-
1
-
-
0035070215
-
Role of modelling and simulation in Phase I drug development
-
Aarons L, Karlsson MO et al (2001) Role of modelling and simulation in Phase I drug development. Eur J Pharm Sci 13(2): 115-122
-
(2001)
Eur J Pharm Sci
, vol.13
, Issue.2
, pp. 115-122
-
-
Aarons, L.1
Karlsson, M.O.2
-
4
-
-
36549073194
-
The role of mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modelling in translational research of biologics
-
Agoram BM, Martin SW, van der Graaf PH (2007) The role of mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modelling in translational research of biologics. Drug Discov Today 12(23-24): 1018-1024
-
(2007)
Drug Discov Today
, vol.12
, Issue.23-24
, pp. 1018-1024
-
-
Agoram, B.M.1
Martin, S.W.2
van der Graaf, P.H.3
-
5
-
-
33750612078
-
Recombinant antibodies: From the laboratory to the clinic
-
Albrecht H, DeNardo SJ (2006) Recombinant antibodies: from the laboratory to the clinic. Cancer Biother Radiopharm 21(4): 285-304
-
(2006)
Cancer Biother Radiopharm
, vol.21
, Issue.4
, pp. 285-304
-
-
Albrecht, H.1
DeNardo, S.J.2
-
9
-
-
0037434552
-
Influence of immunogenicity on the long-term efficacy of infliximab in Crohn's disease
-
Baert F, Noman M et al (2003) Influence of immunogenicity on the long-term efficacy of infliximab in Crohn's disease. N Engl J Med 348(7): 601-608
-
(2003)
N Engl J Med
, vol.348
, Issue.7
, pp. 601-608
-
-
Baert, F.1
Noman, M.2
-
10
-
-
0033506984
-
Population pharmacokinetics and pharmacodynamics of the anti-CD11a antibody hu1124 in human subjects with psoriasis
-
Bauer RJ, Dedrick RL et al (1999) Population pharmacokinetics and pharmacodynamics of the anti-CD11a antibody hu1124 in human subjects with psoriasis. J Pharmacokinet Biopharm 27(4): 397-420
-
(1999)
J Pharmacokinet Biopharm
, vol.27
, Issue.4
, pp. 397-420
-
-
Bauer, R.J.1
Dedrick, R.L.2
-
11
-
-
0028268634
-
Physiologically based pharmacokinetic model for specific and nonspecific monoclonal antibodies and fragments in normal tissues and human tumor xenografts in nude mice
-
Baxter LT, Zhu H et al (1994) Physiologically based pharmacokinetic model for specific and nonspecific monoclonal antibodies and fragments in normal tissues and human tumor xenografts in nude mice. Cancer Res 54(6): 1517-1528
-
(1994)
Cancer Res
, vol.54
, Issue.6
, pp. 1517-1528
-
-
Baxter, L.T.1
Zhu, H.2
-
12
-
-
0028885668
-
Biodistribution of monoclonal antibodies: Scale-up from mouse to human using a physiologically based pharmacokinetic model
-
Baxter LT, Zhu H et al (1995) Biodistribution of monoclonal antibodies: scale-up from mouse to human using a physiologically based pharmacokinetic model. Cancer Res 55(20): 4611-4622
-
(1995)
Cancer Res
, vol.55
, Issue.20
, pp. 4611-4622
-
-
Baxter, L.T.1
Zhu, H.2
-
13
-
-
0030900254
-
Pharmacokinetics of heterologous and homologous immunoglobulin G, F(ab')2 and Fab after intravenous administration in the rat
-
Bazin-Redureau MI, Renard CB et al (1997) Pharmacokinetics of heterologous and homologous immunoglobulin G, F(ab')2 and Fab after intravenous administration in the rat. J Pharm Pharmacol 49(3): 277-281
-
(1997)
J Pharm Pharmacol
, vol.49
, Issue.3
, pp. 277-281
-
-
Bazin-Redureau, M.I.1
Renard, C.B.2
-
15
-
-
30744465920
-
Pharmacokinetics, biodistribution, and radioimmunotherapy with monoclonal antibody 776. 1 in a murine model of human ovarian cancer
-
Berger MA, Masters GR et al (2005) Pharmacokinetics, biodistribution, and radioimmunotherapy with monoclonal antibody 776. 1 in a murine model of human ovarian cancer. Cancer Biother Radiopharm 20(6): 589-602
-
(2005)
Cancer Biother Radiopharm
, vol.20
, Issue.6
, pp. 589-602
-
-
Berger, M.A.1
Masters, G.R.2
-
17
-
-
34848813590
-
Development of radioimmunotherapeutic and diagnostic antibodies: An insideout view
-
Boswell CA, Brechbiel MW (2007) Development of radioimmunotherapeutic and diagnostic antibodies: an insideout view. Nucl Med Biol 34(7): 757-778
-
(2007)
Nucl Med Biol
, vol.34
, Issue.7
, pp. 757-778
-
-
Boswell, C.A.1
Brechbiel, M.W.2
-
18
-
-
0029160004
-
Effective half-life in clinical pharmacology
-
Boxenbaum H, Battle M (1995) Effective half-life in clinical pharmacology. J Clin Pharmacol 35(8): 763-766
-
(1995)
J Clin Pharmacol
, vol.35
, Issue.8
, pp. 763-766
-
-
Boxenbaum, H.1
Battle, M.2
-
19
-
-
0000146003
-
A theoretical model of gamma-globulin catabolism
-
Brambell F, Hemmings W et al (1964) A theoretical model of gamma-globulin catabolism. Nature 203: 1352-1355
-
(1964)
Nature
, vol.203
, pp. 1352-1355
-
-
Brambell, F.1
Hemmings, W.2
-
20
-
-
0033921144
-
Preclinical development of keliximab, a primatized anti-CD4 monoclonal antibody, in human CD4 transgenic mice: Characterization of the model and safety studies
-
Bugelski PJ, Herzyk DJ et al (2000) Preclinical development of keliximab, a primatized anti-CD4 monoclonal antibody, in human CD4 transgenic mice: characterization of the model and safety studies. Hum Exp Toxicol 19(4): 230-243
-
(2000)
Hum Exp Toxicol
, vol.19
, Issue.4
, pp. 230-243
-
-
Bugelski, P.J.1
Herzyk, D.J.2
-
21
-
-
10044271092
-
Enhanced Fcgamma receptor I, alphaMbeta2 integrin receptor expression by monocytes and neutrophils in rheumatoid arthritis: Interaction with platelets
-
Bunescu A, Seideman P et al (2004) Enhanced Fcgamma receptor I, alphaMbeta2 integrin receptor expression by monocytes and neutrophils in rheumatoid arthritis: interaction with platelets. J Rheumatol 31(12): 2347-2355
-
(2004)
J Rheumatol
, vol.31
, Issue.12
, pp. 2347-2355
-
-
Bunescu, A.1
Seideman, P.2
-
23
-
-
7244248664
-
From the bench to the bedside: Ways to improve rituximab efficacy
-
Cartron G, Watier H et al (2004) From the bench to the bedside: ways to improve rituximab efficacy. Blood 104(9): 2635-2642
-
(2004)
Blood
, vol.104
, Issue.9
, pp. 2635-2642
-
-
Cartron, G.1
Watier, H.2
-
24
-
-
33644808298
-
Pharmacokinetics/Pharmacodynamics and the stages of drug development: Role of modeling and simulation
-
Chien, JY, Friedrich S et al (2005) Pharmacokinetics/Pharmacodynamics and the stages of drug development: role of modeling and simulation. AAPS J. 7(3): E544-559
-
(2005)
AAPS J
, vol.7
, Issue.3
, pp. E544-E559
-
-
Chien, J.Y.1
Friedrich, S.2
-
26
-
-
8844220589
-
Evaluation of a surrogate antibody for preclinical safety testing of an anti-CD11a monoclonal antibody
-
Clarke J, Leach W et al (2004) Evaluation of a surrogate antibody for preclinical safety testing of an anti-CD11a monoclonal antibody. Regul Toxicol Pharmacol 40(3): 219-226
-
(2004)
Regul Toxicol Pharmacol
, vol.40
, Issue.3
, pp. 219-226
-
-
Clarke, J.1
Leach, W.2
-
27
-
-
17844361898
-
Tissue distribution and receptormediated clearance of anti-CD11a antibody in mice
-
Coffey GP, Fox JA et al (2005) Tissue distribution and receptormediated clearance of anti-CD11a antibody in mice. Drug Metab Dispos 33(5): 623-629
-
(2005)
Drug Metab Dispos
, vol.33
, Issue.5
, pp. 623-629
-
-
Coffey, G.P.1
Fox, J.A.2
-
28
-
-
33845674883
-
Panitumumab the first fully human monoclonal antibody: From the bench to the clinic
-
Cohenuram M, Saif MW (2007) Panitumumab the first fully human monoclonal antibody: from the bench to the clinic. Anticancer Drugs 18(1): 7-15
-
(2007)
Anticancer Drugs
, vol.18
, Issue.1
, pp. 7-15
-
-
Cohenuram, M.1
Saif, M.W.2
-
29
-
-
17744373658
-
Infliximab induces potent antiinfl ammatory and local immunomodulatory activity but no systemic immune suppression in patients with Crohn's disease
-
Cornillie F, Shealy D et al (2001) Infliximab induces potent antiinfl ammatory and local immunomodulatory activity but no systemic immune suppression in patients with Crohn's disease. Aliment Pharmacol Ther 15(4): 463-473
-
(2001)
Aliment Pharmacol Ther
, vol.15
, Issue.4
, pp. 463-473
-
-
Cornillie, F.1
Shealy, D.2
-
30
-
-
3042743884
-
Rituximab-dependent cytotoxicity by natural killer cells: Influence of FCGR3A polymorphism on the concentration-effect relationship
-
Dall'Ozzo S, Tartas S et al (2004) Rituximab-dependent cytotoxicity by natural killer cells: influence of FCGR3A polymorphism on the concentration-effect relationship. Cancer Res 64(13): 4664-4669
-
(2004)
Cancer Res
, vol.64
, Issue.13
, pp. 4664-4669
-
-
Dall'Ozzo, S.1
Tartas, S.2
-
31
-
-
0034988243
-
Lung uptake of antibodies to endothelial antigens: Key determinants of vascular immunotargeting
-
Danilov SM, Gavrilyuk VD et al (2001) Lung uptake of antibodies to endothelial antigens: key determinants of vascular immunotargeting. Am J Physiol Lung Cell Mol Physiol 280(6): L1335-L1347
-
(2001)
Am J Physiol Lung Cell Mol Physiol
, vol.280
, Issue.6
, pp. L1335-L1347
-
-
Danilov, S.M.1
Gavrilyuk, V.D.2
-
33
-
-
0035746070
-
Anti-adhesion antibodies efalizumab, a humanized anti-CD11a monoclonal antibody
-
Dedrick RL, Walicke P et al (2002) Anti-adhesion antibodies efalizumab, a humanized anti-CD11a monoclonal antibody. Transpl Immunol 9(2-4): 181-186
-
(2002)
Transpl Immunol
, vol.9
, Issue.2-4
, pp. 181-186
-
-
Dedrick, R.L.1
Walicke, P.2
-
34
-
-
0036844296
-
A single dose, placebo controlled study of the fully human anti-tumor necrosis factor-alpha antibody adalimumab (D2E7) in patients with rheumatoid arthritis
-
den Broeder A, van de Putte L et al (2002) A single dose, placebo controlled study of the fully human anti-tumor necrosis factor-alpha antibody adalimumab (D2E7) in patients with rheumatoid arthritis. J Rheumatol 29(11): 2288-2298
-
(2002)
J Rheumatol
, vol.29
, Issue.11
, pp. 2288-2298
-
-
den Broeder, A.1
van de Putte, L.2
-
35
-
-
78651400009
-
Projecting human pharmacokinetics of therapeutic antibodies from nonclinical data
-
Deng R, Iyer S, Theil FP et al (2011) Projecting human pharmacokinetics of therapeutic antibodies from nonclinical data. What have we learned? MAbs 3(1): 61-66
-
(2011)
What have we learned? MAbs
, vol.3
, Issue.1
, pp. 61-66
-
-
Deng, R.1
Iyer, S.2
Theil, F.P.3
-
36
-
-
78751499845
-
Quantitative prediction of human pharmacokinetics for monoclonal antibodies: Retrospective analysis of monkey as a single species for first-in-human prediction
-
Dong JQ, Salinger DH, Endres CJ et al (2011) Quantitative prediction of human pharmacokinetics for monoclonal antibodies: retrospective analysis of monkey as a single species for first-in-human prediction. Clin Pharmacokinet 50: 131-142
-
(2011)
Clin Pharmacokinet
, vol.50
, pp. 131-142
-
-
Dong, J.Q.1
Salinger, D.H.2
Endres, C.J.3
-
37
-
-
0032741975
-
Bidirectional FcRn-dependent IgG transport in a polarized human intestinal epithelial cell line
-
Dickinson BL, Badizadegan K et al (1999) Bidirectional FcRn-dependent IgG transport in a polarized human intestinal epithelial cell line. J Clin Invest 104(7): 903-911
-
(1999)
J Clin Invest
, vol.104
, Issue.7
, pp. 903-911
-
-
Dickinson, B.L.1
Badizadegan, K.2
-
38
-
-
77956388219
-
Population pharmacokinetics of therapeutic monoclonal antibodies
-
Dirks NL, Meibohm B (2010) Population pharmacokinetics of therapeutic monoclonal antibodies. Clin Pharmacokinet 49(10): 633-659
-
(2010)
Clin Pharmacokinet
, vol.49
, Issue.10
, pp. 633-659
-
-
Dirks, N.L.1
Meibohm, B.2
-
39
-
-
0034770328
-
Pharmacokinetics of gemtuzumab ozogamicin, an antibody-targeted chemotherapy agent for the treatment of patients with acute myeloid leukemia in first relapse
-
Dowell JA, Korth-Bradley J et al (2001) Pharmacokinetics of gemtuzumab ozogamicin, an antibody-targeted chemotherapy agent for the treatment of patients with acute myeloid leukemia in first relapse. J Clin Pharmacol 41(11): 1206-1214
-
(2001)
J Clin Pharmacol
, vol.41
, Issue.11
, pp. 1206-1214
-
-
Dowell, J.A.1
Korth-Bradley, J.2
-
40
-
-
0018215540
-
Distribution of heterologous antiperoxidase antibodies and their fragments in the superficial renal cortex of normal Wistar-Munich rat: An ultrastructural study
-
Druet P, Bariety J et al (1978) Distribution of heterologous antiperoxidase antibodies and their fragments in the superficial renal cortex of normal Wistar-Munich rat: an ultrastructural study. Lab Invest 39(6): 623-631
-
(1978)
Lab Invest
, vol.39
, Issue.6
, pp. 623-631
-
-
Druet, P.1
Bariety, J.2
-
41
-
-
0742304308
-
Integrated pharmacokineticpharmacodynamic modeling and allometric scaling for optimizing the dosage regimen of the monoclonal ior EGF/r3 antibody
-
Duconge J, Castillo R et al (2004) Integrated pharmacokineticpharmacodynamic modeling and allometric scaling for optimizing the dosage regimen of the monoclonal ior EGF/r3 antibody. Eur J Pharm Sci 21(2-3): 261-270
-
(2004)
Eur J Pharm Sci
, vol.21
, Issue.2-3
, pp. 261-270
-
-
Duconge, J.1
Castillo, R.2
-
42
-
-
32244438689
-
-
Imclone Systems Inc., Bristol-Myers Squibb Company, Branchburg/Princeton
-
Erbitux ® (2004) Erbitux (Cetuximab) prescribing information. Imclone Systems Inc., Bristol-Myers Squibb Company, Branchburg/Princeton
-
(2004)
Erbitux (Cetuximab) prescribing information
-
-
Erbitux, ®.1
-
43
-
-
29144457336
-
A predictive model of therapeutic monoclonal antibody dynamics and regulation by the neonatal Fc receptor (FcRn)
-
Ferl GZ, Wu AM et al (2005) A predictive model of therapeutic monoclonal antibody dynamics and regulation by the neonatal Fc receptor (FcRn). Ann Biomed Eng 33(11): 1640-1652
-
(2005)
Ann Biomed Eng
, vol.33
, Issue.11
, pp. 1640-1652
-
-
Ferl, G.Z.1
Wu, A.M.2
-
44
-
-
2342551979
-
Combination therapy with etanercept and anakinra in the treatment of patients with rheumatoid arthritis who have been treated unsuccessfully with methotrexate
-
Genovese MC, Cohen S, Moreland L, Lium D, Robbins S, Newmark R et al (2004) Combination therapy with etanercept and anakinra in the treatment of patients with rheumatoid arthritis who have been treated unsuccessfully with methotrexate. Arthritis Rheum 50(5): 1412-1419
-
(2004)
Arthritis Rheum
, vol.50
, Issue.5
, pp. 1412-1419
-
-
Genovese, M.C.1
Cohen, S.2
Moreland, L.3
Lium, D.4
Robbins, S.5
Newmark, R.6
-
45
-
-
0029927482
-
Abnormally short serum half-lives of IgG in beta 2-microglobulin-deficient mice
-
Ghetie V, Hubbard JG et al (1996) Abnormally short serum half-lives of IgG in beta 2-microglobulin-deficient mice. Eur J Immunol 26(3): 690-696
-
(1996)
Eur J Immunol
, vol.26
, Issue.3
, pp. 690-696
-
-
Ghetie, V.1
Hubbard, J.G.2
-
46
-
-
69049088695
-
Target-mediated drug disposition model: Relationships with indirect response models and application to population PK-PD analysis
-
Gibiansky L, Gibiansky E (2009) Target-mediated drug disposition model: relationships with indirect response models and application to population PK-PD analysis. J Pharmacokinet Pharmacodyn 36(4): 341-351
-
(2009)
J Pharmacokinet Pharmacodyn
, vol.36
, Issue.4
, pp. 341-351
-
-
Gibiansky, L.1
Gibiansky, E.2
-
47
-
-
84861479861
-
Linking interleukin-6 receptor blockade with tocilizumab and its hematological effects using a modeling approach
-
Gibiansky L, Frey N (2012) Linking interleukin-6 receptor blockade with tocilizumab and its hematological effects using a modeling approach. J Pharmacokinet Pharmacodyn 39(1): 5-16
-
(2012)
J Pharmacokinet Pharmacodyn
, vol.39
, Issue.1
, pp. 5-16
-
-
Gibiansky, L.1
Frey, N.2
-
48
-
-
0036155035
-
Improved circulating half-life and efficacy of an antibody-interleukin 2 immunocytokine based on reduced intracellular proteolysis
-
Gillies SD, Lo KM et al (2002) Improved circulating half-life and efficacy of an antibody-interleukin 2 immunocytokine based on reduced intracellular proteolysis. Clin Cancer Res 8(1): 210-216
-
(2002)
Clin Cancer Res
, vol.8
, Issue.1
, pp. 210-216
-
-
Gillies, S.D.1
Lo, K.M.2
-
49
-
-
0033136030
-
Improving the efficacy of antibodyinterleukin 2 fusion proteins by reducing their interaction with Fc receptors
-
Gillies SD, Lan Y et al (1999) Improving the efficacy of antibodyinterleukin 2 fusion proteins by reducing their interaction with Fc receptors. Cancer Res 59(9): 2159-2166
-
(1999)
Cancer Res
, vol.59
, Issue.9
, pp. 2159-2166
-
-
Gillies, S.D.1
Lan, Y.2
-
50
-
-
80052604122
-
AAPS workshop report: Strategies to address therapeutic protein-drug interactions during clinical development
-
Girish S, Martin SW, Peterson MC et al (2011) AAPS workshop report: strategies to address therapeutic protein-drug interactions during clinical development. AAPS J 13(3): 405-416
-
(2011)
AAPS J
, vol.13
, Issue.3
, pp. 405-416
-
-
Girish, S.1
Martin, S.W.2
Peterson, M.C.3
-
51
-
-
32844472360
-
Immunoglobulins: Structure and function
-
4th edn. W. H. Freeman and Company, New York
-
Goldsby RA, Kindt TJ et al (1999) Immunoglobulins: structure and function. In: Kuby immunology, 4th edn. W. H. Freeman and Company, New York
-
(1999)
Kuby immunology
-
-
Goldsby, R.A.1
Kindt, T.J.2
-
52
-
-
0037825762
-
Subcutaneously administered efalizumab (anti-CD11a) improves signs and symptoms of moderate to severe plaque psoriasis
-
Gottlieb AB, Miller B et al (2003) Subcutaneously administered efalizumab (anti-CD11a) improves signs and symptoms of moderate to severe plaque psoriasis. J Cutan Med Surg 7(3): 198-207
-
(2003)
J Cutan Med Surg
, vol.7
, Issue.3
, pp. 198-207
-
-
Gottlieb, A.B.1
Miller, B.2
-
53
-
-
34247344172
-
A mechanism-based binding model for the population pharmacokinetics and pharmacodynamics of omalizumab
-
Hayashi N, Tsukamoto Y et al (2007) A mechanism-based binding model for the population pharmacokinetics and pharmacodynamics of omalizumab. Br J Clin Pharmacol 63(5): 548-561
-
(2007)
Br J Clin Pharmacol
, vol.63
, Issue.5
, pp. 548-561
-
-
Hayashi, N.1
Tsukamoto, Y.2
-
55
-
-
33645540973
-
Abatacept
-
discussion 62
-
Hervey PS, Keam SJ (2006) Abatacept. BioDrugs 20(1): 53-61, discussion 62
-
(2006)
BioDrugs
, vol.20
, Issue.1
, pp. 53-61
-
-
Hervey, P.S.1
Keam, S.J.2
-
56
-
-
29644434678
-
An engineered human IgG1 antibody with longer serum half-life
-
Hinton PR, Xiong JM et al (2006) An engineered human IgG1 antibody with longer serum half-life. J Immunol 176(1): 346-356
-
(2006)
J Immunol
, vol.176
, Issue.1
, pp. 346-356
-
-
Hinton, P.R.1
Xiong, J.M.2
-
57
-
-
80155150449
-
Buy buy bispecific antibodies
-
Holmes D (2011) Buy buy bispecific antibodies. Nat Rev Drug Discov 10: 798-800
-
(2011)
Nat Rev Drug Discov
, vol.10
, pp. 798-800
-
-
Holmes, D.1
-
58
-
-
0026022298
-
Muromonab CD-3: A review of its pharmacology, pharmacokinetics, and clinical use in transplantation
-
Hooks MA, Wade CS et al (1991) Muromonab CD-3: a review of its pharmacology, pharmacokinetics, and clinical use in transplantation. Pharmacotherapy 11(1): 26-37
-
(1991)
Pharmacotherapy
, vol.11
, Issue.1
, pp. 26-37
-
-
Hooks, M.A.1
Wade, C.S.2
-
59
-
-
31844447560
-
Impact of variable domain glycosylation on antibody clearance: An LC/MS characterization
-
Huang L, Biolsi S et al (2006) Impact of variable domain glycosylation on antibody clearance: an LC/MS characterization. Anal Biochem 349(2): 197-207
-
(2006)
Anal Biochem
, vol.349
, Issue.2
, pp. 197-207
-
-
Huang, L.1
Biolsi, S.2
-
60
-
-
77949872821
-
Therapeutic protein-drug interactions and implications for drug development
-
Huang S-M, Zhao H, Lee J-I et al (2010) Therapeutic protein-drug interactions and implications for drug development. Clin Pharmacol Ther 87(4): 497-503
-
(2010)
Clin Pharmacol Ther
, vol.87
, Issue.4
, pp. 497-503
-
-
Huang, S.-M.1
Zhao, H.2
Lee, J.-I.3
-
65
-
-
15244357228
-
Mixed-effects modelling of the interspecies pharmacokinetic scaling of pegylated human erythropoietin
-
Jolling K, Perez Ruixo JJ et al (2005) Mixed-effects modelling of the interspecies pharmacokinetic scaling of pegylated human erythropoietin. Eur J Pharm Sci 24(5): 465-475
-
(2005)
Eur J Pharm Sci
, vol.24
, Issue.5
, pp. 465-475
-
-
Jolling, K.1
Perez Ruixo, J.J.2
-
66
-
-
29644438538
-
An overview of the pharmacokinetics and pharmacodynamics of efalizumab: A monoclonal antibody approved for use in psoriasis
-
Joshi A, Bauer R et al (2006) An overview of the pharmacokinetics and pharmacodynamics of efalizumab: a monoclonal antibody approved for use in psoriasis. J Clin Pharmacol 46(1): 10-20
-
(2006)
J Clin Pharmacol
, vol.46
, Issue.1
, pp. 10-20
-
-
Joshi, A.1
Bauer, R.2
-
67
-
-
0030993535
-
Finally! The Brambell receptor (FcRB). Mediator of transmission of immunity and protection from catabolism for IgG
-
Junghans RP (1997) Finally! The Brambell receptor (FcRB). Mediator of transmission of immunity and protection from catabolism for IgG. Immunol Res 16(1): 29-57
-
(1997)
Immunol Res
, vol.16
, Issue.1
, pp. 29-57
-
-
Junghans, R.P.1
-
68
-
-
0029891262
-
The protection receptor for IgG catabolism is the beta2-microglobulin-containing neonatal intestinal transport receptor
-
Junghans RP, Anderson CL (1996) The protection receptor for IgG catabolism is the beta2-microglobulin-containing neonatal intestinal transport receptor. Proc Natl Acad Sci U S A 93(11): 5512-5516
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, Issue.11
, pp. 5512-5516
-
-
Junghans, R.P.1
Anderson, C.L.2
-
70
-
-
77953287466
-
Interspecies scaling of receptor-mediated pharmacokinetics and pharmacodynamics of type I interferons
-
Kagan L, Abraham AK, Harrold JM et al (2010) Interspecies scaling of receptor-mediated pharmacokinetics and pharmacodynamics of type I interferons. Pharm Res 27: 920-932
-
(2010)
Pharm Res
, vol.27
, pp. 920-932
-
-
Kagan, L.1
Abraham, A.K.2
Harrold, J.M.3
-
71
-
-
0035090470
-
In vivo detection of intervertebral disk injury using a radiolabeled monoclonal antibody against keratan sulfate
-
Kairemo KJ, Lappalainen AK et al (2001) In vivo detection of intervertebral disk injury using a radiolabeled monoclonal antibody against keratan sulfate. J Nucl Med 42(3): 476-482
-
(2001)
J Nucl Med
, vol.42
, Issue.3
, pp. 476-482
-
-
Kairemo, K.J.1
Lappalainen, A.K.2
-
72
-
-
33747104543
-
Preclinical pharmacokinetics, pharmacodynamics, and activity of a humanized anti-CD40 antibody (SGN-40) in rodents and non-human primates
-
Kelley SK, Gelzleichter T et al (2006) Preclinical pharmacokinetics, pharmacodynamics, and activity of a humanized anti-CD40 antibody (SGN-40) in rodents and non-human primates. Br J Pharmacol 148(8): 1116-1123
-
(2006)
Br J Pharmacol
, vol.148
, Issue.8
, pp. 1116-1123
-
-
Kelley, S.K.1
Gelzleichter, T.2
-
73
-
-
0028807209
-
Differential inhibition of platelet aggregation induced by adenosine diphosphate or a thrombin receptor-activating peptide in patients treated with bolus chimeric 7E3 Fab: Implications for inhibition of the internal pool of GPIIb/IIIa receptors
-
Kleiman NS, Raizner AE et al (1995) Differential inhibition of platelet aggregation induced by adenosine diphosphate or a thrombin receptor-activating peptide in patients treated with bolus chimeric 7E3 Fab: implications for inhibition of the internal pool of GPIIb/IIIa receptors. J Am Coll Cardiol 26(7): 1665-1671
-
(1995)
J Am Coll Cardiol
, vol.26
, Issue.7
, pp. 1665-1671
-
-
Kleiman, N.S.1
Raizner, A.E.2
-
74
-
-
0016756272
-
Continuous cultures of fused cells secreting antibody of predefined specificity
-
Kohler G, Milstein C (1975) Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256(5517): 495-497
-
(1975)
Nature
, vol.256
, Issue.5517
, pp. 495-497
-
-
Kohler, G.1
Milstein, C.2
-
75
-
-
14044253107
-
Immunoglobulins: Structure and function
-
Paul WE (ed), Lippincott Williams & Wilkins, Philadelphia
-
Kolar GR, Capra JD (2003) Immunoglobulins: structure and function. In: Paul WE (ed) Fundamental immunology, 5th edn. Lippincott Williams & Wilkins, Philadelphia
-
(2003)
Fundamental immunology, 5th edn
-
-
Kolar, G.R.1
Capra, J.D.2
-
76
-
-
28844471518
-
Antileukemic effect of daclizumab in CD25 high-expressing leukemias and impact of tumor burden on antibody dosing
-
Koon HB, Severy P et al (2006) Antileukemic effect of daclizumab in CD25 high-expressing leukemias and impact of tumor burden on antibody dosing. Leuk Res 30(2): 190-203
-
(2006)
Leuk Res
, vol.30
, Issue.2
, pp. 190-203
-
-
Koon, H.B.1
Severy, P.2
-
77
-
-
0035029195
-
A population pharmacokinetic screen to identify demographic-clinical covariates of basiliximab in liver transplantation
-
Kovarik JM, Nashan B et al (2001) A population pharmacokinetic screen to identify demographic-clinical covariates of basiliximab in liver transplantation. Clin Pharmacol Ther 69(4): 201-209
-
(2001)
Clin Pharmacol Ther
, vol.69
, Issue.4
, pp. 201-209
-
-
Kovarik, J.M.1
Nashan, B.2
-
78
-
-
0036145337
-
The immunologic basis for the treatment of psoriasis with new biologic agents
-
quiz 23-6
-
Krueger JG (2002) The immunologic basis for the treatment of psoriasis with new biologic agents. J Am Acad Dermatol 46(1): 1-23, quiz 23-6
-
(2002)
J Am Acad Dermatol
, vol.46
, Issue.1
, pp. 1-23
-
-
Krueger, J.G.1
-
79
-
-
0028468516
-
Will immunogenicity limit the use, efficacy, and future development of therapeutic monoclonal antibodies?
-
Kuus-Reichel K, Grauer LS et al (1994) Will immunogenicity limit the use, efficacy, and future development of therapeutic monoclonal antibodies? Clin Diagn Lab Immunol 1(4): 365-372
-
(1994)
Clin Diagn Lab Immunol
, vol.1
, Issue.4
, pp. 365-372
-
-
Kuus-Reichel, K.1
Grauer, L.S.2
-
80
-
-
0037384060
-
Population pharmacokinetic and pharmacodynamic modeling of etanercept using logistic regression analysis
-
Lee H, Kimko HC et al (2003) Population pharmacokinetic and pharmacodynamic modeling of etanercept using logistic regression analysis. Clin Pharmacol Ther 73(4): 348-365
-
(2003)
Clin Pharmacol Ther
, vol.73
, Issue.4
, pp. 348-365
-
-
Lee, H.1
Kimko, H.C.2
-
81
-
-
79551588087
-
CYP-mediated therapeutic protein-drug interactions: Clinical findings, proposed mechanisms and regulatory implications
-
Lee JI, Zhang L, Men A et al (2010) CYP-mediated therapeutic protein-drug interactions: clinical findings, proposed mechanisms and regulatory implications. Clin Pharmacokinet 49(5): 295-310
-
(2010)
Clin Pharmacokinet
, vol.49
, Issue.5
, pp. 295-310
-
-
Lee, J.I.1
Zhang, L.2
Men, A.3
-
82
-
-
0032962265
-
Preclinical pharmacokinetics, interspecies scaling, and tissue distribution of a humanized monoclonal antibody against vascular endothelial growth factor
-
Lin YS, Nguyen C et al (1999) Preclinical pharmacokinetics, interspecies scaling, and tissue distribution of a humanized monoclonal antibody against vascular endothelial growth factor. J Pharmacol Exp Ther 288(1): 371-378
-
(1999)
J Pharmacol Exp Ther
, vol.288
, Issue.1
, pp. 371-378
-
-
Lin, Y.S.1
Nguyen, C.2
-
83
-
-
71449090902
-
Interspecies scaling of therapeutic monoclonal antibodies: Initial look
-
Ling J, Zhou H, Jiao Q et al (2009) Interspecies scaling of therapeutic monoclonal antibodies: initial look. J Clin Pharmacol 49(12): 1382-1402
-
(2009)
J Clin Pharmacol
, vol.49
, Issue.12
, pp. 1382-1402
-
-
Ling, J.1
Zhou, H.2
Jiao, Q.3
-
84
-
-
8644234910
-
Antibody pharmacokinetics and pharmacodynamics
-
Lobo ED, Hansen RJ et al (2004) Antibody pharmacokinetics and pharmacodynamics. J Pharm Sci 93(11): 2645-2668
-
(2004)
J Pharm Sci
, vol.93
, Issue.11
, pp. 2645-2668
-
-
Lobo, E.D.1
Hansen, R.J.2
-
85
-
-
4043179907
-
B cell depletion as a novel treatment for systemic lupus erythematosus: A phase I/II dose-escalation trial of rituximab
-
Looney RJ, Anolik JH et al (2004) B cell depletion as a novel treatment for systemic lupus erythematosus: a phase I/II dose-escalation trial of rituximab. Arthritis Rheum 50(8): 2580-2589
-
(2004)
Arthritis Rheum
, vol.50
, Issue.8
, pp. 2580-2589
-
-
Looney, R.J.1
Anolik, J.H.2
-
86
-
-
80054092983
-
Trastuzumab emtansine: A unique antibody-drug conjugate in development for human epidermal growth factor receptor 2-positive cancer
-
LoRusso PM, Weiss D, Guardino E et al (2011) Trastuzumab emtansine: a unique antibody-drug conjugate in development for human epidermal growth factor receptor 2-positive cancer. Clin Cancer Res 17(20): 6437-6447
-
(2011)
Clin Cancer Res
, vol.17
, Issue.20
, pp. 6437-6447
-
-
LoRusso, P.M.1
Weiss, D.2
Guardino, E.3
-
87
-
-
84877276833
-
Pharmacokinetics (PK) of Trastuzumab emtansine and paclitaxel or docetaxel in patients with HER2-positive MBS previously treated with trastuzumab-containing regimen
-
San Antonio
-
Lu D, Modi S, Elias A et al (2011) Pharmacokinetics (PK) of Trastuzumab emtansine and paclitaxel or docetaxel in patients with HER2-positive MBS previously treated with trastuzumab-containing regimen. In: 34th annual San Antonio breast cancer symposium. San Antonio
-
(2011)
34th annual San Antonio breast cancer symposium
-
-
Lu, D.1
Modi, S.2
Elias, A.3
-
88
-
-
84865748679
-
Drug interaction potential of trastuzumab emtansine in combination with pertuzumab in patients with HER2-positive metastatic breast cancer
-
Lu D, Burris H, Wang B et al (2012) Drug interaction potential of trastuzumab emtansine in combination with pertuzumab in patients with HER2-positive metastatic breast cancer. Curr Drug Metab 13: 911-922
-
(2012)
Curr Drug Metab
, vol.13
, pp. 911-922
-
-
Lu, D.1
Burris, H.2
Wang, B.3
-
90
-
-
70349482525
-
Population pharmacokinetic analysis of panitumumab in patients with advanced solid tumors
-
Ma P, Yang BB, Wang YM et al (2009) Population pharmacokinetic analysis of panitumumab in patients with advanced solid tumors. J Clin Pharmacol 49(10): 1142-1156
-
(2009)
J Clin Pharmacol
, vol.49
, Issue.10
, pp. 1142-1156
-
-
Ma, P.1
Yang, B.B.2
Wang, Y.M.3
-
91
-
-
0345167205
-
Simultaneous modeling of abciximab plasma concentrations and ex vivo pharmacodynamics in patients undergoing coronary angioplasty
-
Mager DE, Mascelli MA, Kleiman NS, Fitzgerald DJ, Abernethy DR (2003) Simultaneous modeling of abciximab plasma concentrations and ex vivo pharmacodynamics in patients undergoing coronary angioplasty. J Pharmacol Exp Ther 307(3): 969-976
-
(2003)
J Pharmacol Exp Ther
, vol.307
, Issue.3
, pp. 969-976
-
-
Mager, D.E.1
Mascelli, M.A.2
Kleiman, N.S.3
Fitzgerald, D.J.4
Abernethy, D.R.5
-
92
-
-
67649312041
-
Scaling pharmacodynamics from in vitro and preclinical animal studies to humans
-
Mager DE, Woo S, Jusko WJ (2009) Scaling pharmacodynamics from in vitro and preclinical animal studies to humans. Drug Metab Pharmacokinet 24: 16-24
-
(2009)
Drug Metab Pharmacokinet
, vol.24
, pp. 16-24
-
-
Mager, D.E.1
Woo, S.2
Jusko, W.J.3
-
93
-
-
84956603811
-
Prediction of concentration-time profiles in humans
-
Pine House Publishers, Rockville
-
Mahmood I (2005) Prediction of concentration-time profiles in humans. In: Interspecies pharmacokinetics scaling. Pine House Publishers, Rockville, pp 219-241
-
(2005)
Interspecies pharmacokinetics scaling
, pp. 219-241
-
-
Mahmood, I.1
-
94
-
-
18644361997
-
Pharmacokinetic and pharmacodynamic considerations in the development of therapeutic proteins
-
Mahmood I, Green MD (2005) Pharmacokinetic and pharmacodynamic considerations in the development of therapeutic proteins. Clin Pharmacokinet 44(4): 331-347
-
(2005)
Clin Pharmacokinet
, vol.44
, Issue.4
, pp. 331-347
-
-
Mahmood, I.1
Green, M.D.2
-
95
-
-
69949109408
-
Pharmacokinetic allometric scaling of antibodies: Application to the first-in-human dose estimation
-
Mahmood I (2009) Pharmacokinetic allometric scaling of antibodies: application to the first-in-human dose estimation. J Pharm Sci 98: 3850-3861
-
(2009)
J Pharm Sci
, vol.98
, pp. 3850-3861
-
-
Mahmood, I.1
-
96
-
-
0031660364
-
Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor α monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis
-
Maini RN, Breedveld FC, Kalden JR, Smolen JS, Davis D, Macrarlane JD et al (1998) Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor α monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis. Arthritis Rheum 41(9): 1552-1563
-
(1998)
Arthritis Rheum
, vol.41
, Issue.9
, pp. 1552-1563
-
-
Maini, R.N.1
Breedveld, F.C.2
Kalden, J.R.3
Smolen, J.S.4
Davis, D.5
Macrarlane, J.D.6
-
97
-
-
0036166562
-
Mixed-effects modeling of the interspecies pharmacokinetic scaling of oxytetracycline
-
Martin-Jimenez T, Riviere JE (2002) Mixed-effects modeling of the interspecies pharmacokinetic scaling of oxytetracycline. J Pharm Sci 91(2): 331-341
-
(2002)
J Pharm Sci
, vol.91
, Issue.2
, pp. 331-341
-
-
Martin-Jimenez, T.1
Riviere, J.E.2
-
98
-
-
0027819228
-
Disposition of a monoclonal anti-phencyclidine Fab fragment of immunoglobulin G in rats
-
McClurkan MB, Valentine JL et al (1993) Disposition of a monoclonal anti-phencyclidine Fab fragment of immunoglobulin G in rats. J Pharmacol Exp Ther 266(3): 1439-1445
-
(1993)
J Pharmacol Exp Ther
, vol.266
, Issue.3
, pp. 1439-1445
-
-
McClurkan, M.B.1
Valentine, J.L.2
-
99
-
-
0345337254
-
Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: Half of patients respond to a four-dose treatment program
-
McLaughlin P, Grillo-Lopez AJ et al (1998) Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program. J Clin Oncol 16(8): 2825-2833
-
(1998)
J Clin Oncol
, vol.16
, Issue.8
, pp. 2825-2833
-
-
McLaughlin, P.1
Grillo-Lopez, A.J.2
-
100
-
-
0031093498
-
Delineation of the amino acid residues involved in transcytosis and catabolism of mouse IgG1
-
Medesan C, Matesoi D et al (1997) Delineation of the amino acid residues involved in transcytosis and catabolism of mouse IgG1. J Immunol 158(5): 2211-2217
-
(1997)
J Immunol
, vol.158
, Issue.5
, pp. 2211-2217
-
-
Medesan, C.1
Matesoi, D.2
-
101
-
-
0036144662
-
Pharmacokinetic/pharmacodynamic studies in drug product development
-
Meibohm B, Derendorf H (2002) Pharmacokinetic/pharmacodynamic studies in drug product development. J Pharm Sci 91(1): 18-31
-
(2002)
J Pharm Sci
, vol.91
, Issue.1
, pp. 18-31
-
-
Meibohm, B.1
Derendorf, H.2
-
102
-
-
0036137093
-
Pharmacokinetics of murine anti-human CD3 antibodies in man are determined by the disappearance of target antigen
-
Meijer RT, Koopmans RP et al (2002) Pharmacokinetics of murine anti-human CD3 antibodies in man are determined by the disappearance of target antigen. J Pharmacol Exp Ther 300(1): 346-353
-
(2002)
J Pharmacol Exp Ther
, vol.300
, Issue.1
, pp. 346-353
-
-
Meijer, R.T.1
Koopmans, R.P.2
-
103
-
-
0026346187
-
Dose-response clarification in early drug development
-
Meredith PA, Elliott HL et al (1991) Dose-response clarification in early drug development. J Hypertens Suppl 9(6): S356-S357
-
(1991)
J Hypertens Suppl
, vol.9
, Issue.6
, pp. S356-S357
-
-
Meredith, P.A.1
Elliott, H.L.2
-
104
-
-
0038578245
-
Pharmacokinetics of alemtuzumab used for in vivo and in vitro T-cell depletion in allogeneic transplantations: Relevance for early adoptive immunotherapy and infectious complications
-
Morris EC, Rebello P et al (2003) Pharmacokinetics of alemtuzumab used for in vivo and in vitro T-cell depletion in allogeneic transplantations: relevance for early adoptive immunotherapy and infectious complications. Blood 102(1): 404-406
-
(2003)
Blood
, vol.102
, Issue.1
, pp. 404-406
-
-
Morris, E.C.1
Rebello, P.2
-
105
-
-
20144389380
-
Pharmacokinetics and pharmacodynamics of multiple weekly subcutaneous efalizumab doses in patients with plaque psoriasis
-
Mortensen DL, Walicke PA et al (2005) Pharmacokinetics and pharmacodynamics of multiple weekly subcutaneous efalizumab doses in patients with plaque psoriasis. J Clin Pharmacol 45(3): 286-298
-
(2005)
J Clin Pharmacol
, vol.45
, Issue.3
, pp. 286-298
-
-
Mortensen, D.L.1
Walicke, P.A.2
-
106
-
-
33947304452
-
The pharmacokinetics and pharmacodynamics of monoclonal antibodies-mechanistic modeling applied to drug development
-
Mould DR, Sweeney KR (2007) The pharmacokinetics and pharmacodynamics of monoclonal antibodies-mechanistic modeling applied to drug development. Curr Opin Drug Discov Devel 10(1): 84-96
-
(2007)
Curr Opin Drug Discov Devel
, vol.10
, Issue.1
, pp. 84-96
-
-
Mould, D.R.1
Sweeney, K.R.2
-
107
-
-
0032825426
-
A population pharmacokinetic-pharmacodynamic analysis of single doses of clenoliximab in patients with rheumatoid arthritis
-
Mould DR, Davis CB et al (1999) A population pharmacokinetic-pharmacodynamic analysis of single doses of clenoliximab in patients with rheumatoid arthritis. Clin Pharmacol Ther 66(3): 246-257
-
(1999)
Clin Pharmacol Ther
, vol.66
, Issue.3
, pp. 246-257
-
-
Mould, D.R.1
Davis, C.B.2
-
108
-
-
0027509516
-
Potent and effective prolongation by anti-LFA-1 monoclonal antibody monotherapy of non-primarily vascularized heart allograft survival in mice without T cell depletion
-
Nakakura EK, McCabe SM et al (1993) Potent and effective prolongation by anti-LFA-1 monoclonal antibody monotherapy of non-primarily vascularized heart allograft survival in mice without T cell depletion. Transplantation 55(2): 412-417
-
(1993)
Transplantation
, vol.55
, Issue.2
, pp. 412-417
-
-
Nakakura, E.K.1
McCabe, S.M.2
-
109
-
-
23844477187
-
Population pharmacokinetic modeling of subcutaneously administered etanercept in patients with psoriasis
-
Nestorov I, Zitnik R et al (2004) Population pharmacokinetic modeling of subcutaneously administered etanercept in patients with psoriasis. J Pharmacokinet Pharmacodyn 31(6): 463-490
-
(2004)
J Pharmacokinet Pharmacodyn
, vol.31
, Issue.6
, pp. 463-490
-
-
Nestorov, I.1
Zitnik, R.2
-
110
-
-
0029850552
-
Differential clearance of glycoforms of IgG in normal and autoimmune-prone mice
-
Newkirk MM, Novick J et al (1996) Differential clearance of glycoforms of IgG in normal and autoimmune-prone mice. Clin Exp Immunol 106(2): 259-264
-
(1996)
Clin Exp Immunol
, vol.106
, Issue.2
, pp. 259-264
-
-
Newkirk, M.M.1
Novick, J.2
-
111
-
-
23744475396
-
Pharmacokinetic-pharmacodynamic-efficacy analysis of efalizumab in patients with moderate to severe psoriasis
-
Ng CM, Joshi A et al (2005) Pharmacokinetic-pharmacodynamic-efficacy analysis of efalizumab in patients with moderate to severe psoriasis. Pharm Res 22(7): 1088-1100
-
(2005)
Pharm Res
, vol.22
, Issue.7
, pp. 1088-1100
-
-
Ng, C.M.1
Joshi, A.2
-
112
-
-
32244436150
-
Pharmacokinetics/pharmacodynamics of nondepleting anti-CD4 monoclonal antibody (TRX1) in healthy human volunteers
-
Ng CM, Stefanich E et al (2006) Pharmacokinetics/pharmacodynamics of nondepleting anti-CD4 monoclonal antibody (TRX1) in healthy human volunteers. Pharm Res 23(1): 95-103
-
(2006)
Pharm Res
, vol.23
, Issue.1
, pp. 95-103
-
-
Ng, C.M.1
Stefanich, E.2
-
113
-
-
0027462585
-
Consensus statement regarding OKT3-induced cytokine-release syndrome and human antimouse antibodies
-
Norman DJ, Chatenoud L et al (1993) Consensus statement regarding OKT3-induced cytokine-release syndrome and human antimouse antibodies. Transplant Proc 25 (2 Suppl 1): 89-92
-
(1993)
Transplant Proc
, vol.25
, Issue.2
, pp. 89-92
-
-
Norman, D.J.1
Chatenoud, L.2
-
115
-
-
0035210960
-
Differences in promiscuity for antibody-FcRn interactions across species: Implications for therapeutic antibodies
-
Ober RJ, Radu CG et al (2001) Differences in promiscuity for antibody-FcRn interactions across species: implications for therapeutic antibodies. Int Immunol 13(12): 1551-1559
-
(2001)
Int Immunol
, vol.13
, Issue.12
, pp. 1551-1559
-
-
Ober, R.J.1
Radu, C.G.2
-
116
-
-
80052599925
-
Prediction of human pharmacokinetics of therapeutic monoclonal antibodies from simple allometry of monkey data
-
Oitate M, Masubuchi N, Ito T et al (2011) Prediction of human pharmacokinetics of therapeutic monoclonal antibodies from simple allometry of monkey data. Drug Metab Pharmacokinet 26: 423-430
-
(2011)
Drug Metab Pharmacokinet
, vol.26
, pp. 423-430
-
-
Oitate, M.1
Masubuchi, N.2
Ito, T.3
-
117
-
-
84863221758
-
Prediction of human plasma concentration-time profiles of monoclonal antibodies from monkey data by speciesinvariant time method
-
Online advance publication at
-
Oitate M, Nakayama S, Ito T et al (2012) Prediction of human plasma concentration-time profiles of monoclonal antibodies from monkey data by speciesinvariant time method. Drug Metab Pharmacokinet 27: 354-359. Online advance publication at http: //www.jstage. jst. go. jp/article/dmpk/advpub/0/advpub_1111290286/_article
-
(2012)
Drug Metab Pharmacokinet
, vol.27
, pp. 354-359
-
-
Oitate, M.1
Nakayama, S.2
Ito, T.3
-
118
-
-
17944381053
-
The treatment of moderate to severe psoriasis with a new anti-CD11a monoclonal antibody
-
Papp K, Bissonnette R et al (2001) The treatment of moderate to severe psoriasis with a new anti-CD11a monoclonal antibody. J Am Acad Dermatol 45(5): 665-674
-
(2001)
J Am Acad Dermatol
, vol.45
, Issue.5
, pp. 665-674
-
-
Papp, K.1
Bissonnette, R.2
-
119
-
-
33845364560
-
Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: Potential application in humorally mediated autoimmune disease
-
Petkova SB, Akilesh S et al (2006) Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease. Int Immunol 18(12): 1759-1769
-
(2006)
Int Immunol
, vol.18
, Issue.12
, pp. 1759-1769
-
-
Petkova, S.B.1
Akilesh, S.2
-
120
-
-
79960286229
-
Antibody delivery of drugs and radionuclides: Factors influencing clinical pharmacology
-
Prabhu S, Boswell SC, Leipold D et al (2011) Antibody delivery of drugs and radionuclides: factors influencing clinical pharmacology. Ther Deliv 2(6): 769-791
-
(2011)
Ther Deliv
, vol.2
, Issue.6
, pp. 769-791
-
-
Prabhu, S.1
Boswell, S.C.2
Leipold, D.3
-
121
-
-
0036020617
-
Engineering antibodies for therapy
-
Presta LG (2002) Engineering antibodies for therapy. Curr Pharm Biotechnol 3(3): 237-256
-
(2002)
Curr Pharm Biotechnol
, vol.3
, Issue.3
, pp. 237-256
-
-
Presta, L.G.1
-
122
-
-
0036670565
-
Engineering therapeutic antibodies for improved function
-
Presta LG, Shields RL et al (2002) Engineering therapeutic antibodies for improved function. Biochem Soc Trans 30(4): 487-490
-
(2002)
Biochem Soc Trans
, vol.30
, Issue.4
, pp. 487-490
-
-
Presta, L.G.1
Shields, R.L.2
-
124
-
-
77953773942
-
Safety and pharmacokinetics of subcutaneously administered rilonacept in patients with well-controlled end-stage renal disease
-
Radin A, Marbury T, Osgood G, Belomestnov P (2010) Safety and pharmacokinetics of subcutaneously administered rilonacept in patients with well-controlled end-stage renal disease. J Clin Pharmacol 50: 835-841
-
(2010)
J Clin Pharmacol
, vol.50
, pp. 835-841
-
-
Radin, A.1
Marbury, T.2
Osgood, G.3
Belomestnov, P.4
-
128
-
-
0037379288
-
The MHC class I-like IgG receptor controls perinatal IgG transport, IgG homeostasis, and fate of IgG-Fc-coupled drugs
-
Roopenian DC, Christianson GJ et al (2003) The MHC class I-like IgG receptor controls perinatal IgG transport, IgG homeostasis, and fate of IgG-Fc-coupled drugs. J Immunol 170(7): 3528-3533
-
(2003)
J Immunol
, vol.170
, Issue.7
, pp. 3528-3533
-
-
Roopenian, D.C.1
Christianson, G.J.2
-
129
-
-
3843133934
-
The clinical pharmacology of therapeutic monoclonal antibodies
-
Roskos LK, Davis CG et al (2004) The clinical pharmacology of therapeutic monoclonal antibodies. Drug Dev Res 61(3): 108-120
-
(2004)
Drug Dev Res
, vol.61
, Issue.3
, pp. 108-120
-
-
Roskos, L.K.1
Davis, C.G.2
-
130
-
-
0344665785
-
Comparative pharmacology of GP IIb/IIIa antagonists
-
Schror K, Weber AA (2003) Comparative pharmacology of GP IIb/IIIa antagonists. J Thromb Thrombolysis 15(2): 71-80
-
(2003)
J Thromb Thrombolysis
, vol.15
, Issue.2
, pp. 71-80
-
-
Schror, K.1
Weber, A.A.2
-
131
-
-
84861480783
-
Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human
-
Shah DK, Betts AM (2012) Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human. J Pharmacokinet Pharmacodyn 39: 67-86
-
(2012)
J Pharmacokinet Pharmacodyn
, vol.39
, pp. 67-86
-
-
Shah, D.K.1
Betts, A.M.2
-
132
-
-
0033437188
-
Population modelling in drug development
-
Sheiner L, Wakefield J (1999) Population modelling in drug development. Stat Methods Med Res 8(3): 183-193
-
(1999)
Stat Methods Med Res
, vol.8
, Issue.3
, pp. 183-193
-
-
Sheiner, L.1
Wakefield, J.2
-
133
-
-
0031003468
-
Learning versus confirming in clinical drug development
-
Sheiner LB (1997) Learning versus confirming in clinical drug development. Clin Pharmacol Ther 61(3): 275-291
-
(1997)
Clin Pharmacol Ther
, vol.61
, Issue.3
, pp. 275-291
-
-
Sheiner, L.B.1
-
134
-
-
0035794194
-
High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R
-
Shields RL, Namenuk AK et al (2001) High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R. J Biol Chem 276(9): 6591-6604
-
(2001)
J Biol Chem
, vol.276
, Issue.9
, pp. 6591-6604
-
-
Shields, R.L.1
Namenuk, A.K.2
-
135
-
-
0035993387
-
Clinically signifi cant drug interaction between basiliximab and tacrolimus in renal transplant recipients
-
Sifontis NM, Benedetti E, Vasquez EM (2002) Clinically signifi cant drug interaction between basiliximab and tacrolimus in renal transplant recipients. Transplant Proc 34: 1730-1732
-
(2002)
Transplant Proc
, vol.34
, pp. 1730-1732
-
-
Sifontis, N.M.1
Benedetti, E.2
Vasquez, E.M.3
-
136
-
-
0024529856
-
An Fc receptor structurally related to MHC class I antigens
-
Simister NE, Mostov KE (1989a) An Fc receptor structurally related to MHC class I antigens. Nature 337(6203): 184-187
-
(1989)
Nature
, vol.337
, Issue.6203
, pp. 184-187
-
-
Simister, N.E.1
Mostov, K.E.2
-
137
-
-
0024953939
-
Cloning and expression of the neonatal rat intestinal Fc receptor, a major histo-compatibility complex class I antigen homolog
-
Simister NE, Mostov KE (1989b) Cloning and expression of the neonatal rat intestinal Fc receptor, a major histo-compatibility complex class I antigen homolog. Cold Spring Harb Symp Quant Biol 54(Pt 1): 571-580
-
(1989)
Cold Spring Harb Symp Quant Biol
, vol.54
, pp. 571-580
-
-
Simister, N.E.1
Mostov, K.E.2
-
141
-
-
0037025895
-
Receptor-mediated immunoglobulin G transport across mucosal barriers in adult life: Functional expression of FcRn in the mammalian lung
-
Spiekermann GM, Finn PW et al (2002) Receptor-mediated immunoglobulin G transport across mucosal barriers in adult life: functional expression of FcRn in the mammalian lung. J Exp Med 196(3): 303-310
-
(2002)
J Exp Med
, vol.196
, Issue.3
, pp. 303-310
-
-
Spiekermann, G.M.1
Finn, P.W.2
-
142
-
-
84889856889
-
Limitations of noncompartmental pharmacokinetic analysis of biotech drugs
-
Meibohm B (ed), Weinheim, Wiley
-
Straughn AB (2006) Limitations of noncompartmental pharmacokinetic analysis of biotech drugs. In: Meibohm B (ed) Pharmacokinetics and pharmacodynamics of biotech drugs. Weinheim, Wiley, pp 181-188
-
(2006)
Pharmacokinetics and pharmacodynamics of biotech drugs
, pp. 181-188
-
-
Straughn, A.B.1
-
143
-
-
20844461166
-
A phase 1 study of PAmab, a fully human monoclonal antibody against Bacillus anthracis protective antigen, in healthy volunteers
-
Subramanian GM, Cronin PW et al (2005) A phase 1 study of PAmab, a fully human monoclonal antibody against Bacillus anthracis protective antigen, in healthy volunteers. Clin Infect Dis 41(1): 12-20
-
(2005)
Clin Infect Dis
, vol.41
, Issue.1
, pp. 12-20
-
-
Subramanian, G.M.1
Cronin, P.W.2
-
144
-
-
16844374752
-
Population pharmacokinetics of efalizumab (humanized monoclonal anti-CD11a antibody) following long-term subcutaneous weekly dosing in psoriasis subjects
-
Sun YN, Lu JF et al (2005) Population pharmacokinetics of efalizumab (humanized monoclonal anti-CD11a antibody) following long-term subcutaneous weekly dosing in psoriasis subjects. J Clin Pharmacol 45(4): 468-476
-
(2005)
J Clin Pharmacol
, vol.45
, Issue.4
, pp. 468-476
-
-
Sun, Y.N.1
Lu, J.F.2
-
146
-
-
32444438731
-
Elimination mechanisms of therapeutic monoclonal antibodies
-
Tabrizi MA, Tseng CM et al (2006) Elimination mechanisms of therapeutic monoclonal antibodies. Drug Discov Today 11(1-2): 81-88
-
(2006)
Drug Discov Today
, vol.11
, Issue.1-2
, pp. 81-88
-
-
Tabrizi, M.A.1
Tseng, C.M.2
-
147
-
-
23944475573
-
Accuracy of allometrically predicted pharmacokinetic parameters in humans: Role of species selection
-
Tang H, Mayersohn M (2005) Accuracy of allometrically predicted pharmacokinetic parameters in humans: role of species selection. Drug Metab Dispos 33(9): 1288-1293
-
(2005)
Drug Metab Dispos
, vol.33
, Issue.9
, pp. 1288-1293
-
-
Tang, H.1
Mayersohn, M.2
-
148
-
-
4344634877
-
Pharmacokinetic aspects of biotechnology products
-
Tang L, Persky AM, Hochhaus G, Meibohm B (2004) Pharmacokinetic aspects of biotechnology products. J Pharm Sci 93(9): 2184-2204
-
(2004)
J Pharm Sci
, vol.93
, Issue.9
, pp. 2184-2204
-
-
Tang, L.1
Persky, A.M.2
Hochhaus, G.3
Meibohm, B.4
-
149
-
-
24144455629
-
Pharmacokinetics and concentration-effect relationships of therapeutic monoclonal antibodies and fusion proteins
-
Ternant D, Paintaud G (2005) Pharmacokinetics and concentration-effect relationships of therapeutic monoclonal antibodies and fusion proteins. Expert Opin Biol Ther 5(Suppl 1): S37-S47
-
(2005)
Expert Opin Biol Ther
, vol.5
, pp. S37-S47
-
-
Ternant, D.1
Paintaud, G.2
-
150
-
-
46849103828
-
Antibody tumor penetration: Transport opposed by systemic and antigen-mediated clearance
-
Thurber GM, Schmidt MM, Wittrup KD (2008) Antibody tumor penetration: transport opposed by systemic and antigen-mediated clearance. Adv Drug Deliv Rev 60(12): 1421-1434
-
(2008)
Adv Drug Deliv Rev
, vol.60
, Issue.12
, pp. 1421-1434
-
-
Thurber, G.M.1
Schmidt, M.M.2
Wittrup, K.D.3
-
151
-
-
0032713216
-
Dose escalation and pharmacokinetic study of a humanized anti-HER2 monoclonal antibody in patients with HER2/neuoverexpressing metastatic breast cancer
-
Tokuda Y, Watanabe T et al (1999) Dose escalation and pharmacokinetic study of a humanized anti-HER2 monoclonal antibody in patients with HER2/neuoverexpressing metastatic breast cancer. Br J Cancer 81(8): 1419-1425
-
(1999)
Br J Cancer
, vol.81
, Issue.8
, pp. 1419-1425
-
-
Tokuda, Y.1
Watanabe, T.2
-
153
-
-
0033044588
-
Engineered glycoforms of an antineuroblastoma IgG1 with optimized antibodydependent cellular cytotoxic activity
-
Umana P, Jean-Mairet J et al (1999) Engineered glycoforms of an antineuroblastoma IgG1 with optimized antibodydependent cellular cytotoxic activity. Nat Biotechnol 17(2): 176-180
-
(1999)
Nat Biotechnol
, vol.17
, Issue.2
, pp. 176-180
-
-
Umana, P.1
Jean-Mairet, J.2
-
154
-
-
33845484193
-
Divergent activities of an engineered antibody in murine and human systems have implications for therapeutic antibodies
-
Vaccaro C, Bawdon R et al (2006) Divergent activities of an engineered antibody in murine and human systems have implications for therapeutic antibodies. Proc Natl Acad Sci U S A 103(49): 18709-18714
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, Issue.49
, pp. 18709-18714
-
-
Vaccaro, C.1
Bawdon, R.2
-
155
-
-
0037491259
-
Pharmacokinetics, biologic activity, and tolerability of alefacept by intravenous and intramuscular administration
-
Vaishnaw AK, TenHoor CN (2002) Pharmacokinetics, biologic activity, and tolerability of alefacept by intravenous and intramuscular administration. J Pharmacokinet Pharmacodyn 29(5-6): 415-426
-
(2002)
J Pharmacokinet Pharmacodyn
, vol.29
, Issue.5-6
, pp. 415-426
-
-
Vaishnaw, A.K.1
TenHoor, C.N.2
-
156
-
-
0031037211
-
OKT3 therapy increases cyclosporine blood levels
-
Vasquez EM, Pollak R (1997) OKT3 therapy increases cyclosporine blood levels. Clin Transplant 11(1): 38-41
-
(1997)
Clin Transplant
, vol.11
, Issue.1
, pp. 38-41
-
-
Vasquez, E.M.1
Pollak, R.2
-
158
-
-
34250202520
-
A phase I/II randomized open-label multi-center trial of efalizumab, a humanized ani-CD11a, anti-LFA-1 in renal transplantation
-
Vincenti F, Mendez R, Pescovitz M, Rajagopalan PR, Wilkinson AH, Butt K et al (2007) A phase I/II randomized open-label multi-center trial of efalizumab, a humanized ani-CD11a, anti-LFA-1 in renal transplantation. Am J Transplant 7: 1770-1777
-
(2007)
Am J Transplant
, vol.7
, pp. 1770-1777
-
-
Vincenti, F.1
Mendez, R.2
Pescovitz, M.3
Rajagopalan, P.R.4
Wilkinson, A.H.5
Butt, K.6
-
159
-
-
77955297665
-
Prediction of human clearance of therapeutic proteins: Simple allometric scaling method revisited
-
Wang W, Prueksaritanont T (2010) Prediction of human clearance of therapeutic proteins: simple allometric scaling method revisited. Biopharm Drug Dispos 31: 253-263
-
(2010)
Biopharm Drug Dispos
, vol.31
, pp. 253-263
-
-
Wang, W.1
Prueksaritanont, T.2
-
160
-
-
33846140780
-
Antibody structure, instability, and formulation
-
Wang W, Singh S et al (2007) Antibody structure, instability, and formulation. J Pharm Sci 96(1): 1-26
-
(2007)
J Pharm Sci
, vol.96
, Issue.1
, pp. 1-26
-
-
Wang, W.1
Singh, S.2
-
161
-
-
0023691058
-
Continuous internalization of tumor necrosis factor receptors in a human myosarcoma cell line
-
Watanabe N, Kuriyama H et al (1988) Continuous internalization of tumor necrosis factor receptors in a human myosarcoma cell line. J Biol Chem 263(21): 10262-10266
-
(1988)
J Biol Chem
, vol.263
, Issue.21
, pp. 10262-10266
-
-
Watanabe, N.1
Kuriyama, H.2
-
162
-
-
33644819090
-
Fully human therapeutic monoclonal antibodies
-
Weiner LM (2006) Fully human therapeutic monoclonal antibodies. J Immunother 29(1): 1-9
-
(2006)
J Immunother
, vol.29
, Issue.1
, pp. 1-9
-
-
Weiner, L.M.1
-
163
-
-
0038721588
-
Efficacy, pharmacokinetic, and safety assessment of adalimumab, a fully human anti-tumor necrosis factor-alpha monoclonal antibody, in adults with rheumatoid arthritis receiving concomitant methotrexate: A pilot study
-
Weisman MH, Moreland LW et al (2003) Efficacy, pharmacokinetic, and safety assessment of adalimumab, a fully human anti-tumor necrosis factor-alpha monoclonal antibody, in adults with rheumatoid arthritis receiving concomitant methotrexate: a pilot study. Clin Ther 25(6): 1700-1721
-
(2003)
Clin Ther
, vol.25
, Issue.6
, pp. 1700-1721
-
-
Weisman, M.H.1
Moreland, L.W.2
-
164
-
-
0030443253
-
Humanization of an anti-lymphocyte function-associated antigen (LFA)-1 monoclonal antibody and reengineering of the humanized antibody for binding to rhesus LFA-1
-
Werther WA, Gonzalez TN et al (1996) Humanization of an anti-lymphocyte function-associated antigen (LFA)-1 monoclonal antibody and reengineering of the humanized antibody for binding to rhesus LFA-1. J Immunol 157(11): 4986-4995
-
(1996)
J Immunol
, vol.157
, Issue.11
, pp. 4986-4995
-
-
Werther, W.A.1
Gonzalez, T.N.2
-
165
-
-
0034979977
-
Biodistribution and dosimetry results from a phase III prospectively randomized controlled trial of Zevalin radioimmunotherapy for low-grade, follicular, or transformed B-cell non-Hodgkin's lymphoma
-
Wiseman GA, White CA, Sparks RB et al (2001) Biodistribution and dosimetry results from a phase III prospectively randomized controlled trial of Zevalin radioimmunotherapy for low-grade, follicular, or transformed B-cell non-Hodgkin's lymphoma. Crit Rev Oncol Hematol 39(1-2): 181-194
-
(2001)
Crit Rev Oncol Hematol
, vol.39
, Issue.1-2
, pp. 181-194
-
-
Wiseman, G.A.1
White, C.A.2
Sparks, R.B.3
-
166
-
-
0028006565
-
Passage of intravenous immunoglobulin and interaction with the CNS
-
Wurster U, Haas J (1994) Passage of intravenous immunoglobulin and interaction with the CNS. J Neurol Neurosurg Psychiatry 57(Suppl): 21-25
-
(1994)
J Neurol Neurosurg Psychiatry
, vol.57
, pp. 21-25
-
-
Wurster, U.1
Haas, J.2
-
167
-
-
3843136537
-
-
Genentech Inc/Novartis Pharmaceuticals Corp., South San Francisco/East Hanover
-
Xolair ® (2003) Xolair (Omalizumab) [prescribing information]. Genentech Inc/Novartis Pharmaceuticals Corp., South San Francisco/East Hanover
-
(2003)
Xolair (Omalizumab) [prescribing information]
-
-
Xolair, ®.1
-
169
-
-
16844378936
-
Population pharmacokinetic analysis and simulation of the time-concentration profi le of etanercept in pediatric patients with juvenile rheumatoid arthritis
-
Yim DS, Zhou H et al (2005) Population pharmacokinetic analysis and simulation of the time-concentration profi le of etanercept in pediatric patients with juvenile rheumatoid arthritis. J Clin Pharmacol 45(3): 246-256
-
(2005)
J Clin Pharmacol
, vol.45
, Issue.3
, pp. 246-256
-
-
Yim, D.S.1
Zhou, H.2
-
170
-
-
78049515807
-
Brentuximab vedotin (SGN-35) for relapsed CD30-positive lymphomas
-
Younes A, Bartlett NL, Leonard JP et al (2010) Brentuximab vedotin (SGN-35) for relapsed CD30-positive lymphomas. N Engl J Med 363: 1812-1821
-
(2010)
N Engl J Med
, vol.363
, pp. 1812-1821
-
-
Younes, A.1
Bartlett, N.L.2
Leonard, J.P.3
-
173
-
-
78951478220
-
Translational pharmacokinetics and pharmacodynamics of an FcRn-variant anti-CD4 monoclonal antibody from preclinical model to phase I study
-
Zheng Y, Scheerens H, Davis JC et al (2011) Translational pharmacokinetics and pharmacodynamics of an FcRn-variant anti-CD4 monoclonal antibody from preclinical model to phase I study. Clin Pharmacol Ther 89(2): 283-290
-
(2011)
Clin Pharmacol Ther
, vol.89
, Issue.2
, pp. 283-290
-
-
Zheng, Y.1
Scheerens, H.2
Davis, J.C.3
-
174
-
-
17644386569
-
Clinical pharmacokinetics of etanercept: A fully humanized soluble recombinant tumor necrosis factor receptor fusion protein
-
Zhou H (2005) Clinical pharmacokinetics of etanercept: a fully humanized soluble recombinant tumor necrosis factor receptor fusion protein. J Clin Pharmacol 45(5): 490-497
-
(2005)
J Clin Pharmacol
, vol.45
, Issue.5
, pp. 490-497
-
-
Zhou, H.1
-
175
-
-
6344284247
-
Unaltered etanercept pharmacokinetics with concurrent methotrexate in patients with rheumatoid arthritis
-
Zhou H, Mayer PR et al (2004) Unaltered etanercept pharmacokinetics with concurrent methotrexate in patients with rheumatoid arthritis. J Clin Pharmacol 44(11): 1235-1243
-
(2004)
J Clin Pharmacol
, vol.44
, Issue.11
, pp. 1235-1243
-
-
Zhou, H.1
Mayer, P.R.2
-
176
-
-
58849118867
-
Population pharmacokinetic modeling of ustekinumab, a human monoclonal antibody targeting IL-12/23p40, in patients with moderate to severe plaque psoriasis
-
Zhu Y, Hu C, Lu M et al (2009) Population pharmacokinetic modeling of ustekinumab, a human monoclonal antibody targeting IL-12/23p40, in patients with moderate to severe plaque psoriasis. J Clin Pharmacol 49(2): 162-175
-
(2009)
J Clin Pharmacol
, vol.49
, Issue.2
, pp. 162-175
-
-
Zhu, Y.1
Hu, C.2
Lu, M.3
-
177
-
-
0032732953
-
Pharmacokinetics and pharmacodynamics of SB-240563, a humanized monoclonal antibody directed to human interleukin-5, in monkeys
-
Zia-Amirhosseini P, Minthorn E et al (1999) Pharmacokinetics and pharmacodynamics of SB-240563, a humanized monoclonal antibody directed to human interleukin-5, in monkeys. J Pharmacol Exp Ther 291(3): 1060-1067
-
(1999)
J Pharmacol Exp Ther
, vol.291
, Issue.3
, pp. 1060-1067
-
-
Zia-Amirhosseini, P.1
Minthorn, E.2
|