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Volumn 25, Issue 2, 2014, Pages 110-117

Perilipin 5, a lipid droplet protein adapted to mitochondrial energy utilization

Author keywords

ATGL; B oxidation; Fatty acid toxicity; Lipolysis; Steatosis

Indexed keywords

FAT DROPLET; PERILIPIN; PERILIPIN 5; UNCLASSIFIED DRUG;

EID: 84897023312     PISSN: 09579672     EISSN: 14736535     Source Type: Journal    
DOI: 10.1097/MOL.0000000000000057     Document Type: Review
Times cited : (92)

References (74)
  • 1
    • 84880036446 scopus 로고    scopus 로고
    • Balancing the fat: Lipid droplets and human disease
    • Krahmer N, Farese RV Jr, Walther TC. Balancing the fat: Lipid droplets and human disease. EMBO Mol Med 2013; 5:905-915.
    • (2013) EMBO Mol Med , vol.5 , pp. 905-915
    • Krahmer, N.1    Farese Jr., R.V.2    Walther, T.C.3
  • 2
    • 84871820511 scopus 로고    scopus 로고
    • Lipid droplets and peroxisomes: Key players in cellular lipid homeostasis or a matter of fat-store 'em up or burn 'em down
    • Kohlwein SD, Veenhuis M, van der Klei IJ. Lipid droplets and peroxisomes: Key players in cellular lipid homeostasis or a matter of fat-store 'em up or burn 'em down. Genetics 2013; 193:1-50.
    • (2013) Genetics , vol.193 , pp. 1-50
    • Kohlwein, S.D.1    Veenhuis, M.2    Van Der Klei, I.J.3
  • 4
    • 84864293537 scopus 로고    scopus 로고
    • Role of intramyocelluar lipids in human health
    • Coen PM, Goodpaster BH. Role of intramyocelluar lipids in human health. Trends Endocrinol Metab 2012; 238:391-398.
    • (2012) Trends Endocrinol Metab , vol.238 , pp. 391-398
    • Coen, P.M.1    Goodpaster, B.H.2
  • 5
    • 79957889560 scopus 로고    scopus 로고
    • The role of lipid droplets in metabolic disease in rodents and humans
    • Greenberg AS, Coleman RA, Kraemer FB, et al. The role of lipid droplets in metabolic disease in rodents and humans. J Clin Invest 2011; 121:2102-2110.
    • (2011) J Clin Invest , vol.121 , pp. 2102-2110
    • Greenberg, A.S.1    Coleman, R.A.2    Kraemer, F.B.3
  • 6
    • 84893698357 scopus 로고    scopus 로고
    • Role of adipose specific lipid droplet proteins in maintaining whole body energy homeostasis
    • in press
    • Konige M, Wang H, Sztalryd C. Role of adipose specific lipid droplet proteins in maintaining whole body energy homeostasis. Biochim Biophys Acta 2013. (in press.
    • (2013) Biochim Biophys Acta
    • Konige, M.1    Wang, H.2    Sztalryd, C.3
  • 7
    • 58849088969 scopus 로고    scopus 로고
    • Ectopic lipids and organ function
    • Szendroedi J, Roden M. Ectopic lipids and organ function. Curr Opin Lipid 2009; 20:50-56.
    • (2009) Curr Opin Lipid , vol.20 , pp. 50-56
    • Szendroedi, J.1    Roden, M.2
  • 9
    • 84871655682 scopus 로고    scopus 로고
    • Dissociating fatty liver and diabetes
    • Sun Z, Lazar MA. Dissociating fatty liver and diabetes. Trends Endocrinol Metab 2013; 24:4-12.
    • (2013) Trends Endocrinol Metab , vol.24 , pp. 4-12
    • Sun, Z.1    Lazar, M.A.2
  • 10
    • 84857861919 scopus 로고    scopus 로고
    • Mechanisms for insulin resistance: Common threads and missing links
    • Samuel VT, Shulman GI. Mechanisms for insulin resistance: Common threads and missing links. Cell 2012; 148:852-871.
    • (2012) Cell , vol.148 , pp. 852-871
    • Samuel, V.T.1    Shulman, G.I.2
  • 11
    • 83455229494 scopus 로고    scopus 로고
    • Re-evaluating lipotoxic triggers in skeletal muscle: Relating intramyocellular lipid metabolism to insulin sensitivity
    • Bosma M, Kersten S, Hesselink MK, Schrauwen P. Re-evaluating lipotoxic triggers in skeletal muscle: Relating intramyocellular lipid metabolism to insulin sensitivity. Prog Lipid Res 2012; 51:36-49.
    • (2012) Prog Lipid Res , vol.51 , pp. 36-49
    • Bosma, M.1    Kersten, S.2    Hesselink, M.K.3    Schrauwen, P.4
  • 12
    • 79953745343 scopus 로고    scopus 로고
    • Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits
    • GOLD Consortium
    • Speliotes EK, Yerges-Armstrong LM, Wu J, et al., GOLD Consortium. Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. PLoS Genet 2011; 7:e1001324.
    • (2011) PLoS Genet , vol.7
    • Speliotes, E.K.1    Yerges-Armstrong, L.M.2    Wu, J.3
  • 14
    • 66349128492 scopus 로고    scopus 로고
    • PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores
    • Bickel PE, Tansey JT, Welte MA. PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores. Biochim Biophys Acta 2009; 1791:419-440.
    • (2009) Biochim Biophys Acta , vol.1791 , pp. 419-440
    • Bickel, P.E.1    Tansey, J.T.2    Welte, M.A.3
  • 15
    • 84890560014 scopus 로고    scopus 로고
    • Perilipins: Lipid droplet coat proteins adapted for tissue-specific energy storage and utilization, and lipid cytoprotection
    • Sztalryd C, Kimmel AR. Perilipins: Lipid droplet coat proteins adapted for tissue-specific energy storage and utilization, and lipid cytoprotection. Biochimie 2014; 96:96-101.
    • (2014) Biochimie , vol.96 , pp. 96-101
    • Sztalryd, C.1    Kimmel, A.R.2
  • 16
    • 0034861995 scopus 로고    scopus 로고
    • The murine perilipin gene: The lipid droplet-Associated perilipins derive from tissue-specific, mRNA splice variants and define a gene family of ancient origin
    • Lu X, Gruia-Gray J, Copeland NG, et al. The murine perilipin gene: The lipid droplet-Associated perilipins derive from tissue-specific, mRNA splice variants and define a gene family of ancient origin. Mamm Genome 2001; 12:741-749.
    • (2001) Mamm Genome , vol.12 , pp. 741-749
    • Lu, X.1    Gruia-Gray, J.2    Copeland, N.G.3
  • 17
    • 33846820321 scopus 로고    scopus 로고
    • LSDP5 is a PAT protein specifically expressed in fatty acid oxidizing tissues
    • Dalen KT, Dahl T, Holter E, et al. LSDP5 is a PAT protein specifically expressed in fatty acid oxidizing tissues. Biochim Biophys Acta 2007; 1771:210-227.
    • (2007) Biochim Biophys Acta , vol.1771 , pp. 210-227
    • Dalen, K.T.1    Dahl, T.2    Holter, E.3
  • 18
    • 33744913055 scopus 로고    scopus 로고
    • MLDP, a novel PAT family protein localized to lipid droplets and enriched in the heart, is regulated by peroxisome proliferator-Activated receptor alpha
    • Yamaguchi T, Matsushita S, Motojima K, et al. MLDP, a novel PAT family protein localized to lipid droplets and enriched in the heart, is regulated by peroxisome proliferator-Activated receptor alpha. J Biol Chem 2006; 281: 14232-14240.
    • (2006) J Biol Chem , vol.281 , pp. 14232-14240
    • Yamaguchi, T.1    Matsushita, S.2    Motojima, K.3
  • 19
    • 33845517481 scopus 로고    scopus 로고
    • OXPAT/PAT-1 is a PPAR-induced lipid droplet protein that promotes fatty acid utilization
    • Wolins NE, Quaynor BK, Skinner JR, et al. OXPAT/PAT-1 is a PPAR-induced lipid droplet protein that promotes fatty acid utilization. Diabetes 2006; 55:3418-3428.
    • (2006) Diabetes , vol.55 , pp. 3418-3428
    • Wolins, N.E.1    Quaynor, B.K.2    Skinner, J.R.3
  • 21
    • 0032549811 scopus 로고    scopus 로고
    • A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
    • Puigserver P, Wu Z, Park CW, et al. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 1998; 92:829-839.
    • (1998) Cell , vol.92 , pp. 829-839
    • Puigserver, P.1    Wu, Z.2    Park, C.W.3
  • 22
    • 80053403320 scopus 로고    scopus 로고
    • Skeletal muscle triglycerides, diacylglycerols, and ceramides in insulin resistance: Another paradox in endurance-Trained athletes?
    • Amati F, Dubé JJ, Alvarez-Carnero E, et al. Skeletal muscle triglycerides, diacylglycerols, and ceramides in insulin resistance: Another paradox in endurance-Trained athletes? Diabetes 2011; 60:2588-2597.
    • (2011) Diabetes , vol.60 , pp. 2588-2597
    • Amati, F.1    Dubé, J.J.2    Alvarez-Carnero, E.3
  • 23
    • 84872459305 scopus 로고    scopus 로고
    • PPAR coactivator-1 (contributes to exercise-induced regulation of intramuscular lipid droplet programming in mice and humans
    • Koves TR, Sparks LM, Kovalik JP, et al. PPAR (coactivator-1 (contributes to exercise-induced regulation of intramuscular lipid droplet programming in mice and humans. J Lipid Res 2013; 54:522-534.
    • (2013) J Lipid Res , vol.54 , pp. 522-534
    • Koves, T.R.1    Sparks, L.M.2    Kovalik, J.P.3
  • 24
    • 79953160438 scopus 로고    scopus 로고
    • Interactions of perilipin-5 (PLIN5) with adipose trigylceride lipase (ATGL
    • Granneman JG, Moore HP, Mottillo EP, et al. Interactions of perilipin-5 (PLIN5) with adipose trigylceride lipase (ATGL). J Biol Chem 2010; 886: 5126-5135.
    • (2010) J Biol Chem , vol.886 , pp. 5126-5135
    • Granneman, J.G.1    Moore, H.P.2    Mottillo, E.P.3
  • 25
    • 50949093056 scopus 로고    scopus 로고
    • Bioinformatic profiling of the transcriptional response of adult rat cardiomyocytes to distinct fatty acids
    • Lockridge JB, Sailors ML, Durgan DJ, et al. Bioinformatic profiling of the transcriptional response of adult rat cardiomyocytes to distinct fatty acids. J Lipid Res 2008; 49:1395-1408.
    • (2008) J Lipid Res , vol.49 , pp. 1395-1408
    • Lockridge, J.B.1    Sailors, M.L.2    Durgan, D.J.3
  • 26
    • 84878997060 scopus 로고    scopus 로고
    • Fatty acids regulate perilipin5 in muscle by activating PPARd
    • Bindesbøll C, Berg O, Arntsen B, et al. Fatty acids regulate perilipin5 in muscle by activating PPARd. J Lipid Res 2013; 54:1949-1963.
    • (2013) J Lipid Res , vol.54 , pp. 1949-1963
    • Bindesbøll, C.1    Berg, O.2    Arntsen, B.3
  • 27
    • 2342466747 scopus 로고    scopus 로고
    • Adipose tissue expression of the lipid droplet-Associating proteins S3-12 and perilipin is controlled by peroxisome proliferator-Activated receptor-gamma
    • Dalen KT, Schoonjans K, Ulven SM, et al. Adipose tissue expression of the lipid droplet-Associating proteins S3-12 and perilipin is controlled by peroxisome proliferator-Activated receptor-gamma. Diabetes 2004; 53:1243-1252.
    • (2004) Diabetes , vol.53 , pp. 1243-1252
    • Dalen, K.T.1    Schoonjans, K.2    Ulven, S.M.3
  • 28
    • 0346101822 scopus 로고    scopus 로고
    • The lipid droplet-Associated protein adipophilin is expressed in human trophoblasts and is regulated by peroxisomal proliferator-Activated receptor-gamma/retinoid X receptor
    • Bildirici I, Roh CR, Schaiff WT, et al. The lipid droplet-Associated protein adipophilin is expressed in human trophoblasts and is regulated by peroxisomal proliferator-Activated receptor-gamma/retinoid X receptor. J Clin Endocrinol Metab 2003; 88:6056-6062.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 6056-6062
    • Bildirici, I.1    Roh, C.R.2    Schaiff, W.T.3
  • 29
    • 2042437052 scopus 로고    scopus 로고
    • Identification of a functional peroxisome proliferator-Activated receptor responsive element within the murine perilipin gene
    • Nagai S, Shimizu C, Umetsu M, et al. Identification of a functional peroxisome proliferator-Activated receptor responsive element within the murine perilipin gene. Endocrinology 2004; 145:2346-2356.
    • (2004) Endocrinology , vol.145 , pp. 2346-2356
    • Nagai, S.1    Shimizu, C.2    Umetsu, M.3
  • 30
    • 1642378571 scopus 로고    scopus 로고
    • The peroxisome proliferator-Activated receptor gamma regulates expression of the perilipin gene in adipocytes
    • Arimura N, Horiba T, Imagawa M, et al. The peroxisome proliferator-Activated receptor gamma regulates expression of the perilipin gene in adipocytes. J Biol Chem 2004; 279:10070-10076.
    • (2004) J Biol Chem , vol.279 , pp. 10070-10076
    • Arimura, N.1    Horiba, T.2    Imagawa, M.3
  • 32
    • 80455135722 scopus 로고    scopus 로고
    • Perilipin 5, lipid droplet associated protein provides physical and metabolic linkage to mitochondria
    • Wang H, Sreenevasan U, Hu H, et al. Perilipin 5, lipid droplet associated protein provides physical and metabolic linkage to mitochondria. J Lipid Res 2011; 52:2159-2168.
    • (2011) J Lipid Res , vol.52 , pp. 2159-2168
    • Wang, H.1    Sreenevasan, U.2    Hu, H.3
  • 33
    • 84857632171 scopus 로고    scopus 로고
    • The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria
    • Bosma M, Minnaard R, Sparks LM, et al. The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria. Histochem Cell Biol 2012; 137:205-216.
    • (2012) Histochem Cell Biol , vol.137 , pp. 205-216
    • Bosma, M.1    Minnaard, R.2    Sparks, L.M.3
  • 34
    • 84861913952 scopus 로고    scopus 로고
    • Lipid droplets and cellular lipid metabolism
    • Walther TC, Farese RV Jr. Lipid droplets and cellular lipid metabolism. Annu Rev Biochem 2012; 81:687-714.
    • (2012) Annu Rev Biochem , vol.81 , pp. 687-714
    • Walther, T.C.1    Farese Jr., R.V.2
  • 35
    • 84864864505 scopus 로고    scopus 로고
    • Lipid droplet formation on opposing sides of the endoplasmic reticulum
    • Sturley SL, Hussain MM. Lipid droplet formation on opposing sides of the endoplasmic reticulum. J Lipid Res 2012; 53:1800-1810.
    • (2012) J Lipid Res , vol.53 , pp. 1800-1810
    • Sturley, S.L.1    Hussain, M.M.2
  • 37
    • 78650107057 scopus 로고    scopus 로고
    • Lipolysis-A highly regulated multienzyme complex mediates the catabolism of cellular fat stores
    • Lass A, Zimmermann R, Oberer M, Zechner R. Lipolysis-A highly regulated multienzyme complex mediates the catabolism of cellular fat stores. Prog Lipid Res 2011; 50:14-27.
    • (2011) Prog Lipid Res , vol.50 , pp. 14-27
    • Lass, A.1    Zimmermann, R.2    Oberer, M.3    Zechner, R.4
  • 38
    • 77249118270 scopus 로고    scopus 로고
    • The G (0)/G(1) switch gene 2 regulates adipose lipolysis through association with adipose triglyceride lipase
    • Yang X, Lu X, Lombes M, et al. The G(0)/G(1) switch gene 2 regulates adipose lipolysis through association with adipose triglyceride lipase. Cell Metab 2010; 11:194-205.
    • (2010) Cell Metab , vol.11 , pp. 194-205
    • Yang, X.1    Lu, X.2    Lombes, M.3
  • 39
    • 36649015243 scopus 로고    scopus 로고
    • Thematic review series: Adipocyte biology. The perilipin family of structural lipid droplet proteins: Stabilization of lipid droplets and control of lipolysis
    • Brasaemle DL. Thematic review series: Adipocyte biology. The perilipin family of structural lipid droplet proteins: Stabilization of lipid droplets and control of lipolysis. J Lipid Res 2007; 48:2547-2559.
    • (2007) J Lipid Res , vol.48 , pp. 2547-2559
    • Brasaemle, D.L.1
  • 40
    • 84934435436 scopus 로고    scopus 로고
    • Determination of lipolysis in isolated primary adipocytes
    • Viswanadha S, Londos C. Determination of lipolysis in isolated primary adipocytes. Methods Mol Biol 2008; 456:299-306.
    • (2008) Methods Mol Biol , vol.456 , pp. 299-306
    • Viswanadha, S.1    Londos, C.2
  • 41
    • 59149104232 scopus 로고    scopus 로고
    • Functional interactions between Mldp (LSDP5) and Abhd5 in the control of intracellular lipid accumulation
    • Granneman JG, Moore HP, Mottillo EP, Zhu Z. Functional interactions between Mldp (LSDP5) and Abhd5 in the control of intracellular lipid accumulation. J Biol Chem 2009; 284:3049-3057.
    • (2009) J Biol Chem , vol.284 , pp. 3049-3057
    • Granneman, J.G.1    Moore, H.P.2    Mottillo, E.P.3    Zhu, Z.4
  • 42
    • 70450260450 scopus 로고    scopus 로고
    • Activation of hormone-sensitive lipase requires two steps, protein phosphorylation and binding to the PAT-1 domain of lipid droplet coat proteins
    • Wang H, Hu L, Dalen K, et al. Activation of hormone-sensitive lipase requires two steps, protein phosphorylation and binding to the PAT-1 domain of lipid droplet coat proteins. J Biol Chem 2009; 284:32116-32125.
    • (2009) J Biol Chem , vol.284 , pp. 32116-32125
    • Wang, H.1    Hu, L.2    Dalen, K.3
  • 43
    • 79955549893 scopus 로고    scopus 로고
    • Unique regulation of adipose triglyceride lipase (ATGL) by perilipin 5, a lipid droplet-Associated protein
    • Wang H, Bell M, Sreenevasan U, et al. Unique regulation of adipose triglyceride lipase (ATGL) by perilipin 5, a lipid droplet-Associated protein. J Biol Chem 2011; 286:15707-15715.
    • (2011) J Biol Chem , vol.286 , pp. 15707-15715
    • Wang, H.1    Bell, M.2    Sreenevasan, U.3
  • 44
    • 84875828716 scopus 로고    scopus 로고
    • Cardiomyocyte-specific perilipin 5 overexpression leads to myocardial steatosis and modest cardiac dysfunction
    • Wang H, Sreenivasan U, Gong DW, et al. Cardiomyocyte-specific perilipin 5 overexpression leads to myocardial steatosis and modest cardiac dysfunction. J Lipid Res 2013; 54:953-965.
    • (2013) J Lipid Res , vol.54 , pp. 953-965
    • Wang, H.1    Sreenivasan, U.2    Gong, D.W.3
  • 45
    • 84875856324 scopus 로고    scopus 로고
    • Cardiac-specific overexpression of perilipin 5 provokes severe cardiac steatosis via the formation of a lipolytic barrier
    • Pollak NM, Schweiger M, Jaeger D, et al. Cardiac-specific overexpression of perilipin 5 provokes severe cardiac steatosis via the formation of a lipolytic barrier. J Lipid Res 2013; 58:1092-1102.
    • (2013) J Lipid Res , vol.58 , pp. 1092-1102
    • Pollak, N.M.1    Schweiger, M.2    Jaeger, D.3
  • 46
    • 33646462136 scopus 로고    scopus 로고
    • Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase
    • Haemmerle G, Lass A, Zimmermann R, et al. Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. Science 2006; 312:734-737.
    • (2006) Science , vol.312 , pp. 734-737
    • Haemmerle, G.1    Lass, A.2    Zimmermann, R.3
  • 47
    • 80052454265 scopus 로고    scopus 로고
    • ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-(and PGC-1
    • Haemmerle G, Moustafa T, Woelkart G, et al. ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-(and PGC-1. Nat Med 2011; 17:1076-1085.
    • (2011) Nat Med , vol.17 , pp. 1076-1085
    • Haemmerle, G.1    Moustafa, T.2    Woelkart, G.3
  • 48
    • 84863614584 scopus 로고    scopus 로고
    • Perilipin 5, a lipid droplet-binding protein, protects heart from oxidative burden by sequestering fatty acid from excessive oxidation
    • Kuramoto K, Okamura T, Yamaguchi T, et al. Perilipin 5, a lipid droplet-binding protein, protects heart from oxidative burden by sequestering fatty acid from excessive oxidation. J Biol Chem 2012; 287:23852-23863.
    • (2012) J Biol Chem , vol.287 , pp. 23852-23863
    • Kuramoto, K.1    Okamura, T.2    Yamaguchi, T.3
  • 49
    • 84878455001 scopus 로고    scopus 로고
    • Skeletal muscle PLIN proteins, ATGL and CGI-58, interactions at rest and following stimulated contraction
    • MacPherson RE, Ramos SV, Vandenboom R, et al. Skeletal muscle PLIN proteins, ATGL and CGI-58, interactions at rest and following stimulated contraction. Am J Physiol Regul Integr Comp Physiol 2013; 304:R644-650.
    • (2013) Am J Physiol Regul Integr Comp Physiol , vol.304
    • MacPherson, R.E.1    Ramos, S.V.2    Vandenboom, R.3
  • 50
    • 84889810598 scopus 로고    scopus 로고
    • Endurance exercise training up-regulates lipolytic proteins and reduces triglyceride content in skeletal muscle of obese subjects
    • Louche K, Badin PM, Montastier E, et al. Endurance exercise training up-regulates lipolytic proteins and reduces triglyceride content in skeletal muscle of obese subjects. J Clin Endocrinol Metab 2013; 98:4863-4871.
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. 4863-4871
    • Louche, K.1    Badin, P.M.2    Montastier, E.3
  • 51
    • 83455246503 scopus 로고    scopus 로고
    • Distinct cellular pools of perilipin 5 point to roles in lipid trafficking
    • Bartholomew SR, Bell EH, Summerfield T, et al. Distinct cellular pools of perilipin 5 point to roles in lipid trafficking. Biochim Biophys Acta 2012; 1821:268-278.
    • (2012) Biochim Biophys Acta , vol.1821 , pp. 268-278
    • Bartholomew, S.R.1    Bell, E.H.2    Summerfield, T.3
  • 52
    • 71449118409 scopus 로고    scopus 로고
    • Diacylglycerol enrichment of endoplasmic reticulum or lipid droplets recruits perilipin 3/TIP47 during lipid storage and mobilization
    • Skinner JR, Shew TM, Schwartz DM, et al. Diacylglycerol enrichment of endoplasmic reticulum or lipid droplets recruits perilipin 3/TIP47 during lipid storage and mobilization. J Biol Chem 2009; 284:30941-30948.
    • (2009) J Biol Chem , vol.284 , pp. 30941-30948
    • Skinner, J.R.1    Shew, T.M.2    Schwartz, D.M.3
  • 53
    • 84255185211 scopus 로고    scopus 로고
    • Subcellular localization of skeletal muscle lipid droplets and PLIN family proteins OXPAT and ADRP at rest and following contraction in rat soleus muscle
    • MacPherson RE, Herbst EA, Reynolds EJ, et al. Subcellular localization of skeletal muscle lipid droplets and PLIN family proteins OXPAT and ADRP at rest and following contraction in rat soleus muscle. Am J Physiol Regul Integr Comp Physiol 2012; 302:R29-36.
    • (2012) Am J Physiol Regul Integr Comp Physiol , vol.302
    • MacPherson, R.E.1    Herbst, E.A.2    Reynolds, E.J.3
  • 55
    • 84875820468 scopus 로고    scopus 로고
    • Perilipin 5: Putting the brakes on lipolysis
    • Brasaemle DL. Perilipin 5: Putting the brakes on lipolysis. J Lipid Res 2013; 54:876-877.
    • (2013) J Lipid Res , vol.54 , pp. 876-877
    • Brasaemle, D.L.1
  • 56
    • 84866143955 scopus 로고    scopus 로고
    • Perilipin family members preferentially sequester to either triacylglycerol-specific or cholesteryl-ester-specific intracellular lipid storage droplets
    • Hsieh K, Lee YK, Londos C, et al. Perilipin family members preferentially sequester to either triacylglycerol-specific or cholesteryl-ester-specific intracellular lipid storage droplets. J Cell Sci 2012; 125:4067-4076.
    • (2012) J Cell Sci , vol.125 , pp. 4067-4076
    • Hsieh, K.1    Lee, Y.K.2    Londos, C.3
  • 58
    • 0033671833 scopus 로고    scopus 로고
    • Absence of perilipin results in leanness and reverses obesity in Lepr(db/db) mice
    • Martinez-Botas J, Anderson JB, Tessier D, et al. Absence of perilipin results in leanness and reverses obesity in Lepr(db/db) mice. Nat Genet 2000; 4:474-479.
    • (2000) Nat Genet , vol.4 , pp. 474-479
    • Martinez-Botas, J.1    Anderson, J.B.2    Tessier, D.3
  • 59
    • 14344268795 scopus 로고    scopus 로고
    • Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity
    • Tansey JT, Sztalryd C, Gruia-Gray J, et al. Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity. Proc Natl Acad Sci USA 2001; 98:6494-6499.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 6494-6499
    • Tansey, J.T.1    Sztalryd, C.2    Gruia-Gray, J.3
  • 60
    • 84876787028 scopus 로고    scopus 로고
    • Perilipin-2-null mice are protected against diet-induced obesity, adipose inflammation, and fatty liver disease
    • McManaman JL, Bales ES, Orlicky DJ, et al. Perilipin-2-null mice are protected against diet-induced obesity, adipose inflammation, and fatty liver disease. J Lipid Res 2013; 54:1346-1359.
    • (2013) J Lipid Res , vol.54 , pp. 1346-1359
    • McManaman, J.L.1    Bales, E.S.2    Orlicky, D.J.3
  • 61
    • 31344437783 scopus 로고    scopus 로고
    • Protection against fatty liver but normal adipogenesis in mice lacking adipose differentiation-related protein
    • Chang BH, Li L, Paul A, et al. Protection against fatty liver but normal adipogenesis in mice lacking adipose differentiation-related protein. Mol Cell Biol 2006; 3:1063-1076.
    • (2006) Mol Cell Biol , vol.3 , pp. 1063-1076
    • Chang, B.H.1    Li, L.2    Paul, A.3
  • 62
    • 84861742465 scopus 로고    scopus 로고
    • LSDP5 enhances triglyceride storage in hepatocytes by influencing lipolysis and fatty acid b-oxidation of lipid droplets
    • Li H, Song Y, Zhang LJ, et al. LSDP5 enhances triglyceride storage in hepatocytes by influencing lipolysis and fatty acid b-oxidation of lipid droplets. PLoS One 2012; 7:e36712.
    • (2012) PLoS One , vol.7
    • Li, H.1    Song, Y.2    Zhang, L.J.3
  • 63
    • 33847755111 scopus 로고    scopus 로고
    • Influence of endurance exercise training and sex on intramyocellular lipidand mitochondrial ultrastructure, substrate use, and mitochondrial enzyme activity
    • Tarnopolsky MA, Rennie CD, Robertshaw HA, et al. Influence of endurance exercise training and sex on intramyocellular lipidand mitochondrial ultrastructure, substrate use, and mitochondrial enzyme activity. Am J Physiol Regul Integr Comp Physiol 2007; 292:R1271-R1278.
    • (2007) Am J Physiol Regul Integr Comp Physiol , vol.292
    • Tarnopolsky, M.A.1    Rennie, C.D.2    Robertshaw, H.A.3
  • 64
    • 84885643754 scopus 로고    scopus 로고
    • Mitochondrial dysfunction induces formation of lipid droplets as a generalized response to stress
    • Lee SJ, Zhang J, Choi AM, Kim HP. Mitochondrial dysfunction induces formation of lipid droplets as a generalized response to stress. Oxid Med Cell Longev 2013; 2013:327167.
    • (2013) Oxid Med Cell Longev , vol.2013 , pp. 327167
    • Lee, S.J.1    Zhang, J.2    Choi, A.M.3    Kim, H.P.4
  • 65
    • 84858020291 scopus 로고    scopus 로고
    • FAT SIGNALS-lipases and lipolysis in lipid metabolism and signalling
    • Zechner R, Zimmermann R, Eichmann TO, et al. FAT SIGNALS-lipases and lipolysis in lipid metabolism and signalling. Cell Metab 2012; 15:279-291.
    • (2012) Cell Metab , vol.15 , pp. 279-291
    • Zechner, R.1    Zimmermann, R.2    Eichmann, T.O.3
  • 66
    • 84864098852 scopus 로고    scopus 로고
    • Lipolytic products activate peroxisome proliferator-Activated receptor (PPAR) a and d in brown adipocytes to match fatty acid oxidation with supply
    • Mottillo EP, Bloch AE, Leff T, Granneman JG. Lipolytic products activate peroxisome proliferator-Activated receptor (PPAR) a and d in brown adipocytes to match fatty acid oxidation with supply. J Biol Chem 2012; 287: 25038-25048.
    • (2012) J Biol Chem , vol.287 , pp. 25038-25048
    • Mottillo, E.P.1    Bloch, A.E.2    Leff, T.3    Granneman, J.G.4
  • 67
    • 78751496304 scopus 로고    scopus 로고
    • Adipose triglyceride lipase is a major hepatic lipase that regulates triacylglycerol turnover and fatty acid signaling and partitioning
    • Ong KT, Mashek MT, Bu SY, et al. Adipose triglyceride lipase is a major hepatic lipase that regulates triacylglycerol turnover and fatty acid signaling and partitioning. Hepatology 2011; 53:116-126.
    • (2011) Hepatology , vol.53 , pp. 116-126
    • Ong, K.T.1    Mashek, M.T.2    Bu, S.Y.3
  • 68
    • 69449087522 scopus 로고    scopus 로고
    • Hepatic triacylglycerol hydrolysis regulates peroxisome proliferator-Activated receptor alpha activity
    • Sapiro JM, Mashek MT, Greenberg AS, Mashek DG. Hepatic triacylglycerol hydrolysis regulates peroxisome proliferator-Activated receptor alpha activity. J Lipid Res 2009; 50:1621-1629.
    • (2009) J Lipid Res , vol.50 , pp. 1621-1629
    • Sapiro, J.M.1    Mashek, M.T.2    Greenberg, A.S.3    Mashek, D.G.4
  • 69
    • 84876009387 scopus 로고    scopus 로고
    • Functional cardiac lipolysis in mice critically depends on comparative gene identification-58
    • Zierler KA, Jaeger D, Pollak NM, et al. Functional cardiac lipolysis in mice critically depends on comparative gene identification-58. J Biol Chem 2013; 288:9892-9904.
    • (2013) J Biol Chem , vol.288 , pp. 9892-9904
    • Zierler, K.A.1    Jaeger, D.2    Pollak, N.M.3
  • 70
    • 84894455464 scopus 로고    scopus 로고
    • Early structural and metabolic cardiac remodelling in response to inducible adipose triglyceride lipase ablation
    • Kienesberger PC, Pulinilkunnil T, Nagendran J, et al. Early structural and metabolic cardiac remodelling in response to inducible adipose triglyceride lipase ablation. Cardiovasc Res 2013; 99:442-451.
    • (2013) Cardiovasc Res , vol.99 , pp. 442-451
    • Kienesberger, P.C.1    Pulinilkunnil, T.2    Nagendran, J.3
  • 71
    • 73649094432 scopus 로고    scopus 로고
    • DGAT1 expression increases heart triglyceride content but ameliorates lipotoxicity
    • Liu L,Shi X, Bharadwaj KG,et al.DGAT1 expression increases heart triglyceride content but ameliorates lipotoxicity. J Biol Chem 2009; 284:36312-36323.
    • (2009) J Biol Chem , vol.284 , pp. 36312-36323
    • Liu, L.1    Shi, X.2    Bharadwaj, K.G.3
  • 72
    • 79958862625 scopus 로고    scopus 로고
    • Oxidative tissue: Perilipin 5 links storage with the furnace
    • Wang H, Sztalryd C. Oxidative tissue: Perilipin 5 links storage with the furnace. Trends Endocrinol Metab 2011; 22:197-203.
    • (2011) Trends Endocrinol Metab , vol.22 , pp. 197-203
    • Wang, H.1    Sztalryd, C.2
  • 73
    • 84873729674 scopus 로고    scopus 로고
    • Overexpression of plin5 in skeletal muscle promotes oxidative gene expression and intramyocellular lipid content without compromising insulin sensitivity
    • Bosma M, Sparks LM, Hooiveld GJ, et al. Overexpression of PLIN5 in skeletal muscle promotes oxidative gene expression and intramyocellular lipid content without compromising insulin sensitivity. Biochim Biophys Acta 2013; 1831: 844-852.
    • (2013) Biochim Biophys Acta , vol.1831 , pp. 844-852
    • Bosma, M.1    Sparks, L.M.2    Hooiveld, G.J.3
  • 74
    • 84868020505 scopus 로고    scopus 로고
    • Perilipin 2 improves insulin sensitivity in skeletal muscle despite elevated intramuscular lipid levels
    • Bosma M, Hesselink MK, Sparks LM, et al. Perilipin 2 improves insulin sensitivity in skeletal muscle despite elevated intramuscular lipid levels. Diabetes 2012; 61:2679-2690.
    • (2012) Diabetes , vol.61 , pp. 2679-2690
    • Bosma, M.1    Hesselink, M.K.2    Sparks, L.M.3


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