Penetration of verapamil across blood brain barrier following cerebral ischemia depending on both paracellular pathway and P-glycoprotein transportation

Neurochemistry International

Volumn 62, Issue 1, 2013, Pages 23-30

  Fang, Weirong ^a   Lv, Peng ^b   Geng, Xiaohan ^c   Shang, Erxin ^d   Yang, Qichuan ^a   Sha, Lan ^a   Li, Yunman ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b Jiangsu Chia Tai Tianqing Pharmaceutical Co Ltd   (China)

^c GenScript ^*  (China)

^d NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Blood brain barrier; Cerebral ischemia; P glycoprotein; Verapamil

Indexed keywords

ALBUMIN I 125; EVANS BLUE; GELATINASE B; INTERCELLULAR ADHESION MOLECULE 1; MULTIDRUG RESISTANCE PROTEIN; RHODAMINE 123; VERAPAMIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN; BRAIN HYPOXIA; BRAIN ISCHEMIA; BRAIN MICROCIRCULATION; BRAIN TISSUE; CELL LEVEL; CONTRAST MEDIUM EXTRAVASATION; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG PENETRATION; DRUG TISSUE LEVEL; DRUG TRANSPORT; FLOW CYTOMETRY; GENE OVEREXPRESSION; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR TRANSPORT; MALE; MICROVASCULAR ENDOTHELIAL CELL; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TRANSPORT; RAT; REOXYGENATION; REPERFUSION INJURY; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; WESTERN BLOTTING;

ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; BLOOD-BRAIN BARRIER; BLOTTING, WESTERN; BRAIN ISCHEMIA; CALCIUM CHANNEL BLOCKERS; CAPILLARIES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENDOTHELIAL CELLS; FLOW CYTOMETRY; FLUORESCENT DYES; HYPOXIA, BRAIN; IMMUNOHISTOCHEMISTRY; INDICATORS AND REAGENTS; INTERCELLULAR ADHESION MOLECULE-1; MALE; MASS SPECTROMETRY; MATRIX METALLOPROTEINASE 9; P-GLYCOPROTEIN; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; RHODAMINE 123; VERAPAMIL;

RATTUS;

EID: 84870826919     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2012.10.012     Document Type: Article

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