Nonagonistic Dectin-1 ligand transforms CpG into a multitask nanoparticulate TLR9 agonist

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 8, 2014, Pages 3086-3091

  Kobiyama, Kouji ^a,b   Aoshi, Taiki ^a,b   Narita, Hirotaka ^b   Kuroda, Etsushi ^a,b   Hayashi, Masayuki ^a,b   Tetsutani, Kohhei ^a,b   Koyama, Shohei ^c   Mochizuki, Shinichi ^d   Sakurai, Kazuo ^d   Katakai, Yuko ^e   Yasutomi, Yasuhiro ^a   Saijo, Shinobu ^f,g   Iwakura, Yoichiro ^h   Akira, Shizuo ^b   Coban, Cevayir ^b   Ishii, Ken J ^a,b  

^a NATIONAL INSTITUTE OF BIOMEDICAL INNOVATION   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c DANA FARBER CANCER INSTITUTE   (United States)

^d UNIVERSITY OF KITAKYUSHU   (Japan)

^e The Corporation for Production and Research of Laboratory Primates   (Japan)

^f CHIBA UNIVERSITY   (Japan)

^g JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^h TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

glucan; Innate immunity; MARCO; Siglec 1; Two photon microscopy

Indexed keywords

ANTIGEN; DECTIN 1; GAMMA INTERFERON; IMMUNOLOGICAL ADJUVANT; INFLUENZA VACCINE; INTERFERON; K 3SPG; K3 SPG; UNCLASSIFIED DRUG; VIRUS VACCINE;

ADJUVANT THERAPY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELLULAR IMMUNITY; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; DRUG EFFICACY; DRUG POTENCY; ENDOSOME; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; IMMUNOPROPHYLAXIS; IMMUNOSTIMULATION; IN VITRO STUDY; IN VIVO STUDY; INFLUENZA VACCINATION; LOW DRUG DOSE; LYMPH NODE; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIMATE MODEL; PRIORITY JOURNAL; SEASONAL INFLUENZA;

INNATE IMMUNITY; MARCO; SIGLEC-1; TWO-PHOTON MICROSCOPY; Β-GLUCAN;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; CELLS, CULTURED; CPG ISLANDS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOTHERAPY; INTERFERON INDUCERS; LECTINS, C-TYPE; LEUKOCYTES, MONONUCLEAR; MICE; MICE, INBRED C57BL; MICROSCOPY, ELECTRON; NANOPARTICLES; OLIGODEOXYRIBONUCLEOTIDES; SIZOFIRAN; TOLL-LIKE RECEPTOR 9;

EID: 84896843586     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1319268111     Document Type: Article

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