메뉴 건너뛰기




Volumn 20, Issue 12, 2014, Pages 3223-3230

Trefoil factors in inflammatory bowel disease

Author keywords

Crohn's disease; Inflammation; Inflammatory bowel disease; Key words trefoil factors; Ulcerative colitis

Indexed keywords

COMPLEMENTARY DNA; EPIDERMAL GROWTH FACTOR RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTESTINAL TREFOIL FACTOR; MESSENGER RNA; MUCIN; TUMOR NECROSIS FACTOR ALPHA; BIOLOGICAL MARKER; PEPTIDE; TFF1 PROTEIN, HUMAN; TFF3 PROTEIN, HUMAN; TREFOIL FACTOR; TUMOR SUPPRESSOR PROTEIN;

EID: 84896942421     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v20.i12.3223     Document Type: Article
Times cited : (78)

References (76)
  • 1
    • 84884273778 scopus 로고    scopus 로고
    • Advances in infamma-tory bowel disease pathogenesis: Linking host genetics and the microbiome
    • [PMID: 24037875 DOI: 10.1136/gutjnl-2012-303954]
    • Knights D, Lassen KG, Xavier RJ. Advances in infamma-tory bowel disease pathogenesis: linking host genetics and the microbiome. Gut 2013; 62: 1505-1510 [PMID: 24037875 DOI: 10.1136/gutjnl-2012-303954]
    • (2013) Gut , vol.62 , pp. 1505-1510
    • Knights, D.1    Lassen, K.G.2    Xavier, R.J.3
  • 2
    • 0041837509 scopus 로고    scopus 로고
    • Trefoil factors: Initiators of mu-cosal healing
    • [PMID: 14506475 DOI: 10.1038/nrm1203]
    • Taupin D, Podolsky DK. Trefoil factors: initiators of mu-cosal healing. Nat Rev Mol Cell Biol 2003; 4: 721-732 [PMID: 14506475 DOI: 10.1038/nrm1203]
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 721-732
    • Taupin, D.1    Podolsky, D.K.2
  • 3
    • 0034018106 scopus 로고    scopus 로고
    • Mechanisms of regulatory peptide action in the gastrointestinal tract: Trefoil peptides
    • [PMID: 10779222]
    • Podolsky DK. Mechanisms of regulatory peptide action in the gastrointestinal tract: trefoil peptides. J Gastroenterol 2000; 35 Suppl 12: 69-74 [PMID: 10779222]
    • (2000) J Gastroenterol , vol.35 , Issue.SUPPL. 12 , pp. 69-74
    • Podolsky, D.K.1
  • 4
    • 67349192195 scopus 로고    scopus 로고
    • The trefoil factor family - small peptides with multiple functionalities
    • [PMID: 19099184 DOI: 10.1007/s00018-008-8646-5]
    • Kjellev S. The trefoil factor family - small peptides with multiple functionalities. Cell Mol Life Sci 2009; 66: 1350-1369 [PMID: 19099184 DOI: 10.1007/s00018-008-8646-5]
    • (2009) Cell Mol Life Sci , vol.66 , pp. 1350-1369
    • Kjellev, S.1
  • 5
    • 0024349761 scopus 로고
    • A new family of growth factor-like peptides. 'Trefoil' disulphide loop structures as a common feature in breast cancer associated peptide (pS2), pancreatic spasmolytic polypeptide (PSP), and frog skin peptides (spas-molysins)
    • [PMID: 2737304 DOI: 10.1016/0014-5793(89)80690-8]
    • Thim L. A new family of growth factor-like peptides. 'Trefoil' disulphide loop structures as a common feature in breast cancer associated peptide (pS2), pancreatic spasmolytic polypeptide (PSP), and frog skin peptides (spas-molysins). FEBS Lett 1989; 250: 85-90 [PMID: 2737304 DOI: 10.1016/0014-5793(89)80690-8]
    • (1989) FEBS Lett , vol.250 , pp. 85-90
    • Thim, L.1
  • 6
    • 0028938208 scopus 로고
    • Characterization of human and rat intestinal trefoil factor produced in yeast
    • [PMID: 7718582 DOI: 10.1021/ bi00014a033]
    • Thim L, Wöldike HF, Nielsen PF, Christensen M, Lynch-Devaney K, Podolsky DK. Characterization of human and rat intestinal trefoil factor produced in yeast. Biochemistry 1995; 34: 4757-4764 [PMID: 7718582 DOI: 10.1021/ bi00014a033]
    • (1995) Biochemistry , vol.34 , pp. 4757-4764
    • Thim, L.1    Wöldike, H.F.2    Nielsen, P.F.3    Christensen, M.4    Lynch-Devaney, K.5    Podolsky, D.K.6
  • 7
    • 0020085354 scopus 로고
    • Pancreatic spasmolytic polypeptide (PSP): I. Preparation and initial chemical characterization of a new polypeptide from porcine pancreas
    • [PMID: 6896240 DOI: 10.1016/0167-0115(82)90126-4]
    • Jørgensen KH, Thim L, Jacobsen HE. Pancreatic spasmolytic polypeptide (PSP): I. Preparation and initial chemical characterization of a new polypeptide from porcine pancreas. Regul Pept 1982; 3: 207-219 [PMID: 6896240 DOI: 10.1016/0167-0115(82)90126-4]
    • (1982) Regul Pept , vol.3 , pp. 207-219
    • Jørgensen, K.H.1    Thim, L.2    Jacobsen, H.E.3
  • 8
    • 0025164761 scopus 로고
    • Hsp, the domain-duplicated homolog of pS2 protein, is co-expressed with pS2 in stomach but not in breast carcinoma
    • [PMID: 2303034]
    • Tomasetto C, Rio MC, Gautier C, Wolf C, Hareuveni M, Chambon P, Lathe R. hSP, the domain-duplicated homolog of pS2 protein, is co-expressed with pS2 in stomach but not in breast carcinoma. EMBO J 1990; 9: 407-414 [PMID: 2303034]
    • (1990) EMBO J , vol.9 , pp. 407-414
    • Tomasetto, C.1    Rio, M.C.2    Gautier, C.3    Wolf, C.4    Hareuveni, M.5    Chambon, P.6    Lathe, R.7
  • 9
    • 0027228534 scopus 로고
    • Spasmolytic polypeptide is a major antral peptide: Distribution of the trefoil peptides human spasmolytic poly-peptide and pS2 in the stomach
    • [PMID: 8405856]
    • Hanby AM, Poulsom R, Singh S, Elia G, Jeffery RE, Wright NA. Spasmolytic polypeptide is a major antral peptide: distribution of the trefoil peptides human spasmolytic poly-peptide and pS2 in the stomach. Gastroenterology 1993; 105: 1110-1116 [PMID: 8405856]
    • (1993) Gastroenterology , vol.105 , pp. 1110-1116
    • Hanby, A.M.1    Poulsom, R.2    Singh, S.3    Elia, G.4    Jeffery, R.E.5    Wright, N.A.6
  • 10
    • 0020488029 scopus 로고
    • Cloning of cDNA sequences of hormone-regulated genes from the MCF-7 human breast cancer cell line
    • [PMID: 6897676 DOI: 10.1093/nar/10.24.7895]
    • Masiakowski P, Breathnach R, Bloch J, Gannon F, Krust A, Chambon P. Cloning of cDNA sequences of hormone-regulated genes from the MCF-7 human breast cancer cell line. Nucleic Acids Res 1982; 10: 7895-7903 [PMID: 6897676 DOI: 10.1093/nar/10.24.7895]
    • (1982) Nucleic Acids Res , vol.10 , pp. 7895-7903
    • Masiakowski, P.1    Breathnach, R.2    Bloch, J.3    Gannon, F.4    Krust, A.5    Chambon, P.6
  • 11
    • 0023769895 scopus 로고
    • Breast cancer-associated pS2 protein: Synthesis and secretion by normal stomach mucosa
    • [PMID: 3041593 DOI: 10.1126/science.3041593]
    • Rio MC, Bellocq JP, Daniel JY, Tomasetto C, Lathe R, Che-nard MP, Batzenschlager A, Chambon P. Breast cancer-associated pS2 protein: synthesis and secretion by normal stomach mucosa. Science 1988; 241: 705-708 [PMID: 3041593 DOI: 10.1126/science.3041593]
    • (1988) Science , vol.241 , pp. 705-708
    • Rio, M.C.1    Bellocq, J.P.2    Daniel, J.Y.3    Tomasetto, C.4    Lathe, R.5    Che-Nard, M.P.6    Batzenschlager, A.7    Chambon, P.8
  • 12
    • 0026356437 scopus 로고
    • Identifcation and characterization of rat intestinal trefoil factor: Tissue-and cell-specifc member of the trefoil protein family
    • [PMID: 1763017 DOI: 10.1073/pnas.88.24.11017]
    • Suemori S, Lynch-Devaney K, Podolsky DK. Identifcation and characterization of rat intestinal trefoil factor: tissue-and cell-specifc member of the trefoil protein family. Proc Natl Acad Sci USA 1991; 88: 11017-11021 [PMID: 1763017 DOI: 10.1073/pnas.88.24.11017]
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 11017-11021
    • Suemori, S.1    Lynch-Devaney, K.2    Podolsky, D.K.3
  • 13
    • 0027275826 scopus 로고
    • Hp1.B, a human P-domain peptide homologous with rat intestinal trefoil factor, is expressed also in the ulcer-associated cell lineage and the uterus
    • [PMID: 8346203 DOI: 10.1073/pnas.90.15.6961]
    • Hauser F, Poulsom R, Chinery R, Rogers LA, Hanby AM, Wright NA, Hoffmann W. hP1.B, a human P-domain peptide homologous with rat intestinal trefoil factor, is expressed also in the ulcer-associated cell lineage and the uterus. Proc Natl Acad Sci USA 1993; 90: 6961-6965 [PMID: 8346203 DOI: 10.1073/pnas.90.15.6961]
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 6961-6965
    • Hauser, F.1    Poulsom, R.2    Chinery, R.3    Rogers, L.A.4    Hanby, A.M.5    Wright, N.A.6    Hoffmann, W.7
  • 14
    • 0027415669 scopus 로고
    • Identifcation of human intestinal trefoil factor. Goblet cell-specifc expres sion of a peptide targeted for apical secretion
    • [PMID: 8454642]
    • Podolsky DK, Lynch-Devaney K, Stow JL, Oates P, Murgue B, DeBeaumont M, Sands BE, Mahida YR. Identifcation of human intestinal trefoil factor. Goblet cell-specifc expres sion of a peptide targeted for apical secretion. J Biol Chem 1993; 268: 6694-6702 [PMID: 8454642]
    • (1993) J Biol Chem , vol.268 , pp. 6694-6702
    • Podolsky, D.K.1    Lynch-Devaney, K.2    Stow, J.L.3    Oates, P.4    Murgue, B.5    Debeaumont, M.6    Sands, B.E.7    Mahida, Y.R.8
  • 15
    • 34247637616 scopus 로고    scopus 로고
    • Tissue localization of human trefoil factors 1, 2, and 3
    • [PMID: 17242463 DOI: 10.1369/ jhc.6A7100.2007]
    • Madsen J, Nielsen O, Tornøe I, Thim L, Holmskov U. Tissue localization of human trefoil factors 1, 2, and 3. J Histochem Cytochem 2007; 55: 505-513 [PMID: 17242463 DOI: 10.1369/ jhc.6A7100.2007]
    • (2007) J Histochem Cytochem , vol.55 , pp. 505-513
    • Madsen, J.1    Nielsen, O.2    Tornøe, I.3    Thim, L.4    Holmskov, U.5
  • 16
    • 13144266741 scopus 로고    scopus 로고
    • Intestinal trefoil factor controls the expression of the adeno-matous polyposis coli-catenin and the E-cadherin-catenin complexes in human colon carcinoma cells
    • [PMID: 9501226 DOI: 10.1073/ pnas.95.6.3122]
    • Efstathiou JA, Noda M, Rowan A, Dixon C, Chinery R, Jawhari A, Hattori T, Wright NA, Bodmer WF, Pignatelli M. Intestinal trefoil factor controls the expression of the adeno-matous polyposis coli-catenin and the E-cadherin-catenin complexes in human colon carcinoma cells. Proc Natl Acad Sci USA 1998; 95: 3122-3127 [PMID: 9501226 DOI: 10.1073/ pnas.95.6.3122]
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 3122-3127
    • Efstathiou, J.A.1    Noda, M.2    Rowan, A.3    Dixon, C.4    Chinery, R.5    Jawhari, A.6    Hattori, T.7    Wright, N.A.8    Bodmer, W.F.9    Pignatelli, M.10
  • 17
    • 0034681162 scopus 로고    scopus 로고
    • Intestinal trefoil factor confers colonic epithelial resistance to apoptosis
    • [PMID: 10639160 DOI: 10.1073/pnas.97.2.799]
    • Taupin DR, Kinoshita K, Podolsky DK. Intestinal trefoil factor confers colonic epithelial resistance to apoptosis. Proc Natl Acad Sci USA 2000; 97: 799-804 [PMID: 10639160 DOI: 10.1073/pnas.97.2.799]
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 799-804
    • Taupin, D.R.1    Kinoshita, K.2    Podolsky, D.K.3
  • 18
    • 0034042831 scopus 로고    scopus 로고
    • Distinct pathways of cell migration and antiapoptotic response to epithelial injury: Structure-function analysis of human intestinal trefoil factor
    • [PMID: 10848594 DOI: 10.1128/MCB.20.13.4680-4690.2000]
    • Kinoshita K, Taupin DR, Itoh H, Podolsky DK. Distinct pathways of cell migration and antiapoptotic response to epithelial injury: structure-function analysis of human intestinal trefoil factor. Mol Cell Biol 2000; 20: 4680-4690 [PMID: 10848594 DOI: 10.1128/MCB.20.13.4680-4690.2000]
    • (2000) Mol Cell Biol , vol.20 , pp. 4680-4690
    • Kinoshita, K.1    Taupin, D.R.2    Itoh, H.3    Podolsky, D.K.4
  • 19
    • 0037182584 scopus 로고    scopus 로고
    • The trefoil fac tor 1 participates in gastrointestinal cell differentiation by delaying G1-S phase transition and reducing apoptosis
    • [PMID: 12034770 DOI: 10.1083/ jcb200108056]
    • Bossenmeyer-Pourié C, Kannan R, Ribieras S, Wendling C, Stoll I, Thim L, Tomasetto C, Rio MC. The trefoil fac tor 1 participates in gastrointestinal cell differentiation by delaying G1-S phase transition and reducing apoptosis. J Cell Biol 2002; 157: 761-770 [PMID: 12034770 DOI: 10.1083/ jcb200108056]
    • (2002) J Cell Biol , vol.157 , pp. 761-770
    • Bossenmeyer-Pourié, C.1    Kannan, R.2    Ribieras, S.3    Wendling, C.4    Stoll, I.5    Thim, L.6    Tomasetto, C.7    Rio, M.C.8
  • 20
    • 0034637076 scopus 로고    scopus 로고
    • Transcription factor NF-kappaB signals antianoikic function of trefoil factor 3 on intestinal epithelial cells
    • PMID: 10924320 DOI: 10.1006/ bbrc.2000.3176]
    • Chen YH, Lu Y, De Plaen IG, Wang LY, Tan XD. Transcription factor NF-kappaB signals antianoikic function of trefoil factor 3 on intestinal epithelial cells. Biochem Biophys Res Commun 2000; 274: 576-582 [PMID: 10924320 DOI: 10.1006/ bbrc.2000.3176]
    • (2000) Biochem Biophys Res Commun , vol.274 , pp. 576-582
    • Chen, Y.H.1    Lu, Y.2    de Plaen, I.G.3    Wang, L.Y.4    Tan, X.D.5
  • 21
    • 0028972499 scopus 로고
    • Infammatory bowel disease and adenomas in mice expressing a dominant negative N-cad-herin
    • [PMID: 7502046 DOI: 10.1126/science.270.5239.1203]
    • Hermiston ML, Gordon JI. Infammatory bowel disease and adenomas in mice expressing a dominant negative N-cad-herin. Science 1995; 270: 1203-1207 [PMID: 7502046 DOI: 10.1126/science.270.5239.1203]
    • (1995) Science , vol.270 , pp. 1203-1207
    • Hermiston, M.L.1    Gordon, J.I.2
  • 22
    • 84859430262 scopus 로고    scopus 로고
    • Protective effect of intestinal trefoil factor on injury of intestinal epithelial tight junction induced by platelet activating factor
    • [PMID: 21452036 DOI: 10.1007/s10753-011-9320-x]
    • Xu LF, Teng X, Guo J, Sun M. Protective effect of intestinal trefoil factor on injury of intestinal epithelial tight junction induced by platelet activating factor. Infammation 2012; 35: 308-315 [PMID: 21452036 DOI: 10.1007/s10753-011-9320-x]
    • (2012) Infammation , vol.35 , pp. 308-315
    • Xu, L.F.1    Teng, X.2    Guo, J.3    Sun, M.4
  • 23
    • 33750933837 scopus 로고    scopus 로고
    • TFF3-peptide increases transepithelial resistance in epithelial cells by modulating claudin-1 and -2 expression
    • [PMID: 17018241]
    • Meyer zum Büschenfelde D, Tauber R, Huber O. TFF3-peptide increases transepithelial resistance in epithelial cells by modulating claudin-1 and -2 expression. Peptides 2006; 27: 3383-3390 [PMID: 17018241]
    • (2006) Peptides , vol.27 , pp. 3383-3390
    • Meyer zum Büschenfelde, D.1    Tauber, R.2    Huber, O.3
  • 25
    • 0030786887 scopus 로고    scopus 로고
    • Lessons from genetic models of infamma-tory bowel disease
    • [PMID: 9260328]
    • Podolsky DK. Lessons from genetic models of infamma-tory bowel disease. Acta Gastroenterol Belg 1997; 60: 163-165 [PMID: 9260328]
    • (1997) Acta Gastroenterol Belg , vol.60 , pp. 163-165
    • Podolsky, D.K.1
  • 26
    • 0028265506 scopus 로고
    • Thickness of adherent mucus gel on colonic mucosa in humans and its relevance to colitis
    • [PMID: 8150346 DOI: 10.1136/gut.35.3.353]
    • Pullan RD, Thomas GA, Rhodes M, Newcombe RG, Williams GT, Allen A, Rhodes J. Thickness of adherent mucus gel on colonic mucosa in humans and its relevance to colitis. Gut 1994; 35: 353-359 [PMID: 8150346 DOI: 10.1136/gut.35.3.353]
    • (1994) Gut , vol.35 , pp. 353-359
    • Pullan, R.D.1    Thomas, G.A.2    Rhodes, M.3    Newcombe, R.G.4    Williams, G.T.5    Allen, A.6    Rhodes, J.7
  • 27
    • 0029964294 scopus 로고    scopus 로고
    • MUC2 is the prominent colonic mucin expressed in ul-cerative colitis
    • [PMID: 8707087 DOI: 10.1136/gut.38.4.554]
    • Tytgat KM, Opdam FJ, Einerhand AW, Büller HA, Dekker J. MUC2 is the prominent colonic mucin expressed in ul-cerative colitis. Gut 1996; 38: 554-563 [PMID: 8707087 DOI: 10.1136/gut.38.4.554]
    • (1996) Gut , vol.38 , pp. 554-563
    • Tytgat, K.M.1    Opdam, F.J.2    Einerhand, A.W.3    Büller, H.A.4    Dekker, J.5
  • 28
    • 0029133784 scopus 로고
    • Trefoil peptide protection of intestinal epithelial barrier function: Cooperative interaction with mucin glyco-protein
    • [PMID: 7615201 DOI: 10.1016/0016-5085(95)90340-2]
    • Kindon H, Pothoulakis C, Thim L, Lynch-Devaney K, Po-dolsky DK. Trefoil peptide protection of intestinal epithelial barrier function: cooperative interaction with mucin glyco-protein. Gastroenterology 1995; 109: 516-523 [PMID: 7615201 DOI: 10.1016/0016-5085(95)90340-2]
    • (1995) Gastroenterology , vol.109 , pp. 516-523
    • Kindon, H.1    Pothoulakis, C.2    Thim, L.3    Lynch-Devaney, K.4    Po-Dolsky, D.K.5
  • 29
    • 0033674228 scopus 로고    scopus 로고
    • Coordinated localisation of mucins and trefoil peptides in the ulcer associated cell lineage and the gastrointestinal mucosa
    • [PMID: 11076877 DOI: 10.1136/gut.47.6.792]
    • Longman RJ, Douthwaite J, Sylvester PA, Poulsom R, Cor-field AP, Thomas MG, Wright NA. Coordinated localisation of mucins and trefoil peptides in the ulcer associated cell lineage and the gastrointestinal mucosa. Gut 2000; 47: 792-800 [PMID: 11076877 DOI: 10.1136/gut.47.6.792]
    • (2000) Gut , vol.47 , pp. 792-800
    • Longman, R.J.1    Douthwaite, J.2    Sylvester, P.A.3    Poulsom, R.4    Cor-Field, A.P.5    Thomas, M.G.6    Wright, N.A.7
  • 30
    • 0030762994 scopus 로고    scopus 로고
    • Human spasmolytic polypeptide decreases proton permeation through gastric mucus in vivo and in vitro
    • [PMID: 9227484]
    • Tanaka S, Podolsky DK, Engel E, Guth PH, Kaunitz JD. Human spasmolytic polypeptide decreases proton permeation through gastric mucus in vivo and in vitro. Am J Physiol 1997; 272: G1473-G1480 [PMID: 9227484]
    • (1997) Am J Physiol , vol.272
    • Tanaka, S.1    Podolsky, D.K.2    Engel, E.3    Guth, P.H.4    Kaunitz, J.D.5
  • 31
    • 0036997957 scopus 로고    scopus 로고
    • Effect of trefoil factors on the viscoelastic properties of mucus gels
    • [PMID: 12153553 DOI: 10.1046/j.1365-2362.2002.01014. x]
    • Thim L, Madsen F, Poulsen SS. Effect of trefoil factors on the viscoelastic properties of mucus gels. Eur J Clin Invest 2002; 32: 519-527 [PMID: 12153553 DOI: 10.1046/j.1365-2362.2002.01014. x]
    • (2002) Eur J Clin Invest , vol.32 , pp. 519-527
    • Thim, L.1    Madsen, F.2    Poulsen, S.S.3
  • 32
    • 0033970973 scopus 로고    scopus 로고
    • Ps2/TFF1 interacts directly with the VWFC cysteine-rich domains of mucins
    • [PMID: 10611155 DOI: 10.1016/S0016-5085(00)70415-X]
    • Tomasetto C, Masson R, Linares JL, Wendling C, Lefebvre O, Chenard MP, Rio MC. pS2/TFF1 interacts directly with the VWFC cysteine-rich domains of mucins. Gastroenterol-ogy 2000; 118: 70-80 [PMID: 10611155 DOI: 10.1016/S0016-5085(00)70415-X]
    • (2000) Gastroenterol-ogy , vol.118 , pp. 70-80
    • Tomasetto, C.1    Masson, R.2    Linares, J.L.3    Wendling, C.4    Lefebvre, O.5    Chenard, M.P.6    Rio, M.C.7
  • 33
    • 77954611767 scopus 로고    scopus 로고
    • Human intestinal TFF3 forms disulfide-linked heteromers with the mucus-associated FCGBP protein and is released by hydrogen sulfde
    • [PMID: 20423149 DOI: 10.1021/ pr100020c]
    • Albert TK, Laubinger W, Müller S, Hanisch FG, Kalinski T, Meyer F, Hoffmann W. Human intestinal TFF3 forms disulfide-linked heteromers with the mucus-associated FCGBP protein and is released by hydrogen sulfde. J Pro-teome Res 2010; 9: 3108-3117 [PMID: 20423149 DOI: 10.1021/ pr100020c]
    • (2010) J Pro-teome Res , vol.9 , pp. 3108-3117
    • Albert, T.K.1    Laubinger, W.2    Müller, S.3    Hanisch, F.G.4    Kalinski, T.5    Meyer, F.6    Hoffmann, W.7
  • 34
    • 0028360991 scopus 로고
    • Trefoil peptides promote epithelial migration through a transforming growth factor beta-independent pathway
    • [PMID: 8040278 DOI: 10.1172/ JCI117332]
    • Dignass A, Lynch-Devaney K, Kindon H, Thim L, Podolsky DK. Trefoil peptides promote epithelial migration through a transforming growth factor beta-independent pathway. J Clin Invest 1994; 94: 376-383 [PMID: 8040278 DOI: 10.1172/ JCI117332]
    • (1994) J Clin Invest , vol.94 , pp. 376-383
    • Dignass, A.1    Lynch-Devaney, K.2    Kindon, H.3    Thim, L.4    Podolsky, D.K.5
  • 35
    • 0033559755 scopus 로고    scopus 로고
    • Intestinal trefoil factor binds to intestinal epithelial cells and induces nitric oxide production: Priming and enhancing effects of mucin
    • [PMID: 10051448 DOI: 10.1042/0264-6021:3380745]
    • Tan XD, Liu QP, Hsueh W, Chen YH, Chang H, Gonzalez-Crussi F. Intestinal trefoil factor binds to intestinal epithelial cells and induces nitric oxide production: priming and enhancing effects of mucin. Biochem J 1999; 338 (Pt 3): 745-751 [PMID: 10051448 DOI: 10.1042/0264-6021:3380745]
    • (1999) Biochem J , vol.338 , Issue.PART 3 , pp. 745-751
    • Tan, X.D.1    Liu, Q.P.2    Hsueh, W.3    Chen, Y.H.4    Chang, H.5    Gonzalez-Crussi, F.6
  • 36
    • 0029740658 scopus 로고    scopus 로고
    • Nawa Y. cDNA cloning of rat pS2 peptide and expression of trefoil peptides in acetic acid-induced colitis
    • [PMID: 8836141]
    • Itoh H, Tomita M, Uchino H, Kobayashi T, Kataoka H, Seki-ya R, Nawa Y. cDNA cloning of rat pS2 peptide and expression of trefoil peptides in acetic acid-induced colitis. Biochem J 1996; 318 (Pt 3): 939-944 [PMID: 8836141]
    • (1996) Biochem J , vol.318 , Issue.PART 3 , pp. 939-944
    • Itoh, H.1    Tomita, M.2    Uchino, H.3    Kobayashi, T.4    Kataoka, H.5    Seki-Ya, R.6
  • 37
    • 0029828745 scopus 로고    scopus 로고
    • Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor
    • [PMID: 8824194 DOI: 10.1126/science.274.5285.262]
    • Mashimo H, Wu DC, Podolsky DK, Fishman MC. Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor. Science 1996; 274: 262-265 [PMID: 8824194 DOI: 10.1126/science.274.5285.262]
    • (1996) Science , vol.274 , pp. 262-265
    • Mashimo, H.1    Wu, D.C.2    Podolsky, D.K.3    Fishman, M.C.4
  • 38
    • 1542287384 scopus 로고    scopus 로고
    • Chemotherapy- and radiotherapy-induced intestinal damage is regulated by intestinal trefoil factor
    • [PMID: 14988834 DOI: 10.1053/j.gastro.2003.12.004]
    • Beck PL, Wong JF, Li Y, Swaminathan S, Xavier RJ, Dev-aney KL, Podolsky DK. Chemotherapy- and radiotherapy-induced intestinal damage is regulated by intestinal trefoil factor. Gastroenterology 2004; 126: 796-808 [PMID: 14988834 DOI: 10.1053/j.gastro.2003.12.004]
    • (2004) Gastroenterology , vol.126 , pp. 796-808
    • Beck, P.L.1    Wong, J.F.2    Li, Y.3    Swaminathan, S.4    Xavier, R.J.5    Dev-Aney, K.L.6    Podolsky, D.K.7
  • 39
    • 0028894436 scopus 로고
    • Human spasmolytic polypeptide is a cytoprotective agent that stimulates cell migration
    • [PMID: 7806031 DOI: 10.1016/0016-5085(95)90014-4]
    • Playford RJ, Marchbank T, Chinery R, Evison R, Pignatelli M, Boulton RA, Thim L, Hanby AM. Human spasmolytic polypeptide is a cytoprotective agent that stimulates cell migration. Gastroenterology 1995; 108: 108-116 [PMID: 7806031 DOI: 10.1016/0016-5085(95)90014-4]
    • (1995) Gastroenterology , vol.108 , pp. 108-116
    • Playford, R.J.1    Marchbank, T.2    Chinery, R.3    Evison, R.4    Pignatelli, M.5    Boulton, R.A.6    Thim, L.7    Hanby, A.M.8
  • 40
    • 0030749999 scopus 로고    scopus 로고
    • Pancreatic spasmolytic polypeptide protects the gastric mucosa but does not inhibit acid secretion or mo-tility
    • [PMID: 9252516]
    • McKenzie C, Marchbank T, Playford RJ, Otto W, Thim L, Parsons ME. Pancreatic spasmolytic polypeptide protects the gastric mucosa but does not inhibit acid secretion or mo-tility. Am J Physiol 1997; 273: G112-G117 [PMID: 9252516]
    • (1997) Am J Physiol , vol.273
    • McKenzie, C.1    Marchbank, T.2    Playford, R.J.3    Otto, W.4    Thim, L.5    Parsons, M.E.6
  • 41
    • 0032880997 scopus 로고    scopus 로고
    • Metabolism of oral trefoil factor 2 (TFF2) and the effect of oral and parenteral TFF2 on gastric and duodenal ulcer healing in the rat
    • [PMID: 10486358 DOI:10.1136/gut.45.4.516]
    • Poulsen SS, Thulesen J, Christensen L, Nexo E, Thim L. Metabolism of oral trefoil factor 2 (TFF2) and the effect of oral and parenteral TFF2 on gastric and duodenal ulcer healing in the rat. Gut 1999; 45: 516-522 [PMID: 10486358 DOI:10.1136/gut.45.4.516]
    • (1999) Gut , vol.45 , pp. 516-522
    • Poulsen, S.S.1    Thulesen, J.2    Christensen, L.3    Nexo, E.4    Thim, L.5
  • 42
    • 0031978156 scopus 로고    scopus 로고
    • Oral human spasmolytic polypeptide protects against aspirin-induced gastric injury in rats
    • [PMID: 9641298]
    • Cook GA, Thim L, Yeomans ND, Giraud AS. Oral human spasmolytic polypeptide protects against aspirin-induced gastric injury in rats. J Gastroenterol Hepatol 1998; 13: 363-370 [PMID: 9641298]
    • (1998) J Gastroenterol Hepatol , vol.13 , pp. 363-370
    • Cook, G.A.1    Thim, L.2    Yeomans, N.D.3    Giraud, A.S.4
  • 43
    • 0030044720 scopus 로고    scopus 로고
    • Oral trefoil peptides protect against ethanol- and indometh-acin-induced gastric injury in rats
    • [PMID: 8566596 DOI: 10.1053/gast.1996.v110. pm8566596]
    • Babyatsky MW, deBeaumont M, Thim L, Podolsky DK. Oral trefoil peptides protect against ethanol- and indometh-acin-induced gastric injury in rats. Gastroenterology 1996; 110: 489-497 [PMID: 8566596 DOI: 10.1053/gast.1996.v110. pm8566596]
    • (1996) Gastroenterology , vol.110 , pp. 489-497
    • Babyatsky, M.W.1    Debeaumont, M.2    Thim, L.3    Podolsky, D.K.4
  • 44
    • 10744225525 scopus 로고    scopus 로고
    • Trefoil peptide TFF2 treatment reduces VCAM-1 expression and leukocyte recruitment in experimental intestinal infam-mation
    • [PMID: 14597729 DOI: 10.1189/jlb.0803396]
    • Soriano-Izquierdo A, Gironella M, Massaguer A, May FE, Salas A, Sans M, Poulsom R, Thim L, Piqué JM, Panés J. Trefoil peptide TFF2 treatment reduces VCAM-1 expression and leukocyte recruitment in experimental intestinal infam-mation. J Leukoc Biol 2004; 75: 214-223 [PMID: 14597729 DOI: 10.1189/jlb.0803396]
    • (2004) J Leukoc Biol , vol.75 , pp. 214-223
    • Soriano-Izquierdo, A.1    Gironella, M.2    Massaguer, A.3    May, F.E.4    Salas, A.5    Sans, M.6    Poulsom, R.7    Thim, L.8    Piqué, J.M.9    Panés, J.10
  • 45
    • 33947573860 scopus 로고    scopus 로고
    • Cellular localization, binding sites, and pharmacologic effects of TFF3 in experimental colitis in mice
    • [PMID: 17342398 DOI: 10.1007/s10620-006-9256-4]
    • Kjellev S, Thim L, Pyke C, Poulsen SS. Cellular localization, binding sites, and pharmacologic effects of TFF3 in experimental colitis in mice. Dig Dis Sci 2007; 52: 1050-1059 [PMID: 17342398 DOI: 10.1007/s10620-006-9256-4]
    • (2007) Dig Dis Sci , vol.52 , pp. 1050-1059
    • Kjellev, S.1    Thim, L.2    Pyke, C.3    Poulsen, S.S.4
  • 46
    • 2642588848 scopus 로고    scopus 로고
    • Syner-gistic effects of systemic trefoil factor family 1 (TFF1) pep-tide and epidermal growth factor in a rat model of colitis
    • [PMID: 15177874 DOI: 10.1016/ j.peptides.2003.12.022]
    • FitzGerald AJ, Pu M, Marchbank T, Westley BR, May FE, Boyle J, Yadollahi-Farsani M, Ghosh S, Playford RJ. Syner-gistic effects of systemic trefoil factor family 1 (TFF1) pep-tide and epidermal growth factor in a rat model of colitis. Peptides 2004; 25: 793-801 [PMID: 15177874 DOI: 10.1016/ j.peptides.2003.12.022]
    • (2004) Peptides , vol.25 , pp. 793-801
    • Fitzgerald, A.J.1    Pu, M.2    Marchbank, T.3    Westley, B.R.4    May, F.E.5    Boyle, J.6    Yadollahi-Farsani, M.7    Ghosh, S.8    Playford, R.J.9
  • 47
    • 12344318513 scopus 로고    scopus 로고
    • Luminal and parenteral TFF2 and TFF3 dimer and monomer in two models of experimental colitis in the rat
    • [PMID: 15664663 DOI: 10.1016/ j.regpep.2004.09.007]
    • Poulsen SS, Kissow H, Hare K, Hartmann B, Thim L. Luminal and parenteral TFF2 and TFF3 dimer and monomer in two models of experimental colitis in the rat. Regul Pept 2005; 126: 163-171 [PMID: 15664663 DOI: 10.1016/ j.regpep.2004.09.007]
    • (2005) Regul Pept , vol.126 , pp. 163-171
    • Poulsen, S.S.1    Kissow, H.2    Hare, K.3    Hartmann, B.4    Thim, L.5
  • 48
    • 0031813248 scopus 로고    scopus 로고
    • Dimerization of human pS2 (TFF1) plays a key role in its protective/healing effects
    • [PMID: 9713341]
    • Marchbank T, Westley BR, May FE, Calnan DP, Playford RJ. Dimerization of human pS2 (TFF1) plays a key role in its protective/healing effects. J Pathol 1998; 185: 153-158 [PMID: 9713341]
    • (1998) J Pathol , vol.185 , pp. 153-158
    • Marchbank, T.1    Westley, B.R.2    May, F.E.3    Calnan, D.P.4    Playford, R.J.5
  • 49
    • 0002934088 scopus 로고    scopus 로고
    • Trefoil peptide TFF2 (spasmolytic polypeptide) potently accelerates healing and reduces infammation in a rat model of colitis
    • [PMID: 10205199 DOI: 10.1136/ gut.44.5.636]
    • Tran CP, Cook GA, Yeomans ND, Thim L, Giraud AS. Trefoil peptide TFF2 (spasmolytic polypeptide) potently accelerates healing and reduces infammation in a rat model of colitis. Gut 1999; 44: 636-642 [PMID: 10205199 DOI: 10.1136/ gut.44.5.636]
    • (1999) Gut , vol.44 , pp. 636-642
    • Tran, C.P.1    Cook, G.A.2    Yeomans, N.D.3    Thim, L.4    Giraud, A.S.5
  • 50
    • 2642540736 scopus 로고    scopus 로고
    • TFF-2 inhibits iNOS/NO in monocytes, and nitrated protein in healing colon after colitis
    • [PMID: 15177875 DOI: 10.1016/j.peptides.2004.01.019]
    • Giraud AS, Pereira PM, Thim L, Parker LM, Judd LM. TFF-2 inhibits iNOS/NO in monocytes, and nitrated protein in healing colon after colitis. Peptides 2004; 25: 803-809 [PMID: 15177875 DOI: 10.1016/j.peptides.2004.01.019]
    • (2004) Peptides , vol.25 , pp. 803-809
    • Giraud, A.S.1    Pereira, P.M.2    Thim, L.3    Parker, L.M.4    Judd, L.M.5
  • 51
    • 0028934298 scopus 로고
    • Combined intestinal trefoil factor and epidermal growth factor is prophylactic against indo-methacin-induced gastric damage in the rat
    • [PMID: 7789040
    • Chinery R, Playford RJ. Combined intestinal trefoil factor and epidermal growth factor is prophylactic against indo-methacin-induced gastric damage in the rat. Clin Sci (Lond) 1995; 88: 401-403 [PMID: 7789040]
    • (1995) Clin Sci (Lond) , vol.88 , pp. 401-403
    • Chinery, R.1    Playford, R.J.2
  • 52
    • 0031822603 scopus 로고    scopus 로고
    • Distribution and metabolism of intravenously administered trefoil factor 2/porcine spasmolytic polypeptide in the rat
    • [PMID: 10189851 DOI: 10.1136/gut.43.2.240]
    • Poulsen SS, Thulesen J, Nexø E, Thim L. Distribution and metabolism of intravenously administered trefoil factor 2/porcine spasmolytic polypeptide in the rat. Gut 1998; 43: 240-247 [PMID: 10189851 DOI: 10.1136/gut.43.2.240]
    • (1998) Gut , vol.43 , pp. 240-247
    • Poulsen, S.S.1    Thulesen, J.2    Nexø, E.3    Thim, L.4
  • 53
    • 33748030426 scopus 로고    scopus 로고
    • Systemically administered trefoil factors are secreted into the gastric lumen and increase the viscosity of gastric contents
    • [PMID: 16880764 DOI: 10.1038/sj.bjp.0706840]
    • Kjellev S, Nexø E, Thim L, Poulsen SS. Systemically administered trefoil factors are secreted into the gastric lumen and increase the viscosity of gastric contents. Br J Pharmacol 2006; 149: 92-99 [PMID: 16880764 DOI: 10.1038/sj.bjp.0706840]
    • (2006) Br J Pharmacol , vol.149 , pp. 92-99
    • Kjellev, S.1    Nexø, E.2    Thim, L.3    Poulsen, S.S.4
  • 54
    • 4143082646 scopus 로고    scopus 로고
    • Active delivery of trefoil factors by genetically modified Lactococcus lactis prevents and heals acute colitis in mice
    • [PMID: 15300583 DOI: 10.1053/ j.gastro.2004.05.020]
    • Vandenbroucke K, Hans W, Van Huysse J, Neirynck S, Demetter P, Remaut E, Rottiers P, Steidler L. Active delivery of trefoil factors by genetically modified Lactococcus lactis prevents and heals acute colitis in mice. Gastroenter-ology 2004; 127: 502-513 [PMID: 15300583 DOI: 10.1053/ j.gastro.2004.05.020]
    • (2004) Gastroenter-ology , vol.127 , pp. 502-513
    • Vandenbroucke, K.1    Hans, W.2    van Huysse, J.3    Neirynck, S.4    Demetter, P.5    Remaut, E.6    Rottiers, P.7    Steidler, L.8
  • 55
    • 84876544307 scopus 로고    scopus 로고
    • Recom-binant adenovirus-mediated intestinal trefoil factor gene therapy for burn-induced intestinal mucosal injury
    • [PMID: 23638081 DOI: 10.1371/journal. pone.0062429]
    • Sun Y, Zhu Y, Wang L, Mao X, Peng X, Peng Y. Recom-binant adenovirus-mediated intestinal trefoil factor gene therapy for burn-induced intestinal mucosal injury. PLoS One 2013; 8: e62429 [PMID: 23638081 DOI: 10.1371/journal. pone.0062429]
    • (2013) PLoS One , vol.8
    • Sun, Y.1    Zhu, Y.2    Wang, L.3    Mao, X.4    Peng, X.5    Peng, Y.6
  • 56
    • 0041885346 scopus 로고    scopus 로고
    • Tumour necrosis factor alpha and nuclear factor kappaB inhibit transcription of human TFF3 encoding a gastrointestinal healing peptide
    • [PMID: 12912861]
    • Loncar MB, Al-azzeh ED, Sommer PS, Marinovic M, Schmehl K, Kruschewski M, Blin N, Stohwasser R, Gött P, Kayademir T. Tumour necrosis factor alpha and nuclear factor kappaB inhibit transcription of human TFF3 encoding a gastrointestinal healing peptide. Gut 2003; 52: 1297-1303 [PMID: 12912861]
    • (2003) Gut , vol.52 , pp. 1297-1303
    • Loncar, M.B.1    Al-Azzeh, E.D.2    Sommer, P.S.3    Marinovic, M.4    Schmehl, K.5    Kruschewski, M.6    Blin, N.7    Stohwasser, R.8    Gött, P.9    Kayademir, T.10
  • 57
    • 62149085898 scopus 로고    scopus 로고
    • Effects of trefoil peptide 3 on expression of TNF-alpha, TLR4, and NF-kappaB in trinitrobenzene sulphonic acid induced colitis mice
    • [PMID: 19238529 DOI: 10.1007/ s10753-009-9110-x]
    • Teng X, Xu LF, Zhou P, Sun HW, Sun M. Effects of trefoil peptide 3 on expression of TNF-alpha, TLR4, and NF-kappaB in trinitrobenzene sulphonic acid induced colitis mice. In-fammation 2009; 32: 120-129 [PMID: 19238529 DOI: 10.1007/ s10753-009-9110-x]
    • (2009) In-fammation , vol.32 , pp. 120-129
    • Teng, X.1    Xu, L.F.2    Zhou, P.3    Sun, H.W.4    Sun, M.5
  • 58
    • 67649231565 scopus 로고    scopus 로고
    • Colitis-associated variant of TLR2 causes impaired mucosal repair because of TFF3 defciency
    • [PMID: 19303021 DOI: 10.1053/j.gastro.2009.03.007]
    • Podolsky DK, Gerken G, Eyking A, Cario E. Colitis-associated variant of TLR2 causes impaired mucosal repair because of TFF3 defciency. Gastroenterology 2009; 137: 209-220 [PMID: 19303021 DOI: 10.1053/j.gastro.2009.03.007]
    • (2009) Gastroenterology , vol.137 , pp. 209-220
    • Podolsky, D.K.1    Gerken, G.2    Eyking, A.3    Cario, E.4
  • 60
    • 0024454741 scopus 로고
    • The 5' flanking region of the pS2 gene contains a complex enhancer region responsive to oestrogens, epidermal growth factor, a tumour promoter (TPA), the c-Ha-ras oncoprotein and the c-jun protein
    • [PMID: 2498085]
    • Nunez AM, Berry M, Imler JL, Chambon P. The 5' flanking region of the pS2 gene contains a complex enhancer region responsive to oestrogens, epidermal growth factor, a tumour promoter (TPA), the c-Ha-ras oncoprotein and the c-jun protein. EMBO J 1989; 8: 823-829 [PMID: 2498085]
    • (1989) EMBO J , vol.8 , pp. 823-829
    • Nunez, A.M.1    Berry, M.2    Imler, J.L.3    Chambon, P.4
  • 62
    • 84872129507 scopus 로고    scopus 로고
    • Dietary conjugated lin-oleic acid activates PPARγ and the intestinal trefoil factor in SW480 cells and mice with dextran sulfate sodium-induced colitis
    • [PMID: 23077197]
    • Borniquel S, Jädert C, Lundberg JO. Dietary conjugated lin-oleic acid activates PPARγ and the intestinal trefoil factor in SW480 cells and mice with dextran sulfate sodium-induced colitis. J Nutr 2012; 142: 2135-2140 [PMID: 23077197]
    • (2012) J Nutr , vol.142 , pp. 2135-2140
    • Borniquel, S.1    Jädert, C.2    Lundberg, J.O.3
  • 63
    • 0035148302 scopus 로고    scopus 로고
    • Molecular medicine of TFF-peptides: From gut to brain
    • [PMID: 11193208]
    • Hoffmann W, Jagla W, Wiede A. Molecular medicine of TFF-peptides: from gut to brain. Histol Histopathol 2001; 16: 319-334 [PMID: 11193208]
    • (2001) Histol Histopathol , vol.16 , pp. 319-334
    • Hoffmann, W.1    Jagla, W.2    Wiede, A.3
  • 64
    • 0032711596 scopus 로고    scopus 로고
    • Quantitative analysis reveals differential expression of mucin (MUC2) and intestinal trefoil factor mRNAs along the longitudinal axis of rat intestine
    • [PMID: 10673034 DOI: 10.1016/S0167-4781(99)00186-4]
    • Matsuoka Y, Pascall JC, Brown KD. Quantitative analysis reveals differential expression of mucin (MUC2) and intestinal trefoil factor mRNAs along the longitudinal axis of rat intestine. Biochim Biophys Acta 1999; 1489: 336-344 [PMID: 10673034 DOI: 10.1016/S0167-4781(99)00186-4]
    • (1999) Biochim Biophys Acta , vol.1489 , pp. 336-344
    • Matsuoka, Y.1    Pascall, J.C.2    Brown, K.D.3
  • 66
    • 3543091479 scopus 로고    scopus 로고
    • Colonic expression of MUC2, MUC5AC, and TFF1 in infammatory bowel disease in children
    • [PMID: 15097436 DOI: 10.1097/00005176-200405000-00006]
    • Shaoul R, Okada Y, Cutz E, Marcon MA. Colonic expression of MUC2, MUC5AC, and TFF1 in infammatory bowel disease in children. J Pediatr Gastroenterol Nutr 2004; 38: 488-493 [PMID: 15097436 DOI: 10.1097/00005176-200405000-00006]
    • (2004) J Pediatr Gastroenterol Nutr , vol.38 , pp. 488-493
    • Shaoul, R.1    Okada, Y.2    Cutz, E.3    Marcon, M.A.4
  • 68
    • 33751250222 scopus 로고    scopus 로고
    • Alterations in the composition of the su-pramucosal defense barrier in relation to disease severity of ulcerative colitis
    • [PMID: 16924127 DOI: 10.1369/jhc.5A6904.2006]
    • Longman RJ, Poulsom R, Corfeld AP, Warren BF, Wright NA, Thomas MG. Alterations in the composition of the su-pramucosal defense barrier in relation to disease severity of ulcerative colitis. J Histochem Cytochem 2006; 54: 1335-1348 [PMID: 16924127 DOI: 10.1369/jhc.5A6904.2006]
    • (2006) J Histochem Cytochem , vol.54 , pp. 1335-1348
    • Longman, R.J.1    Poulsom, R.2    Corfeld, A.P.3    Warren, B.F.4    Wright, N.A.5    Thomas, M.G.6
  • 69
    • 0025139164 scopus 로고
    • Induction of a novel epidermal growth factor-secreting cell lineage by mucosal ulceration in human gastrointestinal stem cells
    • [PMID: 2296294 DOI: 10.1038/343082a0]
    • Wright NA, Pike C, Elia G. Induction of a novel epidermal growth factor-secreting cell lineage by mucosal ulceration in human gastrointestinal stem cells. Nature 1990; 343: 82-85 [PMID: 2296294 DOI: 10.1038/343082a0]
    • (1990) Nature , vol.343 , pp. 82-85
    • Wright, N.A.1    Pike, C.2    Elia, G.3
  • 70
    • 84877772051 scopus 로고    scopus 로고
    • A variant form of the human deleted in malignant brain tumor 1 (DMBT1) gene shows increased expression in inflammatory bowel diseases and interacts with dimeric trefoil factor 3 (TFF3)
    • [PMID: 23691218 DOI: 10.1371/ journal.pone.0064441]
    • Madsen J, Sorensen GL, Nielsen O, Tornøe I, Thim L, Fenger C, Mollenhauer J, Holmskov U. A variant form of the human deleted in malignant brain tumor 1 (DMBT1) gene shows increased expression in inflammatory bowel diseases and interacts with dimeric trefoil factor 3 (TFF3). PLoS One 2013; 8: e64441 [PMID: 23691218 DOI: 10.1371/ journal.pone.0064441]
    • (2013) PLoS One , vol.8
    • Madsen, J.1    Sorensen, G.L.2    Nielsen, O.3    Tornøe, I.4    Thim, L.5    Fenger, C.6    Mollenhauer, J.7    Holmskov, U.8
  • 71
  • 72
    • 84876154817 scopus 로고    scopus 로고
    • Quantitative measurements of trefoil factor family peptides: Possibilities and pitfalls
    • [PMID: 23391285 DOI: 10.3109/0036 5513.2013.765962]
    • Samson MH. Quantitative measurements of trefoil factor family peptides: possibilities and pitfalls. Scand J Clin Lab Invest 2013; 73: 193-202 [PMID: 23391285 DOI: 10.3109/0036 5513.2013.765962]
    • (2013) Scand J Clin Lab Invest , vol.73 , pp. 193-202
    • Samson, M.H.1
  • 74
    • 1842854757 scopus 로고    scopus 로고
    • Immunoassays of human trefoil factors 1 and 2: Measured on serum from patients with infammatory bowel disease
    • [PMID: 15115253 DOI: 10.1080/00365510410001176]
    • Vestergaard EM, Brynskov J, Ejskjaer K, Clausen JT, Thim L, Nexø E, Poulsen SS. Immunoassays of human trefoil factors 1 and 2: measured on serum from patients with infammatory bowel disease. Scand J Clin Lab Invest 2004; 64: 146-156 [PMID: 15115253 DOI: 10.1080/00365510410001176]
    • (2004) Scand J Clin Lab Invest , vol.64 , pp. 146-156
    • Vestergaard, E.M.1    Brynskov, J.2    Ejskjaer, K.3    Clausen, J.T.4    Thim, L.5    Nexø, E.6    Poulsen, S.S.7
  • 75
    • 33751525342 scopus 로고    scopus 로고
    • Serum trefoil factors in patients with infammatory bowel disease
    • [PMID: 17068395]
    • Grønbaek H, Vestergaard EM, Hey H, Nielsen JN, Nexø E. Serum trefoil factors in patients with infammatory bowel disease. Digestion 2006; 74: 33-39 [PMID: 17068395]
    • (2006) Digestion , vol.74 , pp. 33-39
    • Grønbaek, H.1    Vestergaard, E.M.2    Hey, H.3    Nielsen, J.N.4    Nexø, E.5
  • 76
    • 20444450031 scopus 로고    scopus 로고
    • Trial of trefoil factor 3 enemas, in combination with oral 5-aminosalicylic acid, for the treatment of mild-to-moderate left-sided ulcerative colitis
    • [PMID: 15932366 DOI: 10.1111/ j.1365-2036.2005.02436.x]
    • Mahmood A, Melley L, Fitzgerald AJ, Ghosh S, Playford RJ. Trial of trefoil factor 3 enemas, in combination with oral 5-aminosalicylic acid, for the treatment of mild-to-moderate left-sided ulcerative colitis. Aliment Pharmacol Ther 2005; 21: 1357-1364 [PMID: 15932366 DOI: 10.1111/ j.1365-2036.2005.02436.x]
    • (2005) Aliment Pharmacol Ther , vol.21 , pp. 1357-1364
    • Mahmood, A.1    Melley, L.2    Fitzgerald, A.J.3    Ghosh, S.4    Playford, R.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.