Experimental and theoretical insights into the mechanisms of sulfate and sulfamate ester hydrolysis and the end products of type i sulfatase inactivation by aryl sulfamates

Journal of Organic Chemistry

Volumn 79, Issue 5, 2014, Pages 1995-2005

  Williams, Spencer J ^a,b   Denehy, Emma ^a,b   Krenske, Elizabeth H ^a,c  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

COVALENT MODIFICATIONS; END-PRODUCTS; ESTER HYDROLYSIS; LEAVING GROUPS; PSEUDOMONAS AERUGINOSA; SULFATE ESTERS; SULFUR REACTIONS; UNCATALYZED HYDROLYSIS;

AMINO ACIDS; CATALYSIS; ESTERIFICATION; ESTERS; PHOSPHATASES; SULFUR DIOXIDE;

HYDROLYSIS;

ALKALINE PHOSPHATASE; CYSTEINE; IMINE; SERINE; SULFAMIC ACID DERIVATIVE; SULFATASE; SULFATE; SULFUR; SULFUR DERIVATIVE; TYPE I SULFATASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL BOND; CHEMICAL MODEL; CHEMICAL STRUCTURE; COVALENT BOND; ENERGY; ENTHALPY; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME MODIFICATION; HYDROLYSIS; MICHAELIS MENTEN KINETICS; PROTEIN PROCESSING; PSEUDOMONAS AERUGINOSA; REACTION ANALYSIS; THEORY;

BINDING SITES; CATALYSIS; ESTERS; GLYCINE; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; MODELS, THEORETICAL; SULFATASES; SULFATES; SULFONIC ACIDS; SULFURIC ACID ESTERS;

EID: 84896791741     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo4026513     Document Type: Article

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