Colonic Expression of MUC2, MUC5AC, and TFF1 in Inflammatory Bowel Disease in Children

Journal of Pediatric Gastroenterology and Nutrition

Volumn 38, Issue 5, 2004, Pages 488-493

  Shaoul, Ron ^a   Okada, Yoshio ^b   Cutz, Ernest ^c   Marcon, Margaret A ^c  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b UNIVERSITY OF TORONTO   (Canada)

^c OKAYAMA PREFECTURAL UNIVERSITY   (Japan)

Author keywords

Children; Colon; Crohn's disease; Goblet cells; Inflammatory bowel disease; Mucin; Ulcerative colitis

Indexed keywords

MUC 2 PROTEIN; MUCIN; MUCIN 5AC; MUSCLE PROTEIN; NEUROPEPTIDE; PEPTIDE; TFF3 PROTEIN, RAT; TREFOIL FACTOR;

ADOLESCENT; ARTICLE; CASE CONTROL STUDY; CHILD; ENTERITIS; FEMALE; HOSPITALIZATION; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; METABOLISM; PATHOLOGY; PRESCHOOL CHILD;

ADOLESCENT; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INFLAMMATORY BOWEL DISEASES; MALE; MUCINS; MUSCLE PROTEINS; NEUROPEPTIDES; PEPTIDES; SEVERITY OF ILLNESS INDEX;

EID: 3543091479     PISSN: 02772116     EISSN: 15364801     Source Type: Journal    
DOI: 10.1097/00005176-200405000-00006     Document Type: Article

References (40)

1. McCool DJ, Forstner JF, Forstner GG. Synthesis and secretion of mucin by the human colonic tumour cell line LS180. Biochem J 1994;302:111-8.
2. Smith AC, Podolsky DK. Colonic mucin glycoproteins in health and disease. Clin Gastroenterol 1986;15:815-37.
3. Tytgat KM, Buller HA, Opdam FJ, et al. Biosynthesis of human colonic mucin: Muc2 is the prominent secretory mucin. Gastroenterology 1994;107:1352-63.
4. Van Klinken BJ, Dekker J, Buller HA, et al. Biosynthesis of mucins (MUC2-6) along the longitudinal axis of the human gastrointestinal tract. Am J Physiol 1997;273:G296-302.
5. Mashimo H, Wu DC, Podolsky DK, et al. Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor. Science 1996;274:262-5.
6. Kindon H, Pothoulakis C, Thim L, et al. Trefoil peptide protection of intestinal epithelial barrier function: cooperative interaction with mucin glycoprotein. Gastroenterology 1995;109:516-23.
7. Podolsky DK. Lessons from genetic models of inflammatory bowel disease. Acta Gastroenterol Belg 1997;60:163-5.
8. Pullan RD, Thomas GA, Rhodes M, et al. Thickness of adherent mucus gel on colonic mucosa in humans and its relevance to colitis. Gut 1994;35:353-9.
9. Tytgat KM, Opdam FJ, Einerhand AW, et al. MUC2 is the prominent colonic mucin expressed in ulcerative colitis. Gut 1996;38: 554-63.
10. Podolsky DK, Fournier DA. Alterations in mucosal content of colonic glycoconjugates in inflammatory bowel disease defined by monoclonal antibodies. Gastroenterology 1988;95:379-87.
11. Podolsky DK, Isselbacher KJ. Composition of human colonic mucin. Selective alteration in inflammatory bowel disease. J Clin Invest 1983;72:142-53.
12. Podolsky DK, Isselbacher KJ. Glycoprotein composition of colonic mucosa. Specific alterations in ulcerative colitis. Gastroenterology 1984;87:991-8.
13. Raouf AH, Tsai HH, Parker N, et al. Sulphation of colonic and rectal mucin in inflammatory bowel disease: reduced sulphation of rectal mucus in ulcerative colitis. Clin Sci (Lond.) 1992;83:623-6.
14. Culling CF, Reid PE, Dunn WL. A histochemical comparison of the O-acylated sialic acids of the epithelial mucins in ulcerative colitis, Crohn's disease, and normal controls. J Clin Pathol 1979; 32:1272-7.
15. Smithson JE, Campbell A, Andrews JM, et al. Altered expression of mucins throughout the colon in ulcerative colitis. Gut 1997;40: 234-40.
16. Tytgat KM, van der Wal JW, Einerhand AW, et al. Quantitative analysis of MUC2 synthesis in ulcerative colitis. Biochem Biophys Res Commun 1996;224:397-405.
17. Hinoda Y, Akashi H, Suwa T, et al. Immunohistochemical detection of MUC2 mucin core protein in ulcerative colitis. J Clin Lab Anal 1998;12:150-3.
18. Hanski C, Born M, Foss HD, et al. Defective post-transcriptional processing of MUC2 mucin in ulcerative colitis and in Crohn's disease increases detectability of the MUC2 protein core. J Pathol 1999;188:304-11.
19. Sotozono M, Okada Y, Sasagawa T, et al. Novel monoclonal antibody, SO-MU1, against human gastric MUC5AC apomucin. J Immunol Methods 1996;192:87-96.
20. Shaoul R, Marcon P, Okada Y, et al. The pathogenesis of duodenal gastric metaplasia: the role of local goblet cell transformation. Gut 2000;46:632-8.
21. Rio MC, Chenard MP, Wolf C, et al. Induction of pS2 and hSP genes as markers of mucosal ulceration of the digestive tract. Gastroenterology 1991;100:375-9.
22. Shaoul R, Marcon MA, Okada Y, et al. Gastric metaplasia: a frequently overlooked feature of duodenal biopsy specimens in untreated celiac disease. J Pediatr Gastroenterol Nutr 2000;30: 397-403.
23. Wright NA, Poulsom R, Stamp G, et al. Trefoil peptide gene expression in gastrointestinal epithelial cells in inflammatory bowel disease. Gastroenterology 1993;104:12-20.
24. Kitamura H, Cho M, Lee BH, et al. Alteration in mucin gene expression and biological properties of HT29 colon cancer cell subpopulations. Eur J Cancer 1996;32A:1788-96.
25. Buisine MP, Janin A, Maunoury V, et al. Aberrant expression of a human mucin gene (MUC5AC) in rectosigmoid villous adenoma. Gastroenterology 1996;110:84-91.
26. Balague C, Gambus G, Carrato C, et al. Altered expression of MUC2, MUC4, and MUC5 mucin genes in pancreas tissues and cancer cell lines. Gastroenterology 1994;106:1054-61.
27. Terada T, Ohta T, Sasaki M, et al. Expression of MUC apomucins in normal pancreas and pancreatic tumours. J Pathol 1996;180: 160-5.
28. Sasaki M, Nakanuma Y, Kim YS. Characterization of apomucin expression in intrahepatic cholangiocarcinomas and their precursor lesions: an immunohistochemical study. Hepatology 1996;24: 1074-8.
29. Yu CJ, Yang PC, Shun CT, et al. Overexpression of MUC5 genes is associated with early post-operative metastasis in non-small-cell lung cancer. Int J Cancer 1996;69:457-65.
30. Henry JA, Bennett MK, Piggott NH, et al. Expression of the pNR-2/pS2 protein in diverse human epithelial tumours. Br J Cancer 1991;64:677-82.
31. Lahoti C, Thorner P, Malkin D, et al. Immunohistochemical detection of p53 in Wilms' tumors correlates with unfavorable outcome. Am J Pathol 1996;148:1577-89.
32. Piggott NH, Henry JA, May FE, et al. Antipeptide antibodies against the pNR-2 oestrogen-regulated protein of human breast cancer cells and detection of pNR-2 expression in normal tissues by immunohistochemistry. J Pathol 1991;163:95-104.
33. Stemberger LA. Immunocytochemistry. 3rd ed. New York: John Wiley and Sons; 1986.
34. Clamp JR, Fraser G, Read AE. Study of the carbohydrate content of mucus glycoproteins from normal and diseased colons. Clin Sci 1981;61:229-34.
35. Chambers JA, Hollingsworth MA, Trezise AE, et al. Developmental expression of mucin genes MUC1 and MUC2. J Cell Sci 1994; 107:413-24.
36. Wright NA, Poulsom R, Stamp G, et al. Trefoil peptide gene expression in gastrointestinal epithelial cells in inflammatory bowel disease. Scand J Gastroenterol Suppl 1992;193:76-82.
37. Wright NA, Poulsom R, Stamp GW, et al. Epidermal growth factor (EGF/URO) induces expression of regulatory peptides in damaged human gastrointestinal tissues. J Pathol 1990;162:279-84.
38. Lechago J, Black C, Samloff IM. Immunofluorescence studies of gastric heterotopia of the small intestine in Crohn's disease. Gastroenterology 1976;70:429-32.
39. Yokoyama I, Kozuka S, Ito K, et al. Gastric gland metaplasia in the small and large intestine. Gut 1977;18:214-8.
40. Khulusi S, Hanby AM, Marrero JM, et al. Expression of trefoil peptides pS2 and human spasmolytic polypeptide in gastric metaplasia at the margin of duodenal ulcers. Gut 1995;37:205-9.