyrus following pilocarpine-induced status epilepticus. Neurol. Res. 2009, 31:982-988.
41. Koizumi S., Fujishita K., Tsuda M., Shigemoto-Mogami Y., Inoue K. Dynamic inhibition of excitatory synaptic transmission by astrocyte-derived ATP in hippocampal cultures. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:11023-11028.
42. Koizumi S., Ohsawa K., Inoue K., Kohsaka S. Purinergic receptors in microglia: functional modal shifts of microglia mediated by P2 and P1 receptors. Glia 2013, 61:47-54.
43. Koles L., Leichsenring A., Rubini P., Illes P. P2 receptor signaling in neurons and glial cells of the central nervous system. Adv. Pharmacol. 2011, 61:441-493.
44. 1 receptor is involved in the regulation of cytokine/chemokine transcription and cerebral damage in a rat model of cerebral ischemia. J. Cereb. Blood Flow Metab. 2011, 31:1930-1941.
45. Lalo U., Pankratov Y., Wichert S.P., Rossner M.J., North R.A., Kirchhoff F., Verkhratsky A. P2X1 and P2X5 subunits form the functional P2X receptor in mouse cortical astrocytes. J. Neurosci. 2008, 28:5473-5480.
46. Lammer A.B., Beck A., Grummich B., Forschler A., Krugel T., Kahn T., Schneider D., Illes P., Franke H., Krugel U. The P2 receptor antagonist PPADS supports recovery from experimental stroke in vivo. PLoS ONE 2011, 6:e19983.
47. Ma W., Hui H., Pelegrin P., Surprenant A. Pharmacological characterization of pannexin-1 currents expressed in mammalian cells. J. Pharmacol. Exp. Ther. 2009, 328:409-418.
48. McGraw J., Hiebert G.W., Steeves J.D. Modulating astrogliosis after neurotrauma. J. Neurosci. Res. 2001, 63:109-115.
49. Melani A., Turchi D., Vannucchi M.G., Cipriani S., Gianfriddo M., Pedata F. ATP extracellular concentrations are increased in the rat striatum during in vivo ischemia. Neurochem. Int. 2005, 47:442-448.
50. Milius D., Groger-Arndt H., Stanchev D., Lange-Dohna C., Rossner S., Sperlagh B., Wirkner K., Illes P. Oxygen/glucose deprivation increases the integration of recombinant P2X7 receptors into the plasma membrane of HEK293 cells. Toxicology 2007, 238:60-69.
51. Narcisse L., Scemes E., Zhao Y., Lee S.C., Brosnan C.F. The cytokine IL-1β transiently enhances P2X7 receptor expression and function in human astrocytes. Glia 2005, 49:245-258.
52. Neary J.T., Baker L., Jorgensen S.L., Norenberg M.D. Extracellular ATP induces stellation and increases glial fibrillary acidic protein content and DNA synthesis in primary astrocyte cultures. Acta Neuropathol. 1994, 87:8-13.
53. Neary J.T., Rathbone M.P., Cattabeni F., Abbracchio M.P., Burnstock G. Trophic actions of extracellular nucleotides and nucleosides on glial and neuronal cells. Trends Neurosci. 1996, 19:13-18.
54. Neary J.T., Kang Y., Bu Y., Yu E., Akong K., Peters C.M. Mitogenic signaling by ATP/P2Y purinergic receptors in astrocytes: involvement of a calcium-independent protein kinase C, extracellular signal-regulated protein kinase pathway distinct from the phosphatidylinositol-specific phospholipase C/calcium pathway. J. Neurosci. 1999, 19:4211-4220.
55. Neary J.T., Kang Y., Willoughby K.A., Ellis E.F. Activation of extracellular signal-regulated kinase by stretch-induced injury in astrocytes involves extracellular ATP and P2 purinergic receptors. J. Neurosci. 2003, 23:2348-2356.
56. Norenberg W., Illes P. Neuronal P2X receptors: localisation and functional properties. Naunyn Schmiedebergs Arch. Pharmacol. 2000, 362:324-339.
57. Norenberg W., Schunk J., Fischer W., Sobottka H., Riedel T., Oliveira J.F., Franke H., Illes P. Electrophysiological classification of P2X7 receptors in rat cultured neocortical astroglia. Br. J. Pharmacol. 2010, 160:1941-1952.
58. Ohsawa K., Kohsaka S. Dynamic motility of microglia: purinergic modulation of microglial movement in the normal and pathological brain. Glia 2011, 59:1793-1799.
59. Oliveira J.F., Riedel T., Leichsenring A., Heine C., Franke H., Krugel U., Norenberg W., Illes P. Rodent cortical astroglia express in situ functional P2X7 receptors sensing pathologically high ATP concentrations. Cereb. Cortex 2011, 21:806-820.
60. Quintas C., Fraga S., Goncalves J., Queiroz G. Opposite modulation of astroglial proliferation by adenosine 5'-O-(2-thio)-diphosphate and 2-methylthioadenosine-5'-diphosphate: mechanisms involved. Neuroscience 2011, 182:32-42.
61. Ridet J.L., Malhotra S.K., Privat A., Gage F.H. Reactive astrocytes: cellular and molecular cues to biological function. Trends Neurosci. 1997, 20:570-577.
62. Robson S.C., Sevigny J., Zimmermann H. The E-NTPDase family of ectonucleotidases: structure function relationships and pathophysiological significance. Purinergic Signal. 2006, 2:409-430.
63. Roger S., Pelegrin P., Surprenant A. Facilitation of P2X7 receptor currents and membrane blebbing via constitutive and dynamic calmodulin binding. J. Neurosci. 2008, 28:6393-6401.
64. Rolls A., Shechter R., Schwartz M. The bright side of the glial scar in CNS repair. Nat. Rev. Neurosci. 2009, 10:235-241.
65. Skaper S.D., Debetto P., Giusti P. The P2X7 purinergic receptor: from physiology to neurological disorders. FASEB J. 2010, 24:337-345.
66. Sofroniew M.V. Molecular dissection of reactive astrogliosis and glial scar formation. Trends Neurosci. 2009, 32:638-647.
67. Sperlagh B., Vizi E.S., Wirkner K., Illes P. P2X7 receptors in the nervous system. Prog. Neurobiol. 2006, 78:327-346.
68. Sperlagh B., Illes P. Purinergic modulation of microglial cell activation. Purinergic Signal. 2007, 3:117-127.
69. Talley W.L., Sprague S., Zheng W., Garling R.J., Jimenez D., Digicaylioglu M., Lechleiter J. Purinergic 2Y1 receptor stimulation decreases cerebral edema and reactive gliosis in a traumatic brain injury model. J. Neurotrauma 2013, 30:55-66.
70. Tran M.D. P2 receptor stimulation induces amyloid precursor protein production and secretion in rat cortical astrocytes. Neurosci. Lett. 2011, 492:155-159.
71. Tsuda M., Tozaki-Saitoh H., Inoue K. Pain and purinergic signaling. Brain Res. Rev. 2010, 63:222-232.
72. Verkhratsky A., Orkand R.K., Kettenmann H. Glial calcium: homeostasis and signaling function. Physiol. Rev. 1998, 78:99-141.
73. Verkhratsky A., Krishtal O.A., Burnstock G. Purinoceptors on neuroglia. Mol. Neurobiol. 2009, 39:190-208.
74. Verkhratsky A., Sofroniew M.V., Messing A., deLanerolle N.C., Rempe D., Rodriguez J.J., Nedergaard M. Neurological diseases as primary gliopathies: a reassessment of neurocentrism. ASN Neuro 2012, 4:e00082.
75. Wang X., Arcuino G., Takano T., Lin J., Peng W.G., Wan P., Li P., Xu Q., Liu Q.S., Goldman S.A., Nedergaard M. P2X7 receptor inhibition improves recovery after spinal cord injury. Nat. Med. 2004, 10:821-827.
76. 2 nucleotide receptor function: implications for proliferative and inflammatory pathways in astrocytes. Mol. Neurobiol. 2005, 31:169-183.
77. 2 receptor interactions in neuroinflammation. Mol. Neurobiol. 2012, 46:96-113.
78. Wilquet V., De Strooper S.B. Amyloid-β precursor protein processing in neurodegeneration. Curr. Opin. Neurobiol. 2004, 14:582-588.
79. Wirkner K., Gunther A., Weber M., Guzman S.J., Krause T., Fuchs J., Koles L., Norenberg W., Illes P. Modulation of NMDA receptor current in layer V pyramidal neurons of the rat prefrontal cortex by P2Y receptor activation. Cereb. Cortex 2007, 17:621-631.
80. Yanagisawa D., Kitamura Y., Takata K., Hide I., Nakata Y., Taniguchi T. Possible involvement of P2X7 receptor activation in microglial neuroprotection against focal cerebral ischemia in rats. Biol. Pharm. Bull. 2008, 31:1121-1130.
81. Zhang X., Chen Y., Wang C., Huang L.Y. Neuronal somatic ATP release triggers neuron-satellite glial cell communication in dorsal root ganglia. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:9864-9869.
82. Zheng W., Watts L.T., Holstein D.M., Prajapati S.I., Keller C., Grass E.H., Walter C.A., Lechleiter J.D. Purinergic receptor stimulation reduces cytotoxic edema and brain infarcts in mouse induced by photothrombosis by energizing glial mitochondria. PLoS ONE 2010, 5:e14401.
83. 1R-initiated, IP3R-dependent stimulation of astrocyte mitochondrial metabolism reduces and partially reverses ischemic neuronal damage in mouse. J. Cereb. Blood Flow Metab. 2013, 33:600-611.
84. Zimmermann H., Zebisch M., Strater N. Cellular function and molecular structure of ecto-nucleotidases. Purinergic Signal. 2012, 8:437-502.