GEX1 compounds, novel antitumor antibiotics related to herboxidene, produced by Streptomyces sp. II. The effects on cell cycle progression and gene expression

Journal of Antibiotics

Volumn 55, Issue 10, 2002, Pages 863-872

  Sakai, Yasuhi ^a   Tsujita, Tetsuya ^a   Akiyama, Tadakazu ^a   Yoshida, Tatsuhiko ^a   Mizukami, Tamio ^a   Akinaga, Shiro ^a   Horinouchi, Sueharu ^a   Yoshida, Minoru ^a   Yoshida, Tatsuo ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BETA ACTIN; GENE PRODUCT; GEX 1; GEX 1A; GEX 1Q1; GEX 1Q2; GEX 1Q3; GEX 1Q4; GEX 1Q5; HERBOXIDIENE; HISTONE; HISTONE DEACETYLASE; INTERLEUKIN 2; LUCIFERASE; POLYPEPTIDE ANTIBIOTIC AGENT; PROTEIN BCL XL; PROTEIN CDC2; PROTEIN CDC25A; TRICHOSTATIN A; UNCLASSIFIED DRUG;

ACETYLATION; APOPTOSIS; ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL PROLIFERATION; CONTROLLED STUDY; CULTURE MEDIUM; CYTOTOXICITY; DRUG ISOLATION; DRUG STRUCTURE; ENHANCER REGION; FIBROBLAST; GENE CONTROL; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MOLECULAR SIZE; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; SIMIAN VIRUS 40; STREPTOMYCES; UPREGULATION;

STREPTOMYCES;

EID: 0036808433     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.55.863     Document Type: Article

References (24)

1. YOSHIDA, M.; R. FURUMAI, M. NISHIYAMA, Y. KOMATSU, N. NISHINO & S. HORINOUCHI: Histone deacetylase as a new target for cancer chemotherapy. Cancer Chemother. Pharmacol. 48 (Suppl. 1): S20-26, 2001
2. WARRELL, R. P.; S. R. FRANKEL, W. H. MILLER, D. A. SCHEINBERG, L. M. ITRI, W. N. HITTELMAN, R. VYAS, M. ANDREEFF, A. TAFURI, A. JAKUBOWSKI, et al.: Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid). N. Engl. J. Med. 324: 1385-1393, 1991
3. SAKAI, Y.; T. YOSHIDA, K. OCHIAI, Y. UOSAKI, Y. SAITOH, F. TANAKA, T. AKIYAMA, S. AKINAGA & T. MIZUKAMI: GEX1 compounds, novel antitumor antibiotics related to herboxidiene, produced by Streptomyces sp. I. Taxonomy, production, isolation, physicochemical properties and biological activities. J. Antibiotics 55: 855-862, 2002
4. MILLER-WIDEMAN, M.; N. MAKKAR, M. TRAN, B. ISAAC, N. BIEST & R. STONARD: Herboxidiene, a new herbicidal substance from Streptmyces chromofuscus A7847. J. Antibiotics 45: 914-921, 1992
5. AKIYAMA, T.; T. YOSHIDA, T. TSUJITA, M. SHIMIZU, T. MIZUKAMI, M. OKABE & S. AKINAGA: G1 phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/Sdi1 in p53-mutated human epidermoid carcinoma A431 cells. Cancer Res. 57: 1495-1501, 1997
6. TSUDA, H.; R. W. HUANG, M. KONISHI, T. MIZUKAMI, Y, YOKO-O, M. HASEGAWA, M. SAKAGUCHI, M. KAWAKITA & K. TAKATSUKI: A new system that analyzes erythropoietin-mediated early signal transduction: transfection of the c-fos enhancer/promoter-luciferase gene into a murine erythroid cell line. Eur. J. Haematology 52: 73-79, 1994
7. TAKAHASHI, I.; H. MIYAJI, T. YOSHIDA, S. SATO & T. MIZUKAMI: Selective inhibition of IL-2 gene expression by trichostatin A, potent inhibitor on mammalian histone deacetylase. J. Antibiotics 49: 453-457, 1996
8. MIYAJI, H.; N. HARADA, T. MIZUKAMI, S. SATO N. FUJIYOSHI & S. ITO: Expression of human lymphotoxin in namalwa KJM-1 cells adapted to serum-free medium. Cytotechnology 4: 39-43, 1990
9. GILLILAND, G.; S. PERRIN, K. BLANCHARD & F. BUNN: Analysis of cytokine mRNA and DNA: detection and quantitation by competitive polymerase chain reaction. Proc. Natl. Acad. Sci. U.S.A. 87: 2725-2729, 1990
10. SASAKI, K.; K. KURATA, K. FUNAYAMA, M. NAGATA, E. WATANABE, S. OHTA, N. HANAI & T. NISHI: Expression cloning of a novel α-1,3-fucosyltransferase that is involved in biosynthesis of the sialyl Lewis x carbohydrate determinants in leukocytes. J. Biol. Chem. 269: 14730-14737, 1994
11. BOISE, L. H.; M. GONZALEZ-GARCIA, C. E. POSTEMA, L. DING, T. LINDSTEN, L. A. TURKA, X. MAO, G. NUNEZ & C. B. THOMPSON: bcl-xL, a bcl-2 related gene that functions as a dominant regulator of apoptotic cell death. Cell 74: 597-608, 1993
12. KOMATSU, Y.; K. TAMIZAKI, M. TSUKAMOTO, T. KATO, N. NISHINO, S. SATO, T. YAMORI, T. TSURUO, R. FURUMAI, M. YOSHIDA, S. HORINOUCHI & H. HAYASHI: Cyclic hydroxamic-acid-containing peptide 31, a potent synthetic histone deacetylase inhibitor with antitumor activity. Cancer Res. 61: 4459-4466, 2001
13. YOSHIDA, M. & T. BEPPU: Reversible arrest of proliferation of rat 3Y1 fibroblasts in both the G1 and G2 phases by trichostatin A. Exp. Cell Res. 177: 122-131, 1988.
14. YOSHIDA, M.: M. KIJIMA, M. AKITA & T. BEPPU: Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J. Biol. Chem. 265: 17174-17179, 1990
15. DALTON, S.: Cell cycle regulation of the human cdc2 gene. EMBO J. 11: 1797-1804, 1992
16. SOWA, S.; T. ORITA, S. MINAMIKAWA-HIRAKABE, T. MIZUNO, H. NOMURA & T. SAKAI: Sp3, but not Sp1, mediates the transcriptional activation of the p21/WAF1/Cip1 gene promoter by histone deacetylase inhibitor. Cancer Res. 59: 4266-4270, 1999
17. EGAWA, K.; H. NISHIGORI S. KUNITOMO, T. TAKEUCHI & K. NOSE: Identification of active substances from Streptomyces culture fluids using p53-independent expression of p21/WAF1/Cip1 gene and their mode of action. Biol. Pharm. Bull., 21: 899-904, 1998
18. KOGUCHI, Y.; M. NISHIO, J. KOTERA, K. OMORI, T. ONUKI & S. KOMATSUBARA: Trichostatin A and herboxidiene up-regulate the gene expression of low density lipoprotein receptor. J. Antibiotics 50: 970-971, 1997
19. Japanese patent: Jpn. Kokai Tokkyo Koho PATENT No. JP 1994-022770 (Japanese)
20. KORNBERG, R. D. & Y. LORCH: Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome. Cell 98: 285-294, 1999
21. TURNER, B. M.: Histone acetylation and an epigenetic code. BioEssays 22: 836-845, 2000
22. NAKAJIMA, H.; Y. B. KIM, H. TERANO, M. YOSHIDA & S. HORINOUCHI: FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor. Exp. Cell Res. 241: 126-133, 1998
23. NAKAJIMA, H.; B, SATO, T. FUJITA, S. TAKASE, H. TERANO & M. OKUHARA: New antitumor substances, FR901463, FR901464 and FR901465. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities. J. Antibiotics 49: 1196-1203, 1996
24. NAKAJIMA, H.; H. HORI, H. TERANO, M. OKUHARA, T. MANDA, S. MATSUMOTO & K. SHIMOMURA: New antitumor substances, FR901463, FR901464 and FR901465. II. Activities against experimental tumors in mice and mechanism of action. J. Antibiotics 49: 1204-1211, 1996