Monosaccharide digitoxin derivative sensitize human non-small cell lung cancer cells to anoikis through Mcl-1 proteasomal degradation

Biochemical Pharmacology

Volumn 88, Issue 1, 2014, Pages 23-35

  Pongrakhananon, Varisa ^a,b   Stueckle, Todd A ^b,c   Wang, Hua Yu Leo ^d   O'Doherty, George A ^d   Dinu, Cerasela Zoica ^e   Chanvorachote, Pithi ^a   Rojanasakul, Yon ^b  

^a CHULALONGKORN UNIVERSITY   (Thailand)

^b WEST VIRGINIA UNIVERSITY   (United States)

^c NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

^d NORTHEASTERN UNIVERSITY   (United States)

^e West Virginia University   (United States)

Author keywords

Anoikis; Glycogen synthase kinase 3 ; Mcl 1; Metastasis; Monosaccharide digitoxin derivative; NSCLC

Indexed keywords

ALPHA LEVO RHAMNOSE; CARDIAC GLYCOSIDE; CASPASE 9; DIGITOXIN; GLYCOGEN SYNTHASE KINASE 3BETA; MONOSACCHARIDE DIGITOXIN; PROTEIN BCL 2; PROTEIN MCL 1; RHAMNOSE; UBIQUITIN; UNCLASSIFIED DRUG; ANTIMETASTATIC AGENT; CASPASE 8; D6 MA; MUTANT PROTEIN;

ADVANCED CANCER; ANOIKIS; APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER THERAPY; CARCINOGENESIS; CELL DEATH; CELL LYSATE; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOTOXICITY; EPITHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LUNG NON SMALL CELL CANCER; METASTASIS INHIBITION; METASTASIS POTENTIAL; MOLECULAR THERAPY; PRIORITY JOURNAL; PROTEIN DEGRADATION; REAL TIME POLYMERASE CHAIN REACTION; TRANSIENT TRANSFECTION; TUMOR INVASION; WESTERN BLOTTING; A549 CELL LINE; CANCER CHEMOTHERAPY; CHEMOSENSITIZATION; COMPARATIVE EFFECTIVENESS; DRUG CYTOTOXICITY; DRUG SENSITIZATION; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE OVEREXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; LUNG CANCER CELL LINE; NON SMALL CELL LUNG CANCER; PROTEIN FAMILY; RESPIRATORY EPITHELIUM; SIGNAL TRANSDUCTION;

ANOIKIS; GLYCOGEN SYNTHASE KINASE-3Β; MCL-1; METASTASIS; MONOSACCHARIDE DIGITOXIN DERIVATIVE; NSCLC;

ANOIKIS; ANTINEOPLASTIC AGENTS; CARCINOMA, NON-SMALL-CELL LUNG; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; DIGITOXIN; HUMANS; LUNG NEOPLASMS; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN;

EID: 84896733728     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.10.027     Document Type: Article

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