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Volumn 192, Issue 4, 2014, Pages 1609-1619

Noncore RAG1 regions promote Vβ rearrangements and αβ T cell development by overcoming inherent inefficiency of Vβ recombination signal sequences

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BCL 2; RAG1 PROTEIN; RECOMBINASE; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN;

EID: 84896737443     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1301599     Document Type: Article
Times cited : (10)

References (53)
  • 1
    • 0035008189 scopus 로고    scopus 로고
    • RAG1 and RAG2 in V(D)J recombination and transposition
    • Fugmann, S. D. 2001. RAG1 and RAG2 in V(D)J recombination and transposition. Immunol. Res. 23: 23-39.
    • (2001) Immunol. Res. , vol.23 , pp. 23-39
    • Fugmann, S.D.1
  • 2
    • 80355122714 scopus 로고    scopus 로고
    • V(D)J recombination: Mechanisms of initiation
    • Schatz, D. G., and P. C. Swanson. 2011. V(D)J recombination: mechanisms of initiation. Annu. Rev. Genet. 45: 167-202.
    • (2011) Annu. Rev. Genet. , vol.45 , pp. 167-202
    • Schatz, D.G.1    Swanson, P.C.2
  • 3
    • 77953229115 scopus 로고    scopus 로고
    • The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway
    • Lieber, M. R. 2010. The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu. Rev. Biochem. 79: 181-211.
    • (2010) Annu. Rev. Biochem. , vol.79 , pp. 181-211
    • Lieber, M.R.1
  • 4
    • 84859394323 scopus 로고    scopus 로고
    • The response to and repair of RAGmediated DNA double-strand breaks
    • Helmink, B. A., and B. P. Sleckman. 2012. The response to and repair of RAGmediated DNA double-strand breaks. Annu. Rev. Immunol. 30: 175-202.
    • (2012) Annu. Rev. Immunol. , vol.30 , pp. 175-202
    • Helmink, B.A.1    Sleckman, B.P.2
  • 5
    • 3242886494 scopus 로고    scopus 로고
    • Recombination-activating gene proteins: More regulation, please
    • Sadofsky, M. J. 2004. Recombination-activating gene proteins: more regulation, please. Immunol. Rev. 200: 83-89.
    • (2004) Immunol. Rev. , vol.200 , pp. 83-89
    • Sadofsky, M.J.1
  • 6
    • 34248233500 scopus 로고    scopus 로고
    • Murine models of Omenn syndrome
    • Wong, S. Y., and D. B. Roth. 2007. Murine models of Omenn syndrome. J. Clin. Invest. 117: 1213-1216.
    • (2007) J. Clin. Invest. , vol.117 , pp. 1213-1216
    • Wong, S.Y.1    Roth, D.B.2
  • 8
    • 76749147849 scopus 로고    scopus 로고
    • Primary immunodeficiencies
    • Notarangelo, L. D. 2010. Primary immunodeficiencies. J. Allergy Clin. Immunol. 125(2, Suppl 2)S182-S194.
    • (2010) J. Allergy Clin. Immunol. , vol.125 , Issue.2 SUPPL. 2
    • Notarangelo, L.D.1
  • 9
    • 45449107373 scopus 로고    scopus 로고
    • Genetically determined lymphopenia and autoimmune manifestations
    • Villa, A., V. Marrella, F. Rucci, and L. D. Notarangelo. 2008. Genetically determined lymphopenia and autoimmune manifestations. Curr. Opin. Immunol. 20: 318-324.
    • (2008) Curr. Opin. Immunol. , vol.20 , pp. 318-324
    • Villa, A.1    Marrella, V.2    Rucci, F.3    Notarangelo, L.D.4
  • 10
    • 0036850786 scopus 로고    scopus 로고
    • The "dispensable" portion of RAG2 is necessary for efficient V-to-DJ rearrangement during B and T cell development
    • Liang, H. E., L. Y. Hsu, D. Cado, L. G. Cowell, G. Kelsoe, and M. S. Schlissel. 2002. The "dispensable" portion of RAG2 is necessary for efficient V-to-DJ rearrangement during B and T cell development. Immunity 17: 639-651.
    • (2002) Immunity , vol.17 , pp. 639-651
    • Liang, H.E.1    Hsu, L.Y.2    Cado, D.3    Cowell, L.G.4    Kelsoe, G.5    Schlissel, M.S.6
  • 13
    • 65249145203 scopus 로고    scopus 로고
    • Mechanics of T cell receptor gene rearrangement
    • Krangel, M. S. 2009. Mechanics of T cell receptor gene rearrangement. Curr. Opin. Immunol. 21: 133-139.
    • (2009) Curr. Opin. Immunol. , vol.21 , pp. 133-139
    • Krangel, M.S.1
  • 15
    • 0035160218 scopus 로고    scopus 로고
    • Biased Vβ usage in immature thymocytes is independent of DJβ proximity and pTα pairing
    • Wilson, A., C. Maréchal, and H. R. MacDonald. 2001. Biased Vβ usage in immature thymocytes is independent of DJβ proximity and pTα pairing. J. Immunol. 166: 51-57.
    • (2001) J. Immunol. , vol.166 , pp. 51-57
    • Wilson, A.1    Maréchal, C.2    MacDonald, H.R.3
  • 16
    • 77955506350 scopus 로고    scopus 로고
    • Posttranscriptional silencing of VβDJβCβ genes contributes to TCRβ allelic exclusion in mammalian lymphocytes
    • Steinel, N. C., B. L. Brady, A. C. Carpenter, K. S. Yang-Iott, and C. H. Bassing. 2010. Posttranscriptional silencing of VβDJβCβ genes contributes to TCRβ allelic exclusion in mammalian lymphocytes. J. Immunol. 185: 1055-1062.
    • (2010) J. Immunol. , vol.185 , pp. 1055-1062
    • Steinel, N.C.1    Brady, B.L.2    Carpenter, A.C.3    Yang-Iott, K.S.4    Bassing, C.H.5
  • 17
    • 74049110516 scopus 로고    scopus 로고
    • Checkpoints in lymphocyte development and autoimmune disease
    • von Boehmer, H., and F. Melchers. 2010. Checkpoints in lymphocyte development and autoimmune disease. Nat. Immunol. 11: 14-20.
    • (2010) Nat. Immunol. , vol.11 , pp. 14-20
    • Von Boehmer, H.1    Melchers, F.2
  • 19
    • 3242882807 scopus 로고    scopus 로고
    • Enforcing order within a complex locus: Current perspectives on the control of V(D)J recombination at the murine T-cell receptor α/δ locus
    • Krangel, M. S., J. Carabana, I. Abbarategui, R. Schlimgen, and A. Hawwari. 2004. Enforcing order within a complex locus: current perspectives on the control of V(D)J recombination at the murine T-cell receptor α/δ locus. Immunol. Rev. 200: 224-232.
    • (2004) Immunol. Rev. , vol.200 , pp. 224-232
    • Krangel, M.S.1    Carabana, J.2    Abbarategui, I.3    Schlimgen, R.4    Hawwari, A.5
  • 20
    • 0035253709 scopus 로고    scopus 로고
    • Differential transcriptional regulation of individual TCR Vβ segments before gene rearrangement
    • Chen, F., L. Rowen, L. Hood, and E. V. Rothenberg. 2001. Differential transcriptional regulation of individual TCR Vβ segments before gene rearrangement. J. Immunol. 166: 1771-1780.
    • (2001) J. Immunol. , vol.166 , pp. 1771-1780
    • Chen, F.1    Rowen, L.2    Hood, L.3    Rothenberg, E.V.4
  • 21
    • 0037243276 scopus 로고    scopus 로고
    • Dramatically increased rearrangement and peripheral representation of Vβ14 driven by the 3′Dβ1 recombination signal sequence
    • Wu, C., C. H. Bassing, D. Jung, B. B. Woodman, D. Foy, and F. W. Alt. 2003. Dramatically increased rearrangement and peripheral representation of Vβ14 driven by the 3′Dβ1 recombination signal sequence. Immunity 18: 75-85.
    • (2003) Immunity , vol.18 , pp. 75-85
    • Wu, C.1    Bassing, C.H.2    Jung, D.3    Woodman, B.B.4    Foy, D.5    Alt, F.W.6
  • 24
    • 0023663430 scopus 로고
    • T cell tolerance by clonal elimination in the thymus
    • Kappler, J. W., N. Roehm, and P. Marrack. 1987. T cell tolerance by clonal elimination in the thymus. Cell 49: 273-280.
    • (1987) Cell , vol.49 , pp. 273-280
    • Kappler, J.W.1    Roehm, N.2    Marrack, P.3
  • 25
    • 0023837985 scopus 로고
    • Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex
    • Kappler, J. W., U. Staerz, J. White, and P. C. Marrack. 1988. Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex. Nature 332: 35-40.
    • (1988) Nature , vol.332 , pp. 35-40
    • Kappler, J.W.1    Staerz, U.2    White, J.3    Marrack, P.C.4
  • 27
    • 0023711938 scopus 로고
    • Molecular basis for the nonexpression of Vβ17 in some strains of mice
    • Wade, T., J. Bill, P. C. Marrack, E. Palmer, and J. W. Kappler. 1988. Molecular basis for the nonexpression of Vβ17 in some strains of mice. J. Immunol. 141: 2165-2167.
    • (1988) J. Immunol. , vol.141 , pp. 2165-2167
    • Wade, T.1    Bill, J.2    Marrack, P.C.3    Palmer, E.4    Kappler, J.W.5
  • 29
    • 0025786164 scopus 로고
    • Bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship
    • Strasser, A., A. W. Harris, and S. Cory. 1991. Bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship. Cell 67: 889-899.
    • (1991) Cell , vol.67 , pp. 889-899
    • Strasser, A.1    Harris, A.W.2    Cory, S.3
  • 31
    • 0033559547 scopus 로고    scopus 로고
    • A conserved sequence block in the murine and human TCR Jα region: Assessment of regulatory function in vivo
    • Riegert, P., and S. Gilfillan. 1999. A conserved sequence block in the murine and human TCR Jα region: assessment of regulatory function in vivo. J. Immunol. 162: 3471-3480.
    • (1999) J. Immunol. , vol.162 , pp. 3471-3480
    • Riegert, P.1    Gilfillan, S.2
  • 32
    • 84875431073 scopus 로고    scopus 로고
    • Requirement for dicer in survival of proliferating thymocytes experiencing DNA double-strand breaks
    • Brady, B. L., L. J. Rupp, and C. H. Bassing. 2013. Requirement for dicer in survival of proliferating thymocytes experiencing DNA double-strand breaks. J. Immunol. 190: 3256-3266.
    • (2013) J. Immunol. , vol.190 , pp. 3256-3266
    • Brady, B.L.1    Rupp, L.J.2    Bassing, C.H.3
  • 33
    • 80053065504 scopus 로고    scopus 로고
    • Differential regulation of proximal and distal Vβ segments upstream of a functional VDJβ1 rearrangement upon β-selection
    • Brady, B. L., and C. H. Bassing. 2011. Differential regulation of proximal and distal Vβ segments upstream of a functional VDJβ1 rearrangement upon β-selection. J. Immunol. 187: 3277-3285.
    • (2011) J. Immunol. , vol.187 , pp. 3277-3285
    • Brady, B.L.1    Bassing, C.H.2
  • 35
    • 0024341218 scopus 로고
    • Positive and negative selection of T cell receptor Vβ domains controlled by distinct cell populations in the thymus
    • Speiser, D. E., R. K. Lees, H. Hengartner, R. M. Zinkernagel, and H. R. MacDonald. 1989. Positive and negative selection of T cell receptor Vβ domains controlled by distinct cell populations in the thymus. J. Exp. Med. 170: 2165-2170.
    • (1989) J. Exp. Med. , vol.170 , pp. 2165-2170
    • Speiser, D.E.1    Lees, R.K.2    Hengartner, H.3    Zinkernagel, R.M.4    MacDonald, H.R.5
  • 36
    • 78650370933 scopus 로고    scopus 로고
    • Promoters, enhancers, and transcription target RAG1 binding during V(D)J recombination
    • Ji, Y., A. J. Little, J. K. Banerjee, B. Hao, E. M. Oltz, M. S. Krangel, and D. G. Schatz. 2010. Promoters, enhancers, and transcription target RAG1 binding during V(D)J recombination. J. Exp. Med. 207: 2809-2816.
    • (2010) J. Exp. Med. , vol.207 , pp. 2809-2816
    • Ji, Y.1    Little, A.J.2    Banerjee, J.K.3    Hao, B.4    Oltz, E.M.5    Krangel, M.S.6    Schatz, D.G.7
  • 37
    • 77953638539 scopus 로고    scopus 로고
    • Transcription-dependent mobilization of nucleosomes at accessible TCR gene segments in vivo
    • Kondilis-Mangum, H. D., R. M. Cobb, O. Osipovich, S. Srivatsan, E. M. Oltz, and M. S. Krangel. 2010. Transcription-dependent mobilization of nucleosomes at accessible TCR gene segments in vivo. J. Immunol. 184: 6970-6977.
    • (2010) J. Immunol. , vol.184 , pp. 6970-6977
    • Kondilis-Mangum, H.D.1    Cobb, R.M.2    Osipovich, O.3    Srivatsan, S.4    Oltz, E.M.5    Krangel, M.S.6
  • 38
    • 34547112535 scopus 로고    scopus 로고
    • Essential function for SWI-SNF chromatin-remodeling complexes in the promoter-directed assembly of Tcrb genes
    • Osipovich, O., R. M. Cobb, K. J. Oestreich, S. Pierce, P. Ferrier, and E. M. Oltz. 2007. Essential function for SWI-SNF chromatin-remodeling complexes in the promoter-directed assembly of Tcrb genes. Nat. Immunol. 8: 809-816.
    • (2007) Nat. Immunol. , vol.8 , pp. 809-816
    • Osipovich, O.1    Cobb, R.M.2    Oestreich, K.J.3    Pierce, S.4    Ferrier, P.5    Oltz, E.M.6
  • 39
    • 79953164038 scopus 로고    scopus 로고
    • Recombination centres and the orchestration of V(D)J recombination
    • Schatz, D. G., and Y. Ji. 2011. Recombination centres and the orchestration of V(D)J recombination. Nat. Rev. Immunol. 11: 251-263.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 251-263
    • Schatz, D.G.1    Ji, Y.2
  • 40
    • 68049086918 scopus 로고    scopus 로고
    • Chromatin architecture and the generation of antigen receptor diversity
    • Jhunjhunwala, S., M. C. van Zelm, M. M. Peak, and C. Murre. 2009. Chromatin architecture and the generation of antigen receptor diversity. Cell 138: 435-448.
    • (2009) Cell , vol.138 , pp. 435-448
    • Jhunjhunwala, S.1    Van Zelm, M.C.2    Peak, M.M.3    Murre, C.4
  • 43
    • 0347994908 scopus 로고    scopus 로고
    • Autoubiquitylation of the V(D)J recombinase protein RAG1
    • Jones, J. M., and M. Gellert. 2003. Autoubiquitylation of the V(D)J recombinase protein RAG1. Proc. Natl. Acad. Sci. USA 100: 15446-15451.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 15446-15451
    • Jones, J.M.1    Gellert, M.2
  • 44
    • 0037335702 scopus 로고    scopus 로고
    • The RAG1 N-terminal domain is an E3 ubiquitin ligase
    • Yurchenko, V., Z. Xue, and M. Sadofsky. 2003. The RAG1 N-terminal domain is an E3 ubiquitin ligase. Genes Dev. 17: 581-585.
    • (2003) Genes Dev , vol.17 , pp. 581-585
    • Yurchenko, V.1    Xue, Z.2    Sadofsky, M.3
  • 46
    • 79953029378 scopus 로고    scopus 로고
    • The RAG1 V(D)J recombinase/ubiquitin ligase promotes ubiquitylation of acetylated, phosphorylated histone 3.3
    • Jones, J. M., A. Bhattacharyya, C. Simkus, B. Vallieres, T. D. Veenstra, and M. Zhou. 2011. The RAG1 V(D)J recombinase/ubiquitin ligase promotes ubiquitylation of acetylated, phosphorylated histone 3.3. Immunol. Lett. 136: 156-162.
    • (2011) Immunol. Lett. , vol.136 , pp. 156-162
    • Jones, J.M.1    Bhattacharyya, A.2    Simkus, C.3    Vallieres, B.4    Veenstra, T.D.5    Zhou, M.6
  • 47
    • 74749102792 scopus 로고    scopus 로고
    • The RING domain of RAG1 ubiquitylates histone H3: A novel activity in chromatin-mediated regulation of V(D)J joining
    • Grazini, U., F. Zanardi, E. Citterio, S. Casola, C. R. Goding, and F. McBlane. 2010. The RING domain of RAG1 ubiquitylates histone H3: a novel activity in chromatin-mediated regulation of V(D)J joining. Mol. Cell 37: 282-293.
    • (2010) Mol. Cell , vol.37 , pp. 282-293
    • Grazini, U.1    Zanardi, F.2    Citterio, E.3    Casola, S.4    Goding, C.R.5    McBlane, F.6
  • 49
    • 40049107888 scopus 로고    scopus 로고
    • Biochemical and folding defects in a RAG1 variant associated with Omenn syndrome
    • Simkus, C., P. Anand, A. Bhattacharyya, and J. M. Jones. 2007. Biochemical and folding defects in a RAG1 variant associated with Omenn syndrome. J. Immunol. 179: 8332-8340.
    • (2007) J. Immunol. , vol.179 , pp. 8332-8340
    • Simkus, C.1    Anand, P.2    Bhattacharyya, A.3    Jones, J.M.4
  • 50
    • 70349570163 scopus 로고    scopus 로고
    • Germline transcription: A key regulator of accessibility and recombination
    • Abarrategui, I., and M. S. Krangel. 2009. Germline transcription: a key regulator of accessibility and recombination. Adv. Exp. Med. Biol. 650: 93-102.
    • (2009) Adv. Exp. Med. Biol. , vol.650 , pp. 93-102
    • Abarrategui, I.1    Krangel, M.S.2
  • 52
    • 77953720192 scopus 로고    scopus 로고
    • ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks
    • Shanbhag, N. M., I. U. Rafalska-Metcalf, C. Balane-Bolivar, S. M. Janicki, and R. A. Greenberg. 2010. ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks. Cell 141: 970-981.
    • (2010) Cell , vol.141 , pp. 970-981
    • Shanbhag, N.M.1    Rafalska-Metcalf, I.U.2    Balane-Bolivar, C.3    Janicki, S.M.4    Greenberg, R.A.5
  • 53
    • 0032400975 scopus 로고    scopus 로고
    • Decreased frequency of rearrangement due to the synergistic effect of nucleotide changes in the heptamer and nonamer of the recombination signal sequence of the v kappa gene A2b, which is associated with increased susceptibility of Navajos to Haemophilus influenzae type b disease
    • Nadel, B., A. Tang, G. Lugo, V. Love, G. Escuro, and A. J. Feeney. 1998. Decreased frequency of rearrangement due to the synergistic effect of nucleotide changes in the heptamer and nonamer of the recombination signal sequence of the V kappa gene A2b, which is associated with increased susceptibility of Navajos to Haemophilus influenzae type b disease. J. Immunol. 161: 6068-6073.
    • (1998) J. Immunol. , vol.161 , pp. 6068-6073
    • Nadel, B.1    Tang, A.2    Lugo, G.3    Love, V.4    Escuro, G.5    Feeney, A.J.6


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