The Rac-FRET Mouse Reveals Tight Spatiotemporal Control of Rac Activity in Primary Cells and Tissues

Cell Reports

Volumn 6, Issue 6, 2014, Pages 1153-1164

  Johnsson, Anna Karin E ^a   Dai, Yanfeng ^a,d   Nobis, Max ^b   Baker, Martin J ^a   McGhee, Ewan J ^b   Walker, Simon ^a   Schwarz, Juliane P ^b   Kadir, Shereen ^b   Morton, Jennifer P ^b   Myant, Kevin B ^b   Huels, David J ^b   Segonds Pichon, Anne ^a   Sansom, Owen J ^b   Anderson, Kurt I ^b   Timpson, Paul ^b,c   Welch, Heidi C E ^a  

^a BABRAHAM INSTITUTE   (United Kingdom)

^b BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^c UNIVERSITY OF NEW SOUTH WALES   (Australia)

^d INNER MONGOLIA UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

RAC PROTEIN; RAC1 PROTEIN; RAC2 PROTEIN; 4 AMINO 6 [2 [[4 (DIETHYLAMINO) 1 METHYLBUTYL]AMINO] 6 METHYL 4 PYRIMIDINYL] 2 METHYLQUINOLINE; APC PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; K RAS PROTEIN; ONCOPROTEIN; PLATELET DERIVED GROWTH FACTOR; PROTEIN P53; PROTEIN PREX1; REACTIVE OXYGEN METABOLITE; TAMOXIFEN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL PROLIFERATION; CELL SPREADING; CELL STRUCTURE; CELL SURVIVAL; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; ENZYME LOCALIZATION; ENZYME REGULATION; EXTRACELLULAR MATRIX; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENETIC MANIPULATION; MOUSE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OSCILLATION; POLARIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPATIOTEMPORAL ANALYSIS; ANIMAL; CHEMISTRY; CYTOLOGY; ENZYME ACTIVATION; ENZYMOLOGY; METABOLISM; PROCEDURES; SIGNAL TRANSDUCTION; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; BREAST; BREAST CANCER; CELL LYSATE; CELL MIGRATION; CELLULAR DISTRIBUTION; DRUG TARGETING; ENZYMIC BIOSENSOR; FIBROBLAST CULTURE; GAIN OF FUNCTION MUTATION; GENE; GENE IDENTIFICATION; GENE LOCUS; INTESTINE; INTESTINE CRYPT; LIVER; MELANOMA; MOLECULAR IMAGING; MOUSE MODEL; OSCILLATORY POTENTIAL; PANCREAS; PANCREAS ADENOCARCINOMA; PRIMARY CELL CULTURE; PRIMARY TISSUE CULTURE; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; QUANTITATIVE STUDY; ROSA26 GENE; SKIN; TISSUE DISTRIBUTION; TRANSCRIPTION INITIATION;

ANIMALS; ENZYME ACTIVATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; MICE; NEUTROPHILS; RAC GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION; SPATIO-TEMPORAL ANALYSIS;

EID: 84897090750     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2014.02.024     Document Type: Article

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