메뉴 건너뛰기




Volumn 345, Issue 2, 2014, Pages 249-257

Impact of non-steroidal anti-inflammatory drugs on gastrointestinal cancers: Current state-of-the science

Author keywords

COX 2; Gastrointestinal cancers; NSAIDs

Indexed keywords

ACETYLSALICYLIC ACID; CELECOXIB; CISPLATIN; CYCLOOXYGENASE 2; FLUOROURACIL; GEMCITABINE; INDOMETACIN; NONSTEROID ANTIINFLAMMATORY AGENT; PLACEBO; SULINDAC;

EID: 84896737676     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2013.09.001     Document Type: Review
Times cited : (50)

References (132)
  • 5
    • 0015061262 scopus 로고
    • Studies of the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine
    • Di Rosa M., Giroud J., Willoughby D. Studies of the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine. J. Pathol. 1971, 104:15-29.
    • (1971) J. Pathol. , vol.104 , pp. 15-29
    • Di Rosa, M.1    Giroud, J.2    Willoughby, D.3
  • 6
    • 0028399309 scopus 로고
    • Role of inducible cyclooxygenase (COX-2) in inflammation
    • Seibert K., Masferrer J. Role of inducible cyclooxygenase (COX-2) in inflammation. Receptor 1994, 4:17.
    • (1994) Receptor , vol.4 , pp. 17
    • Seibert, K.1    Masferrer, J.2
  • 7
    • 0033590207 scopus 로고    scopus 로고
    • The role of cyclooxygenases in inflammation, cancer, and development
    • Williams C.S., Mann M., DuBois R.N. The role of cyclooxygenases in inflammation, cancer, and development. Oncogene 1999, 18:7908.
    • (1999) Oncogene , vol.18 , pp. 7908
    • Williams, C.S.1    Mann, M.2    DuBois, R.N.3
  • 8
    • 0030871687 scopus 로고    scopus 로고
    • COX-1 and COX-2 tissue expression: implications and predictions
    • Crofford L. COX-1 and COX-2 tissue expression: implications and predictions. J. Rheumatol. Supp. 1997, 49:15.
    • (1997) J. Rheumatol. Supp. , vol.49 , pp. 15
    • Crofford, L.1
  • 9
    • 0034746919 scopus 로고    scopus 로고
    • NF-kappaB: a key role in inflammatory diseases
    • Tak P.P., Firestein G.S. NF-kappaB: a key role in inflammatory diseases. J. Clin. Invest. 2001, 107:7-12.
    • (2001) J. Clin. Invest. , vol.107 , pp. 7-12
    • Tak, P.P.1    Firestein, G.S.2
  • 10
    • 0035153463 scopus 로고    scopus 로고
    • Role of transforming growth factor beta in cancer
    • Pasche B. Role of transforming growth factor beta in cancer. J. Cell Physiol. 2001, 186:153-168.
    • (2001) J. Cell Physiol. , vol.186 , pp. 153-168
    • Pasche, B.1
  • 11
    • 0037123274 scopus 로고    scopus 로고
    • Gastroesophageal reflux, Barrett esophagus, and esophageal cancer
    • Shaheen N., Ransohoff D.F. Gastroesophageal reflux, Barrett esophagus, and esophageal cancer. JAMA 2002, 287:1972-1981.
    • (2002) JAMA , vol.287 , pp. 1972-1981
    • Shaheen, N.1    Ransohoff, D.F.2
  • 13
    • 0034102269 scopus 로고    scopus 로고
    • Cyclooxygenase 2 expression in Barrett's esophagus and adenocarcinoma: Ex vivo induction by bile salts and acid exposure
    • Shirvani V.N., Ouatu-Lascar R., Kaur B.S., Omary M.B., Triadafilopoulos G. Cyclooxygenase 2 expression in Barrett's esophagus and adenocarcinoma: Ex vivo induction by bile salts and acid exposure. Gastroenterology 2000, 118:487-496.
    • (2000) Gastroenterology , vol.118 , pp. 487-496
    • Shirvani, V.N.1    Ouatu-Lascar, R.2    Kaur, B.S.3    Omary, M.B.4    Triadafilopoulos, G.5
  • 14
    • 0032528178 scopus 로고    scopus 로고
    • Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in Barrett's esophagus and associated adenocarcinomas
    • Wilson K.T., Fu S., Ramanujam K.S., Meltzer S.J. Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in Barrett's esophagus and associated adenocarcinomas. Cancer Res. 1998, 58:2929-2934.
    • (1998) Cancer Res. , vol.58 , pp. 2929-2934
    • Wilson, K.T.1    Fu, S.2    Ramanujam, K.S.3    Meltzer, S.J.4
  • 16
    • 0021325881 scopus 로고
    • Antitumoral activity of indomethacin on experimental esophageal tumors
    • Rubio C. Antitumoral activity of indomethacin on experimental esophageal tumors. J. Natl. Cancer Inst. 1984, 72:705-707.
    • (1984) J. Natl. Cancer Inst. , vol.72 , pp. 705-707
    • Rubio, C.1
  • 19
    • 0034667497 scopus 로고    scopus 로고
    • Selective inhibition of cyclooxygenase-2 suppresses growth and induces apoptosis in human esophageal adenocarcinoma cells
    • Souza R.F., Shewmake K., Beer D.G., Cryer B., Spechler S.J. Selective inhibition of cyclooxygenase-2 suppresses growth and induces apoptosis in human esophageal adenocarcinoma cells. Cancer Res. 2000, 60:5767-5772.
    • (2000) Cancer Res. , vol.60 , pp. 5767-5772
    • Souza, R.F.1    Shewmake, K.2    Beer, D.G.3    Cryer, B.4    Spechler, S.J.5
  • 20
    • 0035874883 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs induce apoptosis in esophageal cancer cells by restoring 15-lipoxygenase-1 expression
    • Shureiqi I., Xu X., Chen D., Lotan R., Morris J.S., Fischer S.M., Lippman S.M. Nonsteroidal anti-inflammatory drugs induce apoptosis in esophageal cancer cells by restoring 15-lipoxygenase-1 expression. Cancer Res. 2001, 61:4879-4884.
    • (2001) Cancer Res. , vol.61 , pp. 4879-4884
    • Shureiqi, I.1    Xu, X.2    Chen, D.3    Lotan, R.4    Morris, J.S.5    Fischer, S.M.6    Lippman, S.M.7
  • 22
    • 0029092874 scopus 로고
    • Aspirin and reduced risk of esophageal carcinoma
    • Funkhouser E.M., Sharp G.B. Aspirin and reduced risk of esophageal carcinoma. Cancer 1995, 76:1116-1119.
    • (1995) Cancer , vol.76 , pp. 1116-1119
    • Funkhouser, E.M.1    Sharp, G.B.2
  • 23
    • 0037219463 scopus 로고    scopus 로고
    • Protective association of aspirin/NSAIDs and esophageal cancer: a systematic review and meta-analysis
    • Corley D.A., Kerlikowske K., Verma R., Buffler P. Protective association of aspirin/NSAIDs and esophageal cancer: a systematic review and meta-analysis. Gastroenterology 2003, 124:47-56.
    • (2003) Gastroenterology , vol.124 , pp. 47-56
    • Corley, D.A.1    Kerlikowske, K.2    Verma, R.3    Buffler, P.4
  • 24
    • 59649106758 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drugs and risk of gastric and oesophageal adenocarcinomas: results from a cohort study and a meta-analysis
    • Abnet C., Freedman N., Kamangar F., Leitzmann M., Hollenbeck A., Schatzkin A. Non-steroidal anti-inflammatory drugs and risk of gastric and oesophageal adenocarcinomas: results from a cohort study and a meta-analysis. Br. J. Cancer 2009, 100:551-557.
    • (2009) Br. J. Cancer , vol.100 , pp. 551-557
    • Abnet, C.1    Freedman, N.2    Kamangar, F.3    Leitzmann, M.4    Hollenbeck, A.5    Schatzkin, A.6
  • 30
    • 33845863415 scopus 로고    scopus 로고
    • A phase I/II trial of celecoxib with chemotherapy and radiotherapy in the treatment of patients with locally advanced oesophageal cancer
    • Dawson S., Michael M., Biagi J., Foo K., Jefford M., Ngan S., Leong T., Hui A., Milner A., Thomas R.J. A phase I/II trial of celecoxib with chemotherapy and radiotherapy in the treatment of patients with locally advanced oesophageal cancer. Invest. New Drugs 2007, 25:123-129.
    • (2007) Invest. New Drugs , vol.25 , pp. 123-129
    • Dawson, S.1    Michael, M.2    Biagi, J.3    Foo, K.4    Jefford, M.5    Ngan, S.6    Leong, T.7    Hui, A.8    Milner, A.9    Thomas, R.J.10
  • 32
    • 78650825618 scopus 로고    scopus 로고
    • Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials
    • Rothwell P.M., Fowkes F.G.R., Belch J.F., Ogawa H., Warlow C.P., Meade T.W. Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials. Lancet 2011, 377:31-41.
    • (2011) Lancet , vol.377 , pp. 31-41
    • Rothwell, P.M.1    Fowkes, F.G.R.2    Belch, J.F.3    Ogawa, H.4    Warlow, C.P.5    Meade, T.W.6
  • 34
    • 69749083191 scopus 로고    scopus 로고
    • Aspirin is not chemoprotective for Barrett's adenocarcinoma of the oesophagus in multicentre cohort
    • Gatenby P.A., Ramus J.R., Caygill C.P., Winslet M.C., Watson A. Aspirin is not chemoprotective for Barrett's adenocarcinoma of the oesophagus in multicentre cohort. Eur. J. Cancer Prev. 2009, 18:381.
    • (2009) Eur. J. Cancer Prev. , vol.18 , pp. 381
    • Gatenby, P.A.1    Ramus, J.R.2    Caygill, C.P.3    Winslet, M.C.4    Watson, A.5
  • 35
    • 0028082386 scopus 로고
    • Helicobacter pylori infection as a cause of gastritis, duodenal ulcer, gastric cancer and nonulcer dyspepsia: a systematic overview
    • Veldhuyzen v.Z.S., Sherman P. Helicobacter pylori infection as a cause of gastritis, duodenal ulcer, gastric cancer and nonulcer dyspepsia: a systematic overview. CMAJ 1994, 150:177.
    • (1994) CMAJ , vol.150 , pp. 177
    • Veldhuyzen, V.1    Sherman, P.2
  • 39
    • 0025988416 scopus 로고
    • Inhibitory effect of the non-steroidal anti-inflammatory drug, indomethacin on the naturally occurring carcinogen, 1-hydroxyanthraquinone in male ACI/N rats
    • Tanaka T., Kojima T., Yoshimi N., Sugie S., Mori H. Inhibitory effect of the non-steroidal anti-inflammatory drug, indomethacin on the naturally occurring carcinogen, 1-hydroxyanthraquinone in male ACI/N rats. Carcinogenesis 1991, 12:1949-1952.
    • (1991) Carcinogenesis , vol.12 , pp. 1949-1952
    • Tanaka, T.1    Kojima, T.2    Yoshimi, N.3    Sugie, S.4    Mori, H.5
  • 41
    • 0032445736 scopus 로고    scopus 로고
    • Effects of NSAIDs on proliferation of gastric cancer cells in vitro: possible implication of cyclooxygenase-2 in cancer development
    • Sawaoka H., Kawano S., Tsuji S., Tsujii M., Murata H., Hori M. Effects of NSAIDs on proliferation of gastric cancer cells in vitro: possible implication of cyclooxygenase-2 in cancer development. J. Clin. Gastroenterol. 1998, 27:S47-S52.
    • (1998) J. Clin. Gastroenterol. , vol.27
    • Sawaoka, H.1    Kawano, S.2    Tsuji, S.3    Tsujii, M.4    Murata, H.5    Hori, M.6
  • 42
    • 0034806996 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drugs induce apoptosis in gastric cancer cells through up-regulation of bax and bak
    • Zhou X.M., Wong B.C.Y., Fan X.M., Zhang H.B., Lin M.C.M., Kung H.F., Lam S.K. Non-steroidal anti-inflammatory drugs induce apoptosis in gastric cancer cells through up-regulation of bax and bak. Carcinogenesis 2001, 22:1393-1397.
    • (2001) Carcinogenesis , vol.22 , pp. 1393-1397
    • Zhou, X.M.1    Wong, B.C.Y.2    Fan, X.M.3    Zhang, H.B.4    Lin, M.C.M.5    Kung, H.F.6    Lam, S.K.7
  • 44
    • 0032816236 scopus 로고    scopus 로고
    • Aspirin protects against gastric cancer: results of a case-control study from Moscow, Russia
    • Zaridze D., Borisova E., Maximovitch D., Chkhikvadze V. Aspirin protects against gastric cancer: results of a case-control study from Moscow, Russia. Int. J. Cancer 1999, 82:473-476.
    • (1999) Int. J. Cancer , vol.82 , pp. 473-476
    • Zaridze, D.1    Borisova, E.2    Maximovitch, D.3    Chkhikvadze, V.4
  • 45
    • 0346258154 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drug use and the risk of gastric cancer: a systematic review and meta-analysis
    • Wang W.H., Huang J.Q., Zheng G.F., Lam S.K., Karlberg J., Wong B.C.-Y. Non-steroidal anti-inflammatory drug use and the risk of gastric cancer: a systematic review and meta-analysis. J. Natl. Cancer Inst. 2003, 95:1784-1791.
    • (2003) J. Natl. Cancer Inst. , vol.95 , pp. 1784-1791
    • Wang, W.H.1    Huang, J.Q.2    Zheng, G.F.3    Lam, S.K.4    Karlberg, J.5    Wong, B.C.-Y.6
  • 46
    • 0032957424 scopus 로고    scopus 로고
    • Helicobacter pylori infection and risk of cardia cancer and non-cardia gastric cancer: a nested case-control study
    • Hansen S., Melby K., Aase S., Jellum E., Vollset S. Helicobacter pylori infection and risk of cardia cancer and non-cardia gastric cancer: a nested case-control study. Scand. J. Gastroenterol. 1999, 34:353-360.
    • (1999) Scand. J. Gastroenterol. , vol.34 , pp. 353-360
    • Hansen, S.1    Melby, K.2    Aase, S.3    Jellum, E.4    Vollset, S.5
  • 47
    • 0035815222 scopus 로고    scopus 로고
    • Aspirin and risk for gastric cancer: a population-based case - control study in Sweden
    • Akre K., Ekström A., Signorello L., Hansson L., Nyren O. Aspirin and risk for gastric cancer: a population-based case - control study in Sweden. Br. J. Cancer 2001, 84:965.
    • (2001) Br. J. Cancer , vol.84 , pp. 965
    • Akre, K.1    Ekström, A.2    Signorello, L.3    Hansson, L.4    Nyren, O.5
  • 48
    • 77953538362 scopus 로고    scopus 로고
    • Meta-analysis on the relationship between nonsteroidal anti-inflammatory drug use and gastric cancer
    • Tian W., Zhao Y., Liu S., Li X. Meta-analysis on the relationship between nonsteroidal anti-inflammatory drug use and gastric cancer. Eur. J. Cancer Prev. 2010, 19:288-298.
    • (2010) Eur. J. Cancer Prev. , vol.19 , pp. 288-298
    • Tian, W.1    Zhao, Y.2    Liu, S.3    Li, X.4
  • 49
    • 77954613539 scopus 로고    scopus 로고
    • Effective reduction of gastric cancer risk with regular use of nonsteroidal anti-inflammatory drugs in Helicobacter pylori - infected patients
    • Wu C.-Y., Wu M.-S., Kuo K.N., Wang C.-B., Chen Y.-J., Lin J.-T. Effective reduction of gastric cancer risk with regular use of nonsteroidal anti-inflammatory drugs in Helicobacter pylori - infected patients. J. Clin. Oncol. 2010, 28:2952-2957.
    • (2010) J. Clin. Oncol. , vol.28 , pp. 2952-2957
    • Wu, C.-Y.1    Wu, M.-S.2    Kuo, K.N.3    Wang, C.-B.4    Chen, Y.-J.5    Lin, J.-T.6
  • 52
  • 55
    • 0035863223 scopus 로고    scopus 로고
    • Increased expression of cyclooxygenase-2 in human pancreatic neoplasms and potential for chemoprevention by cyclooxygenase inhibitors
    • Kokawa A., Kondo H., Gotoda T., Ono H., Saito D., Nakadaira S., Kosuge T., Yoshida S. Increased expression of cyclooxygenase-2 in human pancreatic neoplasms and potential for chemoprevention by cyclooxygenase inhibitors. Cancer 2001, 91:333-338.
    • (2001) Cancer , vol.91 , pp. 333-338
    • Kokawa, A.1    Kondo, H.2    Gotoda, T.3    Ono, H.4    Saito, D.5    Nakadaira, S.6    Kosuge, T.7    Yoshida, S.8
  • 56
    • 0038489501 scopus 로고    scopus 로고
    • Potential involvement of the cyclooxygenase-2 pathway in the regulation of tumor-associated angiogenesis and growth in pancreatic cancer1
    • Chu J., Lloyd F.L., Trifan O.C., Knapp B., Rizzo M.T. Potential involvement of the cyclooxygenase-2 pathway in the regulation of tumor-associated angiogenesis and growth in pancreatic cancer1. Mol. Cancer Ther. 2003, 2:1-7.
    • (2003) Mol. Cancer Ther. , vol.2 , pp. 1-7
    • Chu, J.1    Lloyd, F.L.2    Trifan, O.C.3    Knapp, B.4    Rizzo, M.T.5
  • 57
    • 0033199017 scopus 로고    scopus 로고
    • Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines growth inhibition by nonsteroidal anti-inflammatory drugs
    • Molina M.A., Sitja-Arnau M., Lemoine M.G., Frazier M.L., Sinicrope F.A. Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines growth inhibition by nonsteroidal anti-inflammatory drugs. Cancer Res. 1999, 59:4356-4362.
    • (1999) Cancer Res. , vol.59 , pp. 4356-4362
    • Molina, M.A.1    Sitja-Arnau, M.2    Lemoine, M.G.3    Frazier, M.L.4    Sinicrope, F.A.5
  • 58
    • 9444296055 scopus 로고    scopus 로고
    • Cyclooxygenase-2-dependent and-independent effects of celecoxib in pancreatic cancer cell lines
    • El-Rayes B.F., Ali S., Sarkar F.H., Philip P.A. Cyclooxygenase-2-dependent and-independent effects of celecoxib in pancreatic cancer cell lines. Mol. Cancer Ther. 2004, 3:1421-1426.
    • (2004) Mol. Cancer Ther. , vol.3 , pp. 1421-1426
    • El-Rayes, B.F.1    Ali, S.2    Sarkar, F.H.3    Philip, P.A.4
  • 60
    • 1542615084 scopus 로고    scopus 로고
    • Celecoxib inhibits vascular endothelial growth factor expression in and reduces angiogenesis and metastasis of human pancreatic cancer via suppression of Sp1 transcription factor activity
    • Wei D., Wang L., He Y., Xiong H.Q., Abbruzzese J.L., Xie K. Celecoxib inhibits vascular endothelial growth factor expression in and reduces angiogenesis and metastasis of human pancreatic cancer via suppression of Sp1 transcription factor activity. Cancer Res. 2004, 64:2030-2038.
    • (2004) Cancer Res. , vol.64 , pp. 2030-2038
    • Wei, D.1    Wang, L.2    He, Y.3    Xiong, H.Q.4    Abbruzzese, J.L.5    Xie, K.6
  • 61
    • 57349145254 scopus 로고    scopus 로고
    • Nitric oxide-donating aspirin inhibits the growth of pancreatic cancer cells through redox-dependent signaling
    • Zhou H., Huang L., Sun Y., Rigas B. Nitric oxide-donating aspirin inhibits the growth of pancreatic cancer cells through redox-dependent signaling. Cancer Lett. 2009, 273:292-299.
    • (2009) Cancer Lett. , vol.273 , pp. 292-299
    • Zhou, H.1    Huang, L.2    Sun, Y.3    Rigas, B.4
  • 62
    • 34547613903 scopus 로고    scopus 로고
    • Delayed progression of pancreatic intraepithelial neoplasia in a conditional KrasG12D mouse model by a selective cyclooxygenase-2 inhibitor
    • Funahashi H., Satake M., Dawson D., Huynh N.-A., Reber H.A., Hines O.J., Eibl G. Delayed progression of pancreatic intraepithelial neoplasia in a conditional KrasG12D mouse model by a selective cyclooxygenase-2 inhibitor. Cancer Res. 2007, 67:7068-7071.
    • (2007) Cancer Res. , vol.67 , pp. 7068-7071
    • Funahashi, H.1    Satake, M.2    Dawson, D.3    Huynh, N.-A.4    Reber, H.A.5    Hines, O.J.6    Eibl, G.7
  • 63
    • 0037036670 scopus 로고    scopus 로고
    • Association between nonsteroidal anti-inflammatory drug use and the incidence of pancreatic cancer
    • Anderson K.E., Johnson T.W., Lazovich D., Folsom A.R. Association between nonsteroidal anti-inflammatory drug use and the incidence of pancreatic cancer. J. Natl. Cancer Inst. 2002, 94:1168-1171.
    • (2002) J. Natl. Cancer Inst. , vol.94 , pp. 1168-1171
    • Anderson, K.E.1    Johnson, T.W.2    Lazovich, D.3    Folsom, A.R.4
  • 64
    • 77951666450 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drugs and pancreatic cancer risk: a nested case-control study
    • Bradley M., Hughes C., Cantwell M., Napolitano G., Murray L. Non-steroidal anti-inflammatory drugs and pancreatic cancer risk: a nested case-control study. Br. J. Cancer 2010, 102:1415-1421.
    • (2010) Br. J. Cancer , vol.102 , pp. 1415-1421
    • Bradley, M.1    Hughes, C.2    Cantwell, M.3    Napolitano, G.4    Murray, L.5
  • 65
    • 81555195411 scopus 로고    scopus 로고
    • Aspirin, nonsteroidal anti-inflammatory drugs, acetaminophen, and pancreatic cancer risk: a clinic-based case-control study
    • Tan X.-L., Lombardo K.M.R., Bamlet W.R., Oberg A.L., Robinson D.P., Anderson K.E., Petersen G.M. Aspirin, nonsteroidal anti-inflammatory drugs, acetaminophen, and pancreatic cancer risk: a clinic-based case-control study. Cancer Prev. Res. 2011, 4:1835-1841.
    • (2011) Cancer Prev. Res. , vol.4 , pp. 1835-1841
    • Tan, X.-L.1    Lombardo, K.M.R.2    Bamlet, W.R.3    Oberg, A.L.4    Robinson, D.P.5    Anderson, K.E.6    Petersen, G.M.7
  • 67
    • 33846023679 scopus 로고    scopus 로고
    • Aspirin and nonsteroidal anti-inflammatory drug use and risk of pancreatic cancer: a meta-analysis
    • Larsson S.C., Giovannucci E., Bergkvist L., Wolk A. Aspirin and nonsteroidal anti-inflammatory drug use and risk of pancreatic cancer: a meta-analysis. Cancer Epidemiol. Biomarkers Prev. 2006, 15:2561-2564.
    • (2006) Cancer Epidemiol. Biomarkers Prev. , vol.15 , pp. 2561-2564
    • Larsson, S.C.1    Giovannucci, E.2    Bergkvist, L.3    Wolk, A.4
  • 76
    • 17044453428 scopus 로고    scopus 로고
    • Increased expression of COX-2 in nontumor liver tissue is associated with shorter disease-free survival in patients with hepatocellular carcinoma
    • Kondo M., Yamamoto H., Nagano H., Okami J., Ito Y., Shimizu J., Eguchi H., Miyamoto A., Dono K., Umeshita K. Increased expression of COX-2 in nontumor liver tissue is associated with shorter disease-free survival in patients with hepatocellular carcinoma. Clin. Cancer Res. 1999, 5:4005-4012.
    • (1999) Clin. Cancer Res. , vol.5 , pp. 4005-4012
    • Kondo, M.1    Yamamoto, H.2    Nagano, H.3    Okami, J.4    Ito, Y.5    Shimizu, J.6    Eguchi, H.7    Miyamoto, A.8    Dono, K.9    Umeshita, K.10
  • 77
    • 0037411105 scopus 로고    scopus 로고
    • Expression of cyclooxygenase 2 and cytosolic phospholipase A(2) in the liver tissue of patients with chronic hepatitis and liver cirrhosis
    • Cheng J., Imanishi H., Iijima H., Shimomura S., Yamamoto T., Amuro Y., Kubota A., Hada T. Expression of cyclooxygenase 2 and cytosolic phospholipase A(2) in the liver tissue of patients with chronic hepatitis and liver cirrhosis. Hepatol. Res. 2002, 23:185-195.
    • (2002) Hepatol. Res. , vol.23 , pp. 185-195
    • Cheng, J.1    Imanishi, H.2    Iijima, H.3    Shimomura, S.4    Yamamoto, T.5    Amuro, Y.6    Kubota, A.7    Hada, T.8
  • 78
    • 0041822007 scopus 로고    scopus 로고
    • Cyclooxygenase-2 promotes hepatocellular carcinoma cell growth through AKT activation: evidence for AKT inhibition in celecoxib-induced apoptosis
    • Leng J., Han C., Demetris A.J., Michalopoulos G.K., Wu T. Cyclooxygenase-2 promotes hepatocellular carcinoma cell growth through AKT activation: evidence for AKT inhibition in celecoxib-induced apoptosis. Hepatology 2003, 38:756-768.
    • (2003) Hepatology , vol.38 , pp. 756-768
    • Leng, J.1    Han, C.2    Demetris, A.J.3    Michalopoulos, G.K.4    Wu, T.5
  • 79
    • 28144445331 scopus 로고    scopus 로고
    • In vitro and in vivo effects and mechanisms of celecoxib-induced growth inhibition of human hepatocellular carcinoma cells
    • Cui W., Yu C.-H., Hu K.-Q. In vitro and in vivo effects and mechanisms of celecoxib-induced growth inhibition of human hepatocellular carcinoma cells. Clin. Cancer Res. 2005, 11:8213-8221.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 8213-8221
    • Cui, W.1    Yu, C.-H.2    Hu, K.-Q.3
  • 83
    • 0344275593 scopus 로고    scopus 로고
    • Specific COX-2 inhibitor, NS-398, suppresses cellular proliferation and induces apoptosis in human hepatocellular carcinoma cells
    • Cheng A., Chan H., Leung W.K., Wong N., Johnson P.J., Sung J. Specific COX-2 inhibitor, NS-398, suppresses cellular proliferation and induces apoptosis in human hepatocellular carcinoma cells. Int. J. Cancer 2003, 23:113.
    • (2003) Int. J. Cancer , vol.23 , pp. 113
    • Cheng, A.1    Chan, H.2    Leung, W.K.3    Wong, N.4    Johnson, P.J.5    Sung, J.6
  • 84
    • 0034655190 scopus 로고    scopus 로고
    • Sulindac and exisulind exhibit a significant antiproliferative effect and induce apoptosis in human hepatocellular carcinoma cell lines
    • Rahman M.A., Dhar D.K., Masunaga R., Yamanoi A., Kohno H., Nagasue N. Sulindac and exisulind exhibit a significant antiproliferative effect and induce apoptosis in human hepatocellular carcinoma cell lines. Cancer Res. 2000, 60:2085-2089.
    • (2000) Cancer Res. , vol.60 , pp. 2085-2089
    • Rahman, M.A.1    Dhar, D.K.2    Masunaga, R.3    Yamanoi, A.4    Kohno, H.5    Nagasue, N.6
  • 86
    • 0042666923 scopus 로고    scopus 로고
    • K.i. Wakasa, Y. Sugita, J. Chang-de, S. Kobayashi, B. Damdinsuren, K. Dono, JTE-522, a cyclooxygenase-2 inhibitor, is an effective chemopreventive agent against rat experimental liver fibrosis
    • Yamamoto H., Kondo M., Nakamori S., Nagano H. K.i. Wakasa, Y. Sugita, J. Chang-de, S. Kobayashi, B. Damdinsuren, K. Dono, JTE-522, a cyclooxygenase-2 inhibitor, is an effective chemopreventive agent against rat experimental liver fibrosis. Gastroenterology 2003, 125:556-571.
    • (2003) Gastroenterology , vol.125 , pp. 556-571
    • Yamamoto, H.1    Kondo, M.2    Nakamori, S.3    Nagano, H.4
  • 89
  • 91
    • 0031984810 scopus 로고    scopus 로고
    • Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells
    • Sheng H., Shao J., Morrow J.D., Beauchamp R.D., DuBois R.N. Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells. Cancer Res. 1998, 58:362-366.
    • (1998) Cancer Res. , vol.58 , pp. 362-366
    • Sheng, H.1    Shao, J.2    Morrow, J.D.3    Beauchamp, R.D.4    DuBois, R.N.5
  • 92
    • 0035869678 scopus 로고    scopus 로고
    • Tumor invasiveness and liver metastasis of colon cancer cells correlated with cyclooxygenase-2 (COX-2) expression and inhibited by a COX-2-selective inhibitor, etodolac
    • Chen W.S., Wei S.J., Liu J.M., Hsiao M., Kou-Lin J., Yang W.K. Tumor invasiveness and liver metastasis of colon cancer cells correlated with cyclooxygenase-2 (COX-2) expression and inhibited by a COX-2-selective inhibitor, etodolac. Int. J. Cancer 2001, 91:894-899.
    • (2001) Int. J. Cancer , vol.91 , pp. 894-899
    • Chen, W.S.1    Wei, S.J.2    Liu, J.M.3    Hsiao, M.4    Kou-Lin, J.5    Yang, W.K.6
  • 94
    • 0025998557 scopus 로고
    • Aspirin use and reduced risk of fatal colon cancer
    • Thun M.J., Namboodiri M.M., Heath C.W. Aspirin use and reduced risk of fatal colon cancer. N. Engl. J. Med. 1991, 325:1593-1596.
    • (1991) N. Engl. J. Med. , vol.325 , pp. 1593-1596
    • Thun, M.J.1    Namboodiri, M.M.2    Heath, C.W.3
  • 97
    • 21444450527 scopus 로고    scopus 로고
    • Low-dose aspirin in the primary prevention of cancer: the women's health study: a randomized controlled trial
    • Cook N.R., Lee I.M., Gaziano J.M., Gordon D., Ridker P.M., Manson J.E., Hennekens C.H., Buring J.E. Low-dose aspirin in the primary prevention of cancer: the women's health study: a randomized controlled trial. JAMA 2005, 294:47-55.
    • (2005) JAMA , vol.294 , pp. 47-55
    • Cook, N.R.1    Lee, I.M.2    Gaziano, J.M.3    Gordon, D.4    Ridker, P.M.5    Manson, J.E.6    Hennekens, C.H.7    Buring, J.E.8
  • 98
    • 34248157118 scopus 로고    scopus 로고
    • Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studies
    • Flossmann E., Rothwell P.M. Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studies. Lancet 2007, 369:1603-1613.
    • (2007) Lancet , vol.369 , pp. 1603-1613
    • Flossmann, E.1    Rothwell, P.M.2
  • 99
    • 78650215449 scopus 로고    scopus 로고
    • Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials
    • Rothwell P.M., Wilson M., Elwin C.-E., Norrving B., Algra A., Warlow C.P., Meade T.W. Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials. Lancet 2010, 376:1741-1750.
    • (2010) Lancet , vol.376 , pp. 1741-1750
    • Rothwell, P.M.1    Wilson, M.2    Elwin, C.-E.3    Norrving, B.4    Algra, A.5    Warlow, C.P.6    Meade, T.W.7
  • 100
    • 34249673868 scopus 로고    scopus 로고
    • Aspirin and the risk of colorectal cancer in relation to the expression of COX-2
    • Chan A.T., Ogino S., Fuchs C.S. Aspirin and the risk of colorectal cancer in relation to the expression of COX-2. N. Engl. J. Med. 2007, 356:2131-2142.
    • (2007) N. Engl. J. Med. , vol.356 , pp. 2131-2142
    • Chan, A.T.1    Ogino, S.2    Fuchs, C.S.3
  • 108
    • 23944436934 scopus 로고    scopus 로고
    • Long-term use of aspirin and nonsteroidal anti-inflammatory drugs and risk of colorectal cancer
    • Chan A.T., Giovannucci E.L., Meyerhardt J.A., Schernhammer E.S., Curhan G.C., Fuchs C.S. Long-term use of aspirin and nonsteroidal anti-inflammatory drugs and risk of colorectal cancer. JAMA 2005, 294:914-923.
    • (2005) JAMA , vol.294 , pp. 914-923
    • Chan, A.T.1    Giovannucci, E.L.2    Meyerhardt, J.A.3    Schernhammer, E.S.4    Curhan, G.C.5    Fuchs, C.S.6
  • 113
    • 68849123400 scopus 로고    scopus 로고
    • Aspirin use and survival after diagnosis of colorectal cancer
    • Chan A.T., Ogino S., Fuchs C.S. Aspirin use and survival after diagnosis of colorectal cancer. JAMA 2009, 302:649-658.
    • (2009) JAMA , vol.302 , pp. 649-658
    • Chan, A.T.1    Ogino, S.2    Fuchs, C.S.3
  • 117
    • 84867897314 scopus 로고    scopus 로고
    • Aspirin and other non-steroidal anti-inflammatory drug use and colorectal cancer survival: a cohort study
    • Walker A., Grainge M., Card T. Aspirin and other non-steroidal anti-inflammatory drug use and colorectal cancer survival: a cohort study. Br. J. Cancer 2012.
    • (2012) Br. J. Cancer
    • Walker, A.1    Grainge, M.2    Card, T.3
  • 118
    • 84860467522 scopus 로고    scopus 로고
    • Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials
    • Algra A.M., Rothwell P.M. Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials. Lancet Oncol. 2012.
    • (2012) Lancet Oncol.
    • Algra, A.M.1    Rothwell, P.M.2
  • 119
    • 36849055147 scopus 로고    scopus 로고
    • Thinking in and out of the box when it comes to gastric cancer and cyclooxygenase-2
    • Izzo J.G., Ajani J.A. Thinking in and out of the box when it comes to gastric cancer and cyclooxygenase-2. J. Clin. Oncol. 2007, 25:4865-4867.
    • (2007) J. Clin. Oncol. , vol.25 , pp. 4865-4867
    • Izzo, J.G.1    Ajani, J.A.2
  • 121
    • 67449116215 scopus 로고    scopus 로고
    • Chronic nonsteroidal anti-inflammatory drug (NSAID) use suppresses multiple CpG islands hyper methylation (CIHM) of tumor suppressor genes in the human gastric mucosa
    • Tahara T., Shibata T., Yamashita H., Nakamura M., Yoshioka D., Okubo M., Hirata I., Arisawa T. Chronic nonsteroidal anti-inflammatory drug (NSAID) use suppresses multiple CpG islands hyper methylation (CIHM) of tumor suppressor genes in the human gastric mucosa. Cancer Sci. 2009, 100:1192-1197.
    • (2009) Cancer Sci. , vol.100 , pp. 1192-1197
    • Tahara, T.1    Shibata, T.2    Yamashita, H.3    Nakamura, M.4    Yoshioka, D.5    Okubo, M.6    Hirata, I.7    Arisawa, T.8
  • 123
    • 33644846509 scopus 로고    scopus 로고
    • Epigenetic gene silencing in cancer-a mechanism for early oncogenic pathway addiction?
    • Baylin S.B., Ohm J.E. Epigenetic gene silencing in cancer-a mechanism for early oncogenic pathway addiction?. Nat. Rev. Cancer 2006, 6:107-116.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 107-116
    • Baylin, S.B.1    Ohm, J.E.2
  • 127
    • 28044436484 scopus 로고    scopus 로고
    • Nitric oxide-donating aspirin induces apoptosis in human colon cancer cells through induction of oxidative stress
    • Gao J., Liu X., Rigas B. Nitric oxide-donating aspirin induces apoptosis in human colon cancer cells through induction of oxidative stress. Proc. Natl. Acad. Sci. USA 2005, 102:17207-17212.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 17207-17212
    • Gao, J.1    Liu, X.2    Rigas, B.3
  • 128
    • 77953478344 scopus 로고    scopus 로고
    • The proapoptotic BH3-only protein Bim is downregulated in a subset of colorectal cancers and is repressed by antiapoptotic COX-2/PGE2 signalling in colorectal adenoma cells
    • Greenhough A., Wallam C.A., Hicks D.J., Moorghen M., Williams A.C., Paraskeva C. The proapoptotic BH3-only protein Bim is downregulated in a subset of colorectal cancers and is repressed by antiapoptotic COX-2/PGE2 signalling in colorectal adenoma cells. Oncogene 2010, 29:3398-3410.
    • (2010) Oncogene , vol.29 , pp. 3398-3410
    • Greenhough, A.1    Wallam, C.A.2    Hicks, D.J.3    Moorghen, M.4    Williams, A.C.5    Paraskeva, C.6
  • 129
    • 0036829336 scopus 로고    scopus 로고
    • Cyclooxygenase-2 overexpression reduces apoptotic susceptibility by inhibiting the cytochrome c-dependent apoptotic pathway in human colon cancer cells
    • Sun Y., Tang X.M., Half E., Kuo M.T., Sinicrope F.A. Cyclooxygenase-2 overexpression reduces apoptotic susceptibility by inhibiting the cytochrome c-dependent apoptotic pathway in human colon cancer cells. Cancer Res. 2002, 62:6323-6328.
    • (2002) Cancer Res. , vol.62 , pp. 6323-6328
    • Sun, Y.1    Tang, X.M.2    Half, E.3    Kuo, M.T.4    Sinicrope, F.A.5
  • 132
    • 0037328659 scopus 로고    scopus 로고
    • 15-Lipoxygenase-1 mediates cyclooxygenase-2 inhibitor-induced apoptosis in gastric cancer
    • Wu J., Xia H.H.X., Tu S.P., Lin M.C.M., Kung H.F., Lam S.K., Wong B.C.Y. 15-Lipoxygenase-1 mediates cyclooxygenase-2 inhibitor-induced apoptosis in gastric cancer. Carcinogenesis 2003, 24:243-247.
    • (2003) Carcinogenesis , vol.24 , pp. 243-247
    • Wu, J.1    Xia, H.H.X.2    Tu, S.P.3    Lin, M.C.M.4    Kung, H.F.5    Lam, S.K.6    Wong, B.C.Y.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.