A mechanistic model of drug-induced liver injury aids the interpretation of elevated liver transaminase levels in a phase I clinical trial

CPT: Pharmacometrics and Systems Pharmacology

Volumn 3, Issue 2, 2014, Pages

  Howell, B A ^a   Siler, S Q ^a   Shoda, L K M ^a   Yang, Y ^a   Woodhead, J L ^a   Watkins, P B ^a,b  

^a HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; AMINOTRANSFERASE; BIOLOGICAL MARKER; ENTOLIMOD; HEPARIN;

AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; CELL DEATH; CLINICAL OBSERVATION; COMPARATIVE STUDY; DRUG EFFICACY; DRUG SAFETY; HEALTH HAZARD; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; HYPERTRANSAMINASEMIA; LIVER CELL; LIVER DYSFUNCTION; LIVER REGENERATION; LIVER TRANSPLANTATION; NORMAL HUMAN; PATIENT SAFETY; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; RISK ASSESSMENT; SINGLE DRUG DOSE; TOXIC HEPATITIS; WHOLE BODY RADIATION;

EID: 84896776892     PISSN: None     EISSN: 21638306     Source Type: Journal    
DOI: 10.1038/psp.2013.74     Document Type: Article

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