Chrysin activates Notch1 signaling and suppresses tumor growth of anaplastic thyroid carcinoma in vitro and in vivo

Cancer

Volumn 119, Issue 4, 2013, Pages 774-781

  Yu, Xiao Min ^a   Phan, Tramanh ^a   Patel, Priyesh N ^a   Jaskula Sztul, Renata ^a   Chen, Herbert ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

anaplastic thyroid carcinoma; chrysin; Notch1 signaling; thyroid cancer; tumor growth

Indexed keywords

BINDING PROTEIN; C PROMOTER BINDING FACTOR 1; CHRYSIN; DIMETHYL SULFOXIDE; LUCIFERASE; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NOTCH1 RECEPTOR; TRANSCRIPTION FACTOR HES 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; ASSAY; BINDING SITE; CANCER CELL; CELL GROWTH; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME INDUCTION; GROWTH INHIBITION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; REPORTER GENE; SIGNAL TRANSDUCTION; THYROID CARCINOMA; TUMOR XENOGRAFT; UPREGULATION;

ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL LINE, TUMOR; CELL PROLIFERATION; FLAVONOIDS; GENE EXPRESSION REGULATION, NEOPLASTIC; HOMEODOMAIN PROTEINS; HUMANS; MALE; MICE; MICE, NUDE; POLY(ADP-RIBOSE) POLYMERASES; RECEPTOR, NOTCH1; SIGNAL TRANSDUCTION; THYROID NEOPLASMS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84873331103     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.27742     Document Type: Article

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