Platelet activating factor induces transient blood-brain barrier opening to facilitate edaravone penetration into the brain

Journal of Neurochemistry

Volumn 128, Issue 5, 2014, Pages 662-671

  Fang, Weirong ^a   Zhang, Rui ^a   Sha, Lan ^a   Lv, Peng ^a   Shang, Erxin ^b   Han, Dan ^a   Wei, Jie ^a   Geng, Xiaohan ^a   Yang, Qichuan ^a   Li, Yunman ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

blood brain barrier; edaravone; microdialysis; platelet activating factor

Indexed keywords

ALBUMIN I 125; EVANS BLUE; GELATINASE B; INTERCELLULAR ADHESION MOLECULE 1; MULTIDRUG RESISTANCE PROTEIN; NORPHENAZONE; THROMBOCYTE ACTIVATING FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BLOOD VESSEL PERMEABILITY; BRAIN BLOOD FLOW; BRAIN CAPILLARY ENDOTHELIAL CELL; BRAIN EDEMA; CELL VIABILITY; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG BRAIN LEVEL; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG MECHANISM; DRUG PENETRATION; DRUG POTENTIATION; EXTRAVASATION; IN VITRO STUDY; IN VIVO STUDY; INTERSTITIAL FLUID; MALE; MEMBRANE DAMAGE; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; TIME OF FLIGHT MASS SPECTROMETRY; TRANSIENT BLOOD BRAIN BARRIER OPENING; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

RATTUS;

BLOOD-BRAIN BARRIER; EDARAVONE; MICRODIALYSIS; PLATELET ACTIVATING FACTOR;

ANIMALS; ANTIPYRINE; BLOOD-BRAIN BARRIER; BLOTTING, WESTERN; BRAIN; BRAIN EDEMA; CAPILLARIES; CEREBROSPINAL FLUID; CEREBROVASCULAR CIRCULATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COLORING AGENTS; E-SELECTIN; ENDOTHELIAL CELLS; EVANS BLUE; FLOW CYTOMETRY; INFUSIONS, INTRAVENOUS; MALE; MATRIX METALLOPROTEINASE 9; MICRODIALYSIS; NEUROPROTECTIVE AGENTS; P-GLYCOPROTEINS; PLATELET ACTIVATING FACTOR; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; SERUM ALBUMIN, RADIO-IODINATED; TETRAZOLIUM SALTS; THIAZOLES;

EID: 84896730268     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12507     Document Type: Article

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