Aqueous extract of Gardenia jasminoides targeting oxidative stress to reduce polyQ aggregation in cell models of spinocerebellar ataxia 3

Neuropharmacology

Volumn 81, Issue , 2014, Pages 166-175

  Chang, Kuo Hsuan ^a   Chen, Wan Ling ^a   Wu, Yih Ru ^a   Lin, Te Hsien ^b   Wu, Yi Ci ^b   Chao, Chih Ying ^a   Lin, Jung Yaw ^b,c   Lee, Li Ching ^b   Chen, Yi Chun ^a   Lee Chen, Guey Jen ^b   Chen, Chiung Mei ^a  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b NATIONAL TAIWAN NORMAL UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

ATXN3; Gardeniajasminoides; NFE2L2; Oxidative stress; Spinocerebellar ataxia

Indexed keywords

CROCIN; GARDENIA JASMINOIDES EXTRACT; GENIPIN; GENIPOSIDE; POLYGLUTAMINE; REACTIVE OXYGEN METABOLITE; 2,2-DIPHENYL-1-PICRYLHYDRAZYL; ANTIOXIDANT; ATXN3 PROTEIN, HUMAN; BIPHENYL DERIVATIVE; CASPASE 3; GREEN FLUORESCENT PROTEIN; JASMINODIOL; NERVE PROTEIN; NFE2L2 PROTEIN, HUMAN; NUCLEAR PROTEIN; PEPTIDE; PICRIC ACID; PLANT EXTRACT; REPRESSOR PROTEIN; TERPENE; TRANSCRIPTION FACTOR NRF2;

ANTI AGGREGATION ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; ATXN3 GENE; CELL DEATH; CELL DIFFERENTIATION; CELL MEMBRANE; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOTOXICITY; DPPH RADICAL SCAVENGING ASSAY; DRUG ACTIVITY; GCLC GENE; GENE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE REPRESSION; GENE SILENCING; GSTP1 GENE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; INHIBITION KINETICS; INTRANUCLEAR SPACE; MTT ASSAY; NFE2L2 GENE; NQO1 GENE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN AGGREGATION; RECEPTOR UPREGULATION; SPINOCEREBELLAR ATAXIA 3; SPINOCEREBELLAR DEGENERATION; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; IC50; METABOLISM; NEUROBLASTOMA; PATHOLOGY; TIME; TUMOR CELL LINE;

ANTIOXIDANTS; BIPHENYL COMPOUNDS; CASPASE 3; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; GREEN FLUORESCENT PROTEINS; HEK293 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MONOTERPENES; NERVE TISSUE PROTEINS; NEUROBLASTOMA; NF-E2-RELATED FACTOR 2; NUCLEAR PROTEINS; OXIDATIVE STRESS; PEPTIDES; PICRATES; PLANT EXTRACTS; REACTIVE OXYGEN SPECIES; REPRESSOR PROTEINS; TIME FACTORS; TRANSFECTION;

EID: 84896891344     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2014.01.032     Document Type: Article

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