Differential function of Themis CABIT domains during T cell development

PLoS ONE

Volumn 9, Issue 2, 2014, Pages

  Okada, Toshiyuki ^a   Nitta, Takeshi ^a   Kaji, Kentaro ^a   Takashima, Akiko ^a   Oda, Hiroyo ^a   Tamehiro, Norimasa ^a   Goto, Motohito ^a   Okamura, Tadashi ^a   Patrick, Michael S ^a   Suzuki, Harumi ^a  

^a NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; CYSTEINE CONTAINING ALL BETA IN THEMIS 1 DOMAIN PROTEIN; CYSTEINE CONTAINING ALL BETA IN THEMIS 2 DOMAIN PROTEIN; CYSTEINE CONTAINING ALL BETA IN THEMIS DOMAIN PROTEIN; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; T LYMPHOCYTE RECEPTOR; THYMOCYTE EXPRESSED MOLECULE INVOLVED IN SELECTION PROTEIN; TYROSINE; UNCLASSIFIED DRUG; PROTEIN; THEMIS PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEMALE; GENE DELETION; GENETIC SELECTION; IN VIVO STUDY; LYMPHOCYTOPOIESIS; MOUSE; MOUSE MUTANT; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PROLINE RICH PROTEIN DOMAIN; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; T LYMPHOCYTE; THYMUS; TRANSGENIC MOUSE; ANIMAL; CELL DIFFERENTIATION; CYTOLOGY; GENETICS; IMMUNOLOGY; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; THYMOCYTE;

ANIMALS; CELL DIFFERENTIATION; MICE; MICE, TRANSGENIC; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; PROTEINS; T-LYMPHOCYTES; THYMOCYTES;

EID: 84896767207     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0089115     Document Type: Article

References (18)

1. Rothenberg EV, Taghon T (2005) Molecular genetics of T cell development. Anne Rev Immunol 23: 601-649 (Pubitemid 40563181)
2. Patrick MS, Oda H, Hayakawa K, Sato Y, Eshima K, et al. (2009) Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes. Proc Natl Acad Sci USA 106: 16345-16350
3. Lesourne R, Uehara S, Lee J, Song KD, Li L, et al. (2009) Themis, a T cell-specific protein important for late thymocyte development. Nat Immunol 10: 840-847
4. Johnson AL, Aravind L, Shulzhenko N, Morgun A, Choi SY, et al. (2009) Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection. Nat Immunol 10: 831-839
5. Fu G, Vallée S, Rybakin V, McGuire MV, Ampudia J, et al. (2009) Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling. Nat Immunol 10: 848-856
6. Kakugawa K, Yasuda T, Miura I, Kobayashi A, Fukiage H, et al. (2009) A novel gene essential for the development of single positive thymocytes. Mol Cell Biol 29: 5128-5135
7. Marson A, Kretschmer K, Frampton GM, Jacobsen ES, Polansky JK, et al. (2007) Foxp3 occupancy and regulation of key target gens during T-cell stimulation. Nature 445: 931-935
8. Chabod M, Pedros C, Lamouroux L, Colacios C, Bernard I, et al. (2012) A spontaneous mutation of the rat Themis gene leads to impaired function of regulatory T cells linked to inflammatory bowel disease. PLoS Genet 8: e1002461
9. Lesourne R, Zvezdova E, Song KD, EI-Khoury, Uehara S, et al. (2012) Interchangeability of Themis1 and Themis2 in Thymocyte Development Reveals Two Related Proteins with Conserved Molecular Function. J Immunol 189: 1154-1161
10. Brockmeyer C, Paster W, Pepper D, Tan CP, Trudgian DC, et al. (2011) T cell receptor (TCR)- induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component. J Biol Chem 286: 7535-7547
11. Paster W, Brockmeyer C, Fu G, Simister PC, de Wet B, et al. (2013) GRB2-Mediated Recruitment of THEMIS to LAT Is Essential for Thymocyte Development. J Immunol 190: 3749-3756
12. Zhumabekov T, Corbella P, Tolaini M, Kioussis D (1995) Improved version of a human CD2 minigenebased vector for T cell-specific expression in transgenic mice. J Immunol Methods 185: 133-140
13. Pagès G, Guérin S, Grall D, Bonino F, Smith A, et al. (1999) Defective thymocyte maturation in p44 MAP kinase (Erk1) knockout mice. Science 286: 1374-1377
14. Jang IK, Chiang YJ, Kole HK, Cronshaw DG, Zou Y, et al. (2010) Grb2 functions at the top of the T-cell antigen receptor-induced tyrosine kinase cascade to control thymic selection. Proc Natl Acad Sci USA 107: 10620-10625
15. Chardin P, Camonis JH, Gale NW, van Aelst L, Schlessinger J, et al. (1993) Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. Science 260: 1338-1343 (Pubitemid 23231980)
16. Rozakis-Adock M, McGlade J, Mbamalu G, Pelicci G, Daly R, et al. (1992) Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases. Nature 360: 689-692. (Pubitemid 23007687)
17. Schlaepfer DD, Hunter T (1996) Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-familyprotein-tyrosine kinases. Mol Cell Biol 16: 5623-5633 (Pubitemid 26315082)
18. Kortum RL, Sommers CL, Pinski JM, Alexander CP, Merrill RK, et al. (2012) Deconstructing Ras signaling in the thymus. Mol Cell Biol 32: 2748-2759.