Efemp1 induces γ-secretase/notch-mediated temozolomide resistance in glioblastoma

Oncotarget

Volumn 5, Issue 2, 2014, Pages 363-374

  Hiddingh, Lotte ^a,b   Tannous, Bakhos A ^c   Teng, Jian ^c   Tops, Bas ^d   Jeuken, Judith ^d,e   Hulleman, Esther ^a,b   Boots Sprenger, Sandra H ^d   Peter Vandertop, W ^a   Noske, David P ^a,b   Kaspers, Gertjan J L ^a   Wesseling, Pieter ^a,d   Wurdinger, Thomas ^a,b,c  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b Amsterdam Gastroenterology Metabolism   (Netherlands)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^e Stichting Laboratoria voor Pathologie en Medische Microbiologie   (Netherlands)

Author keywords

EFEMP1; Glioblastoma; GSI; Notch; Temozolomide resistance; secretase

Indexed keywords

GAMMA SECRETASE; MESSENGER RNA; N (6,7 DIHYDRO 6 OXO 5H DIBENZ[B,D]AZEPIN 7 YL) 2,2 DIMETHYL N' (2,2,3,3,3 PENTAFLUOROPROPYL)PROPANEDIAMIDE; NOTCH RECEPTOR; TEMOZOLOMIDE; 2,2-DIMETHYL-N-(6-OXO-6,7-DIHYDRO-5H-DIBENZO(B,D)AZEPIN-7-YL)-N'-(2,2,3,3,3-PENTAFLUOROPROPYL)MALONAMIDE; ALKYLATING AGENT; ANTINEOPLASTIC AGENT; BENZAZEPINE DERIVATIVE; DACARBAZINE; EFEMP1 PROTEIN, HUMAN; SCLEROPROTEIN; SECRETASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CANCER COMBINATION CHEMOTHERAPY; CANCER SURVIVAL; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; EFEMP1 GENE; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE INDUCTION; GENE OVEREXPRESSION; GENE SILENCING; GLIOBLASTOMA; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PHENOTYPIC VARIATION; SIGNAL TRANSDUCTION; TUMOR GENE; UPREGULATION; ANALOGS AND DERIVATIVES; ANIMAL; BIOSYNTHESIS; BRAIN NEOPLASMS; DRUG RESISTANCE; GENE EXPRESSION; GENETIC TRANSFECTION; GENETICS; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BENZAZEPINES; BRAIN NEOPLASMS; CELL LINE, TUMOR; DACARBAZINE; DRUG RESISTANCE, NEOPLASM; EXTRACELLULAR MATRIX PROTEINS; FEMALE; GENE EXPRESSION; GLIOBLASTOMA; HUMANS; MICE; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 84896734240     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.1620     Document Type: Article

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