-
1
-
-
34547692622
-
Trinucleotide repeat disorders
-
Orr, H.T. and Zoghbi, H.Y. (2007) Trinucleotide repeat disorders. Annu. Rev. Neurosci., 30, 575-621.
-
(2007)
Annu. Rev. Neurosci.
, vol.30
, pp. 575-621
-
-
Orr, H.T.1
Zoghbi, H.Y.2
-
2
-
-
0033818112
-
Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription
-
Shimohata, T., Nakajima, T., Yamada, M., Uchida, C., Onodera, O., Naruse, S., Kimura, T., Koide, R., Nozaki, K., Sano, Y. et al. (2000) Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription. Nat. Genet., 26, 29-36.
-
(2000)
Nat. Genet.
, vol.26
, pp. 29-36
-
-
Shimohata, T.1
Nakajima, T.2
Yamada, M.3
Uchida, C.4
Onodera, O.5
Naruse, S.6
Kimura, T.7
Koide, R.8
Nozaki, K.9
Sano, Y.10
-
3
-
-
0035060505
-
Recruitment of nonexpanded polyglutamine proteins to intranuclear aggregates in neuronal intranuclear hyaline inclusion disease
-
Takahashi, J., Tanaka, J., Arai, K., Funata, N., Hattori, T., Fukuda, T., Fujigasaki, H. and Uchihara, T. (2001) Recruitment of nonexpanded polyglutamine proteins to intranuclear aggregates in neuronal intranuclear hyaline inclusion disease. J. Neuropathol. Exp. Neurol., 60, 369-376.
-
(2001)
J. Neuropathol. Exp. Neurol.
, vol.60
, pp. 369-376
-
-
Takahashi, J.1
Tanaka, J.2
Arai, K.3
Funata, N.4
Hattori, T.5
Fukuda, T.6
Fujigasaki, H.7
Uchihara, T.8
-
4
-
-
0034285017
-
CREB-binding protein sequestration by expanded polyglutamine
-
McCampbell, A., Taylor, J.P., Taye, A.A., Robitschek, J., Li, M., Walcott, J., Merry, D., Chai, Y., Paulson, H., Sobue, G. et al.. (2000) CREB-binding protein sequestration by expanded polyglutamine. Hum. Mol. Genet., 9, 2197-2202.
-
(2000)
Hum. Mol. Genet.
, vol.9
, pp. 2197-2202
-
-
McCampbell, A.1
Taylor, J.P.2
Taye, A.A.3
Robitschek, J.4
Li, M.5
Walcott, J.6
Merry, D.7
Chai, Y.8
Paulson, H.9
Sobue, G.10
-
5
-
-
0037047123
-
Live-cell imaging reveals divergent intracellular dynamics of polyglutamine disease proteins and supports a sequestration model of pathogenesis
-
Chai, Y., Shao, J., Miller, V.M., Williams, A. and Paulson, H.L. (2002) Live-cell imaging reveals divergent intracellular dynamics of polyglutamine disease proteins and supports a sequestration model of pathogenesis. Proc. Natl Acad. Sci. USA, 99, 9310-9315.
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 9310-9315
-
-
Chai, Y.1
Shao, J.2
Miller, V.M.3
Williams, A.4
Paulson, H.L.5
-
6
-
-
0033867992
-
Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B
-
Wang, G., Sawai, N., Kotliarova, S., Kanazawa, I. and Nukina, N. (2000) Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B. Hum. Mol. Genet., 9, 1795-1803.
-
(2000)
Hum. Mol. Genet.
, vol.9
, pp. 1795-1803
-
-
Wang, G.1
Sawai, N.2
Kotliarova, S.3
Kanazawa, I.4
Nukina, N.5
-
7
-
-
15444372240
-
The polyglutamine neurodegenerative protein ataxin 3 regulates aggresome formation
-
Burnett, B.G. and Pittman, R.N. (2005) The polyglutamine neurodegenerative protein ataxin 3 regulates aggresome formation. Proc. Natl Acad. Sci. SA, 102, 4330-4335.
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 4330-4335
-
-
Burnett, B.G.1
Pittman, R.N.2
-
8
-
-
33750962224
-
Ataxin-3 represses transcription via chromatin binding, interaction with histone deacetylase 3, and histone deacetylation
-
Evert, B.O., Araujo, J., Vieira-Saecker, A.M., de Vos, R.A., Harendza, S., Klockgether, T. and Wüllner, U. (2006) Ataxin-3 represses transcription via chromatin binding, interaction with histone deacetylase 3, and histone deacetylation. J. Neurosci., 26, 11474-11486.
-
(2006)
J. Neurosci.
, vol.26
, pp. 11474-11486
-
-
Evert, B.O.1
Araujo, J.2
Vieira-Saecker, A.M.3
de Vos, R.A.4
Harendza, S.5
Klockgether, T.6
Wüllner, U.7
-
9
-
-
0035425649
-
Inflammatory genes are upregulated in expanded ataxin-3-expressing cell lines and spinocerebellar ataxia type 3 brains
-
Evert, B.O., Vogt, I.R., Kindermann, C., Ozimek, L., de Vos, R.A., Brunt, E.R., Schmitt, I., Klockgether, T. and Wüllner, U. (2001) Inflammatory genes are upregulated in expanded ataxin-3-expressing cell lines and spinocerebellar ataxia type 3 brains. J. Neurosci., 21, 5389-5396.
-
(2001)
J. Neurosci.
, vol.21
, pp. 5389-5396
-
-
Evert, B.O.1
Vogt, I.R.2
Kindermann, C.3
Ozimek, L.4
de Vos, R.A.5
Brunt, E.R.6
Schmitt, I.7
Klockgether, T.8
Wüllner, U.9
-
10
-
-
0141891166
-
L., de Vos, R.A., Brunt, E.R., Klock-gether, T. and Wüllner, U
-
Evert, B.O., Vogt, I.R., Vieira-Saecker, A.M., Ozimek, L., de Vos, R.A., Brunt, E.R., Klock-gether, T. and Wüllner, U. (2003) Gene expression profiling in ataxin-3 expressing cell lines reveals distinct effects of normal and mutant ataxin-3. J. Neuropathol. Exp. Neurol., 62, 1006-1018.
-
(2003)
J. Neuropathol. Exp. Neurol.
, vol.62
, pp. 1006-1018
-
-
Evert, B.O.1
Vogt, I.R.2
Vieira-Saecker, A.M.3
Ozimek4
-
11
-
-
45049085458
-
Poly-glutamine-expanded ataxin-3 causes cerebellar dysfunction of SCA3 transgenic mice by inducing transcriptional dysregulation
-
Chou, A.H., Yeh, T.H., Ouyang, P., Chen, Y.L., Chen, S.Y. and Wang, H.L. (2008) Poly-glutamine-expanded ataxin-3 causes cerebellar dysfunction of SCA3 transgenic mice by inducing transcriptional dysregulation. Neurobiol. Dis., 31, 89-101.
-
(2008)
Neurobiol. Dis.
, vol.31
, pp. 89-101
-
-
Chou, A.H.1
Yeh, T.H.2
Ouyang, P.3
Chen, Y.L.4
Chen, S.Y.5
Wang, H.L.6
-
12
-
-
0037160106
-
Ataxin-3 is a histone-binding protein with two independent transcriptional corepressor activities
-
Li, F., Macfarlan, T., Pittman, R.N. and Chakravarti, D. (2002) Ataxin-3 is a histone-binding protein with two independent transcriptional corepressor ctivities. J. Biol. Chem., 277, 45004-45012.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 45004-45012
-
-
Li, F.1
Macfarlan, T.2
Pittman, R.N.3
Chakravarti, D.4
-
13
-
-
68749103450
-
CK2-dependent phosphorylation determines cellular localization and stability of ataxin-3
-
Mueller, T., Breuer, P., Schmitt, I., Walter, J., Evert, B.O. and Wüllner, U. (2009) CK2-dependent phosphorylation determines cellular localization and stability of ataxin-3. Hum. Mol. Genet., 18, 3334-3343.
-
(2009)
Hum. Mol. Genet.
, vol.18
, pp. 3334-3343
-
-
Mueller, T.1
Breuer, P.2
Schmitt, I.3
Walter, J.4
Evert, B.O.5
Wüllner, U.6
-
14
-
-
77949450752
-
Proteotoxic stress increases nuclear localization of ataxin-3
-
Reina, C.P., Zhong, X. and Pittman, R.N. (2010) Proteotoxic stress increases nuclear localization of ataxin-3. Hum. Mol. Genet., 19, 235-249.
-
(2010)
Hum. Mol. Genet.
, vol.19
, pp. 235-249
-
-
Reina, C.P.1
Zhong, X.2
Pittman, R.N.3
-
15
-
-
2942726155
-
The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation
-
Van der Heide, L.P., Hoekman, M.F. and Smidt, M.P. (2004) The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation. Biochem. J., 380, 297-309.
-
(2004)
Biochem. J.
, vol.380
, pp. 297-309
-
-
Van der Heide, L.P.1
Hoekman, M.F.2
Smidt, M.P.3
-
16
-
-
34249281690
-
Stressing the role of FoxO proteins in lifespan and disease
-
Van der Horst, A. and Burgering, B.M. (2007) Stressing the role of FoxO proteins in lifespan and disease. Nat. Rev. Mol. Cell Biol., 8, 440-450.
-
(2007)
Nat. Rev. Mol. Cell Biol.
, vol.8
, pp. 440-450
-
-
Van der Horst, A.1
Burgering, B.M.2
-
17
-
-
0345436080
-
High level expression of expanded full-length ataxin-3 in vitro causes cell death and formation of intranuclear inclusions in neuronal cells
-
Evert, B.O., Wüllner, U., Schulz, J.B., Weller, M., Groscurth, P., Trottier, Y., Brice, A. and Klockgether, T. (1999) High level expression of expanded full-length ataxin-3 in vitro causes cell death and formation of intranuclear inclusions in neuronal cells. Hum. Mol. Genet., 8, 1169-1176.
-
(1999)
Hum. Mol. Genet.
, vol.8
, pp. 1169-1176
-
-
Evert, B.O.1
Wüllner, U.2
Schulz, J.B.3
Weller, M.4
Groscurth, P.5
Trottier, Y.6
Brice, A.7
Klockgether, T.8
-
18
-
-
33749188883
-
FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP
-
Van der Horst, A., de Vries-Smits, A.M., Brenkman, A.B., van Triest, M.H., van den Broek, N., Colland, F., Maurice, M.M. and Burgering, B.M. (2006) FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP. Nat. Cell Biol., 8, 1064-1073.
-
(2006)
Nat. Cell Biol.
, vol.8
, pp. 1064-1073
-
-
Van der Horst, A.1
de Vries-Smits, A.M.2
Brenkman, A.B.3
van Triest, M.H.4
van den Broek, N.5
Colland, F.6
Maurice, M.M.7
Burgering, B.M.8
-
19
-
-
49849100725
-
Mdm2 induces mono-ubiquitination of FOXO4
-
Brenkman, A.B., de Keizer, P.L., van den Broek, N.J., Jochemsen, A.G. and Burgering, B.M. (2008) Mdm2 induces mono-ubiquitination of FOXO4. LoS ONE, 3, e2819.
-
(2008)
PLoS ONE
, vol.3
-
-
Brenkman, A.B.1
de Keizer, P.L.2
van den Broek, N.J.3
Jochemsen, A.G.4
Burgering, B.M.5
-
20
-
-
13444252337
-
Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation
-
Huang, H., Regan, K.M., Wang, F., Wang, D., Smith, D.I., van Deursen, J.M. and Tindall, D.J. (2005) Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation. Proc. Natl Acad. Sci. USA, 102, 1649-1654.
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 1649-1654
-
-
Huang, H.1
Regan, K.M.2
Wang, F.3
Wang, D.4
Smith, D.I.5
van Deursen, J.M.6
Tindall, D.J.7
-
21
-
-
0141706357
-
Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation
-
Matsuzaki, H., Daitoku, H., Hatta, M., Tanaka, K. and Fukamizu, A. (2003) Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradation. Proc. Natl Acad. Sci. USA, 100, 11285-11290.
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 11285-11290
-
-
Matsuzaki, H.1
Daitoku, H.2
Hatta, M.3
Tanaka, K.4
Fukamizu, A.5
-
22
-
-
0345099501
-
The polyglutamine neurodegenerative protein ataxin-3 binds polyubiquitylated proteins and has ubiquitin protease activity
-
Burnett, B., Li, F. and Pittman, R.N. (2003) The polyglutamine neurodegenerative protein ataxin-3 binds polyubiquitylated proteins and has ubiquitin rotease activity. Hum. Mol. Genet., 12, 3195-3205.
-
(2003)
Hum. Mol. Genet.
, vol.12
, pp. 3195-3205
-
-
Burnett, B.1
Li, F.2
Pittman, R.N.3
-
23
-
-
0942287194
-
Poly-ubiquitin binding by the polyglutamine disease protein ataxin-3 links its normal function to protein surveillance pathways
-
Chai, Y., Berke, S.S., Cohen, R.E. and Paulson, H.L. (2004) Poly-ubiquitin binding by the polyglutamine disease protein ataxin-3 links its normal function to protein surveillance pathways. J. Biol. Chem., 279, 3605-3611.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 3605-3611
-
-
Chai, Y.1
Berke, S.S.2
Cohen, R.E.3
Paulson, H.L.4
-
24
-
-
55549086868
-
The deubiquitinating enzyme ataxin-3, a polyglutamine disease protein, edits Lys63 linkages in mixed linkage ubiquitin chains
-
Winborn, B.J., Travis, S.M., Todi, S.V., Scaglione, K.M., Xu, P., Williams, A.J., Cohen, R.E., Peng, J. and Paulson, H.L. (2008) The deubiquitinating enzyme ataxin-3, a polyglutamine disease protein, edits Lys63 linkages in mixed linkage ubiquitin chains. J. Biol. Chem., 283, 26436-26443.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 26436-26443
-
-
Winborn, B.J.1
Travis, S.M.2
Todi, S.V.3
Scaglione, K.M.4
Xu, P.5
Williams, A.J.6
Cohen, R.E.7
Peng, J.8
Paulson, H.L.9
-
25
-
-
11244320393
-
FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK
-
Essers, M.A., Weijzen, S., de Vries-Smits, A.M., Saarloos, I., de Ruiter, N.D., Bos, J.L. and Burgering, B.M. (2004) FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK. EMBO J., 23, 4802-4812.
-
(2004)
EMBO J.
, vol.23
, pp. 4802-4812
-
-
Essers, M.A.1
Weijzen, S.2
de Vries-Smits, A.M.3
Saarloos, I.4
de Ruiter, N.D.5
Bos, J.L.6
Burgering, B.M.7
-
26
-
-
0037136563
-
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
-
Kops, G.J., Dansen, T.B., Polderman, P.E., Saarloos, I., Wirtz, K.W., Coffer, P.J., Huang, T.T., Bos, J.L., Medema, R.H. and Burgering, B.M. (2002) Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature, 419, 316-321.
-
(2002)
Nature
, vol.419
, pp. 316-321
-
-
Kops, G.J.1
Dansen, T.B.2
Polderman, P.E.3
Saarloos, I.4
Wirtz, K.W.5
Coffer, P.J.6
Huang, T.T.7
Bos, J.L.8
Medema, R.H.9
Burgering, B.M.10
-
27
-
-
0037192473
-
Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway
-
Nemoto, S. and Finkel, T. (2002) Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway. Science, 295, 2450-2452.
-
(2002)
Science
, vol.295
, pp. 2450-2452
-
-
Nemoto, S.1
Finkel, T.2
-
28
-
-
18844382368
-
Functional interaction between beta-catenin and FOXO in oxidative stress signaling
-
Essers, M.A., de Vries-Smits, L.M., Barker, N., Polderman, P.E., Burgering, B.M. and Kors-wagen, H.C. (2005) Functional interaction between beta-catenin and FOXO in oxidative stress signaling. Science, 308, 1181-1184.
-
(2005)
Science
, vol.308
, pp. 1181-1184
-
-
Essers, M.A.1
de Vries-Smits, L.M.2
Barker, N.3
Polderman, P.E.4
Burgering, B.M.5
Kors-wagen, H.C.6
-
29
-
-
67749122517
-
14-3-3 protein masks the DNA binding interface of forkhead transcription factor FOXO4
-
Silhan, J., Vacha, P., Strnadova, P., Vecer, J., Herman, P., Sulc, M., Teisinger, J., Obsilova, V. and Obsil, T. (2009) 14-3-3 protein masks the DNA binding interface of forkhead transcription factor FOXO4. J. Biol. Chem., 284, 19349-19360.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 19349-19360
-
-
Silhan, J.1
Vacha, P.2
Strnadova, P.3
Vecer, J.4
Herman, P.5
Sulc, M.6
Teisinger, J.7
Obsilova, V.8
Obsil, T.9
-
30
-
-
0036499459
-
Transcriptional regulation of the human manganese superoxide dismutase gene: the role of specificity protein 1 (Sp1) and activating protein-2 (AP-2)
-
Xu, Y., Porntadavity, S. and St Clair, D.K. (2002) Transcriptional regulation of the human manganese superoxide dismutase gene: the role of specificity protein 1 (Sp1) and activating protein-2 (AP-2). Biochem. J., 362, 401-412.
-
(2002)
Biochem. J.
, vol.362
, pp. 401-412
-
-
Xu, Y.1
Porntadavity, S.2
St Clair, D.K.3
-
31
-
-
25444442080
-
Triple layer control: phosphorylation, acetylation and ubiquitination of FOXO proteins
-
Vogt, P.K., Jiang, H. and Aoki, M. (2005) Triple layer control: phosphorylation, acetylation and ubiquitination of FOXO proteins. Cell Cycle, 4, 908-13.
-
(2005)
Cell Cycle
, vol.4
, pp. 908-913
-
-
Vogt, P.K.1
Jiang, H.2
Aoki, M.3
-
32
-
-
0029838063
-
Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice
-
Lebovitz, R.M., Zhang, H., Vogel, H., Cartwright, J. Jr, Dionne, L., Lu, N., Huang, S. and Matzuk, M.M. (1996) Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice. Proc. Natl Acad. Sci. USA, 93, 9782-9787.
-
(1996)
Proc. Natl Acad. Sci. USA
, vol.93
, pp. 9782-9787
-
-
Lebovitz, R.M.1
Zhang, H.2
Vogel, H.3
Cartwright Jr., J.4
Dionne, L.5
Lu, N.6
Huang, S.7
Matzuk, M.M.8
-
33
-
-
0032561328
-
Increased oxidative damage is correlated to altered mitochondrial function in heterozygous manganese superoxide dismutase knockout mice
-
Williams, M.D., Van Remmen, H., Conrad, C.C., Huang, T.T., Epstein, C.J. and Richardson, A. (1998) Increased oxidative damage is correlated to altered mitochondrial function in heterozygous manganese superoxide dismutase knockout mice. J. Biol. Chem., 273, 28510-28515.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 28510-28515
-
-
Williams, M.D.1
Van Remmen, H.2
Conrad, C.C.3
Huang, T.T.4
Epstein, C.J.5
Richardson, A.6
-
34
-
-
0034838078
-
Knockout mice heterozygous for Sod2 show alterations in cardiac mitochondrial function and apoptosis
-
Van Remmen, H., Williams, M.D., Guo, Z., Estlack, L., Yang, H., Carlson, E.J., Epstein, C.J., Huang, T.T. and Richardson, A. (2001) Knockout mice heterozygous for Sod2 show alterations in cardiac mitochondrial function and apoptosis. Am. J. Physiol. Heart Circ. Physiol., 281, H1422-H1432.
-
(2001)
Am. J. Physiol. Heart Circ. Physiol.
, vol.281
-
-
Van Remmen, H.1
Williams, M.D.2
Guo, Z.3
Estlack, L.4
Yang, H.5
Carlson, E.J.6
Epstein, C.J.7
Huang, T.T.8
Richardson, A.9
-
35
-
-
12144288373
-
Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging
-
Van Remmen, H., Ikeno, Y., Hamilton, M., Pahlavani, M., Wolf, N., Thorpe, S.R., Alderson, N.L., Baynes, J.W., Epstein, C.J., Huang, T.T. et al.. (2003) Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiol. enomics, 16, 29-37.
-
(2003)
Physiol. Genomics
, vol.16
, pp. 29-37
-
-
Van Remmen, H.1
Ikeno, Y.2
Hamilton, M.3
Pahlavani, M.4
Wolf, N.5
Thorpe, S.R.6
Alderson, N.L.7
Baynes, J.W.8
Epstein, C.J.9
Huang, T.T.10
-
36
-
-
21044450045
-
Heterozygous deficiency of manganese superoxide dismutase results in severe lipid peroxidation and spontaneous apoptosis in murine myocardium in vivo
-
Strassburger, M., Bloch, W., Sulyok, S., Schüller, J., Keist, A.F., Schmidt, A., Wenk, J., Peters, T., Wlaschek, M., Lenart, J. et al. (2005) Heterozygous deficiency of manganese superoxide dismutase results in severe lipid peroxidation and spontaneous apoptosis in murine myocardium in vivo. Free adic. Biol. Med., 38, 1458-1470.
-
(2005)
Free Radic. Biol. Med.
, vol.38
, pp. 1458-1470
-
-
Strassburger, M.1
Bloch, W.2
Sulyok, S.3
Schüller, J.4
Keist, A.F.5
Schmidt, A.6
Wenk, J.7
Peters, T.8
Wlaschek, M.9
Lenart, J.10
-
37
-
-
0030894162
-
Oxidative stress: oxidants and antioxidants
-
Sies, H. (1997) Oxidative stress: oxidants and antioxidants. Exp. Physiol., 82, 291-295.
-
(1997)
Exp. Physiol.
, vol.82
, pp. 291-295
-
-
Sies, H.1
-
38
-
-
57649171133
-
Evidence of oxidant damage in Hunting-ton's disease: translational strategies using antioxidants
-
Stack, E.C., Matson, W.R. and Ferrante, R.J. (2008) Evidence of oxidant damage in Hunting-ton's disease: translational strategies using antioxidants. nn. N. Y. Acad. Sci., 1147, 79-92.
-
(2008)
Ann. N. Y. Acad. Sci.
, vol.1147
, pp. 79-92
-
-
Stack, E.C.1
Matson, W.R.2
Ferrante, R.J.3
-
39
-
-
67649366086
-
FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases
-
Mojsilovic-Petrovic, J., Nedelsky, N., Boccitto, M., Mano, I., Georgiades, S.N., Zhou, W., Liu, Y., Neve, R.L., Taylor, J.P., Driscoll, M. et al. (2009) FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases. J. Neurosci., 29, 8236-8247.
-
(2009)
J. Neurosci.
, vol.29
, pp. 8236-8247
-
-
Mojsilovic-Petrovic, J.1
Nedelsky, N.2
Boccitto, M.3
Mano, I.4
Georgiades, S.N.5
Zhou, W.6
Liu, Y.7
Neve, R.L.8
Taylor, J.P.9
Driscoll, M.10
-
40
-
-
0037150524
-
Neurodegeneration. A glutamine-rich trail leads to transcription factors
-
Freiman, R.N. and Tjian, R. (2002) Neurodegeneration. A glutamine-rich trail leads to transcription factors. Science, 296, 2149-2150.
-
(2002)
Science
, vol.296
, pp. 2149-2150
-
-
Freiman, R.N.1
Tjian, R.2
-
41
-
-
0037150687
-
Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease
-
Dunah, A.W., Jeong, H., Griffin, A., Kim, Y.M., Standaert, D.G., Hersch, S.M., Mouradian, M.M., Young, A.B., Tanese, N. and Krainc, D. (2002) Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease. Science, 296, 2238-2243.
-
(2002)
Science
, vol.296
, pp. 2238-2243
-
-
Dunah, A.W.1
Jeong, H.2
Griffin, A.3
Kim, Y.M.4
Standaert, D.G.5
Hersch, S.M.6
Mouradian, M.M.7
Young, A.B.8
Tanese, N.9
Krainc, D.10
-
42
-
-
29244462838
-
In vitro analysis of huntingtin-mediated transcriptional repression reveals multiple transcription factor targets
-
Zhai, W., Jeong, H., Cui, L., Krainc, D. and Tjian, R. (2005) In vitro analysis of huntingtin-mediated transcriptional repression reveals multiple ranscription factor targets. Cell, 123, 1241-1253.
-
(2005)
Cell
, vol.123
, pp. 1241-1253
-
-
Zhai, W.1
Jeong, H.2
Cui, L.3
Krainc, D.4
Tjian, R.5
-
43
-
-
34548410374
-
Inactivation of the mouse Atxn3 (ataxin-3) gene increases protein ubiquitination
-
Schmitt, I., Linden, M., Khazneh, H., Evert, B.O., Breuer, P., Klockgether, T. and Wuellner, U. (2007) Inactivation of the mouse Atxn3 (ataxin-3) gene increases protein ubiquitination. Biochem. Biophys. Res. Commun., 362, 734-739.
-
(2007)
Biochem. Biophys. Res. Commun.
, vol.362
, pp. 734-739
-
-
Schmitt, I.1
Linden, M.2
Khazneh, H.3
Evert, B.O.4
Breuer, P.5
Klockgether, T.6
Wuellner, U.7
-
44
-
-
77955290123
-
Silencing ataxin-3 mitigates degeneration in a rat model of Machado-Joseph disease: no role for wild-type ataxin-3?
-
Alves, S., Nascimento-Ferreira, I., Dufour, N., Hassig, R., Auregan, G., Nóbrega, C., Brouillet, E., Hantraye, P., Pedroso de Lima, M.C., Déglon, N. et al. (2010) Silencing ataxin-3 mitigates degeneration in a rat model of Machado-Joseph disease: no role for wild-type ataxin-3? Hum. Mol. Genet., 19, 2380-394.
-
(2010)
Hum. Mol. Genet.
, vol.19
, pp. 2380-2394
-
-
Alves, S.1
Nascimento-Ferreira, I.2
Dufour, N.3
Hassig, R.4
Auregan, G.5
Nóbrega, C.6
Brouillet, E.7
Hantraye, P.8
Pedroso de Lima, M.C.9
Déglon, N.10
-
45
-
-
33947637692
-
Functional genomics and biochemical characterization of the C. elegans orthologue of the Machado-Joseph disease protein ataxin-3
-
Rodrigues, A.J., Coppola, G., Santos, C., Costa, Mdo, C., Ailion, M., Sequeiros, J., Geschwind, D.H. and Maciel, P. (2007) Functional genomics and biochemical characterization of the C. elegans orthologue of the Machado-Joseph disease protein ataxin-3. FASEB J., 21, 1126-1136.
-
(2007)
FASEB J.
, vol.21
, pp. 1126-1136
-
-
Rodrigues, A.J.1
Coppola, G.2
Santos, C.3
Costa4
Mdo, C.5
Ailion, M.6
Sequeiros, J.7
Geschwind, D.H.8
Maciel, P.9
-
46
-
-
79952280797
-
The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis
-
Kuhlbrodt, K., Janiesch, P.C., Kevei, E., Segref, A., Barikbin, R. and Hoppe, T. (2011) The Machado-Joseph disease deubiquitylase ATX-3 couples ongevity and proteostasis. Nat. Cell Biol., 13, 273-281.
-
(2011)
Nat. Cell Biol.
, vol.13
, pp. 273-281
-
-
Kuhlbrodt, K.1
Janiesch, P.C.2
Kevei, E.3
Segref, A.4
Barikbin, R.5
Hoppe, T.6
-
47
-
-
0038701745
-
Regulation of aging and age-related disease by DAF-16 and heat-shock factor
-
Hsu, A.L., Murphy, C.T. and Kenyon, C. (2003) Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science, 300, 1142-145.
-
(2003)
Science
, vol.300
, pp. 1142-1145
-
-
Hsu, A.L.1
Murphy, C.T.2
Kenyon, C.3
-
48
-
-
0022553788
-
A routine method for the establishment of permanent growing lympho-blastoid cell lines
-
Neitzel, H. (1986) A routine method for the establishment of permanent growing lympho-blastoid cell lines. Hum. Genet., 73, 320-326.
-
(1986)
Hum. Genet.
, vol.73
, pp. 320-326
-
-
Neitzel, H.1
-
49
-
-
32144436256
-
Proteolytic cleavage of polyglutamine-expanded ataxin-3 is critical for aggregation and sequestration of non-expanded ataxin-3
-
Haacke, A., Broadley, S.A., Boteva, R., Tzvetkov, N., Hartl, F.U. and Breuer, P. (2006) Proteolytic cleavage of polyglutamine-expanded ataxin-3 is critical for aggregation and sequestration of non-expanded ataxin-3. Hum. Mol. Genet., 15, 555-568.
-
(2006)
Hum. Mol. Genet.
, vol.15
, pp. 555-568
-
-
Haacke, A.1
Broadley, S.A.2
Boteva, R.3
Tzvetkov, N.4
Hartl, F.U.5
Breuer, P.6
-
51
-
-
31944447039
-
Stable knock-down of CFTR establishes a role for the channel in P2Y receptor-stimulated anion secretion
-
Palmer, M.L., Lee, S.Y., Carlson, D., Fahrenkrug, S. and O'Grady, S.M. (2006) Stable knock-down of CFTR establishes a role for the channel in P2Y receptor-stimulated anion secretion. J. Cell Physiol., 206, 759-770.
-
(2006)
J. Cell Physiol.
, vol.206
, pp. 759-770
-
-
Palmer, M.L.1
Lee, S.Y.2
Carlson, D.3
Fahrenkrug, S.4
O'Grady, S.M.5
-
52
-
-
33645735557
-
An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis
-
Boeddrich, A., Gaumer, S., Haacke, A., Tzvetkov, N., Albrecht, M., Evert, B.O., Müller, E.C., Lurz, R., Breuer, P., Schugardt, N. et al.. (2006) An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis. EMBO J., 25, 1547-1558.
-
(2006)
EMBO J
, vol.25
, pp. 1547-1558
-
-
Boeddrich, A.1
Gaumer, S.2
Haacke, A.3
Tzvetkov, N.4
Albrecht, M.5
Evert, B.O.6
Müller, E.C.7
Lurz, R.8
Breuer, P.9
Schugardt, N.10
|