Extracellular nucleotides differentially regulate interleukin-1β signaling in primary human astrocytes: Implications for inflammatory gene expression

Journal of Neuroscience

Volumn 21, Issue 12, 2001, Pages 4134-4142

  John, G R ^a   Simpson, J E ^a   Woodroofe, M N ^a   Lee, S C ^a   Brosnan, C F ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Chemokines; Extracellular nucleotides; Human fetal astrocytes; IL 1 ; P2 receptors; Transcription factors NF B and AP 1

Indexed keywords

ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 8; NUCLEOTIDE; PERIODATE; PURINE ANTAGONIST; PURINE P2 RECEPTOR; PURINE P2X RECEPTOR; PURINE P2Y RECEPTOR; RECEPTOR SUBTYPE; SURAMIN; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG; XAMR 0721;

ARTICLE; ASTROCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EXTRACELLULAR SPACE; FETUS; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IMMUNOMODULATION; INFLAMMATION; PRIORITY JOURNAL; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 0035875994     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-12-04134.2001     Document Type: Article

References (63)

1. Amyloid beta-peptide stimulates nitric oxide production in astrocytes through an NFkappaB-dependent mechanism
2. Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo
3. Chemokines in the CNS: Plurifunctional mediators in diverse states
4. Cloning and chromosomal localization of the human P2Y1 purinoceptor
5. Detection of local ATP release from activated platelets using cell surface-attached firefly luciferase
6. Signals and receptors involved in recruitment of inflammatory cells
7. Differential modulation of astrocyte cytokine gene expression by TGF-beta
8. Cyclo-oxygenase-2 mediates P2Y receptor-induced reactive astrogliosis
9. Interleukin-1 immunoreactive innervation of the human hypothalamus
10. Molecular biology of glia: Astrocytes
11. Neuroprotective activity of chemokines against N-methyl-D-aspartate or beta-amyloid-induced toxicity in culture
12. Purinergic receptors
13. Cloning and functional expression of a human uridine nucleotide receptor
14. Signal transduction by the JNK group of MAP kinases
15. Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation
16. Purinergic signaling at immunological synapses
17. Signal transduction via P2-purinergic receptors for extracellular ATP and other nucleotides
18. P2Y(1) purinoceptor-mediated Ca(2+) signaling and Ca(2+) wave propagation in dorsal spinal cord astrocytes
19. Extracellular ATP activates transcription factor NF-kappaB through the P2Z purinoreceptor by selectively targeting NF-kappaB p65
20. Purinergic modulation of interleukin-1 beta release from microglial cells stimulated with bacterial endotoxin
21. Extracellular ATP in T-lymphocyte activation: Possible role in effector functions
22. The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-kappa B p50 homodimers
23. Regulation by retinoids of P2Y2 nucleotide receptor mRNA in human uterine cervical cells
24. ATP released from astrocytes mediates glial calcium waves
25. ATP derivatives are antagonists of the P2Y1 receptor: Similarities to the platelet ADP receptor
26. Purinergic receptor modulation of lipopolysaccharide signaling and inducible nitric-oxide synthase expression in RAW 264.7 macrophages
27. Distinct patterns of stimulus-inducible chemokine mRNA accumulation in human fetal astrocytes and microglia
28. Stress-activated protein kinase/JNK activation and apoptotic induction by the macrophage P2X7 nucleotide receptor
29. Coexpression of several types of metabotropic nucleotide receptors in single cerebellar astrocytes
30. IL-1β differentially regulates calcium wave propagation between primary human fetal astrocytes via pathways involving P2 receptors and gap junction channels
31. The I kappa B kinase (IKK) and NF-kappa B: Key elements of proinflammatory signalling
32. Constitutive release of ATP and evidence for major contribution of ecto-nucleotide pyrophosphatase and nucleoside diphosphokinase to extracellular nucleotide concentrations
33. Constitutive release and extracellular interconversion of nucleotides
34. Characterization of primary human fetal dissociated central nervous system cultures with an emphasis on microglia
35. Cytokine production by human fetal microglia and astrocytes. Differential induction by lipopolysaccharide and IL-1 beta
36. P(2Y) purinoceptor subtypes recruit different mek activators in astrocytes
37. Modulation of interleukin-1β and tumor necrosis factor a signaling by P2 purinergic receptors in human fetal astrocytes
38. IP-10, a -C-X-C - chemokine, elicits a potent thymus-dependent antitumor response in vivo
39. Hepatitis B virus X protein transactivates human interleukin-8 gene through acting on nuclear factor kB and CCAAT/enhancer-binding protein-like cis-elements
40. Regulation of human IP-10 gene expression in astrocytoma cells by inflammatory cytokines
41. Characterization of two distinct P2Y receptors in human tracheal gland cells
42. Extracellular ATP induces formation of AP-1 complexes in astrocytes via P2 purinoceptors
43. Mitogenic signaling by ATP/P2Y purinergic receptors in astrocytes: Involvement of a calcium-independent protein kinase C, extracellular signal-regulated protein kinase pathway distinct from the phosphatidylinositol-specific phospholipase C/calcium pathway
44. The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway
45. Astrocytes
46. Cytokine regulation of CC and CXC chemokine expression by human astrocytes
47. Agonist action of adenosine triphosphates at the human P2Y1 receptor
48. P2X7 receptors in Muller glial cells from the human retina
49. 2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy
50. Astrocyte expression of mRNA encoding cytokines IP-10 and JE/MCP-1 in experimental autoimmune encephalomyelitis
51. The neurophysiology of glial cells
52. 7. Cloning and expression of a human cDNA
53. Annual review prize lecture cytokines-killers in the brain?
54. Intercellular communication in spinal cord astrocytes: Fine tuning between gap junctions and P2 nucleotide receptors in calcium wave propagation
55. Cutting edge: Purinergic signaling regulates radical-mediated bacterial killing mechanisms in macrophages through a P2X7-independent mechanism
56. Altered cytokine production in mice lacking P2X(7) receptors
57. C-X-C and C-C chemokines are expressed in the cerebrospinal fluid in bacterial meningitis and mediate chemotactic activity on peripheral blood-derived polymorphonuclear and mononuclear cells in vitro
58. Interleukin-1 enhances the ATP-evoked release of arachidonic acid from mouse astrocytes
59. The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7)
60. Intrathecal release of pro- and anti-inflammatory cytokines during stroke
61. Interleukin-8 is increased in cerebrospinal fluid of children with severe head injury
62. Partial agonists and antagonists reveal a second permeability state of human lymphocyte P2Z/P2X7 channel
63. Tumor necrosis factor alpha and interferon gamma synergistically induce interleukin 8 production in a human gastric cancer cell line through acting concurrently on AP-1 and NF-kB-like binding sites of the interleukin 8 gene