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Volumn 5, Issue 3, 2014, Pages 693-703

AKT mediates actinomycin D-induced p53 expression

Author keywords

Actinomycin D; AKT; P53

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; DACTINOMYCIN; DEGUELIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P53; STRESS ACTIVATED PROTEIN KINASE; WORTMANNIN; TP53 PROTEIN, HUMAN;

EID: 84896896949     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.1328     Document Type: Article
Times cited : (30)

References (48)
  • 1
    • 0036674617 scopus 로고    scopus 로고
    • Live or let die: the cell's response to p53
    • Vousden KH and Lu X. Live or let die: the cell's response to p53. Nat Rev Cancer. 2002; 2(8):594-604.
    • (2002) Nat Rev Cancer , vol.2 , Issue.8 , pp. 594-604
    • Vousden, K.H.1    Lu, X.2
  • 2
    • 1542353401 scopus 로고    scopus 로고
    • Control of apoptosis by p53
    • Fridman JS and Lowe SW. Control of apoptosis by p53. Oncogene. 2003; 22(56):9030-9040.
    • (2003) Oncogene , vol.22 , Issue.56 , pp. 9030-9040
    • Fridman, J.S.1    Lowe, S.W.2
  • 3
    • 53049108040 scopus 로고    scopus 로고
    • Targeting the MDM2-p53 interaction for cancer therapy
    • Shangary S and Wang S. Targeting the MDM2-p53 interaction for cancer therapy. Clin Cancer Res. 2008; 14(17):5318-5324.
    • (2008) Clin Cancer Res , vol.14 , Issue.17 , pp. 5318-5324
    • Shangary, S.1    Wang, S.2
  • 4
    • 34548842816 scopus 로고    scopus 로고
    • Inhibition of tumor angiogenesis by p53: a new role for the guardian of the genome
    • Teodoro JG, Evans SK and Green MR. Inhibition of tumor angiogenesis by p53: a new role for the guardian of the genome. J Mol Med. 2007; 85(11):1175-1186.
    • (2007) J Mol Med , vol.85 , Issue.11 , pp. 1175-1186
    • Teodoro, J.G.1    Evans, S.K.2    Green, M.R.3
  • 5
    • 33746616991 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence
    • Kortlever RM, Higgins PJ and Bernards R. Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence. Nat Cell Biol. 2006; 8(8):877-884.
    • (2006) Nat Cell Biol , vol.8 , Issue.8 , pp. 877-884
    • Kortlever, R.M.1    Higgins, P.J.2    Bernards, R.3
  • 7
    • 36549009637 scopus 로고    scopus 로고
    • Restoration of p53 to limit tumor growth
    • Wang W and El-Deiry WS. Restoration of p53 to limit tumor growth. Curr Opin Oncol. 2008; 20(1):90-96.
    • (2008) Curr Opin Oncol , vol.20 , Issue.1 , pp. 90-96
    • Wang, W.1    El-Deiry, W.S.2
  • 8
    • 1342321750 scopus 로고    scopus 로고
    • PI 3-kinase, Akt and cell survival
    • Downward J. PI 3-kinase, Akt and cell survival. Semin Cell Dev Biol. 2004; 15(2):177-182.
    • (2004) Semin Cell Dev Biol , vol.15 , Issue.2 , pp. 177-182
    • Downward, J.1
  • 9
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: navigating downstream
    • Manning BD and Cantley LC. AKT/PKB signaling: navigating downstream. Cell. 2007; 129(7):1261-1274.
    • (2007) Cell , vol.129 , Issue.7 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 10
    • 77952163120 scopus 로고    scopus 로고
    • p53 regulation of the IGF-1/AKT/mTOR pathways and the endosomal compartment
    • Feng Z. p53 regulation of the IGF-1/AKT/mTOR pathways and the endosomal compartment. Cold Spring Harb Perspect Biol. 2010; 2(2):a001057.
    • (2010) Cold Spring Harb Perspect Biol , vol.2 , Issue.2
    • Feng, Z.1
  • 11
    • 0034183276 scopus 로고    scopus 로고
    • Actinomycin D induces apoptosis and inhibits growth of pancreatic cancer cells
    • Kleeff J, Kornmann M, Sawhney H and Korc M. Actinomycin D induces apoptosis and inhibits growth of pancreatic cancer cells. Int J Cancer. 2000; 86(3):399-407.
    • (2000) Int J Cancer , vol.86 , Issue.3 , pp. 399-407
    • Kleeff, J.1    Kornmann, M.2    Sawhney, H.3    Korc, M.4
  • 12
    • 0004820949 scopus 로고
    • Actinomycin and DNA transcription
    • Sobell HM. Actinomycin and DNA transcription. Proc Natl Acad Sci USA. 1985; 82(16):5328-5331.
    • (1985) Proc Natl Acad Sci USA , vol.82 , Issue.16 , pp. 5328-5331
    • Sobell, H.M.1
  • 13
    • 84888029022 scopus 로고    scopus 로고
    • Methylated actinomycin D, a novel actinomycin D analog induces apoptosis in HepG2 cells through fas-and mitochondria-mediated pathways
    • Chen Y, Liu J, Yuan B, Cao C, Qin S, Cao X, Bian G, Wang Z and Jiang J. Methylated actinomycin D, a novel actinomycin D analog induces apoptosis in HepG2 cells through fas-and mitochondria-mediated pathways. Mol Carcinog. 2013; 52(12):983-996.
    • (2013) Mol Carcinog , vol.52 , Issue.12 , pp. 983-996
    • Chen, Y.1    Liu, J.2    Yuan, B.3    Cao, C.4    Qin, S.5    Cao, X.6    Bian, G.7    Wang, Z.8    Jiang, J.9
  • 14
    • 69749128490 scopus 로고    scopus 로고
    • Specific activation of the p53 pathway by low dose actinomycin D: a new route to p53 based cyclotherapy
    • Choong ML, Yang H, Lee MA and Lane DP. Specific activation of the p53 pathway by low dose actinomycin D: a new route to p53 based cyclotherapy. Cell Cycle. 2009; 8(17):2810-2818.
    • (2009) Cell Cycle , vol.8 , Issue.17 , pp. 2810-2818
    • Choong, M.L.1    Yang, H.2    Lee, M.A.3    Lane, D.P.4
  • 17
    • 84890435387 scopus 로고    scopus 로고
    • p53-Based cyclotherapy: exploiting the 'guardian of the genome' to protect normal cells from cytotoxic therapy
    • Rao B, Lain S and Thompson AM. p53-Based cyclotherapy: exploiting the 'guardian of the genome' to protect normal cells from cytotoxic therapy. Br J Cancer. 2013; 109(12):2954-2958.
    • (2013) Br J Cancer , vol.109 , Issue.12 , pp. 2954-2958
    • Rao, B.1    Lain, S.2    Thompson, A.M.3
  • 18
    • 84868615579 scopus 로고    scopus 로고
    • Cyclotherapy: opening a therapeutic window in cancer treatment
    • van Leeuwen IM. Cyclotherapy: opening a therapeutic window in cancer treatment. Oncotarget. 2012; 3(6):596-600.
    • (2012) Oncotarget , vol.3 , Issue.6 , pp. 596-600
    • van Leeuwen, I.M.1
  • 19
    • 0242721592 scopus 로고    scopus 로고
    • Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway
    • Zhang Y, Wolf GW, Bhat K, Jin A, Allio T, Burkhart WA and Xiong Y. Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway. Mol Cell Biol. 2003; 23(23):8902-8912.
    • (2003) Mol Cell Biol , vol.23 , Issue.23 , pp. 8902-8912
    • Zhang, Y.1    Wolf, G.W.2    Bhat, K.3    Jin, A.4    Allio, T.5    Burkhart, W.A.6    Xiong, Y.7
  • 20
    • 80052063360 scopus 로고    scopus 로고
    • The RP-Mdm2-p53 pathway and tumorigenesis
    • Miliani de Marval PL and Zhang Y. The RP-Mdm2-p53 pathway and tumorigenesis. Oncotarget. 2011; 2(3):234-238.
    • (2011) Oncotarget , vol.2 , Issue.3 , pp. 234-238
    • Miliani de Marval, P.L.1    Zhang, Y.2
  • 22
    • 80054840046 scopus 로고    scopus 로고
    • The tumor suppressor p53 connects ribosome biogenesis to cell cycle control: a double-edged sword
    • Holzel M, Burger K, Muhl B, Orban M, Kellner M and Eick D. The tumor suppressor p53 connects ribosome biogenesis to cell cycle control: a double-edged sword. Oncotarget. 2010; 1(1):43-47.
    • (2010) Oncotarget , vol.1 , Issue.1 , pp. 43-47
    • Holzel, M.1    Burger, K.2    Muhl, B.3    Orban, M.4    Kellner, M.5    Eick, D.6
  • 23
    • 33845270990 scopus 로고    scopus 로고
    • Regulating the p53 pathway: in vitro hypotheses, in vivo veritas
    • Toledo F and Wahl GM. Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nat Rev Cancer. 2006; 6(12):909-923.
    • (2006) Nat Rev Cancer , vol.6 , Issue.12 , pp. 909-923
    • Toledo, F.1    Wahl, G.M.2
  • 24
    • 4444240191 scopus 로고    scopus 로고
    • The functional interactions between the p53 and MAPK signaling pathways
    • Wu GS. The functional interactions between the p53 and MAPK signaling pathways. Cancer Biol Ther. 2004; 3(2):156-161.
    • (2004) Cancer Biol Ther , vol.3 , Issue.2 , pp. 156-161
    • Wu, G.S.1
  • 25
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • Levine AJ. p53, the cellular gatekeeper for growth and division. Cell. 1997; 88(3):323-331.
    • (1997) Cell , vol.88 , Issue.3 , pp. 323-331
    • Levine, A.J.1
  • 27
    • 77953408308 scopus 로고    scopus 로고
    • Physiological regulation of Akt activity and stability
    • Liao Y and Hung MC. Physiological regulation of Akt activity and stability. Am J Transl Res. 2010; 2(1):19-42.
    • (2010) Am J Transl Res , vol.2 , Issue.1 , pp. 19-42
    • Liao, Y.1    Hung, M.C.2
  • 28
    • 0036710512 scopus 로고    scopus 로고
    • The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network
    • Mayo LD and Donner DB. The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network. Trends Biochem Sci. 2002; 27(9):462-467.
    • (2002) Trends Biochem Sci , vol.27 , Issue.9 , pp. 462-467
    • Mayo, L.D.1    Donner, D.B.2
  • 29
    • 85047699328 scopus 로고    scopus 로고
    • Crosstalk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis
    • Gottlieb TM, Leal JF, Seger R, Taya Y and Oren M. Crosstalk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis. Oncogene. 2002; 21(8):1299-1303.
    • (2002) Oncogene , vol.21 , Issue.8 , pp. 1299-1303
    • Gottlieb, T.M.1    Leal, J.F.2    Seger, R.3    Taya, Y.4    Oren, M.5
  • 30
    • 0037031848 scopus 로고    scopus 로고
    • p38 kinase regulates nitric oxide-induced apoptosis of articular chondrocytes by accumulating p53 via NFkappa B-dependent transcription and stabilization by serine 15 phosphorylation
    • Kim SJ, Hwang SG, Shin DY, Kang SS and Chun JS. p38 kinase regulates nitric oxide-induced apoptosis of articular chondrocytes by accumulating p53 via NFkappa B-dependent transcription and stabilization by serine 15 phosphorylation. J Biol Chem. 2002; 277(36):33501-33508.
    • (2002) J Biol Chem , vol.277 , Issue.36 , pp. 33501-33508
    • Kim, S.J.1    Hwang, S.G.2    Shin, D.Y.3    Kang, S.S.4    Chun, J.S.5
  • 31
    • 0037151032 scopus 로고    scopus 로고
    • p38 Mitogen-activated protein kinase mediates hypoxic regulation of Mdm2 and p53 in neurons
    • Zhu Y, Mao XO, Sun Y, Xia Z and Greenberg DA. p38 Mitogen-activated protein kinase mediates hypoxic regulation of Mdm2 and p53 in neurons. J Biol Chem. 2002; 277(25):22909-22914.
    • (2002) J Biol Chem , vol.277 , Issue.25 , pp. 22909-22914
    • Zhu, Y.1    Mao, X.O.2    Sun, Y.3    Xia, Z.4    Greenberg, D.A.5
  • 32
    • 38749087578 scopus 로고    scopus 로고
    • Aldo-keto reductase 1C2 is essential for 1-nitropyrene's but not for benzo[a]pyrene's induction of p53 phosphorylation and apoptosis
    • Su JG, Liao PJ, Huang MC, Chu WC, Lin SC and Chang YJ. Aldo-keto reductase 1C2 is essential for 1-nitropyrene's but not for benzo[a]pyrene's induction of p53 phosphorylation and apoptosis. Toxicology. 2008; 244(2-3):257-270.
    • (2008) Toxicology , vol.244 , Issue.2-3 , pp. 257-270
    • Su, J.G.1    Liao, P.J.2    Huang, M.C.3    Chu, W.C.4    Lin, S.C.5    Chang, Y.J.6
  • 33
    • 0037444791 scopus 로고    scopus 로고
    • Low levels of glutathione peroxidase 1 activity in selenium-deficient mouse liver affect c-Jun N-terminal kinase activation and p53 phosphorylation on Ser-15 in pro-oxidant-induced aponecrosis
    • Cheng WH, Zheng X, Quimby FR, Roneker CA and Lei XG. Low levels of glutathione peroxidase 1 activity in selenium-deficient mouse liver affect c-Jun N-terminal kinase activation and p53 phosphorylation on Ser-15 in pro-oxidant-induced aponecrosis. Biochem J. 2003; 370(Pt 3):927-934.
    • (2003) Biochem J , vol.370 , Issue.PART 3 , pp. 927-934
    • Cheng, W.H.1    Zheng, X.2    Quimby, F.R.3    Roneker, C.A.4    Lei, X.G.5
  • 34
    • 0035931854 scopus 로고    scopus 로고
    • p53 activation in response to microtubule disruption is mediated by integrin-Erk signaling
    • Sablina AA, Chumakov PM, Levine AJ and Kopnin BP. p53 activation in response to microtubule disruption is mediated by integrin-Erk signaling. Oncogene. 2001; 20(8):899-909.
    • (2001) Oncogene , vol.20 , Issue.8 , pp. 899-909
    • Sablina, A.A.1    Chumakov, P.M.2    Levine, A.J.3    Kopnin, B.P.4
  • 35
    • 0035866404 scopus 로고    scopus 로고
    • Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase
    • She QB, Bode AM, Ma WY, Chen NY and Dong Z. Resveratrol-induced activation of p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase. Cancer Res. 2001; 61(4):1604-1610.
    • (2001) Cancer Res , vol.61 , Issue.4 , pp. 1604-1610
    • She, Q.B.1    Bode, A.M.2    Ma, W.Y.3    Chen, N.Y.4    Dong, Z.5
  • 36
    • 84868126155 scopus 로고    scopus 로고
    • Dracorhodin perchlorate inhibits PI3K/Akt and NF-kappaB activation, up-regulates the expression of p53, and enhances apoptosis
    • Rasul A, Ding C, Li X, Khan M, Yi F, Ali M and Ma T. Dracorhodin perchlorate inhibits PI3K/Akt and NF-kappaB activation, up-regulates the expression of p53, and enhances apoptosis. Apoptosis. 2012; 17(10):1104-1119.
    • (2012) Apoptosis , vol.17 , Issue.10 , pp. 1104-1119
    • Rasul, A.1    Ding, C.2    Li, X.3    Khan, M.4    Yi, F.5    Ali, M.6    Ma, T.7
  • 37
    • 84859499770 scopus 로고    scopus 로고
    • Identification of an Akt interaction protein, PHF20/TZP, that transcriptionally regulates p53
    • Park S, Kim D, Dan HC, Chen H, Testa JR and Cheng JQ. Identification of an Akt interaction protein, PHF20/TZP, that transcriptionally regulates p53. J Biol Chem. 2012; 287:11151-11163.
    • (2012) J Biol Chem , vol.287 , pp. 11151-11163
    • Park, S.1    Kim, D.2    Dan, H.C.3    Chen, H.4    Testa, J.R.5    Cheng, J.Q.6
  • 38
    • 84862807650 scopus 로고    scopus 로고
    • The dietary phytochemical 3,3'-diindolylmethane induces G2/M arrest and apoptosis in oral squamous cell carcinoma by modulating Akt-NF-kappaB, MAPK, and p53 signaling
    • Weng JR, Bai LY, Chiu CF, Wang YC and Tsai MH. The dietary phytochemical 3,3'-diindolylmethane induces G2/M arrest and apoptosis in oral squamous cell carcinoma by modulating Akt-NF-kappaB, MAPK, and p53 signaling. Chem Biol Interact. 2012; 195(3):224-230.
    • (2012) Chem Biol Interact , vol.195 , Issue.3 , pp. 224-230
    • Weng, J.R.1    Bai, L.Y.2    Chiu, C.F.3    Wang, Y.C.4    Tsai, M.H.5
  • 39
    • 84859364854 scopus 로고    scopus 로고
    • PP2A mediates diosmin p53 activation to block HA22T cell proliferation and tumor growth in xenografted nude mice through PI3K-Akt-MDM2 signaling suppression
    • Dung TD, Day CH, Binh TV, Lin CH, Hsu HH, Su CC, Lin YM, Tsai FJ, Kuo WW, Chen LM and Huang CY. PP2A mediates diosmin p53 activation to block HA22T cell proliferation and tumor growth in xenografted nude mice through PI3K-Akt-MDM2 signaling suppression. Food Chem Toxicol. 2012; 50(5):1802-1810.
    • (2012) Food Chem Toxicol , vol.50 , Issue.5 , pp. 1802-1810
    • Dung, T.D.1    Day, C.H.2    Binh, T.V.3    Lin, C.H.4    Hsu, H.H.5    Su, C.C.6    Lin, Y.M.7    Tsai, F.J.8    Kuo, W.W.9    Chen, L.M.10    Huang, C.Y.11
  • 41
    • 81955167355 scopus 로고    scopus 로고
    • CYR61 controls p53 and NF-kappaB expression through PI3K/Akt/mTOR pathways in carboplatin-induced ovarian cancer cells
    • Lee KB, Byun HJ, Park SH, Park CY, Lee SH and Rho SB. CYR61 controls p53 and NF-kappaB expression through PI3K/Akt/mTOR pathways in carboplatin-induced ovarian cancer cells. Cancer Lett. 2012; 315(1):86-95.
    • (2012) Cancer Lett , vol.315 , Issue.1 , pp. 86-95
    • Lee, K.B.1    Byun, H.J.2    Park, S.H.3    Park, C.Y.4    Lee, S.H.5    Rho, S.B.6
  • 42
    • 84861914228 scopus 로고    scopus 로고
    • AKT-dependent phosphorylation of Niban regulates nucleophosmin-and MDM2-mediated p53 stability and cell apoptosis
    • Ji H, Ding Z, Hawke D, Xing D, Jiang BH, Mills GB and Lu Z. AKT-dependent phosphorylation of Niban regulates nucleophosmin-and MDM2-mediated p53 stability and cell apoptosis. EMBO Rep. 2012; 13(6):554-560.
    • (2012) EMBO Rep , vol.13 , Issue.6 , pp. 554-560
    • Ji, H.1    Ding, Z.2    Hawke, D.3    Xing, D.4    Jiang, B.H.5    Mills, G.B.6    Lu, Z.7
  • 44
    • 45549104364 scopus 로고    scopus 로고
    • p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK
    • Boehme KA, Kulikov R and Blattner C. p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK. Proc Natl Acad Sci USA. 2008; 105(22):7785-7790.
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.22 , pp. 7785-7790
    • Boehme, K.A.1    Kulikov, R.2    Blattner, C.3
  • 45
    • 84859754266 scopus 로고    scopus 로고
    • AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy
    • Astle MV, Hannan KM, Ng PY, Lee RS, George AJ, Hsu AK, Haupt Y, Hannan RD and Pearson RB. AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy. Oncogene. 2012; 31(15):1949-1962.
    • (2012) Oncogene , vol.31 , Issue.15 , pp. 1949-1962
    • Astle, M.V.1    Hannan, K.M.2    Ng, P.Y.3    Lee, R.S.4    George, A.J.5    Hsu, A.K.6    Haupt, Y.7    Hannan, R.D.8    Pearson, R.B.9
  • 46
    • 79956035239 scopus 로고    scopus 로고
    • Evaluation of an Actinomycin D/VX-680 aurora kinase inhibitor combination in p53-based cyclotherapy
    • Rao B, van Leeuwen IM, Higgins M, Campbel J, Thompson AM, Lane DP and Lain S. Evaluation of an Actinomycin D/VX-680 aurora kinase inhibitor combination in p53-based cyclotherapy. Oncotarget. 2010; 1(7):639-650.
    • (2010) Oncotarget , vol.1 , Issue.7 , pp. 639-650
    • Rao, B.1    van Leeuwen, I.M.2    Higgins, M.3    Campbel, J.4    Thompson, A.M.5    Lane, D.P.6    Lain, S.7
  • 47
    • 84860780032 scopus 로고    scopus 로고
    • An evaluation of small-molecule p53 activators as chemoprotectants ameliorating adverse effects of anticancer drugs in normal cells
    • van Leeuwen IM, Rao B, Sachweh MC and Lain S. An evaluation of small-molecule p53 activators as chemoprotectants ameliorating adverse effects of anticancer drugs in normal cells. Cell Cycle. 2012; 11(9):1851-1861.
    • (2012) Cell Cycle , vol.11 , Issue.9 , pp. 1851-1861
    • van Leeuwen, I.M.1    Rao, B.2    Sachweh, M.C.3    Lain, S.4
  • 48
    • 83455219427 scopus 로고    scopus 로고
    • Fluoranthene enhances p53 expression and decreases mutagenesis induced by benzo[a]pyrene
    • Huang MC, Chen FY, Chou MT and Su JG. Fluoranthene enhances p53 expression and decreases mutagenesis induced by benzo[a]pyrene. Toxicol Lett. 2012; 208(3):214-224.
    • (2012) Toxicol Lett , vol.208 , Issue.3 , pp. 214-224
    • Huang, M.C.1    Chen, F.Y.2    Chou, M.T.3    Su, J.G.4


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