γ-secretase inhibitor DAPT prevents neuronal death and memory impairment in sepsis associated encephalopathy in septic rats

Chinese Medical Journal

Volumn 127, Issue 5, 2014, Pages 924-928

  Huang, Man ^a   Liu, Chun Hui ^c   Hu, Yue Yu ^a   Wang, Peng Fei ^a   Ding, Mei Ping ^b  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c ZHEJIANG UNIVERSITY   (China)

Author keywords

secretase; DAPT; Memory impairment; Notch; Sepsis

Indexed keywords

GAMMA SECRETASE INHIBITOR; N [N (3 5 DIFLUOROPHENACETYL) 1 ALANYL] S PHENYLGLYCINE T BUTYL ESTER; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NOTCH RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; DIPEPTIDE; N-(N-(3,5-DIFLUOROPHENACETYL)ALANYL)PHENYLGLYCINE TERT-BUTYL ESTER; NEUROPROTECTIVE AGENT; PARP1 PROTEIN, RAT; SECRETASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN DISEASE; COMPARATIVE STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; INFLAMMATION; MALE; MEMORY DISORDER; NERVE CELL NECROSIS; NICK END LABELING; NONHUMAN; NOVEL OBJECT RECOGNITION TEST; PROTEIN EXPRESSION; RAT; SEPSIS; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; COMPLICATION; CYTOLOGY; DRUG EFFECTS; ENZYMOLOGY; HIPPOCAMPUS; METABOLISM; NERVE CELL; SEPSIS-ASSOCIATED ENCEPHALOPATHY; SPRAGUE DAWLEY RAT;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; APOPTOSIS; DIPEPTIDES; HIPPOCAMPUS; MALE; NEURONS; NEUROPROTECTIVE AGENTS; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NOTCH; SEPSIS; SEPSIS-ASSOCIATED ENCEPHALOPATHY; SIGNAL TRANSDUCTION;

EID: 84896828047     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.20132366     Document Type: Article

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