Localized in situ hydrogel-mediated protein digestion and extraction technique for on-tissue analysis

Analytical Chemistry

Volumn 85, Issue 5, 2013, Pages 2717-2723

  Harris, Glenn A ^a   Nicklay, Joshua J ^a   Caprioli, Richard M ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANALYTICAL APPROACH; CHAOTROPES; ENZYMATIC DIGESTIONS; EXTRACTION METHOD; EXTRACTION TECHNIQUES; HYDROGEL NETWORKS; IMAGING MASS SPECTROMETRY; IN-SITU ANALYSIS; LC-MS/MS; LIPID SPECIES; PROTEIN DIGESTION; PROTEOLYTIC DIGESTION; RAT BRAIN; SPATIAL DIFFERENCES; TANDEM MS; TISSUE SECTIONS; TISSUE STRUCTURE; TRAVELING WAVE ION MOBILITIES;

EXPERIMENTS; EXTRACTION; ION MOBILITY SPECTROMETERS; LIQUID CHROMATOGRAPHY; PROTEINS; SECONDARY ION MASS SPECTROMETRY; SOAPS (DETERGENTS); TISSUE;

HYDROGELS;

PROTEIN;

ANIMAL; ARTICLE; BRAIN; CHEMISTRY; FRACTIONATION; HYDROGEL; ISOLATION AND PURIFICATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; METHODOLOGY; MOLECULAR WEIGHT; PROTEIN DEGRADATION; RAT; SPRAGUE DAWLEY RAT; TANDEM MASS SPECTROMETRY;

ANIMALS; CEREBRUM; CHEMICAL FRACTIONATION; CHROMATOGRAPHY, LIQUID; HYDROGELS; MOLECULAR WEIGHT; PROTEINS; PROTEOLYSIS; RATS; RATS, SPRAGUE-DAWLEY; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 84874640134     PISSN: 00032700     EISSN: 15206882     Source Type: Journal    
DOI: 10.1021/ac3031493     Document Type: Article

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