메뉴 건너뛰기




Volumn 565, Issue , 2014, Pages 53-58

Neuroprotection by astrocytes in brain ischemia: Importance of microRNAs

Author keywords

Astrocyte; Cerebral ischemia; MicroRNA; MiR 146a; MiR 181; MiR 29

Indexed keywords

MICRORNA; MICRORNA 146A; MICRORNA 181; MICRORNA 181A; MICRORNA 29; MICRORNA 29A; MICRORNA 29B; PROTEIN BCL 2; UNCLASSIFIED DRUG;

EID: 84897049671     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2013.11.015     Document Type: Review
Times cited : (72)

References (67)
  • 1
    • 34748924281 scopus 로고    scopus 로고
    • Bcl-2-regulated apoptosis: mechanism and therapeutic potential
    • Adams J.M., Cory S. Bcl-2-regulated apoptosis: mechanism and therapeutic potential. Curr. Opin. Immunol. 2007, 19:488-496.
    • (2007) Curr. Opin. Immunol. , vol.19 , pp. 488-496
    • Adams, J.M.1    Cory, S.2
  • 5
    • 34548179532 scopus 로고    scopus 로고
    • Thrombolytic therapy for acute ischemic stroke
    • Blakeley J.O., Llinas R.H. Thrombolytic therapy for acute ischemic stroke. J. Neurol. Sci. 2007, 261:55-62.
    • (2007) J. Neurol. Sci. , vol.261 , pp. 55-62
    • Blakeley, J.O.1    Llinas, R.H.2
  • 6
    • 84858722006 scopus 로고    scopus 로고
    • MicroRNAs, new effectors and regulators of NF-kappaB
    • Boldin M.P., Baltimore D. MicroRNAs, new effectors and regulators of NF-kappaB. Immunol. Rev. 2012, 246:205-220.
    • (2012) Immunol. Rev. , vol.246 , pp. 205-220
    • Boldin, M.P.1    Baltimore, D.2
  • 7
  • 8
    • 84881155159 scopus 로고    scopus 로고
    • An unsolved mystery: the target-recognizing RNA species of microRNA genes
    • Chen C.Z. An unsolved mystery: the target-recognizing RNA species of microRNA genes. Biochimie 2013, 95:1663-1676.
    • (2013) Biochimie , vol.95 , pp. 1663-1676
    • Chen, C.Z.1
  • 9
    • 0346727524 scopus 로고    scopus 로고
    • MicroRNAs modulate hematopoietic lineage differentiation
    • Chen C.Z., Li L., Lodish H.F., Bartel D.P. MicroRNAs modulate hematopoietic lineage differentiation. Science 2004, 303:83-86.
    • (2004) Science , vol.303 , pp. 83-86
    • Chen, C.Z.1    Li, L.2    Lodish, H.F.3    Bartel, D.P.4
  • 10
    • 77949445582 scopus 로고    scopus 로고
    • MicroRNA-181a sensitizes human malignant glioma U87MG cells to radiation by targeting Bcl-2
    • Chen G., Zhu W., Shi D., Lv L., Zhang C., Liu P., Hu W. MicroRNA-181a sensitizes human malignant glioma U87MG cells to radiation by targeting Bcl-2. Oncol. Rep. 2010, 23:997-1003.
    • (2010) Oncol. Rep. , vol.23 , pp. 997-1003
    • Chen, G.1    Zhu, W.2    Shi, D.3    Lv, L.4    Zhang, C.5    Liu, P.6    Hu, W.7
  • 11
    • 84875181791 scopus 로고    scopus 로고
    • Down-regulation of microRNA-146a in the early stage of liver ischemia-reperfusion injury
    • Chen Q., Kong L., Xu X., Geng Q., Tang W., Jiang W. Down-regulation of microRNA-146a in the early stage of liver ischemia-reperfusion injury. Transplant. Proc. 2013, 45:492-496.
    • (2013) Transplant. Proc. , vol.45 , pp. 492-496
    • Chen, Q.1    Kong, L.2    Xu, X.3    Geng, Q.4    Tang, W.5    Jiang, W.6
  • 12
    • 84876668625 scopus 로고    scopus 로고
    • Emerging roles of astrocytes in neural circuit development
    • Clarke L.E., Barres B.A. Emerging roles of astrocytes in neural circuit development. Nat. Rev. Neurosci. 2013, 14:311-321.
    • (2013) Nat. Rev. Neurosci. , vol.14 , pp. 311-321
    • Clarke, L.E.1    Barres, B.A.2
  • 13
    • 78649863208 scopus 로고    scopus 로고
    • Differential regulation of interleukin-1 receptor-associated kinase-1 (IRAK-1) and IRAK-2 by microRNA-146a and NF-kappaB in stressed human astroglial cells and in Alzheimer disease
    • Cui J.G., Li Y.Y., Zhao Y., Bhattacharjee S., Lukiw W.J. Differential regulation of interleukin-1 receptor-associated kinase-1 (IRAK-1) and IRAK-2 by microRNA-146a and NF-kappaB in stressed human astroglial cells and in Alzheimer disease. J. Biol. Chem. 2010, 285:38951-38960.
    • (2010) J. Biol. Chem. , vol.285 , pp. 38951-38960
    • Cui, J.G.1    Li, Y.Y.2    Zhao, Y.3    Bhattacharjee, S.4    Lukiw, W.J.5
  • 14
    • 63949084047 scopus 로고    scopus 로고
    • Transient focal ischemia induces extensive temporal changes in rat cerebral microRNAome
    • Dharap A., Bowen K., Place R., Li L.C., Vemuganti R. Transient focal ischemia induces extensive temporal changes in rat cerebral microRNAome. J. Cereb. Blood Flow Metab. 2009, 29:675-687.
    • (2009) J. Cereb. Blood Flow Metab. , vol.29 , pp. 675-687
    • Dharap, A.1    Bowen, K.2    Place, R.3    Li, L.C.4    Vemuganti, R.5
  • 15
    • 84885051411 scopus 로고    scopus 로고
    • The interplay of microRNA and neuronal activity in health and disease
    • Eacker S.M., Dawson T.M., Dawson V.L. The interplay of microRNA and neuronal activity in health and disease. Front. Cell. Neurosci. 2013, 7.
    • (2013) Front. Cell. Neurosci. , vol.7
    • Eacker, S.M.1    Dawson, T.M.2    Dawson, V.L.3
  • 16
    • 0037384802 scopus 로고    scopus 로고
    • Signaling of cell death and cell survival following focal cerebral ischemia: life and death struggle in the penumbra
    • Ferrer I., Planas A.M. Signaling of cell death and cell survival following focal cerebral ischemia: life and death struggle in the penumbra. J. Neuropathol. Exp. Neurol. 2003, 62:329-339.
    • (2003) J. Neuropathol. Exp. Neurol. , vol.62 , pp. 329-339
    • Ferrer, I.1    Planas, A.M.2
  • 18
    • 64049107465 scopus 로고    scopus 로고
    • MiR-29a suppresses tristetraprolin, which is a regulator of epithelial polarity and metastasis
    • Gebeshuber C.A., Zatloukal K., Martinez J. miR-29a suppresses tristetraprolin, which is a regulator of epithelial polarity and metastasis. EMBO Rep. 2009, 10:400-405.
    • (2009) EMBO Rep. , vol.10 , pp. 400-405
    • Gebeshuber, C.A.1    Zatloukal, K.2    Martinez, J.3
  • 19
    • 61849113819 scopus 로고    scopus 로고
    • Mouse cerebellar astrocytes protect cerebellar granule neurons against toxicity of the polybrominated diphenyl ether (PBDE) mixture DE-71
    • Giordano G., Kavanagh T.J., Costa L.G. Mouse cerebellar astrocytes protect cerebellar granule neurons against toxicity of the polybrominated diphenyl ether (PBDE) mixture DE-71. Neurotoxicology 2009, 30:326-329.
    • (2009) Neurotoxicology , vol.30 , pp. 326-329
    • Giordano, G.1    Kavanagh, T.J.2    Costa, L.G.3
  • 20
    • 77949518018 scopus 로고    scopus 로고
    • MicroRNA-29a induces aberrant self-renewal capacity in hematopoietic progenitors, biased myeloid development, and acute myeloid leukemia
    • Han Y.C., Park C.Y., Bhagat G., Zhang J., Wang Y., Fan J.B., Liu M., Zou Y., Weissman I.L., Gu H. microRNA-29a induces aberrant self-renewal capacity in hematopoietic progenitors, biased myeloid development, and acute myeloid leukemia. J. Exp. Med. 2010, 207:475-489.
    • (2010) J. Exp. Med. , vol.207 , pp. 475-489
    • Han, Y.C.1    Park, C.Y.2    Bhagat, G.3    Zhang, J.4    Wang, Y.5    Fan, J.B.6    Liu, M.7    Zou, Y.8    Weissman, I.L.9    Gu, H.10
  • 24
    • 84872934580 scopus 로고    scopus 로고
    • Association of the miR-146a, miR-149, miR-196a2, and miR-499 polymorphisms with ischemic stroke and silent brain infarction risk
    • Jeon Y.J., Kim O.J., Kim S.Y., Oh S.H., Oh D., Kim O.J., Shin B.S., Kim N.K. Association of the miR-146a, miR-149, miR-196a2, and miR-499 polymorphisms with ischemic stroke and silent brain infarction risk. Arterioscler. Thromb. Vasc. Biol. 2013, 33:420-430.
    • (2013) Arterioscler. Thromb. Vasc. Biol. , vol.33 , pp. 420-430
    • Jeon, Y.J.1    Kim, O.J.2    Kim, S.Y.3    Oh, S.H.4    Oh, D.5    Kim, O.J.6    Shin, B.S.7    Kim, N.K.8
  • 25
    • 41249102422 scopus 로고    scopus 로고
    • MicroRNA expression in the blood and brain of rats subjected to transient focal ischemia by middle cerebral artery occlusion
    • Jeyaseelan K., Lim K.Y., Armugam A. MicroRNA expression in the blood and brain of rats subjected to transient focal ischemia by middle cerebral artery occlusion. Stroke 2008, 39:959-966.
    • (2008) Stroke , vol.39 , pp. 959-966
    • Jeyaseelan, K.1    Lim, K.Y.2    Armugam, A.3
  • 27
    • 84877092851 scopus 로고    scopus 로고
    • Comprehensive expression analyses of neural cell-type-specific miRNAs identify new determinants of the specification and maintenance of neuronal phenotypes
    • Jovicic A., Roshan R., Moisoi N., Pradervand S., Moser R., Pillai B., Luthi-Carter R. Comprehensive expression analyses of neural cell-type-specific miRNAs identify new determinants of the specification and maintenance of neuronal phenotypes. J. Neurosci. 2013, 33:5127-5137.
    • (2013) J. Neurosci. , vol.33 , pp. 5127-5137
    • Jovicic, A.1    Roshan, R.2    Moisoi, N.3    Pradervand, S.4    Moser, R.5    Pillai, B.6    Luthi-Carter, R.7
  • 29
    • 78651511540 scopus 로고    scopus 로고
    • MiR-29b is activated during neuronal maturation and targets BH3-only genes to restrict apoptosis
    • Kole A.J., Swahari V., Hammond S.M., Deshmukh M. miR-29b is activated during neuronal maturation and targets BH3-only genes to restrict apoptosis. Genes Dev. 2011, 25:125-130.
    • (2011) Genes Dev. , vol.25 , pp. 125-130
    • Kole, A.J.1    Swahari, V.2    Hammond, S.M.3    Deshmukh, M.4
  • 30
    • 33745480963 scopus 로고    scopus 로고
    • Specific microRNAs modulate embryonic stem cell-derived neurogenesis
    • Krichevsky A.M., Sonntag K.C., Isacson O., Kosik K.S. Specific microRNAs modulate embryonic stem cell-derived neurogenesis. Stem Cells 2006, 24:857-864.
    • (2006) Stem Cells , vol.24 , pp. 857-864
    • Krichevsky, A.M.1    Sonntag, K.C.2    Isacson, O.3    Kosik, K.S.4
  • 34
    • 80052381531 scopus 로고    scopus 로고
    • Protection by pyruvate against glutamate neurotoxicity is mediated by astrocytes through a glutathione-dependent mechanism
    • Miao Y., Qiu Y., Lin Y., Miao Z., Zhang J., Lu X. Protection by pyruvate against glutamate neurotoxicity is mediated by astrocytes through a glutathione-dependent mechanism. Mol. Biol. Rep. 2011, 38:3235-3242.
    • (2011) Mol. Biol. Rep. , vol.38 , pp. 3235-3242
    • Miao, Y.1    Qiu, Y.2    Lin, Y.3    Miao, Z.4    Zhang, J.5    Lu, X.6
  • 36
    • 84889097694 scopus 로고    scopus 로고
    • Inhibition of microRNA-181 reduces forebrain ischemia induced neuronal loss
    • (in press)
    • Moon J.M., Xu L., Giffard R.G. Inhibition of microRNA-181 reduces forebrain ischemia induced neuronal loss. J. Cereb. Blood Flow Metab. 2013, (in press).
    • (2013) J. Cereb. Blood Flow Metab.
    • Moon, J.M.1    Xu, L.2    Giffard, R.G.3
  • 38
    • 84880132992 scopus 로고    scopus 로고
    • Inflammation and stroke
    • Ouyang Y.B. Inflammation and stroke. Neurosci. Lett. 2013, 548:1-3.
    • (2013) Neurosci. Lett. , vol.548 , pp. 1-3
    • Ouyang, Y.B.1
  • 39
    • 84861050854 scopus 로고    scopus 로고
    • ER-mitochondria crosstalk during cerebral ischemia: molecular chaperones and ER-mitochondrial calcium transfer
    • Ouyang Y.B., Giffard R.G. ER-mitochondria crosstalk during cerebral ischemia: molecular chaperones and ER-mitochondrial calcium transfer. Int. J. Cell Biol. 2012, 2012:493934.
    • (2012) Int. J. Cell Biol. , vol.2012 , pp. 493934
    • Ouyang, Y.B.1    Giffard, R.G.2
  • 40
    • 84888293891 scopus 로고    scopus 로고
    • MicroRNAs regulate the chaperone network in cerebral ischemia
    • Ouyang Y.B., Giffard R.G. MicroRNAs regulate the chaperone network in cerebral ischemia. Transl. Stroke Res. 2013, 1-11.
    • (2013) Transl. Stroke Res. , pp. 1-11
    • Ouyang, Y.B.1    Giffard, R.G.2
  • 41
    • 84858005054 scopus 로고    scopus 로고
    • MiR-181 targets multiple Bcl-2 family members and influences apoptosis and mitochondrial function in astrocytes
    • Ouyang Y.B., Lu Y., Yue S., Giffard R.G. miR-181 targets multiple Bcl-2 family members and influences apoptosis and mitochondrial function in astrocytes. Mitochondrion 2012, 12:213-219.
    • (2012) Mitochondrion , vol.12 , pp. 213-219
    • Ouyang, Y.B.1    Lu, Y.2    Yue, S.3    Giffard, R.G.4
  • 44
    • 84876706275 scopus 로고    scopus 로고
    • MicroRNAs: innovative targets for cerebral ischemia and stroke
    • Ouyang Y.B., Stary C.M., Yang G.Y., Giffard R. microRNAs: innovative targets for cerebral ischemia and stroke. Curr. Drug Targets 2013, 14:90-101.
    • (2013) Curr. Drug Targets , vol.14 , pp. 90-101
    • Ouyang, Y.B.1    Stary, C.M.2    Yang, G.Y.3    Giffard, R.4
  • 45
    • 34247345825 scopus 로고    scopus 로고
    • Selective dysfunction of hippocampal CA1 astrocytes contributes to delayed neuronal damage after transient forebrain ischemia
    • Ouyang Y.B., Voloboueva L.A., Xu L.J., Giffard R.G. Selective dysfunction of hippocampal CA1 astrocytes contributes to delayed neuronal damage after transient forebrain ischemia. J. Neurosci. 2007, 27:4253-4260.
    • (2007) J. Neurosci. , vol.27 , pp. 4253-4260
    • Ouyang, Y.B.1    Voloboueva, L.A.2    Xu, L.J.3    Giffard, R.G.4
  • 46
    • 84884711856 scopus 로고    scopus 로고
    • Astrocyte-enriched miR-29a targets PUMA and reduces neuronal vulnerability to forebrain ischemia
    • Ouyang Y.B., Xu L., Lu Y., Sun X., Yue S., Xiong X.X., Giffard R.G. Astrocyte-enriched miR-29a targets PUMA and reduces neuronal vulnerability to forebrain ischemia. Glia 2013, 61 (Nov11):1784-1794. 10.1002/glia.22556.
    • (2013) Glia , pp. 1784-1794
    • Ouyang, Y.B.1    Xu, L.2    Lu, Y.3    Sun, X.4    Yue, S.5    Xiong, X.X.6    Giffard, R.G.7
  • 47
    • 79955070135 scopus 로고    scopus 로고
    • Is miR-29 an oncogene or tumor suppressor in CLL?
    • Pekarsky Y., Croce C.M. Is miR-29 an oncogene or tumor suppressor in CLL?. Oncotarget 2010, 1:224-227.
    • (2010) Oncotarget , vol.1 , pp. 224-227
    • Pekarsky, Y.1    Croce, C.M.2
  • 49
    • 78449279872 scopus 로고    scopus 로고
    • Galectin-1 enhances astrocytic BDNF production and improves functional outcome in rats following ischemia
    • Qu W.S., Wang Y.H., Wang J.P., Tang Y.X., Zhang Q., Tian D.S., Yu Z.Y., Xie M.J., Wang W. Galectin-1 enhances astrocytic BDNF production and improves functional outcome in rats following ischemia. Neurochem. Res. 2010, 35:1716-1724.
    • (2010) Neurochem. Res. , vol.35 , pp. 1716-1724
    • Qu, W.S.1    Wang, Y.H.2    Wang, J.P.3    Tang, Y.X.4    Zhang, Q.5    Tian, D.S.6    Yu, Z.Y.7    Xie, M.J.8    Wang, W.9
  • 51
    • 84856250463 scopus 로고    scopus 로고
    • Upregulated miR-29b promotes neuronal cell death by inhibiting Bcl2L2 after ischemic brain injury
    • Shi G., Liu Y., Liu T., Yan W., Liu X., Wang Y., Shi J., Jia L. Upregulated miR-29b promotes neuronal cell death by inhibiting Bcl2L2 after ischemic brain injury. Exp. Brain Res. 2012, 216:225-230.
    • (2012) Exp. Brain Res. , vol.216 , pp. 225-230
    • Shi, G.1    Liu, Y.2    Liu, T.3    Yan, W.4    Liu, X.5    Wang, Y.6    Shi, J.7    Jia, L.8
  • 52
    • 53049107572 scopus 로고    scopus 로고
    • Hsa-mir-181a and hsa-mir-181b function as tumor suppressors in human glioma cells
    • Shi L., Cheng Z., Zhang J., Li R., Zhao P., Fu Z., You Y. hsa-mir-181a and hsa-mir-181b function as tumor suppressors in human glioma cells. Brain Res. 2008, 1236:185-193.
    • (2008) Brain Res. , vol.1236 , pp. 185-193
    • Shi, L.1    Cheng, Z.2    Zhang, J.3    Li, R.4    Zhao, P.5    Fu, Z.6    You, Y.7
  • 56
    • 0037148926 scopus 로고    scopus 로고
    • Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest
    • THACAS
    • THACAS Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N. Engl J. Med. 2002, 346:549-556.
    • (2002) N. Engl J. Med. , vol.346 , pp. 549-556
  • 59
    • 50249087472 scopus 로고    scopus 로고
    • Selective overexpression of excitatory amino acid transporter 2 (EAAT2) in astrocytes enhances neuroprotection from moderate but not severe hypoxia-ischemia
    • Weller M.L., Stone I.M., Goss A., Rau T., Rova C., Poulsen D.J. Selective overexpression of excitatory amino acid transporter 2 (EAAT2) in astrocytes enhances neuroprotection from moderate but not severe hypoxia-ischemia. Neuroscience 2008, 155:1204-1211.
    • (2008) Neuroscience , vol.155 , pp. 1204-1211
    • Weller, M.L.1    Stone, I.M.2    Goss, A.3    Rau, T.4    Rova, C.5    Poulsen, D.J.6
  • 60
    • 84871893820 scopus 로고    scopus 로고
    • Ginkgolide B preconditioning on astrocytes promotes neuronal survival in ischemic injury via up-regulating erythropoietin secretion
    • Wu X., Zhou C., Du F., Lu Y., Peng B., Chen L., Zhu L. Ginkgolide B preconditioning on astrocytes promotes neuronal survival in ischemic injury via up-regulating erythropoietin secretion. Neurochem. Int. 2013, 62:157-164.
    • (2013) Neurochem. Int. , vol.62 , pp. 157-164
    • Wu, X.1    Zhou, C.2    Du, F.3    Lu, Y.4    Peng, B.5    Chen, L.6    Zhu, L.7
  • 62
    • 79957631904 scopus 로고    scopus 로고
    • The role of microRNA in modulating myocardial ischemia-reperfusion injury
    • Ye Y., Perez-Polo J.R., Qian J., Birnbaum Y. The role of microRNA in modulating myocardial ischemia-reperfusion injury. Physiol. Genomics 2011, 43:534-542.
    • (2011) Physiol. Genomics , vol.43 , pp. 534-542
    • Ye, Y.1    Perez-Polo, J.R.2    Qian, J.3    Birnbaum, Y.4
  • 63
    • 77549088509 scopus 로고    scopus 로고
    • MiR-497 regulates neuronal death in mouse brain after transient focal cerebral ischemia
    • Yin K.J., Deng Z., Huang H., Hamblin M., Xie C., Zhang J., Chen Y.E. miR-497 regulates neuronal death in mouse brain after transient focal cerebral ischemia. Neurobiol. Dis. 2010, 38:17-26.
    • (2010) Neurobiol. Dis. , vol.38 , pp. 17-26
    • Yin, K.J.1    Deng, Z.2    Huang, H.3    Hamblin, M.4    Xie, C.5    Zhang, J.6    Chen, Y.E.7
  • 64
    • 77953132647 scopus 로고    scopus 로고
    • MicroRNA expression changes in the hippocampi of rats subjected to global ischemia
    • Yuan Y., Wang J.Y., Xu L.Y., Cai R., Chen Z., Luo B.Y. MicroRNA expression changes in the hippocampi of rats subjected to global ischemia. J. Clin. Neurosci. 2010, 17:774-778.
    • (2010) J. Clin. Neurosci. , vol.17 , pp. 774-778
    • Yuan, Y.1    Wang, J.Y.2    Xu, L.Y.3    Cai, R.4    Chen, Z.5    Luo, B.Y.6
  • 65
    • 84864280520 scopus 로고    scopus 로고
    • Combination therapy with VELCADE and tissue plasminogen activator is neuroprotective in aged rats after stroke and targets microRNA-146a and the toll-like receptor signaling pathway
    • Zhang L., Chopp M., Liu X., Teng H., Tang T., Kassis H., Zhang Z.G. Combination therapy with VELCADE and tissue plasminogen activator is neuroprotective in aged rats after stroke and targets microRNA-146a and the toll-like receptor signaling pathway. Arterioscler. Thromb. Vasc. Biol. 2012, 32:1856-1864.
    • (2012) Arterioscler. Thromb. Vasc. Biol. , vol.32 , pp. 1856-1864
    • Zhang, L.1    Chopp, M.2    Liu, X.3    Teng, H.4    Tang, T.5    Kassis, H.6    Zhang, Z.G.7
  • 66
    • 77957076579 scopus 로고    scopus 로고
    • Targeting astrocytes for stroke therapy
    • Zhao Y., Rempe D. Targeting astrocytes for stroke therapy. Neurotherapeutics 2010, 7:439-451.
    • (2010) Neurotherapeutics , vol.7 , pp. 439-451
    • Zhao, Y.1    Rempe, D.2
  • 67
    • 84876415041 scopus 로고    scopus 로고
    • 1R-initiated, IP3R-dependent stimulation of astrocyte mitochondrial metabolism reduces and partially reverses ischemic neuronal damage in mouse
    • 1R-initiated, IP3R-dependent stimulation of astrocyte mitochondrial metabolism reduces and partially reverses ischemic neuronal damage in mouse. J. Cereb. Blood Flow Metab. 2013, 33:600-611.
    • (2013) J. Cereb. Blood Flow Metab. , vol.33 , pp. 600-611
    • Zheng, W.1    Talley Watts, L.2    Holstein, D.M.3    Wewer, J.4    Lechleiter, J.D.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.