Targeted metabolomics connects thioredoxin-interacting protein (TXNIP) to mitochondrial fuel selection and regulation of specific oxidoreductase enzymes in skeletal muscle

Journal of Biological Chemistry

Volumn 289, Issue 12, 2014, Pages 8106-8120

  DeBalsi, Karen L ^a,b   Wong, Kari E ^a   Koves, Timothy R ^a,b   Slentz, Dorothy H ^a   Seiler, Sarah E ^a,b   Wittmann, April H ^a   Ilkayeva, Olga R ^a   Stevens, Robert D ^a   Perry, Christopher G R ^c   Lark, Daniel S ^c   Hui, Simon T ^d   Szweda, Luke ^e   Neufer, P Darrell ^c   Muoio, Deborah M ^a,b  

^a DUKE UNIVERSITY   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c EAST CAROLINA UNIVERSITY   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CHAINS; ENZYMES; KETONES; MAMMALS; METABOLISM; PROTEINS;

BRANCHED CHAIN AMINO ACIDS; ELECTRON TRANSPORT CHAIN; METABOLIC PROFILING; MITOCHONDRIAL FUNCTION; NUTRIENT AVAILABILITY; OXIDATIVE METABOLISM; REACTIVE OXYGEN SPECIES; TRICARBOXYLIC ACID CYCLE;

MUSCLE;

BRANCHED CHAIN AMINO ACID; GLUCOSE; KETONE; LACTIC ACID; OXIDOREDUCTASE; REACTIVE OXYGEN METABOLITE; THIOREDOXIN INTERACTING PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOENERGY; CATABOLISM; CITRIC ACID CYCLE; CONTROLLED STUDY; DIABETES MELLITUS; ENERGY METABOLISM; ENZYME ACTIVITY; EXERCISE TOLERANCE; LIVER MITOCHONDRION; MALE; METABOLOMICS; MITOCHONDRIAL ENERGY TRANSFER; MITOCHONDRIAL RESPIRATION; MOUSE; MUSCLE MITOCHONDRION; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STABILITY; PROTEIN SYNTHESIS; SKELETAL MUSCLE; STARVATION;

BRANCHED CHAIN AMINO ACIDS; DIABETES; ENERGY METABOLISM; KETONE BODY METABOLISM; MITOCHONDRIAL METABOLISM; REDOX; SKELETAL MUSCLE METABOLISM; THIOREDOXIN INTERACTING PROTEIN;

ANIMALS; CARRIER PROTEINS; ENERGY METABOLISM; METABOLOMICS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA; MUSCLE, SKELETAL; OXIDATION-REDUCTION; OXIDOREDUCTASES; THIOREDOXINS;

EID: 84896903522     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.511535     Document Type: Article

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