CD8+ T cell granzyme B activates keratinocyte endogenous IL-18

Archives of Dermatological Research

Volumn 306, Issue 2, 2014, Pages 125-130

  Akeda, Tomoko ^a   Yamanaka, Keiichi ^a   Tsuda, Kenshiro ^a   Omoto, Youichi ^a   Gabazza, Esteban C ^a   Mizutani, Hitoshi ^a  

^a MIE UNIVERSITY   (Japan)

Author keywords

Granzyme B; HaCaT cell; IL 18

Indexed keywords

CHYMASE; GAMMA INTERFERON; GRANZYME B; INTERLEUKIN 18; INTERLEUKIN 1BETA CONVERTING ENZYME; MESSENGER RNA;

ARTICLE; CD8+ T LYMPHOCYTE; CELL ACTIVATION; CELL CULTURE; CELL INTERACTION; CELL LINE; CELL SPECIFICITY; COCULTURE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; KERATINOCYTE; PERIPHERAL BLOOD MONONUCLEAR CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; SUPERNATANT;

APOPTOSIS; CASPASE 1; CD8-POSITIVE T-LYMPHOCYTES; CELL COMMUNICATION; CELL LINE; COCULTURE TECHNIQUES; GENE EXPRESSION REGULATION; GRANZYMES; HUMANS; INFLAMMATION; INTERFERON-GAMMA; INTERLEUKIN-18; KERATINOCYTES; PROTEIN PROCESSING, POST-TRANSLATIONAL; SKIN DISEASES;

EID: 84896736292     PISSN: 03403696     EISSN: 1432069X     Source Type: Journal    
DOI: 10.1007/s00403-013-1382-1     Document Type: Article

References (19)

1. Basham TY, Nickoloff BJ, Merigan TC, Morhenn VB (1984) Recombinant gamma interferon induces HLA-DR expression on cultured human keratinocytes. J Invest Dermatol 83:88-90
2. Gracie JA, Robertson SE, McInnes IB (2003) Interleukin-18. J Leukoc Biol 73:213-224
3. Gu Y, Kuida K, Tsutsui H, Ku G, Hsiao K, Fleming MA, Hayashi N, Higashino K, Okamura H, Nakanishi K, Kurimoto M, Tanimoto T, Flavell RA, Sato V, Harding MW, Livingston DJ, Su MS (1997) Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme. Science 275:206-209
4. Hernandez-Pigeon H, Jean C, Charruyer A, Haure MJ, Baudouin C, Charveron M, Quillet-Mary A, Laurent G (2007) UVA induces granzyme B in human keratinocytes through MIF: implication in extracellular matrix remodeling. J Biol Chem 282:8157-8164
5. Hernandez-Pigeon H, Jean C, Charruyer A, Haure MJ, Titeux M, Tonasso L, Quillet-Mary A, Baudouin C, Charveron M, Laurent G (2006) Human keratinocytes acquire cellular cytotoxicity under UV-B irradiation. Implication of granzyme B and perforin. J Biol Chem 281:13525-13532
6. Kanda N, Shimizu T, Tada Y, Watanabe S (2007) IL-18 enhances IFN-gamma-induced production of CXCL9, CXCL10, and CXCL11 in human keratinocytes. Eur J Immunol 37:338-350
7. Lebre MC, Antons JC, Kalinski P, Schuitemaker JH, van Capel TM, Kapsenberg ML, De Jong EC (2003) Double-stranded RNA-exposed human keratinocytes promote Th1 responses by inducing a type-1 polarized phenotype in dendritic cells: role of keratinocyte-derived tumor necrosis factor alpha, type I interferons, and interleukin-18. J Invest Dermatol 120:990-997
8. Mariathasan S, Newton K, Monack DM, Vucic D, French DM, Lee WP, Roose-Girma M, Erickson S, Dixit VM (2004) Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 430:213-218
9. Mauduit G, Vincent C, Gielen V, Faure M, Demidem A, Thivolet J (1987) Expression of class I-MHC antigens by cultured human epidermis and epidermal allografts. Tissue Antigens 29:65-70
10. Mizutani H, Black R, Kupper TS (1991) Human keratinocytes produce but do not process pro-interleukin-1 (IL-1) beta. Different strategies of IL-1 production and processing in monocytes and keratinocytes. J Clin Invest 87:1066-1071
11. Nakanishi K, Yoshimoto T, Tsutsui H, Okamura H (2001) Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu. Cytokine Growth Factor Rev 12:53-72
12. Nakanishi K, Yoshimoto T, Tsutsui H, Okamura H (2001) Interleukin-18 regulates both Th1 and Th2 responses. Annu Rev Immunol 19:423-474
13. Omoto Y, Tokime K, Yamanaka K, Habe K, Morioka T, Kurokawa I, Tsutsui H, Yamanishi K, Nakanishi K, Mizutani H (2006) Human mast cell chymase cleaves pro-IL-18 and generates a novel and biologically active IL-18 fragment. J Immunol 177:8315-8319
14. Omoto Y, Yamanaka K, Tokime K, Kitano S, Kakeda M, Akeda T, Kurokawa I, Gabazza EC, Tsutsui H, Katayama N, Yamanishi K, Nakanishi K, Mizutani H (2010) Granzyme B is a novel interleukin-18 converting enzyme. J Dermatol Sci 59:129-135
15. Park HJ, Kim JE, Lee JY, Cho BK, Lee WJ, Kim T, Yoon D, Cho D (2004) Increased expression of IL-18 in cutaneous graft-versus-host disease. Immunol Lett 95:57-61
16. Tsutsui H, Kayagaki N, Kuida K, Nakano H, Hayashi N, Takeda K, Matsui K, Kashiwamura S, Hada T, Akira S, Yagita H, Okamura H, Nakanishi K (1999) Caspase-1-independent, Fas/Fas ligand-mediated IL-18 secretion from macrophages causes acute liver injury in mice. Immunity 11:359-367
17. Wang D, Drenker M, Eiz-Vesper B, Werfel T, Wittmann M (2008) Evidence for a pathogenetic role of interleukin-18 in cutaneous lupus erythematosus. Arthritis Rheum 58:3205-3215
18. Wittmann M, Macdonald A, Renne J (2009) IL-18 and skin inflammation. Autoimmun Rev 9:45-48
19. Yamanaka K, Clark R, Dowgiert R, Hurwitz D, Shibata M, Rich BE, Hirahara K, Jones DA, Eapen S, Mizutani H, Kupper TS (2006) Expression of interleukin-18 and caspase-1 in cutaneous T-cell lymphoma. Clin Cancer Res 12:376-382