Intermittent PTH(1-34) does not increase union rates in open rat femoral fractures and exhibits attenuated anabolic effects compared to closed fractures

Bone

Volumn 46, Issue 3, 2010, Pages 852-859

  Tägil, Magnus ^a,c   McDonald, Michelle M ^a   Morse, Alyson ^a   Peacock, Lauren ^a   Mikulec, Kathy ^a   Amanat, Negin ^a,b   Godfrey, Craig ^a   Little, David G ^a,d  

^a CHILDREN S HOSPITAL AT WESTMEAD   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c LUND UNIVERSITY   (Sweden)

^d University of Sydney   (Australia)

Author keywords

Fracture healing; Non union; Open fracture; QCT; Strength

Indexed keywords

PARATHYROID HORMONE[1-34]; RECOMBINANT PARATHYROID HORMONE; ANABOLIC AGENT; PARATHYROID HORMONE; RECOMBINANT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; BONE METABOLISM; BONE MINERAL; BONE STRENGTH; CALLUS; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG INTERMITTENT THERAPY; FEMUR FRACTURE; FRACTURE HEALING; HISTOPATHOLOGY; MALE; MECHANICAL STRESS; NONHUMAN; OUTCOME ASSESSMENT; RAT; TRABECULAR BONE; TREATMENT DURATION; TREATMENT RESPONSE; ANIMAL; CELL CULTURE; COMPARATIVE STUDY; DRUG ADMINISTRATION; DRUG EFFECTS; FEMORAL FRACTURES; FRACTURES, CLOSED; MOUSE; PATHOLOGY; PHYSIOLOGY; RANDOMIZATION; WISTAR RAT;

ANABOLIC AGENTS; ANIMALS; CELLS, CULTURED; DRUG ADMINISTRATION SCHEDULE; FEMORAL FRACTURES; FRACTURE HEALING; FRACTURES, CLOSED; MALE; MICE; PARATHYROID HORMONE; RANDOM ALLOCATION; RATS; RATS, WISTAR; RECOMBINANT PROTEINS;

EID: 77649192186     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2009.11.009     Document Type: Article

References (37)

1. Gaebler C., Berger U., Schandelmaier P., Geitbauer M., Schaumecker H.H., Appelgate B., et al. Rate and odds ratios for complications in closed and open tibial fractures treated with unreamed, small diameter tibial nails: a multi-center analysis of 467 cases. J. Orthop. Trauma 2001, 15:243-415.
2. Karladani A.H., Granhed H., Karrholm J., Styf J. The influence of fracture etiology and type on fracture healing: a review of 104 consecutive tibial shaft fractures. Arch. Orthop. Trauma Surg. 2001, 121:325-328.
3. Govender S., Csimma C., Genant H.K., Valentin-Opran A., Amit Y., Arbel R., et al. BMP-2 Evaluation in Surgery for Tibial Trauma (BESTT) Study Group. Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: a prospective, controlled, randomized study of four hundred and fifty patients. J. Bone Joint Surg. 2002, 84A:2123-2134.
4. Ristiniemi J., Flinkkilä T., Hyvönen P., Lakovaara M., Pakarinen H., Jalovaara P. RhBMP-7 accelerates the healing in distal tibial fractures treated by external fixation. J. Bone Joint Surg. 2007, 89B:265-272.
5. Oxlund H., Ejersted C., Andreassen T.T., Torring O., Nilsson M.H. Parathyroid hormone (1-34) and (1-84) stimulate cortical bone formation both from periosteum and endosteum. Calcif. Tissue Int. 1993, 53:394-399.
6. Ejersted C., Oxlund H., Eriksen E.F., Andreassen T.T. Withdrawal of parathyroid hormone treatment causes rapid resorption of newly formed vertebral cancellous and endocortical bone in old rats. Bone 1998, 23:43-52.
7. Neer R.M., Arnaud C.D., Zanchetta J.R., Prince R., Gaich G.A., Reginster J.Y., et al. Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N. Engl. J. Med. 2001, 344:1434-1441.
8. Cosman F., Nieves J.W., Zion M., Barbuto N., Lindsay R. Effect of prior and ongoing raloxifene therapy on response to PTH and maintenance of BMD after PTH therapy. Osteoporosis Int. 2008, 19:529-535.
9. Andreassen T.T., Ejersted C., Oxlund H. Intermittent parathyroid hormone (1-34) treatment increases callus formation and mechanical strength of healing rat fractures. J. Bone Miner. Res. 1999, 14:960-968.
10. Alkhiary Y.M., Gerstenfeld L.C., Krall E., Westmore M., Sato M., Mitlak B.H., et al. Enhancement of experimental fracture-healing by systemic administration of recombinant human parathyroid hormone (PTH 1-34). J. Bone Joint Surg. 2005, 87A:731-741.
11. Nakajima A., Shimoji N., Shiomi K., Shimizu S., Moriya H., Einhorn T.A., Yamazaki M. Mechanisms for the enhancement of fracture healing in rats treated with intermittent low-dose human parathyroid hormone (1-34). J. Bone Miner. Res. 2002, 17:2038-2047.
12. Warden S.J., Komatsu D.E., Rydberg J., Bond J.L., Hassett S.M. Recombinant human parathyroid hormone (PTH 1-34) and low-intensity pulsed ultrasound have contrasting additive effects during fracture healing. J. Bone Min. Res. 2009, 44:485-494.
13. Einhorn T.A., Majeska R.J., Mohaideen A., Kagel E.M., Bouxsein M.L., Turek T.J., et al. A single percutaneous injection of recombinant human bone morphogenetic protein-2 accelerates fracture repair. J. Bone Joint Surg. 2003, 85A:1425-1435.
14. Amanat N., McDonald M., Godfrey C., Bilston L., Little D. Optimal timing of a single dose of zoledronic acid to increase strength in rat fracture repair. J. Bone Miner. Res. 2007, 22:867-876.
15. McDonald M.M., Dulai S., Godfrey C., Amanat N., Sztynda T., Little D.G. Bolus or weekly zoledronic acid administration does not delay endochondral fracture repair but weekly dosing enhances delays in hard callus remodeling. Bone 2008, 43:653-662.
16. Andreassen T.T., Fledelius C., Ejerstad C., Oxlund H. Increases in callus formation and mechanical strength of healing fractures in old rats treated with parathyroid hormone. Acta. Orthop. Scand. 2001, 72:304-307.
17. Jahng J.S., Kim H.W. Effect of intermittent administration of parathyroid hormone on fracture healing in ovariectomized rats. Orthopaedics 2000, 23:1089-1094.
18. Bonnarens F., Einhorn T.A. Production of a standard closed fracture in laboratory animal bone. J. Orthop. Res. 1984, 2:97-101.
19. Armamento-Villareal R., Ziambaras K., Abbasi-Jarhomi S.H., Dimarogonas A., Halstead L., Fausto A., et al. An intact N terminus is required for the anabolic action of parathyroid hormone on adult female rats. J. Bone Miner. Res. 1997, 3:384-392.
20. Allen H.L., Wase A., Bear W.T. Indomethacin and aspirin: effect of nonsteroidal anti-inflammatory agents on fracture repair in the rat. Act Orthop. Scand. 1980, 51:595-600.
21. Holzer G., Majeska R.J., Lundy M.W., Hartke J.R., Einhorn T.A. Parathyroid hormone enhances fracture healing. A preliminary report. Clin. Orthop. Relat. Res. 1999, 366:258-263.
22. Jahng J.S., Kim H.W. Effect of intermittent administration of parathyroid hormone on fracture healing in ovariectomized rats. Orthopedics 2000, 23:1089-1094.
23. Nakazawa T., Nakajima A., Shiomi K., Moriya H., Einhorn T.A., Yamazaki M. Effects of low-dose, intermittent treatment with recombinant human parathyroid hormone (1-34) on chondrogenesis in a model of experimental fracture healing. Bone 2005, 37:711-719.
24. Kakar S., Einhorn T.A., Vora S., Miara L.J., Hon G., Wigner N.A., et al. Enhanced chondrogenesis and Wnt signaling in PTH-treated fractures. J. Bone Miner. Res. 2007, 22:1903-1912.
25. Manabe T., Mori S., Mashiba T., Kaji Y., Iwata K., Komatsubara S., et al. Human parathyroid hormone (1-34) accelerates natural fracture healing process in the femoral osteotomy model of cynomolgus monkeys. Bone 2007, 40:1475-1482.
26. Andreassen T.T., Willick G.E., Morley P., Whitfield J.F. Treatment with parathyroid hormone hPTH(1-34), hPTH(1-31), and monocyclic hPTH(1-31) enhances fracture strength and callus amount after withdrawal fracture strength and callus mechanical quality continue to increase. Calcif. Tissue Int. 2004, 74:351-356.
27. Gardner M.J., Van der Meulen M.C.H., Carson J., Zelken J., Ricciardi B.F., Wright T.M., et al. Role of parathyroid hormone in the mechanosensitivity of fracture healing. J. Orthop. Res. 2007, 25:1474-1480.
28. Li M., Liang H., Shen Y., Wronski T.J. Parathyroid hormone stimulates cancellous bone formation at skeletal sites regardless of marrow composition in ovariectomized rats. Bone 1999, 24:95-100.
29. Dobnig H., Turner R.T. Evidence that intermittent treatment with parathyroid hormone increases bone formation in adult rats by activation of bone lining cells. Endocrinology 1995, 136:3632-3638.
30. Kaback L.A., Soung D.Y., Naik A., Geneau G., Schwarz E.M., Rosier R.N., et al. Teriparatide (1-34 human PTH) regulation of osterix during fracture repair. J. Cell. Biochem. 2008, 105:219-226.
31. Ai-Aql Z.S., Alagl A.S., Graves D.T., Gerstenfeld L.C., Einhorn T.A. Molecular mechanisms controlling bone formation during fracture healing and distraction osteogenesis. J. Dent. Res. 2008, 2:107-118.
32. Deckers M.M., van Bezooijen R.L., van der Horst G., Hoogendam J., van Der Bent C., Papapoulos S.E., et al. Bone morphogenetic proteins stimulate angiogenesis through osteoblast-derived vascular endothelial growth factor A. Endocrinology 2002, 143:1545-1553.
33. Little D.G., McDonald M., Bransford R., Godfrey C.B., Amanat N. Manipulation of the anabolic and catabolic responses with OP-1 and zoledronic acid in a rat critical defect model. J. Bone Miner. Res. 2005, 20:2044-2045.
34. Morgan E.F., Mason Z.D., Bishop G., Davis A.D., Wigner N.A., et al. Combined effects of recombinant human BMP-7 (rhBMP-7) and parathyroid hormone(1-34) in metaphyseal bone healing. Bone 2008, 43:1031-1038.
35. Li M., Ke H.Z., Qi H., Healy D.R., Li Y., Crawford D.T., Paralkar V.M., et al. A novel, non-prostanoid EP2 receptor-selective prostaglandin E2 agonist stimulates local bone formation and enhances fracture healing. J. Bone Miner. Res. 2003, 18:2033-2042.
36. Shen X., Wan C., Ramaswamy G., Mavalli M., Wang Y., Duvall C.L., et al. Prolyl hydroxylase inhibitors increase neoangiogenesis and callus formation following femur fracture in mice. J. Orthop. Res. 2009, 27:1298-1305.
37. Garrett I.R., Gutierrez G.E., Rossini G., Nyman J., McCluskey B., Flores A., et al. Locally delivered lovastatin nanoparticles enhance fracture healing in rats. J. Orthop. Res. 2007, 25:1351-1357.