Synthesis and characterization of polyaspartamide copolymers obtained by ATRP for nucleic acid delivery

International Journal of Pharmaceutics

Volumn 466, Issue 1-2, 2014, Pages 246-257

  Cavallaro, G ^a   Licciardi, M ^a   Amato, G ^a   Sardo, C ^a   Giammona, G ^a   Farra, R ^b   Dapas, B ^c   Grassi, M ^b   Grassi, G ^c  

^a UNIVERSITY OF PALERMO   (Italy)

^b UNIVERSITY OF TRIESTE   (Italy)

^c UNIVERSITY OF TRIESTE   (Italy)

Author keywords

ATRP; DNA delivery; Polyaspartamide; SiRNA delivery

Indexed keywords

AMIDE; COPOLYMER; MONOMER; PLASMID DNA; POLYASPARTAMIDE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ALPHA,BETA-POLY((2-HYDROXYETHYL)-ASPARTAMIDE); DIETHYLAMINOETHYL METHACRYLATE; DNA; E2F1 PROTEIN, HUMAN; MESSENGER RNA; METHACRYLIC ACID DERIVATIVE; PEPTIDE; TRANSCRIPTION FACTOR E2F1;

ANIMAL CELL; ARTICLE; ARTIFACT; ATOM TRANSFER RADICAL POLYMERIZATION; CELL CULTURE; CONTROLLED STUDY; GENE DELIVERY SYSTEM; GENE SILENCING; NANOPHARMACEUTICS; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SYNTHESIS; ANIMAL; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; GENETIC TRANSFECTION; GENETICS; HUMAN; MOUSE; PLASMID; POLYMERIZATION; PROCEDURES; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; CELL SURVIVAL; DNA; E2F1 TRANSCRIPTION FACTOR; HUMANS; METHACRYLATES; MICE; PEPTIDES; PLASMIDS; POLYMERIZATION; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 84897053339     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.03.026     Document Type: Article

References (46)

1. D. Baiz, G. Pozzato, B. Dapas, R. Farra, B. Scaggiante, M. Grassi, L. Uxa, C. Giansante, C. Zennaro, G. Guarnieri, and G. Grassi Bortezomib arrests the proliferation of hepatocellular carcinoma cells HepG2 and JHH6 by differentially affecting E2F1, p21 and p27 levels Biochimie 91 2009 309 456
2. D. Baiz, B. Dapas, R. Farra, B. Scaggiante, G. Pozzato, F. Zanconati, N. Fiotti, L. Consoloni, S. Chiaretti, and G. Grassi Bortezomib effect on E2F and cyclin family members in human hepatocellular carcinoma cell lines World Journal of Gastroenterology 20 3 2014 795 803
3. G. Cavallaro, S. Scirè, M. Licciardi, M. Ogris, E. Wagner, and G. Giammona Polyhydroethylaspartamide-spermine copolymers: efficient vectors for gene delivery Journal of Controlled Release 131 2008 54 63
4. G. Cavallaro, M. Licciardi, S. Scirè, and G. Giammona New pegylated polyaspartamide based polyplexes as gene delivery vectors Nanomedicine 4 2009 291 303
5. G. Cavallaro, M. Licciardi, M. Di Stefano, and G.G. Pitarresi Giammona New self-assembling polyaspartamide-based brush copolymers obtained by atom transfer radical polymerization Macromolecules 42 2009 3247 3257
6. B. Dapas, R. Farra, and M. Grassi et al. Role of E2F1-cyclinE1-cyclinE2 circuit in human coronary smooth muscle cell proliferation and therapeutic potential of its down regulation by siRNAs Molecular Medicine 15 2009 297 306
7. S. Danielsen, G. Maurstad, and B.T. Stokke DNA-polycation complexation and polyplex stability in the presence of competing polyanions Biopolymers 77 2005 86 97
8. M.C. Deshpande, M.C. Davies, M.C. Garnett, P.M. Williams, D. Armitage, L. Bailey, M. Vamvakaki, S.P. Armes, and S. Stolnik The effect of poly(ethylene glycol) molecular architecture on cellular interaction and uptake of DNA complexes Journal of Controlled Release 97 2004 143 156
9. P. Dubruel, and E. Schacht Vinyl polymers as non-viral gene delivery carriers: current status and prospects Macromolecular Bioscience 6 2006 789 810
10. R. Farra, B. Dapas, G. Pozzato, B. Scaggiante, F. Agostini, C. Zennaro, M. Grassi, N. Rosso, C. Giansante, N. Fiotti, and G. Grassi Effects of E2F1-cyclin E1-E2 circuit down regulation in hepatocellular carcinoma cells Digestive and Liver Disease 43 2011 1006 1014
11. R. Farra, B. Dapas, G. Pozzato, C. Giansante, O. Heidenreich, L. Uxa, C. Zennaro, G.G. Guarnieri, and G. Grassi Serum response factor depletion affects the proliferation of the hepatocellular carcinoma cells HepG2 and JHH6 Biochimie 92 2010 455 463
12. A.M. Funhoff, C.F. van Nostrum, M.C. Lok, J.A.W. Kruijtzer, D.J.A. Crommelin, and W.E. Hennink Cationic polymethacrylates with covalently linked membrane destabilizing peptides as gene delivery vectors Journal of Controlled Release 101 2005 233 246
13. J.W. Gaynor, B.J. Campbell, and R. Cosstick RNA interference: a chemist's perspective Chemical Society Reviews 39 2010 4169 4184
14. G. Giammona, B. Carlisi, and S. Palazzo Reaction of α,β- poly(N-hydroxyethyl)-d,l-aspartamide with derivatives of carboxylic acids Journal of Polymer Science Part A- Polymer Chemistry 25 1987 2813 2818
15. G. Grassi, and J.C. Marini Ribozymes: structure, function and potential therapy for dominant genetic disorders Annals of Medicine 28 1996 499 510
16. M. Grassi, G. Cavallaro, S. Scirè, B. Scaggiante, B. Dapas, R. Farra, D. Baiz, C. Giansante, G. Guarnieri, D. Perin, and G. Grassi Current strategies to improve the efficacy and the delivery of nucleic acid based drugs Current Signal Transduction Therapy 5 2010 92 120
17. G. Grassi, R. Farra, E. Noro, D. Voinovich, R. Lapasin, B. Dapas, O. Alpar, C. Zennaro, M. Carraro, C. Giansante, G. Guarnieri, A. Pascotto, B. Rehimers, and M. Grassi Characterization of nucleic acid molecule/liposome complexes and rheological effects on pluronic/alginate matrices Journal of Drug Delivery Science and Technology 17 2007 325 331
18. G. Grassi, A. Schneider, S. Engel, R. Kandolf, and A. Kuhn Hammerhead ribozymes targeted against cyclin E and E2F1 co-operate to down regulate coronary smooth muscle cell proliferation Journal of Gene Medicine 7 2005 1223 1234
19. J. Haupenthal, C. Baehr, S. Kiermayer, S. Zeuzem, and A. Piiper Inhibition of RNAse A family enzymes prevents degradation and loss of silencing activity of siRNAs in serum Biochemical Pharmacology 71 2006 702 710
20. W.H. Heath, A.F. Senyurt, J. Layman, and T.E. Long Charged polymers via controlled radical polymerization and their implications for gene delivery Macromolecular Chemistry and Physics 208 2007 1243 1249
21. K.L. Heredia, T.H. Nguyen, C.W. Chang, V. Bulmus, T.P. Davis, and H.D. Maynard Reversible siRNA-polymer conjugates by RAFT polymerization Chemical Communications 2008 3245 3247
22. K.A. Howard Delivery of RNA interference therapeutics using polycation-based nanoparticles Advanced Drug Delivery Reviews 61 2009 710 720
23. A. Kichler, C. Leborgne, P.B. Savage, and O. Danos Cationic steroid antibiotics demonstrate DNA delivery properties Journal of Controlled Release 107 2005 174 182
24. J.K.W. Lam, S.P. Armes, and S. Stolnik The involvement of microtubules and actin filaments in the intracellular transport of non-viral gene delivery system Journal of Drug Targeting 19 2011 56 66
25. S.-D. Li, and L. Huang Gene therapy properties and prospects: non-viral gene therapy by systemic delivery Gene Therapy 13 2006 1313 1319
26. M. Licciardi, M. Campisi, G. Cavallaro, M. Cervello, A. Azzolina, and G. Gammona Synthesis and characterization of polyaminoacidic polycations for gene delivery Biomaterials 27 2006 2066 2075
27. M. Licciardi, G. Cavallaro, G. Amato, C. Fiorica, and G. Giammona New copolymers graft of α,β-poly(N-2-hydroyethyl)-d,l-aspartamide obtained from atom transfer radical polymerization such as vectors for gene delivery Reactive and Functional Polymers 72 2012 268 278
28. L. Liu, C. Wu, J. Zhang, M. Zhang, Y. Liu, X. Wang, and G. Fu Controlled polymerization of 2-(diethylamino)ethyl methacrylate and its block copolymer with N-isopropylacrylamide by RAFT polymerization Journal of Polymer Science Part A 46 2008 3294 3305
29. B. Lucas, E. Van Rompaey, K. Remaut, N. Sanders, S.C. De Smedt, and J. Demeester On the biological activity of anti-ICAM-1 oligonucleotides complexed to non-viral carriers Journal of Controlled Release 96 2004 207 219
30. R. Mendichi, A.G. Schieroni, G. Cavallaro, M. Licciardi, and G. Giammona Molecular characterization of α,β-poly(N-2-hydroxyethyl)-d,l- aspartamide derivatives as potential self-assembling copolymers forming polymeric micelles Polymer 44 2003 4871 4879
31. M. Meyer, C. Dohmen, A. Philipp, D. Kiener, G. Maiwald, C. Scheu, M. Ogris, and E. Wagner Synthesis and biological evaluation of a bioresponsive and endosomolytic siRNA-polymer conjugate Molecular Pharmacology 6 2009 752 762
32. T. Maniatis, E.F. Fritsch, and J. Sambrook Molecular Cloning: A Laboratory Manual second ed. 1986 Cold Spring Harbour Press NewYork 24
33. D. Oupicky, C. Konak, P.R. Dash, L.W. Seymour, and K. Ulbrich Effect of albumin and polyanion on the structure of DNA complexes with polycation containing hydrophilic non-ionic block Bioconjugate Chemistry 10 1999 764 772
34. F.A. Plamper, A. Schmalz, E. Penott-Chang, M. Drechsler, A. Jusufi, M. Ballauff, and A.H.E. Muller Synthesis and characterization of star-shaped poly(N,N-dimethylaminoethyl methacrylate) and its quaternized ammonium salts Macromolecules 40 2007 5689 5697
35. K. Raemdonck, R.E. Vandenbroucke, J. Demeester, N.N. Sanders, and S. De Smedt Maintaining the silence: reflections on long-term RNAi Drug Discovery Today 2008 917 931
36. B. Scaggiante, M. Kazemi, G. Pozzato, B. Dapas, R. Farra, M. Grassi, F. Zanconati, and G. Grassi Novel hepatocellular carcinoma molecules with prognostic and therapeutic potentials World Journal of Gastroenterology 20 5 2014 1268 1288
37. B. Scaggiante, B. Dapas, R. Farra, M. Grassi, G. Pozzato, C. Giansante, N. Fiotti, E. Tamai, F. Tonon, and G. Grassi Aptamers as nano-targeting delivery devices or anti-cancer drugs for fighting tumours Current Drug Metabolism 14 2013 565 582
38. B. Scaggiante, B. Dapas, R. Farra, M. Grassi, G. Pozzato, C. Giansante, N. Fiotti, and G. Grassi Improving siRNA bio-distribution and minimizing side effects Current Drug Metabolism 12 2011 11 23
39. A. Schallon, V. Jerome, A. Walther, C.V. Synatschke, A.H.E. Muller, and R. Freitag Performance of three PDMAEMA-based polycation architectures as gene delivery agents in comparison to linear and branched PEI Reactive and Functional Polymers 70 2010 1 10
40. C. Tros de Ilarduya, Y. Sun, and N. Duzgunes Gene delivery by lipoplexes and polyplexes European Journal of Pharmaceutical Sciences 40 2010 159 170
41. A.W. York, F. Huang, and C.L. McCormick Rational design of targeted cancer therapeutics through the multiconjugation of folate and cleavable siRNA to RAFT-synthesized (HPMA-s-APMA) copolymers Biomacromolecules 11 2010 505 514
42. Z.H. Wang, W.B. Li, J. Ma, G.P. Tang, W.T. Yang, and F.J. Xu Functionalized nonionic dextran backbones by atom transfer radical polymerization for efficient gene delivery Macromolecules 44 2011 230 239
43. F.J. Xu, Y. Ping, J. Ma, G.P. Tang, W.T. Yang, J. Li, E.T. Kang, and K.G. Neoh Comb-shaped copolymers composed of hydroxypropyl cellulose backbones and cationic poly((2-dimethyl amino)ethyl methacrylate) side chains for gene delivery Bioconjugate Chemistry 20 2009 1449 1458
44. L. Xu, and T. Anchordoquy Drug delivery trends in clinical trials and translational medicine: challenges and opportunities in the delivery of nucleic acid-based therapeutics Journal of Pharmaceutical Sciences 100 2011 38 52
45. F.J. Xu, and W.T. Yang Polymer vectors via controlled/living radical polymerization for gene delivery Progress in Polymer Science 36 2011 1099 1131
46. L. Zhan, C. Huang, X.M. Meng, Y. Song, X.Q. Wu, C.G. Miu, X.S. Zhan, and J. Li Promising roles of mammalian E2Fs in hepatocellular carcinoma Cellular Signalling 2014 10.1016/j.cellsig.2014.01.008 pii: S0898-6568(14)00019-9