Synthesis and evaluation of general mechanism-based inhibitors of sulfatases based on (difluoro)methyl phenyl sulfate and cyclic phenyl sulfamate motifs

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 24, 2006, Pages 8386-8395

  Hanson, Sarah R ^a   Whalen, Lisa J ^a   Wong, Chi Huey ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Inhibition; Mechanism based inhibition; Proteomics; Sulfatase

Indexed keywords

ARYLSULFATASE; ENZYME INHIBITOR; QUINONE DERIVATIVE; SULFATASE; SULFATE;

ARTICLE; CATALYSIS; COMPETITIVE INHIBITION; DRUG CONFORMATION; DRUG DESIGN; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME ASSAY; ENZYME INACTIVATION; ENZYME MECHANISM; ENZYME SUBSTRATE; EVALUATION; MOLECULAR PROBE; MOLECULE; PSEUDOMONAS AERUGINOSA;

ARYLSULFATASES; BINDING SITES; BINDING, COMPETITIVE; CATALYSIS; ENZYME INHIBITORS; PSEUDOMONAS AERUGINOSA; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONIC ACIDS; SULFURIC ACID ESTERS;

EID: 33750532080     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.09.002     Document Type: Article

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