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Volumn 82, Issue 3, 2004, Pages 183-190

Ginsenosides 20(S)-protopanaxadiol and Rh2 reduce cell proliferation and increase sub-G1 cells in two cultured intestinal cell lines, Int-407 and Caco-2

Author keywords

Apoptosis; Ginseng; Ginsenosides; Protopanaxadiol; Protopanaxatriol; Rh2

Indexed keywords

ANTINEOPLASTIC AGENT; GINSENG EXTRACT; GINSENOSIDE; LACTATE DEHYDROGENASE; PROTOPANAXADIOL; PROTOPANAXATRIOL; UNCLASSIFIED DRUG;

EID: 2442452643     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y04-001     Document Type: Article
Times cited : (76)

References (25)
  • 1
    • 0033950741 scopus 로고    scopus 로고
    • Effects of beta-carotene on antioxidant enzyme activity, intracellular reactive oxygen and membrane integrity within post confluent Caco-2 intestinal cells
    • Bestwick, C.S., and Milne, L. 2000. Effects of beta-carotene on antioxidant enzyme activity, intracellular reactive oxygen and membrane integrity within post confluent Caco-2 intestinal cells. Biochim. Biophys. Acta, 1474: 47-55.
    • (2000) Biochim. Biophys. Acta , vol.1474 , pp. 47-55
    • Bestwick, C.S.1    Milne, L.2
  • 2
    • 0002490743 scopus 로고    scopus 로고
    • The booming U.S. botanical market - A new overview
    • Brevoort, P. 1998. The booming U.S. botanical market - a new overview. Herbalgralm, 44: 33-46.
    • (1998) Herbalgralm , vol.44 , pp. 33-46
    • Brevoort, P.1
  • 3
    • 0033062107 scopus 로고    scopus 로고
    • The effect of mucin on bacterial translocation in I-407 fetal and Caco-2 adult enterocyte cultured cell lines
    • Gork, A.S., Usui, N., Ceriati, E., Drongowski, R.A., Epstein, M.D., Coran, A.G., and Harmon, C.M. 1999. The effect of mucin on bacterial translocation in I-407 fetal and Caco-2 adult enterocyte cultured cell lines. Pediatr. Surg. Int. 15: 155-159.
    • (1999) Pediatr. Surg. Int. , vol.15 , pp. 155-159
    • Gork, A.S.1    Usui, N.2    Ceriati, E.3    Drongowski, R.A.4    Epstein, M.D.5    Coran, A.G.6    Harmon, C.M.7
  • 4
    • 0028987246 scopus 로고
    • The regulation of leukotriene D4-induced calcium influx in human epithelial cells involves protein tyrosine phosphorylation
    • Gronroos, E., Schippert, A., Engstrom, M., and Sjolander, A. 1995. The regulation of leukotriene D4-induced calcium influx in human epithelial cells involves protein tyrosine phosphorylation. Cell Calcium, 17: 177-186.
    • (1995) Cell Calcium , vol.17 , pp. 177-186
    • Gronroos, E.1    Schippert, A.2    Engstrom, M.3    Sjolander, A.4
  • 5
    • 0032774704 scopus 로고    scopus 로고
    • Protopanaxatriol ginsenosides inhibit glucose uptake in primary cultured rabbit renal proximal tubular cells by arachidonic acid release
    • Han, H.J., Park, S.H., Koh, H.J., Nah, S.Y., Shin, D.H., and Choi, H.S. 1999. Protopanaxatriol ginsenosides inhibit glucose uptake in primary cultured rabbit renal proximal tubular cells by arachidonic acid release. Kidney Blood Press. Res. 22: 114-120.
    • (1999) Kidney Blood Press. Res. , vol.22 , pp. 114-120
    • Han, H.J.1    Park, S.H.2    Koh, H.J.3    Nah, S.Y.4    Shin, D.H.5    Choi, H.S.6
  • 6
    • 0030864673 scopus 로고    scopus 로고
    • Role of human intestinal Prevotella oris in hydrolyzing ginseng saponins
    • Hasegawa, H., Sung, J.H., and Benno, Y. 1997. Role of human intestinal Prevotella oris in hydrolyzing ginseng saponins. Planta Med. 63: 436-440.
    • (1997) Planta Med. , vol.63 , pp. 436-440
    • Hasegawa, H.1    Sung, J.H.2    Benno, Y.3
  • 7
    • 0002233236 scopus 로고
    • The establishment of strains of human cells in tissue culture
    • Henle, G., and Deinhardt, F. 1957. The establishment of strains of human cells in tissue culture. J. Immunol. 79: 54-59.
    • (1957) J. Immunol. , vol.79 , pp. 54-59
    • Henle, G.1    Deinhardt, F.2
  • 8
    • 0016724624 scopus 로고
    • A color reaction of panaxadiol with vanillin and sulfuric acid
    • Hiai, S., Oura, H., Hamanaka, H., and Odaka, Y. 1975. A color reaction of panaxadiol with vanillin and sulfuric acid. Planta Med. 28: 131-138.
    • (1975) Planta Med. , vol.28 , pp. 131-138
    • Hiai, S.1    Oura, H.2    Hamanaka, H.3    Odaka, Y.4
  • 9
    • 0035270718 scopus 로고    scopus 로고
    • Free radical scavenging capacity as related to antioxidant activity and ginsenoside composition of Asian and North American ginseng extracts
    • Hu, C., and Kitts, D.D. 2001. Free radical scavenging capacity as related to antioxidant activity and ginsenoside composition of Asian and North American ginseng extracts. J. Am. Oil Chem. Soc. 78: 249-255.
    • (2001) J. Am. Oil Chem. Soc. , vol.78 , pp. 249-255
    • Hu, C.1    Kitts, D.D.2
  • 11
    • 0034730527 scopus 로고    scopus 로고
    • Caspase 3-mediated cleavage of p21WAF1/CIP1 associated with the cyclin A-cyclin-dependent kinase 2 complex is a prerequisite for apoptosis in SK-HEP-1 cells
    • Jin, Y.H., Yoo, K.J., Lee, Y.H., and Lee, S.K. 2000. Caspase 3-mediated cleavage of p21WAF1/CIP1 associated with the cyclin A-cyclin-dependent kinase 2 complex is a prerequisite for apoptosis in SK-HEP-1 cells. J. Biol. Chem. 275: 30256-30 263.
    • (2000) J. Biol. Chem. , vol.275 , pp. 30256-30263
    • Jin, Y.H.1    Yoo, K.J.2    Lee, Y.H.3    Lee, S.K.4
  • 12
    • 0028914837 scopus 로고
    • Ginsenosides of the protopanaxatriol group cause endothelium-dependent relaxation in the rat aorta
    • Kang, S.Y., Schini-Kerth, V.B., and Kim, N.D. 1995. Ginsenosides of the protopanaxatriol group cause endothelium-dependent relaxation in the rat aorta. Life Sci. 56: 1577-1586.
    • (1995) Life Sci. , vol.56 , pp. 1577-1586
    • Kang, S.Y.1    Schini-Kerth, V.B.2    Kim, N.D.3
  • 13
    • 0030596179 scopus 로고    scopus 로고
    • Ginsenoside-Rh2 blocks the cell cycle of SK-HEP-1 cells at the G1/S boundary by selectively inducing the protein expression of p27kip1
    • Lee, K.Y., Park, J.A., Chung, E., Lee, Y.H., Kim, S.I., and Lee, S.K. 1996. Ginsenoside-Rh2 blocks the cell cycle of SK-HEP-1 cells at the G1/S boundary by selectively inducing the protein expression of p27kip1. Cancer Lett. 110: 193-200.
    • (1996) Cancer Lett. , vol.110 , pp. 193-200
    • Lee, K.Y.1    Park, J.A.2    Chung, E.3    Lee, Y.H.4    Kim, S.I.5    Lee, S.K.6
  • 14
    • 0034284840 scopus 로고    scopus 로고
    • Induction of apoptosis by a novel intestinal metabolite of ginseng saponin via cytochrome c-mediated activation of caspase-3 protease
    • Lee, S.J., Ko, W.G., Kim, J.H., Sung, J.H., Moon, C.K., and Lee, B.H. 2000. Induction of apoptosis by a novel intestinal metabolite of ginseng saponin via cytochrome c-mediated activation of caspase-3 protease. Biochem. Pharmacol. 60: 677-685.
    • (2000) Biochem. Pharmacol. , vol.60 , pp. 677-685
    • Lee, S.J.1    Ko, W.G.2    Kim, J.H.3    Sung, J.H.4    Moon, C.K.5    Lee, B.H.6
  • 15
    • 0000606533 scopus 로고    scopus 로고
    • Ginseno-sides in roots and leaves of American ginseng
    • Li, T.S.C., Mazza, G., Cottrell, A.C., and Gao, L. 1996. Ginseno-sides in roots and leaves of American ginseng. J. Agric. Food Chem. 44: 717-720.
    • (1996) J. Agric. Food Chem. , vol.44 , pp. 717-720
    • Li, T.S.C.1    Mazza, G.2    Cottrell, A.C.3    Gao, L.4
  • 16
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
    • Mosmann, T. 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65: 55-63.
    • (1983) J. Immunol. Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 17
    • 0001740590 scopus 로고
    • Use of flow ctometry for DNA analysis. Unit 5.7
    • Edited by J.E. Coligan, A.M. Kruisbeek, D.H. Margulies, E.M. Shevach, and W. Strober. John Wiley & Sons, Inc.
    • Noguch, P.D. 1991. Use of flow ctometry for DNA analysis. Unit 5.7. In Current protocols in immunology. Edited by J.E. Coligan, A.M. Kruisbeek, D.H. Margulies, E.M. Shevach, and W. Strober. John Wiley & Sons, Inc. 5.7.1-5.7.6.
    • (1991) Current Protocols in Immunology , pp. 571-576
    • Noguch, P.D.1
  • 18
    • 0033126998 scopus 로고    scopus 로고
    • Anti-proliferating effects of ginsenoside Rh2 on MCF-7 human breast cancer cells
    • Oh, M., Choi, Y.H., Choi, S., Chung, H., Kim, K., Kim, S.I., Kim, D.K., and Kim, N.D. 1999. Anti-proliferating effects of ginsenoside Rh2 on MCF-7 human breast cancer cells. Int. J. Oncol. 14: 869-875.
    • (1999) Int. J. Oncol. , vol.14 , pp. 869-875
    • Oh, M.1    Choi, Y.H.2    Choi, S.3    Chung, H.4    Kim, K.5    Kim, S.I.6    Kim, D.K.7    Kim, N.D.8
  • 19
    • 0026322969 scopus 로고
    • Mechanism of action of ginsenoside Rh2: Uptake and metabolism of ginsenoside Rh2 by cultured B16 melanoma cells
    • Ota, T., Maeda, M., and Odashima, S. 1991. Mechanism of action of ginsenoside Rh2: uptake and metabolism of ginsenoside Rh2 by cultured B16 melanoma cells. J. Pharm. Sci. 80: 1141-1146.
    • (1991) J. Pharm. Sci. , vol.80 , pp. 1141-1146
    • Ota, T.1    Maeda, M.2    Odashima, S.3
  • 20
    • 0036519174 scopus 로고    scopus 로고
    • Comparative study of cytotoxic and hemolytic effects of triterpenoids isolated from ginseng and sea cucumber
    • Popov, A.M. 2002. Comparative study of cytotoxic and hemolytic effects of triterpenoids isolated from ginseng and sea cucumber. Izv. Akad. Nauk. Ser. Biol 2: 155-164.
    • (2002) Izv. Akad. Nauk. Ser. Biol , vol.2 , pp. 155-164
    • Popov, A.M.1
  • 21
    • 0036403187 scopus 로고    scopus 로고
    • Structure-function relationship exists for ginsenosides in reducing cell proliferation and inducing apoptosis in the human leukemia (THP-1) cell line
    • Popovich, D.G., and Kitts, D.D. 2002. Structure-function relationship exists for ginsenosides in reducing cell proliferation and inducing apoptosis in the human leukemia (THP-1) cell line. Arch. Biochem. Biophys. 406: 1-8.
    • (2002) Arch. Biochem. Biophys. , vol.406 , pp. 1-8
    • Popovich, D.G.1    Kitts, D.D.2
  • 22
    • 0016379039 scopus 로고
    • Studies on the saponins of ginseng. I. Structures of ginsenoside - Ro, Rb1, Rb2, Rc and Rd
    • Sanada, S., Kondo, N., Shoji, J., Tanaka, O., and Shibata, S. 1974. Studies on the saponins of ginseng. I. Structures of ginsenoside - Ro, Rb1, Rb2, Rc and Rd. Chem. Pharm. Bull. 22: 421-428.
    • (1974) Chem. Pharm. Bull. , vol.22 , pp. 421-428
    • Sanada, S.1    Kondo, N.2    Shoji, J.3    Tanaka, O.4    Shibata, S.5
  • 23
    • 0029006713 scopus 로고
    • Effect of soybean saponins and gypsophilla saponin on growth and viability of colon carcinoma cells in culture
    • Sung M., Kendall, C., Koo, M., and Rao, A. 1995. Effect of soybean saponins and gypsophilla saponin on growth and viability of colon carcinoma cells in culture. Nutr. Cancer 23: 259-269.
    • (1995) Nutr. Cancer , vol.23 , pp. 259-269
    • Sung, M.1    Kendall, C.2    Koo, M.3    Rao, A.4
  • 25
    • 0031844243 scopus 로고    scopus 로고
    • Non-organ specific cancer prevention of ginseng: A prospective study in Korea
    • Yun, T.K., and Choi, S.Y. 1998. Non-organ specific cancer prevention of ginseng: a prospective study in Korea. Int. J. Epid. 27: 359-364.
    • (1998) Int. J. Epid. , vol.27 , pp. 359-364
    • Yun, T.K.1    Choi, S.Y.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.