The de novo synthesis of oligosaccharides: Application to the medicinal chemistry SAR-study of digitoxin

Current Topics in Medicinal Chemistry

Volumn 8, Issue 2, 2008, Pages 114-125

  Zhou, Maoquan ^a   O'Doherty, George ^a  

^a WEST VIRGINIA UNIVERSITY   (United States)

Author keywords

Antitumor agent; Carbohydrate synthesis; Cardiac glycoside; De novo synthesis; Digitoxin; Oligosaccharide synthesis; Palladium catalyzed glycosylation; Unnatural sugars

Indexed keywords

AGLYCONE; ANTINEOPLASTIC AGENT; AOB 0401; CARDIAC GLYCOSIDE; DIGITALIS; DIGITOXIGENIN; DIGITOXIN; DIGOXIGENIN; DIGOXIN; DISACCHARIDE; GITOXIGENIN; GITOXIN; MONOSACCHARIDE; NATURAL PRODUCT; NEOGLYCOSIDE; OLEANDRIN; OLIGOSACCHARIDE; PALLADIUM; PLANT EXTRACT; TRISACCHARIDE; XENAVEX; DRUG DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CANCER CELL; CANCER INHIBITION; CATALYSIS; CHIRALITY; CLINICAL TRIAL; CONGESTIVE HEART FAILURE; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG EFFICACY; DRUG HYDROXYLATION; DRUG MECHANISM; DRUG POTENCY; DRUG RESEARCH; DRUG SAFETY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOSELECTIVITY; GLYCOSYLATION; HEART ARRHYTHMIA; HEART MUSCLE CONTRACTILE FORCE; HUMAN; MALIGNANT NEOPLASTIC DISEASE; METHODOLOGY; NONHUMAN; REVIEW; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; UNSPECIFIED SIDE EFFECT; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; STEREOISOMERISM; SYNTHESIS;

ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; CHEMISTRY, PHARMACEUTICAL; DIGITOXIN; HUMANS; MOLECULAR STRUCTURE; OLIGOSACCHARIDES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 40549101093     PISSN: 15680266     EISSN: None     Source Type: Journal    
DOI: 10.2174/156802608783378828     Document Type: Review

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