Thiamine deficiency induces anorexia by inhibiting hypothalamic AMPK

Neuroscience

Volumn 267, Issue , 2014, Pages 102-113

  Liu, M ^a   Alimov, A P ^a   Wang, H ^a   Frank, J A ^a   Katz, W ^a   Xu, M ^a   Ke, Z J ^b   Luo, J ^a,c  

^a UNIVERSITY OF KENTUCKY   (United States)

^b Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^c LEXINGTON VA MEDICAL CENTER   (United States)

Author keywords

AMP activated protein kinase; Neurological disorders; Nutrition; Obesity; Vitamin B1

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; THIAMINE; UNCOUPLING PROTEIN 1; ION CHANNEL; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN; NEUROPEPTIDE Y;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANOREXIA; ARCUATE NUCLEUS; ARTICLE; BODY MASS; BROWN ADIPOSE TISSUE; CONTROLLED STUDY; DIET SUPPLEMENTATION; ENZYME ACTIVITY; ENZYME INHIBITION; FAT MASS; FEEDBACK SYSTEM; FEMALE; FOOD INTAKE; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; HYPOTHALAMUS; LOSS OF APPETITE; MALE; MOUSE; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RESTING ENERGY EXPENDITURE; SKELETAL MUSCLE; THIAMINE DEFICIENCY; WEIGHT REDUCTION; ANALYSIS OF VARIANCE; ANIMAL; BODY COMPOSITION; BODY WEIGHT; C57BL MOUSE; CALORIMETRY; COMPLICATION; DIET; EATING; ENERGY METABOLISM; ENZYMOLOGY; GENE EXPRESSION REGULATION; METABOLISM; PATHOLOGY; PHYSIOLOGY;

AMP-ACTIVATED PROTEIN KINASES; ANALYSIS OF VARIANCE; ANIMALS; ANOREXIA; BODY COMPOSITION; BODY WEIGHT; CALORIMETRY; DIET; EATING; ENERGY METABOLISM; FEMALE; GENE EXPRESSION REGULATION; HYPOTHALAMUS; ION CHANNELS; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIAL PROTEINS; NEUROPEPTIDE Y; THIAMINE DEFICIENCY;

EID: 84897054967     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2014.02.033     Document Type: Article

References (47)

1. Andersson U., Filipsson K., Abbott C.R., Woods A., Smith K., Bloom S.R., Carling D., Small C.J. AMP-activated protein kinase plays a role in the control of food intake. J Biol Chem 2004, 279:12005-12008.
2. Blanco Martinez de Morentin P., Gonzalez C.R., Saha A.K., Martins L., Dieguez C., Vidal-Puig A., Tena-Sempere M., Lopez M. Hypothalamic AMP-activated protein kinase as a mediator of whole body energy balance. Rev Endocr Metab Disord 2011, 12:127-140.
3. Butterworth R.F., Giguere J.F., Besnard A.M. Activities of thiamine-dependent enzymes in two experimental models of thiamine-deficiency encephalopathy. 2. Alpha-Ketoglutarate dehydrogenase. Neurochem Res 1986, 11:567-577.
4. Claret M., Smith M.A., Batterham R.L., Selman C., Choudhury A.I., Fryer L.G., Clements M., Al-Qassab H., Heffron H., Xu A.W., Speakman J.R., Barsh G.S., Viollet B., Vaulont S., Ashford M.L., Carling D., Withers D.J. AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons. J Clin Invest 2007, 117:2325-2336.
5. Enerback S., Jacobsson A., Simpson E.M., Guerra C., Yamashita H., Harper M.E., Kozak L.P. Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature 1997, 387:90-94.
6. Even P.C., Nadkarni N.A. Indirect calorimetry in laboratory mice and rats: principles, practical considerations, interpretation and perspectives. Am J Physiol Regul Integr Comp Physiol 2012, 303:R459-R476.
7. Flier J.S. Obesity wars: molecular progress confronts an expanding epidemic. Cell 2004, 116:337-350.
8. Fritah A., Steel J.H., Parker N., Nikolopoulou E., Christian M., Carling D., Parker M.G. Absence of RIP140 reveals a pathway regulating glut4-dependent glucose uptake in oxidative skeletal muscle through UCP1-mediated activation of AMPK. PLoS One 2012, 7:e32520.
9. Gibson G.E., Hirsch J.A., Cirio R.T., Jordan B.D., Fonzetti P., Elder J. Abnormal thiamine-dependent processes in Alzheimer's disease. Lessons from diabetes. Mol Cell Neurosci 2013, 55:17-25.
10. Heroux M., Butterworth R.F. Reversible alterations of cerebral gamma-aminobutyric acid in pyrithiamine-treated rats: implications for the pathogenesis of Wernicke's encephalopathy. J Neurochem 1988, 51:1221-1226.
11. Jhala S.S., Hazell A.S. Modeling neurodegenerative disease pathophysiology in thiamine deficiency: consequences of impaired oxidative metabolism. Neurochem Int 2011, 58:248-260.
12. Kim M.S., Park J.Y., Namkoong C., Jang P.G., Ryu J.W., Song H.S., Yun J.Y., Namgoong I.S., Ha J., Park I.S., Lee I.K., Viollet B., Youn J.H., Lee H.K., Lee K.U. Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase. Nat Med 2004, 10:727-733.
13. Klaus S., Keipert S., Rossmeisl M., Kopecky J. Augmenting energy expenditure by mitochondrial uncoupling: a role of AMP-activated protein kinase. Genes Nutr 2012, 7:369-386.
14. Langlais P.J., Zhang S.X. Extracellular glutamate is increased in thalamus during thiamine deficiency-induced lesions and is blocked by MK-801. J Neurochem 1993, 61:2175-2182.
15. Lee W.J., Koh E.H., Won J.C., Kim M.S., Park J.Y., Lee K.U. Obesity: the role of hypothalamic AMP-activated protein kinase in body weight regulation. Int J Biochem Cell Biol 2005, 37:2254-2259.
16. Lee S., Yang G., Yong Y., Liu Y., Zhao L., Xu J., Zhang X., Wan Y., Feng C., Fan Z., Luo J., Ke Z.J. ADAR2-dependent RNA editing of GluR2 is involved in thiamine deficiency-induced alteration of calcium dynamics. Mol Neurodegener 2010, 5:54.
17. Lim C.T., Kola B., Korbonits M. AMPK as a mediator of hormonal signalling. J Mol Endocrinol 2010, 44:87-97.
18. Liu M., Sun A., Shin E.J., Liu X., Kim S.G., Runyons C.R., Markesbery W., Kim H.C., Bing G. Expression of microsomal epoxide hydrolase is elevated in Alzheimer's hippocampus and induced by exogenous beta-amyloid and trimethyl-tin. Eur J Neurosci 2006, 23:2027-2034.
19. Liu M., Hunter R., Nguyen X.V., Kim H.C., Bing G. Microsomal epoxide hydrolase deletion enhances tyrosine hydroxylase phosphorylation in mice after MPTP treatment. J Neurosci Res 2008, 86:2792-2801.
20. Liu M., Choi D.Y., Hunter R.L., Pandya J.D., Cass W.A., Sullivan P.G., Kim H.C., Gash D.M., Bing G. Trichloroethylene induces dopaminergic neurodegeneration in Fisher 344 rats. J Neurochem 2010, 112:773-783.
21. Lowell B.B., S-Susulic V., Hamann A., Lawitts J.A., Himms-Hagen J., Boyer B.B., Kozak L.P., Flier J.S. Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature 1993, 366:740-742.
22. Meng Y., Yong Y., Yang G., Ding H., Fan Z., Tang Y., Luo J., Ke Z.J. Autophagy alleviates neurodegeneration caused by mild impairment of oxidative metabolism. J Neurochem 2013, 126:805-818.
23. Minokoshi Y., Alquier T., Furukawa N., Kim Y.B., Lee A., Xue B., Mu J., Foufelle F., Ferre P., Birnbaum M.J., Stuck B.J., Kahn B.B. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 2004, 428:569-574.
24. Minokoshi Y., Shiuchi T., Lee S., Suzuki A., Okamoto S. Role of hypothalamic AMP-kinase in food intake regulation. Nutrition 2008, 24:786-790.
25. Mitchell A.S., Dalrymple-Alford J.C. Dissociable memory effects after medial thalamus lesions in the rat. Eur J Neurosci 2005, 22:973-985.
26. Mousseau D.D., Rao V.L., Butterworth R.F. Vesicular dysfunction during experimental thiamine deficiency is indicated by alterations in dopamine metabolism. Eur J Pharmacol 1996, 317:263-267.
27. Nakagawasai O., Tadano T., Hozumi S., Tan-No K., Niijima F., Kisara K. Immunohistochemical estimation of brain choline acetyltransferase and somatostatin related to the impairment of avoidance learning induced by thiamine deficiency. Brain Res Bull 2000, 52:189-196.
28. Nakagawasai O., Tadano T., Hozumi S., Taniguchi R., Tan-No K., Esashi A., Niijima F., Kisara K. Characteristics of depressive behavior induced by feeding thiamine-deficient diet in mice. Life Sci 2001, 69:1181-1191.
29. Nakagawasai O., Yamadera F., Iwasaki K., Arai H., Taniguchi R., Tan-No K., Sasaki H., Tadano T. Effect of kami-untan-to on the impairment of learning and memory induced by thiamine-deficient feeding in mice. Neuroscience 2004, 125:233-241.
30. Okamatsu-Ogura Y., Nio-Kobayashi J., Iwanaga T., Terao A., Kimura K., Saito M. Possible involvement of uncoupling protein 1 in appetite control by leptin. Exp Biol Med (Maywood) 2011, 236:1274-1281.
31. Paxino G., Franklin K.B.J. The mouse brain in stereotaxic coordinates 2001.
32. Pimentel G.D., Ropelle E.R., Rocha G.Z., Carvalheira J.B. The role of neuronal AMPK as a mediator of nutritional regulation of food intake and energy homeostasis. Metabolism 2013, 62(2):171-178.
33. Pitkin S.R., Savage L.M. Age-related vulnerability to diencephalic amnesia produced by thiamine deficiency: the role of time of insult. Behav Brain Res 2004, 148:93-105.
34. Saad L., Silva L.F., Banzato C.E., Dantas C.R., Garcia C. Anorexia nervosa and Wernicke-Korsakoff syndrome: a case report. J Med Case Rep 2010, 4:217.
35. Sechi G., Serra A. Wernicke's encephalopathy: new clinical settings and recent advances in diagnosis and management. Lancet Neurol 2007, 6:442-455.
36. Shaw R.J., Kosmatka M., Bardeesy N., Hurley R.L., Witters L.A., DePinho R.A., Cantley L.C. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci U S A 2004, 101:3329-3335.
37. Shi Y.C., Lau J., Lin Z., Zhang H., Zhai L., Sperk G., Heilbronn R., Mietzsch M., Weger S., Huang X.F., Enriquez R.F., Baldock P.A., Zhang L., Sainsbury A., Herzog H., Lin S. Arcuate NPY controls sympathetic output and BAT function via a relay of tyrosine hydroxylase neurons in the PVN. Cell Metab 2013, 17:236-248.
38. Stark R., Ashley S.E., Andrews Z.B. AMPK and the neuroendocrine regulation of appetite and energy expenditure. Mol Cell Endocrinol 2013, 366(2):215-223.
39. Steinberg G.R., Kemp B.E. AMPK in health and disease. Physiol Rev 2009, 89:1025-1078.
40. Tadano T., Asao T., Aizawa T., Sakurada S., Abe Y., Yonezawa A., Ando R., Arai Y., Kinemuchi H., Kisara K. Immunohistochemical determination of rat spinal cord substance P, and antinociceptive effect during development of thiamine deficiency. Brain Res 1995, 696:21-29.
41. Vetreno R.P., Ramos R.L., Anzalone S., Savage L.M. Brain and behavioral pathology in an animal model of Wernicke's encephalopathy and Wernicke-Korsakoff Syndrome. Brain Res 2012, 1436:178-192.
42. Volvert M.L., Seyen S., Piette M., Evrard B., Gangolf M., Plumier J.C., Bettendorff L. Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives. BMC Pharmacol 2008, 8:10.
43. Watterson K.R., Bestow D., Gallagher J., Hamilton D.L., Ashford F.B., Meakin P.J., Ashford M.L. Anorexigenic and orexigenic hormone modulation of Mammalian target of rapamycin complex 1 activity and the regulation of hypothalamic agouti-related protein mRNA expression. Neurosignals 2013, 21:28-41.
44. Xue B., Kahn B.B. AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues. J Physiol 2006, 574:73-83.
45. Xue B., Pulinilkunnil T., Murano I., Bence K.K., He H., Minokoshi Y., Asakura K., Lee A., Haj F., Furukawa N., Catalano K.J., Delibegovic M., Balschi J.A., Cinti S., Neel B.G., Kahn B.B. Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues. Mol Cell Biol 2009, 29:4563-4573.
46. Yang G., Meng Y., Li W., Yong Y., Fan Z., Ding H., Wei Y., Luo J., Ke Z.J. Neuronal MCP-1 mediates microglia recruitment and neurodegeneration induced by the mild impairment of oxidative metabolism. Brain Pathol 2011, 21:279-297.
47. Zhang S.X., Weilersbacher G.S., Henderson S.W., Corso T., Olney J.W., Langlais P.J. Excitotoxic cytopathology, progression, and reversibility of thiamine deficiency-induced diencephalic lesions. J Neuropathol Exp Neurol 1995, 54:255-267.