Neuro2a cell death induced by 6-hydroxydopamine is attenuated by genipin

Journal of Health Science

Volumn 54, Issue 6, 2008, Pages 638-644

  Yamazaki, Matsumi ^a   Chiba, Kenzo ^a   Satoh, Keiko ^a  

^a HOKURIKU UNIVERSITY   (Japan)

Author keywords

6 hydroxydopamine; Genipin; Hydrogen peroxide; Neuro2a cell; Neuroprotection

Indexed keywords

GENIPIN; HYDROGEN PEROXIDE; OXIDOPAMINE; OXYGEN; QUINONE DERIVATIVE;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL LINE; CELL PROTECTION; CELL VIABILITY; CONCENTRATION RESPONSE; CYTOTOXICITY; DNA FRAGMENTATION; ENZYME METABOLISM; NERVE DEGENERATION; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; POLYMERIZATION; RAT;

RATTUS;

EID: 57349112359     PISSN: 13449702     EISSN: 13475207     Source Type: Journal    
DOI: 10.1248/jhs.54.638     Document Type: Article

References (24)

1. Hardy, J. A. and Higgins, G. A. (1992) Alzheimer's disease: The amyloid cascade hypothesis. Science, 256, 184-185.
2. Giasson, B. I., Duda, J. E., Murray, I. V. J., Chen, Q., Souza, J. M., Hurtig, H. I., Ischiropoulos, H., Trojanowski, J. Q. and Lee, V. M. Y. (2000) Oxidative damage linked to neurodegeneration by selective α-synuclein nitration in synucleinopathy lesions. Science, 290, 985-989.
3. Hensley, K., Carney, J. M., Mattson, M. P., Aksenova, M., Harris, M., Wu, J. F., Floyd, R. A. and Butterfield, D. A. (1994) A model for β-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: Relevance to Alzheimer disease. Proc. Natl. Acad. Sci. U.S.A., 91, 3270-3274.
4. Jenner, P., Dexter D. T., Sian, J., Schapira, A. H. and Marsden, C. D. (1992) Oxidative stress as a cause of nigral cell death in Parkinson's disease and incidental Lewy body disease. Ann. Neurol., 32, S82-S87.
5. Yamazaki, M., Chiba, K., Mohri, T. and Hatanaka, H. (2001) Activation of the mitogen-activated protein kinase cascade through nitric oxide synthesis as a mechanism of neuritogenic effect of genipin in PC12h cells. J. Neurochem., 79, 45-54.
6. Yamazaki, M., Chiba, K., Mohri, T. and Hatanaka, H. (2004) Cyclic GMP-dependent neurite outgrowth by genipin and nerve growth factor in PC12h cells. Eur. J. Pharmacol., 488, 35-43.
7. Yamazaki, M. and Chiba, K. (2006) Expression of functional nitric oxide synthase for neuritogenesis in PC12h cells. J. Health Sci., 52, 769-773.
8. Yamazaki, M. and Chiba, K. (2008) Genipin exhibits neurotrophic effects through a common signaling pathway in nitric oxide synthase-expressing cells. Eur. J. Pharmacol., 581, 255-261.
9. Ohkubo, T., Yamazaki, M., Yoshida, A., Chiba, K. and Mohri, T. (2004) Detection of genipin/ geniposide-target molecules by a geniposide overlay method using anti-geniposide antibody. J. Health Sci., 50, 193-196.
10. Yamazaki, M., Chiba, K. and Mohri, T. (2006) Differences in neuritogenic response to nitric oxide in PC12 and PC12h cells. Neurosci. Lett., 393, 222-225.
11. Suzuki, H., Yamazaki, M., Chiba, K. and Sawanishi, H. (2007) Characteristic properties of genipin as an activator in neuronal nitric oxide synthase. J. Health Sci., 53, 730-733.
12. Yamazaki, M., Sakura, N., Chiba, K. and Mohri, T. (2002) Prevention of the neurotoxicity of the amyloid β protein by genipin. Biol. Pharm. Bull., 24, 1454-1455.
13. Yamazaki, M. and Chiba, K. (2005) Neurotrophic effects of genipin on Neuro2a cells. J. Health Sci., 51, 687-692.
14. Sauer, H. and Oertal, W. H. (1994) Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: a combined retrograde tracing and immunocytochemical study in the rat. Neuroscience, 59, 401-415.
15. Crocker, S. J., Wigle, N., Liston, P., Thompson, C. S., Lee, C. J., Xu, D., Roy, S., Nicholson, D. W., Park, D. S., MacKenzie, A., Korneluk, R. G. and Robertson, G. S. (2001) NAIP protects the nigrostriatal dopamine pathway in an intrastriatal 6-OHDA rat model of Parkinson's disease. Eur. J. Neurosci., 14, 391-400.
16. Soto-Otero, R., Méndez-Álvarez, E., Hermida-Ameijeiras, Á., Muňoz-Patiňo, A. M. and Labandeira-Garcia, J. L. (2000) Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants: Potential implication in relation to the pathogenesis of Parkinson's disease. J. Neurochem., 74, 1605-1612.
17. Irwin, I. and Langston, J. W. (1995) Endogenous toxins as potential etiologic agents in Parkinson's disease. In Etiology of Parkinson's Disease (Ellenberg, J. H., Koller, W. C. and Langston, J. W., Eds.), Marcel Dekker, New York, pp. 153-201.
18. Jellinger, K., Linert, L., Kienzl, E., Herlinger, E. and Youdim, M. B. H. (1995) Chemical evidence for 6-hydroxydopamine to be an endogenous toxic factor in the pathogenesis of Parkinson's disease. J. Neural Transm., 46, 297-314.
19. Saner, A. and Thoenen, H. (1971) Model experiments on the molecular mechanism of action of 6-hydroxydopamine. Mol. Pharmacol., 7, 147-154.
20. Jonsson, G. and Sachs, C. (1970) Effects of 6-hydroxydopamine on the uptake and storage of noradrenaline in sympathetic adrenergic neurons. Eur. J. Pharmacol., 9, 141-155.
21. Sampaio-Maia, B. and Soares-da-Silva, P. (2000) Ca2+/calmodulin mediated pathways regulate the uptake of L-DOPA in mouse neuroblastoma neuro 2A cells. Life Sci., 67, 3209-3220.
22. Yamamoto, M., Miura, M., Ohtake, N., Amagaya, S., Ishige, A., Sasaki, H., Komatsu, Y., Fukuda, K., Ito, T. and Terasawa, K. (2000) Genipin, a metabolite derived from the herbal medicine Inchin-ko-to, and suppression of Fas-induced lethal liver apoptosis in mice. Gastroenterology, 118, 380-389.
23. Ha, K. S., Kim, K. S., Kwon, Y. G., Bai, S. K., Nam, W. D., Yoo, Y. M., Kim, P. K. M., Chung, H. T., Billiar, T. R. and Kim, Y. M. (2003) Nitric oxide prevents 6-hydroxydopamine-induced apoptosis in PC12 cells through cGMP-dependent PI3 kinase/ Akt activation. FASEB J., 17, 1036-1047.
24. Moon, M. K., Choi, B. M., Oh, G. S., Pae, H. O., Kim, J. D., Oh, H., Oh, C. S., Kim, D. H., Rho, Y. D., Shin, M. K., Lee, H. S. and Chung, H. T. (2003) Catalposide protects Neuro2A cells from hydrogen peroxide-induced cytotoxicity via the expression of heme oxygenase-1. Toxicol. Lett., 145, 46-54.