Fibulin-3 is associated with tumour progression and a poor prognosis in nasopharyngeal carcinomas and inhibits cell migration and invasion via suppressed AKT activity

Journal of Pathology

Volumn 222, Issue 4, 2010, Pages 367-379

  Hwang, Chung Feng ^a,b   Chien, Chih Yen ^a,b   Huang, Shun Cheng ^a   Yin, Yu Fang ^a,b   Huang, Chao Cheng ^a,b   Fang, Fu Min ^a,b   Tsai, Hsin Ting ^a,b   Su, Li Jen ^c   Chen, Chang Han ^a,b  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^c NATIONAL CENTRAL UNIVERSITY   (Taiwan)

Author keywords

Fibulin 3; Invasion; Migration; Nasopharyngeal carcinoma; P AKT

Indexed keywords

FIBULIN 3; PROTEIN; PROTEIN KINASE B; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ADVANCED CANCER; ARTICLE; CANCER STAGING; CANCER SURVIVAL; CELL INVASION; CELL MIGRATION; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; NASOPHARYNX CARCINOMA; PRIORITY JOURNAL; PROGNOSIS; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SURVIVAL RATE; TUMOR GROWTH;

CELL MOVEMENT; DISEASE PROGRESSION; DNA METHYLATION; DNA, NEOPLASM; DOWN-REGULATION; EXTRACELLULAR MATRIX PROTEINS; FEMALE; GENE KNOCKDOWN TECHNIQUES; HUMANS; MALE; MIDDLE AGED; NASOPHARYNGEAL NEOPLASMS; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; NEOPLASM STAGING; POLYMERASE CHAIN REACTION; PROGNOSIS; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-AKT; RNA, SMALL INTERFERING; SURVIVAL ANALYSIS; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL;

EID: 78349279900     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2776     Document Type: Article

References (36)

1. Zeng ZY, Zhou YH, Zhang WL, et al., Gene expression profiling of nasopharyngeal carcinoma reveals the abnormally regulated Wnt signaling pathway. Hum Pathol 2007; 38: 120-133.
2. Yu MC, Yuan JM,. Epidemiology of nasopharyngeal carcinoma. Semin Cancer Biol 2002; 12: 421-429.
3. Pegtel DM, Subramanian A, Sheen TS, et al., Epstein"Barr-virus- encoded LMP2A induces primary epithelial cell migration and invasion: possible role in nasopharyngeal carcinoma metastasis. J Virol 2005; 79: 15430-15442.
4. Vokes EE, Liebowitz DN, Weichselbaum RR,. Nasopharyngeal carcinoma. Lancet 1997; 350: 1087-1091.
5. Hildesheim A, Levine PH,. Etiology of nasopharyngeal carcinoma: a review. Epidemiol Rev 1993; 15: 466-485.
6. Zeng Z, Zhou Y, Xiong W, et al., Analysis of gene expression identifies candidate molecular markers in nasopharyngeal carcinoma using microdissection and cDNA microarray. J Cancer Res Clin Oncol 2007; 133: 71-81.
7. Lo KW, To KF, Huang DP,. Focus on nasopharyngeal carcinoma. Cancer Cell 2004; 5: 423-428.
8. Du ZM, Hu CF, Shao Q, et al., Upregulation of caveolin-1 and CD147 expression in nasopharyngeal carcinoma enhanced tumor cell migration and correlated with poor prognosis of the patients. Int J Cancer 2009; 125: 1832-1841.
9. Steeg PS,. Metastasis suppressors alter the signal transduction of cancer cells. Nature Rev Cancer 2003; 3: 55-63.
10. Horikawa T, Yoshizaki T, Sheen TS, et al., Association of latent membrane protein 1 and matrix metalloproteinase 9 with metastasis in nasopharyngeal carcinoma. Cancer 2000; 89: 715-723.
11. Chou J, Lin YC, Kim J, et al., Nasopharyngeal carcinoma"review of the molecular mechanisms of tumorigenesis. Head Neck 2008; 30: 946-963.
12. Zhang Y, Marmorstein LY,. Focus on molecules: fibulin-3 (EFEMP1). Exp Eye Res 2010; 90: 374-375.
13. Gallagher WM, Currid CA, Whelan LC,. Fibulins and cancer: friend or foe? Trends Mol Med 2005; 11: 336-340.
14. Yoeli-Lerner M, Toker A,. Akt/PKB signaling in cancer: a function in cell motility and invasion. Cell Cycle 2006; 5: 603-605.
15. Cantley LC,. The phosphoinositide 3-kinase pathway. Science 2002; 296: 1655-1657.
16. Ramesh R, Ito I, Gopalan B, et al., Ectopic production of MDA-7/IL-24 inhibits invasion and migration of human lung cancer cells. Mol Ther 2004; 9: 510-518.
17. Chen CH, Lai JM, Chou TY, et al., VEGFA upregulates FLJ10540 and modulates migration and invasion of lung cancer via PI3K/AKT pathway. PLoS One 2009; 4: e5052.
18. Kim D, Kim S, Koh H, et al., Akt/PKB promotes cancer cell invasion via increased motility and metalloproteinase production. FASEB J 2001; 15: 1953-1962.
19. Yoeli-Lerner M, Yiu GK, Rabinovitz I, et al., Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT. Mol Cell 2005; 20: 539-550.
20. Tanno S, Mitsuuchi Y, Altomare DA, et al., AKT activation up-regulates insulin-like growth factor I receptor expression and promotes invasiveness of human pancreatic cancer cells. Cancer Res 2001; 61: 589-593.
21. Greene FL, Page DL, Fleming DI, et al., Pharynx. In: Cancer. American Joint Committee on Cancer, Editor. Cancer Staging Manual (6th edition). Springer-Verlag: New York, 2002; 33-45.
22. Fang FM, Tsai WL, Go SF, et al., Implications of quantitative tumor and nodal regression rates for nasopharyngeal carcinomas after 45 Gy of radiotherapy. Int J Radiat Oncol Biol Phys 2001; 50: 961-969.
23. Lin CT, Wong CI, Chan WY, et al., Establishment and characterization of two nasopharyngeal carcinoma cell lines. Lab Invest 1990; 62: 713-724.
24. Lin CT, Chan WY, Chen W, et al., Characterization of seven newly established nasopharyngeal carcinoma cell lines. Lab Invest 1993; 68: 716-727.
25. Glaser R, Zhang HY, Yao KT, et al., Two epithelial tumor cell lines (HNE-1 and HONE-1) latently infected with Epstein"Barr virus that were derived from nasopharyngeal carcinomas. Proc Natl Acad Sci U S A 1989; 6: 9524-9528.
26. Bhattacharya N, Sarno A, Idler IS, et al., High-throughput detection of nuclear factor-kappaB activity using a sensitive oligo-based chemiluminescent enzyme-linked immunosorbent assay. Int J Cancer 2010; 127: 404-411.
27. Sengupta S, den Boon JA, Chen IH, et al., Genome-wide expression profiling reveals EBV-associated inhibition of MHC class I expression in nasopharyngeal carcinoma. Cancer Res 2006; 66: 7999-8006.
28. Nomoto S, Kanda M, Okamura Y, et al., Epidermal growth factor-containing fibulin-like extracellular matrix protein 1, EFEMP1, a novel tumor-suppressor gene detected in hepatocellular carcinoma using double combination array analysis. Ann Surg Oncol 2010; 17: 923-932.
29. Sadr-Nabavi A, Ramser J, Volkmann J, et al., Decreased expression of angiogenesis antagonist EFEMP1 in sporadic breast cancer is caused by aberrant promoter methylation and points to an impact of EFEMP1 as molecular biomarker. Int J Cancer 2009; 124: 1727-1735.
30. Yue W, Dacic S, Sun Q, et al., Frequent inactivation of RAMP2, EFEMP1 and Dutt1 in lung cancer by promoter hypermethylation. Clin Cancer Res 2007; 13: 4336-4344.
31. Albig AR, Neil JR, Schiemann WP,. Fibulins 3 and 5 antagonize tumor angiogenesis in vivo. Cancer Res 2006; 66: 2621-2629.
32. Hu B, Thirtamara-Rajamani KK, Sim H, et al., Fibulin-3 is uniquely upregulated in malignant gliomas and promotes tumor cell motility and invasion. Mol Cancer Res 2009; 7: 1756-1770.
33. Yang L, Xiao L, Ma X, et al., Effect of DNAzymes targeting Akt1 on cell proliferation and apoptosis in nasopharyngeal carcinoma. Cancer Biol Ther 2009; 8: 366-371.
34. Worsham MJ, Pals G, Schouten JP, et al., Delineating genetic pathways of disease progression in head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 2003; 129: 702-708.
35. Chen CH, Lu PJ, Chen YC, et al., FLJ10540-elicited cell transformation is through the activation of PI3-kinase/AKT pathway. Oncogene 2007; 26: 4272-4283.
36. Toker A, Yoeli-Lerner M,. Akt signaling and cancer: surviving but not moving on. Cancer Res 2006; 66: 3963-3966.