Mechanisms of regulatory peptide action in the gastrointestinal tract: Trefoil peptides

Journal of Gastroenterology

Volumn 35, Issue SUPPL. 12, 2000, Pages 69-74

  Podolsky, Daniel K ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Cytokines; Growth factors; Healing; Trefoil peptides; Ulceration

Indexed keywords

CATENIN; DEXTRAN SULFATE; EPIDERMAL GROWTH FACTOR RECEPTOR; GASTROINTESTINAL POLYPEPTIDE; INTESTINAL TREFOIL FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P53; PROTEIN PS2; REGULATOR PROTEIN; TREFOIL PEPTIDE; UVOMORULIN;

ANIMAL CELL; APOPTOSIS; CELL DEATH; CELL MIGRATION; COLON INJURY; CONFERENCE PAPER; DISULFIDE BOND; ENZYME ACTIVITY; EPITHELIUM CELL; GASTROINTESTINAL TRACT; GENE DELETION; GOBLET CELL; HUMAN; INTESTINE MUCOSA; MOUSE; NONHUMAN; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN SECRETION; PROTEIN STRUCTURE; RAT; REGULATORY MECHANISM; TISSUE REPAIR;

ANIMALS; CELL MOVEMENT; DIGESTIVE SYSTEM; GASTRIC MUCOSA; GROWTH SUBSTANCES; HUMANS; INTESTINAL MUCOSA; MUCINS; MUSCLE PROTEINS; NEUROPEPTIDES; PEPTIC ULCER; PEPTIDES; WOUND HEALING;

EID: 0034018106     PISSN: 09441174     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (31)

1. Thim L. A new family of growth factor-like peptides. FEBS Lett 1989;250:85-90.
2. Sands BE, Podolsky DK. The trefoil peplide family. Annu Rev Physiol 1996;58:253-73.
3. Suemori S, Lynch-Devaney K, Podolsky DK. Identification and characterization of rat intestinal trefoil factor: tissue-and cell-specific member of the trefoil protein family. Proc Natl Acad Sci USA 1991;88:11017-21.
4. Podolsky DK, Lynch-Devaney K, Stow J, Gates P, Murgue B, deBeaumont M. et al. Identification of human intestinal trefoil factor: goblet cell specific expression of a peptide targeted for apical secretion. J Biol Chem 1993;268:6694-702.
5. Jørgensen K, Thim K, Jacobsen H. Pancreatic spasmolytic polypeptide: preparation and initial chemical characterization of a new polypeptide from porcine pancreas. Regul Peptides 1982;3:207-19.
6. Jeffrey G, Oates P, Wang T, Babyatsky M, Brand S. Spasmolytic polypeptide: a trefoil peptide secreted by rat gastric mucous cells. Gastroenterology 1994;106:336-45.
7. Hanby A, Poulsom R, Singh S, Elia G, Jeffery R, Wright N. Spasmolytic polypeptide is a major antral peptide: distribution of the trefoil peptides human spasmolytic polypeptide and pS2 in the stomach. Gastroenterology 1993;105:1110-16.
8. Ogata H, Inoue N, Podolsky D. Identification of a goblet cell-specific enhancer element in the rat intestinal trefoil factor gene promoter bound by a goblet cell nuclear protein. J Biol Chem 1998;273:3060-7.
9. De A, Brown D, Gorman M, Carr M, Sanderson M, Freemont P. Crystal structure of a disulfide-linked "trefoil" motif found in a large family of putative growth factors. Proc Natl Acad Sci USA 1994;91:1084-8.
10. Carr M, Bauer C, Gradwell M, Feeney J. Solution structure of a trefoil-motif-containing cell growth factor, porcine spasmolytic protein. Proc Natl Acad Sci USA 1994;91:2206-10.
11. Gajhede M, Petersen T, Henriksen A, Petersen J, Dauter Z, Wilson K, et al. Pancreatic spasmolytic polypeptide: first three-dimensional structure of a member of the mammalian trefoil family of peptides. Structure 1993;1:253-62.
12. Kindon H, Pothoulakis C, Thim L, Lynch-Devaney K, Podolsky DK. Trefoil peptide protection of intestinal epithelial barrier function: cooperative interaction with mucin glycoprotein. Gastroenterology 1995;109:516-23.
13. Playford RJ, Marchbank T, Chinery R, Evison R, Pignatelli M. Boulton RA. et al. Human spasmolytic polypeptide is a cytoprotective agent that stimulates cell migration. Gastroenterology 1995;108:108-16.
14. Dieckgraefe BK, Stenson WF, Alpers DH. Gastrointestinal epithelial response to injury. Curr Opin Gastroenterol 1996;12:109-14.
15. Feil W, Lacy ER, Wong YM, Burger D, Wenzl E, Starlinger M, et al. Rapid epithelial restitution of human and rabbit colonic mucosa. Gastroenterology 1989;97:685-701.
16. Ciacci C, Lind Se, Podolsky DK. Transforming growth factor β regulation of migration in wounded rat intestinal epithelial monolayers. Gastroenterology 1993;105:93-101.
17. Dignass A, Lynch-Devaney K, Kindon H, Thim L, Podolsky DK. Trefoil peptides promote epithelial migration through a transforming growth factor β-independent pathway. J Clin Invest 1994;94:376-83.
18. Dignass A, Podolsky DK. Cytokine modulation of intestinal epithelial cell restitution: central role of transforming growth factor β. Gastroenterology 1993;105:1323-32.
19. Takahashi M, Ota S, Shimada T, Hamada E, Kawabe T, Okudaira T, et al. Hepatocyte growth factor is the most potent endogenous stimulant of rabbit gastric epithelial cell proliferation and migration in primary culture. J Clin Invest 1995;95:1994-2003.
20. Wright NA, Poulsom R, Stamp G, Van Noorden S, Sarraf C, Elia G, et al. Trefoil peptide gene expression in gastrointestinal epithelial cells in inflammatory bowel disease. Gastroenterology 1993; 104:12-20.
21. Rio MC, Chenard MP, Wolf C, Marcellin L, Tomasetto C, Lathe R, et al. Induction of pS2 and hSP genes as markers of mucosal ulceration of the digestive tract. Gastroenterology 1991;100:375-9.
22. Alison MR. Chinery R, Poulsom R, Ashwood P, Longcroft JM, Wright NA. Experimental ulceration leads to sequential expression of spasmolytic polypeptide, intestinal trefoil factor, epidermal growth factor and transforming growth factor alpha mRNAs in rat stomach. J Pathol 1995;175:405-14.
23. Babyatsky MW, deBeaumont M, Thim L, Podolsky DK. Oral trefoil peptides protect against ethanol-and indomethacin-induced gastric injury in rats. Gastroenterology 1996;110:489-97.
24. Playford R, Marchbank T, Goodlad R, Chinery R, Poulsom R, Hanby A, et al. Transgenic mice that overexpress the human trefoil peptide pS2 have an increased resistance to intestinal damage. Proc Natl Acad Sci USA 1996;93:2137-42.
25. Mashimo H, Wu DC, Podolsky DK, Fishman MC. Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor. Science 1996;274:262-5.
26. Lefebvre O, Chenard MP, Massen R, Linares J, Dierich A. LeMeur M, et al. Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein. Science 1996;274:258-62.
27. Kanai M, Mullen C, Podolsky DK. Intestinal trefoil factor induces inactivation of extracellular signal-regulated protein kinase in intestinal epithelial cells. Proc Natl Acad Sci USA 1998;95:178-82.
28. Efstathiou J, Noda M, Rowan A, Dixon C, Chinery R, Jawhari A, et al. Intestinal trefoil factor controls the expression of the adenomatous polyposis coli-catenin and the E-cadherin-catenin complexes in human colon carcinoma cells. Proc Natl Acad Sci USA 1998;95:3122-7.
29. Chinery R, Cox H. Immunoprecipitation and characterization of a binding protein specific for the peptide, intestinal trefoil factor. Peptides 1995;16:749-55.
30. Tan X, Hsueh W, Change H, Wei K, Gonzalez-Crussi F. Characterization of a putative receptor for intestinal trefoil factor in rat small intestine; identification by in situ binding and ligand blotting. Biochem Biophys Res Commun 1997;237:673-7.
31. Taupin D, Ooi K, Yeomans N, Giraud A. Conserved expression of intestinal trefoil factor in the human colonic adenoma-carcinoma sequence. Lab Invest 1996;75:25-32.