Microgels on-demand

Nature Communications

Volumn 5, Issue , 2014, Pages

  Eydelnant, Irwin A ^a,b   Betty Li, Bingyu ^a,b   Wheeler, Aaron R ^a,b,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

REAGENT; HYDROGEL;

GEL; GEOMETRY; RHEOLOGY; THREE-DIMENSIONAL MODELING;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CROSS LINKING; EPITHELIZATION; FLOW KINETICS; GEL; GEOMETRY; HYDROGEL; MICROGEL; NONHUMAN; PH; SCANNING ELECTRON MICROSCOPY; SELF CONCEPT; TEMPERATURE;

HYDROGEL;

EID: 84896864058     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms4355     Document Type: Article

References (57)

1. Khademhosseini, A., Langer, R., Borenstein, J. & Vacanti, J. P. Microscale technologies for tissue engineering and biology. Proc. Natl Acad. Sci. USA 103, 2480-2487 (2006).
2. He, X. et al. Synthetic homeostatic materials with chemo-mechano-chemical self-regulation. Nature 487, 214-218 (2012).
3. Harris, G. A., Nicklay, J. J. & Caprioli, R. M. Localized in situ hydrogelmediated protein digestion and extraction technique for on-tissue analysis. Anal. Chem. 85, 2717-2723 (2013).
4. Finkel, N. H., Lou, X., Wang, C. & He, L. Barcoding the microworld. Anal. Chem. 76, 352A-359A (2004).
5. Lu, Y., Yin, Y. & Xia, Y. Three-dimensional photonic crystals with nonspherical colloids as building blocks. Adv. Mater. 13, 415-420 (2001). (Pubitemid 32327252)
6. Balagaddé, F. K., You, L., Hansen, C. L., Arnold, F. H. & Quake, S. R. Longterm monitoring of bacteria undergoing programmed population control in a microchemostat. Science 309, 137-140 (2005). (Pubitemid 40934993)
7. Liu, T. et al. A microfluidic device for characterizing the invasion of cancer cells in 3-D matrix. Electrophoresis 30, 4285-4291 (2009).
8. Eddington, D. T. & Beebe, D. J. Flow control with hydrogels. Adv. Drug Deliv. Rev. 56, 199-210 (2004). (Pubitemid 38114931)
9. Agresti, J. J. et al. Ultrahigh-throughput screening in drop-based microfluidics for directed evolution. Proc. Natl Acad. Sci. 107, 4004-4009 (2010).
10. Leung, K. et al. A programmable droplet-based microfluidic device applied to multiparameter analysis of single microbes and microbial communities. Proc. Natl Acad. Sci. USA 109, 7665-7670 (2012).
11. Tan, W.-H. & Takeuchi, S. Monodisperse alginate hydrogel microbeads for cell encapsulation. Adv. Mater. 19, 2696-2701 (2007). (Pubitemid 47481838)
12. Tumarkin, E. et al. High-throughput combinatorial cell co-culture using microfluidics. Integr. Biol. (Camb.) 3, 653-662 (2011).
13. Edd, J. F. et al. Controlled encapsulation of single-cells into monodisperse picolitre drops. Lab. Chip. 8, 1262-1264 (2008).
14. An, H. Z., Helgeson, M. E. & Doyle, P. S. Nanoemulsion composite microgels for orthogonal encapsulation and release. Adv. Mater. 24, 3838-3844 (2012).
15. Dendukuri, D., Pregibon, D. C., Collins, J., Hatton, T. A. & Doyle, P. S. Continuous-flow lithography for high-throughput microparticle synthesis. Nat. Mater. 5, 365-369 (2006).
16. Kloxin, A. M. et al. Responsive culture platform to examine the influence of microenvironmental geometry on cell function in 3D. Integr. Biol. (Camb.) 4, 1540-1549 (2012).
17. Yeh, J. et al. Micromolding of shape-controlled, harvestable cell-laden hydrogels. Biomaterials 27, 5391-5398 (2006). (Pubitemid 44093713)
18. Matsunaga, Y. T., Morimoto, Y. & Takeuchi, S. Molding cell beads for rapid construction of macroscopic 3D tissue architecture. Adv. Mater. 23, H90-H94 (2011).
19. Cho, S. K., Moon, H. & Kim, C.-J. Creating, transporting, cutting, and merging liquid droplets by electrowetting-based actuation for digital microfluidic circuits. J. Microelectromech. Syst. 12, 70-80 (2003).
20. Luk, V. N., Fiddes, L. K., Luk, V. M., Kumacheva, E. & Wheeler, A. R. Digital microfluidic hydrogel microreactors for proteomics. Proteomics 12, 1310-1318 (2012).
21. Nelson, W. C. et al. Incubated protein reduction and digestion on an electrowetting-on-dielectric digital microfluidic chip for MALDI-MS. Anal. Chem. 82, 9932-9937 (2010).
22. Eydelnant, I. A., Uddayasankar, U., Li, B., Liao, M. W. & Wheeler, A. R. Virtual microwells for digital microfluidic reagent dispensing and cell culture. Lab Chip 12, 750-757 (2012).
23. Srigunapalan, S., Eydelnant, I. A., Simmons, C. A. & Wheeler, A. R. A digital microfluidic platform for primary cell culture and analysis. Lab Chip. 12, 369 (2012).
24. Bogojevic, D., Chamberlain, M. D., Barbulovic-Nad, I. & Wheeler, A. R. A digital microfluidic method for multiplexed cell-based apoptosis assays. Lab Chip 12, 627 (2012).
25. Sista, R. S. et al. Heterogeneous immunoassays using magnetic beads on a digital microfluidic platform. Lab Chip 8, 2188-2196 (2008).
26. Ng, A. H. C., Choi, K., Luoma, R. P., Robinson, J. M. & Wheeler, A. R. Digital microfluidic magnetic separation for particle-based immunoassays. Anal. Chem. 84, 8805-8812 (2012).
27. Jebrail, M. J. et al. Synchronized synthesis of peptide-based macrocycles by digital microfluidics. Angew. Chem. Int. Ed. 49, 8625-8629 (2010).
28. Keng, P. Y. et al. Micro-chemical synthesis of molecular probes on an electronic microfluidic device. Proc Natl Acad. Sci. USA 109, 690-695 (2012).
29. Kuehne, A. J. C. et al. A switchable digital microfluidic droplet dye-laser. Lab Chip 11, 3716 (2011).
30. Jebrail, M. J. et al. A digital microfluidic method for dried blood spot analysis. Lab Chip 11, 3218 (2011).
31. Shih, S. C. C. et al. Dried blood spot analysis by digital microfluidics coupled to nanoelectrospray ionization mass spectrometry. Anal. Chem. 84, 3731-3738 (2012).
32. Yang, H., Mudrik, J. M., Jebrail, M. J. & Wheeler, A. R. A digital microfluidic method for in situ formation of porous polymer monoliths with application to solid-phase extraction. Anal. Chem. 83, 3824-3830 (2011).
33. Fiddes, L. K. et al. Hydrogel discs for digital microfluidics. Biomicrofluidics 6, 14112-1411211 (2012).
34. Pampaloni, F., Reynaud, E. G. & Stelzer, E. H. K. The third dimension bridges the gap between cell culture and live tissue. Nat. Rev. Mol. Cell Biol. 8, 839-845 (2007). (Pubitemid 47462131)
35. Zhang, Y. & Wang, T.-H. Full-range magnetic manipulation of droplets via surface energy traps enables complex bioassays. Adv. Mater. 25, 2903-2908 (2013).
36. Kleinman, H. K. & Martin, G. R. Matrigel: basement membrane matrix with biological activity. Semin. Cancer Biol. 15, 378-386 (2005). (Pubitemid 41140305)
37. Tuvikene, R. et al. Gel-forming structures and stages of red algal galactans of different sulfation levels. J. Appl. Phycol. 20, 527-535 (2008).
38. Park, J. H. et al. Microporous cell-laden hydrogels for engineered tissue constructs. Biotechnol. Bioeng. 106, 138-148 (2010).
39. Rani, S. A., Pitts, B. & Stewart, P. S. Rapid diffusion of fluorescent tracers into staphylococcus epidermidis biofilms visualized by time lapse microscopy. Antimicrob. Agents Chemother. 49, 728-732 (2005). (Pubitemid 40175686)
40. Kim, B. et al. Tuning payload delivery in tumour cylindroids using gold nanoparticles. Nat. Nanotechnol. 5, 465-472 (2010).
41. Walker, G. M. et al. Effects of flow and diffusion on chemotaxis studies in a microfabricated gradient generator. Lab Chip 5, 611-618 (2005). (Pubitemid 40863107)
42. Cornelissen, L. H., Bronneberg, D., Oomens, C. W. J. & Baaijens, F. P. T. Diffusion measurements in epidermal tissues with fluorescent recovery after photobleaching. Skin Res. Technol. 14, 462-467 (2008).
43. Hall, H. G., Farson, D. A. & Bissell, M. J. Lumen formation by epithelial cell lines in response to collagen overlay: a morphogenetic model in culture. Proc. Natl Acad. Sci. USA 79, 4672 (1982).
44. Elia, N. & Lippincott-Schwartz, J. Culturing three dimensional MDCK cells for analyzing intracellular dynamics. Curr. Protoc. Cell. Biol. Unit-4, 22 (2009).
45. Barbulovic-Nad, I., Au, S. H. & Wheeler, A. R. A microfluidic platform for complete mammalian cell culture. Lab Chip 10, 1536-1542 (2010).
46. Au, S. H., Fobel, R., Desai, S. P., Voldman, J. & Wheeler, A. R. Cellular bias on the microscale: probing the effects of digital microfluidic actuation on mammalian cell health, fitness and phenotype. Integr. Biol. (Camb.) 5, 1014-1025 (2013).
47. Flaim, C. J., Chien, S. & Bhatia, S. N. An extracellular matrix microarray for probing cellular differentiation. Nat. Methods 2, 119-125 (2005). (Pubitemid 41131033)
48. Du, Y., Lo, E., Vidula, M. K., Khabiry, M. & Khademhosseini, A. Method of bottom-up directed assembly of cell-laden microgels. Cell Mol. Bioeng. 1, 157-162 (2008).
49. Montanez-Sauri, S. I., Sung, K. E., Puccinelli, J. P., Pehlke, C. & Beebe, D. J. Automation of three-dimensional cell culture in arrayed microfluidic devices. J. Lab Autom. 16, 171-185 (2011).
50. Zaman, M. H. et al. Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis. Proc. Natl Acad. Sci. USA 103, 10889-10894 (2006). (Pubitemid 44148391)
51. Santos, O. F. P. & Nigam, S. K. HGF-induced tubulogenesis and branching of epithelial cells is modulated by extracellular matrix and TGF-b. Dev. Biol. 160, 293-302 (1993). (Pubitemid 24024121)
52. Albrecht, D. R., Underhill, G. H., Wassermann, T. B., Sah, R. L. & Bhatia, S. N. Probing the role of multicellular organization in three-dimensional microenvironments. Nat. Methods 3, 369-375 (2006).
53. Tsang, V. L. et al. Fabrication of 3D hepatic tissues by additive photopatterning of cellular hydrogels. FASEB J. 21, 790-801 (2007). (Pubitemid 46348254)
54. Liu, T., Lin, B. & Qin, J. Carcinoma-associated fibroblasts promoted tumor spheroid invasion on a microfluidic 3D co-culture device. Lab Chip 10, 1671-1677 (2010).
55. Fobel, R., Fobel, C. & Wheeler, A. R. DropBot: An open-source digital microfluidic control system with precise control of electrostatic driving force and instantaneous drop velocity measurement. Appl. Phys. Lett. 102, 193513-193513-5 (2013).
56. Luk, V. N., Mo, G. C. & Wheeler, A. R. Pluronic additives: a solution to sticky problems in digital microfluidics. Langmuir 24, 6382-6389 (2008).
57. Axelrod, D., Koppel, D. E., Schlessinger, J., Elson, E. & Webb, W. W. Mobility measurement by analysis of fluorescence photobleaching recovery kinetics. Biophys. J. 16, 1055-1069 (1976).